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Protein

T-box transcription factor 18

Gene

sea-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi171 – 364T-boxPROSITE-ProRule annotationAdd BLAST194

GO - Molecular functioni

GO - Biological processi

  • dosage compensation by hypoactivation of X chromosome Source: WormBase
  • positive regulation of transcription by RNA polymerase II Source: WormBase
  • sex determination Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor 18
Alternative name(s):
Signal element on autosome protein 1
Gene namesi
Name:sea-1
Synonyms:tbx-18
ORF Names:F19B10.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF19B10.9 ; CE09476 ; WBGene00004750 ; sea-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844751 – 376T-box transcription factor 18Add BLAST376

Proteomic databases

PaxDbiO02073

Expressioni

Gene expression databases

BgeeiWBGene00004750 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F19B10.9

Structurei

3D structure databases

ProteinModelPortaliO02073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 71Ser-richAdd BLAST38

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00730000114153
InParanoidiO02073
OMAiHAYLRNT
OrthoDBiEOG091G1PF4
PhylomeDBiO02073

Family and domain databases

Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

O02073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTIININNN NQKYPQSAEE YHKVLCNYFI TLQSAMQSTS RPSSSSPPSL
60 70 80 90 100
PAVSSELLSS SFPTNAPESS SRDLAPKQNQ FTINVVLFDE KKKKNPEENL
110 120 130 140 150
PANGDQLATL RSLMMQINPS SPPSIPATSP QLPLAESENV PESSSTLKDH
160 170 180 190 200
KFSLNTMLFN VKKNDAVKIS LANQEQWAKF HEIGTEMMVF NSGRRLFPLL
210 220 230 240 250
AYKVSGLDPH KLYCAGVHMI PDSAYKQEYD HDLQQWVNCL NQKKTIFKPT
260 270 280 290 300
SEILGRIENG FKLMSLGIDM SDVKIFNIAI RKKTPLQIEK SRKPNLDKTI
310 320 330 340 350
EVLIQYKYLP VIKIYELSNS GMEKKEIAQA TFPETSFVTV SIYRNQKIKE
360 370
MKTLGNKYCR TDRKQIVMEQ RGELEQ
Length:376
Mass (Da):42,705
Last modified:July 1, 1997 - v1
Checksum:i627864FA475D8D07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081177 Genomic DNA Translation: CCD69699.1
PIRiT15166
RefSeqiNP_494611.1, NM_062210.5
UniGeneiCel.15351

Genome annotation databases

EnsemblMetazoaiF19B10.9; F19B10.9; WBGene00004750
GeneIDi173710
KEGGicel:CELE_F19B10.9
UCSCiF19B10.9 c. elegans

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081177 Genomic DNA Translation: CCD69699.1
PIRiT15166
RefSeqiNP_494611.1, NM_062210.5
UniGeneiCel.15351

3D structure databases

ProteinModelPortaliO02073
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F19B10.9

Proteomic databases

PaxDbiO02073

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF19B10.9; F19B10.9; WBGene00004750
GeneIDi173710
KEGGicel:CELE_F19B10.9
UCSCiF19B10.9 c. elegans

Organism-specific databases

CTDi173710
WormBaseiF19B10.9 ; CE09476 ; WBGene00004750 ; sea-1

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00730000114153
InParanoidiO02073
OMAiHAYLRNT
OrthoDBiEOG091G1PF4
PhylomeDBiO02073

Miscellaneous databases

PROiPR:O02073

Gene expression databases

BgeeiWBGene00004750 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS50252 TBOX_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBX18_CAEEL
AccessioniPrimary (citable) accession number: O02073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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