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Protein

Proliferating cell nuclear antigen

Gene

pcn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA polymerase binding Source: WormBase
  • DNA polymerase processivity factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-4615885 SUMOylation of DNA replication proteins
R-CEL-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching
R-CEL-69166 Removal of the Flap Intermediate
R-CEL-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen
Short name:
PCNA
Gene namesi
Name:pcn-1
ORF Names:W03D2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiW03D2.4 ; CE14512 ; WBGene00003955 ; pcn-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491681 – 263Proliferating cell nuclear antigenAdd BLAST263

Proteomic databases

EPDiO02115
PaxDbiO02115
PeptideAtlasiO02115
PRIDEiO02115

Expressioni

Gene expression databases

BgeeiWBGene00003955 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
mrt-2G5EC443EBI-318162,EBI-323732

GO - Molecular functioni

Protein-protein interaction databases

BioGridi42297, 9 interactors
ComplexPortaliCPX-3721 PCNA homotrimer
DIPiDIP-25347N
IntActiO02115, 12 interactors
MINTiO02115
STRINGi6239.W03D2.4.1

Structurei

3D structure databases

ProteinModelPortaliO02115
SMRiO02115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
GeneTreeiENSGT00390000004965
HOGENOMiHOG000211098
InParanoidiO02115
KOiK04802
OMAiKILRCAG
OrthoDBiEOG091G0GQ7

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

O02115-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEAKLANAG LLKKIVESIK DLVTDAPFDC SETAMSLQAM DSSHVALVSL
60 70 80 90 100
KLEVGLFDTY RCDRTINLGL SLANMSKALK CANNDDTCML KYEENEGDSI
110 120 130 140 150
IFTFADPKRD KTQDVTVKMM DIDSEHLGIP DQDYAVVCEM PAGEFQKTCK
160 170 180 190 200
DLSTFSDSLN ITATKAGIVF TGKGDIGSSV VTYSPSSNTD DETEAVTLEV
210 220 230 240 250
KDPVNVNFSI KYMNQFTKAT ALSDRVRLSL CNDVPVVVEY PIEENGYLRF
260
YLAPKIDDDE NMD
Length:263
Mass (Da):29,036
Last modified:October 19, 2011 - v3
Checksum:iED56F971AC68471C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080786 Genomic DNA Translation: CCD66765.1
PIRiT28761
RefSeqiNP_500466.3, NM_068065.6
UniGeneiCel.6560

Genome annotation databases

EnsemblMetazoaiW03D2.4; W03D2.4; WBGene00003955
GeneIDi177161
KEGGicel:CELE_W03D2.4
UCSCiW03D2.4.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080786 Genomic DNA Translation: CCD66765.1
PIRiT28761
RefSeqiNP_500466.3, NM_068065.6
UniGeneiCel.6560

3D structure databases

ProteinModelPortaliO02115
SMRiO02115
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42297, 9 interactors
ComplexPortaliCPX-3721 PCNA homotrimer
DIPiDIP-25347N
IntActiO02115, 12 interactors
MINTiO02115
STRINGi6239.W03D2.4.1

Proteomic databases

EPDiO02115
PaxDbiO02115
PeptideAtlasiO02115
PRIDEiO02115

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW03D2.4; W03D2.4; WBGene00003955
GeneIDi177161
KEGGicel:CELE_W03D2.4
UCSCiW03D2.4.1 c. elegans

Organism-specific databases

CTDi177161
WormBaseiW03D2.4 ; CE14512 ; WBGene00003955 ; pcn-1

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
GeneTreeiENSGT00390000004965
HOGENOMiHOG000211098
InParanoidiO02115
KOiK04802
OMAiKILRCAG
OrthoDBiEOG091G0GQ7

Enzyme and pathway databases

ReactomeiR-CEL-110312 Translesion synthesis by REV1
R-CEL-110314 Recognition of DNA damage by PCNA-containing replication complex
R-CEL-110320 Translesion Synthesis by POLH
R-CEL-174411 Polymerase switching on the C-strand of the telomere
R-CEL-4615885 SUMOylation of DNA replication proteins
R-CEL-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-CEL-5696400 Dual Incision in GG-NER
R-CEL-6782135 Dual incision in TC-NER
R-CEL-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-CEL-69091 Polymerase switching
R-CEL-69166 Removal of the Flap Intermediate
R-CEL-69183 Processive synthesis on the lagging strand

Miscellaneous databases

PROiPR:O02115

Gene expression databases

BgeeiWBGene00003955 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_CAEEL
AccessioniPrimary (citable) accession number: O02115
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 19, 2011
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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