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Entry version 96 (07 Apr 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene
N/A
Organism
Cyanea capillata (Lion's mane jellyfish) (Cyanea arctica)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.11.14, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCyanea capillata (Lion's mane jellyfish) (Cyanea arctica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri27804 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaScyphozoaSemaeostomeaeCyaneidaeCyanea

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei153 – 172HelicalSequence analysisAdd BLAST20
Transmembranei184 – 201HelicalSequence analysisAdd BLAST18
Transmembranei246 – 263HelicalSequence analysisAdd BLAST18
Transmembranei358 – 380HelicalSequence analysisAdd BLAST23
Transmembranei498 – 516HelicalSequence analysisAdd BLAST19
Transmembranei536 – 557HelicalSequence analysisAdd BLAST22
Transmembranei627 – 646HelicalSequence analysisAdd BLAST20
Transmembranei701 – 727HelicalSequence analysisAdd BLAST27
Transmembranei870 – 889HelicalSequence analysisAdd BLAST20
Transmembranei901 – 923HelicalSequence analysisAdd BLAST23
Transmembranei943 – 967HelicalSequence analysisAdd BLAST25
Transmembranei988 – 1021HelicalSequence analysisAdd BLAST34
Transmembranei1113 – 1137HelicalSequence analysisAdd BLAST25
Transmembranei1190 – 1211HelicalSequence analysisAdd BLAST22
Transmembranei1223 – 1243HelicalSequence analysisAdd BLAST21
Transmembranei1255 – 1274HelicalSequence analysisAdd BLAST20
Transmembranei1315 – 1333HelicalSequence analysisAdd BLAST19
Transmembranei1403 – 1426HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1564 – 1598Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 54DisorderedSequence analysisAdd BLAST54
Regioni758 – 823DisorderedSequence analysisAdd BLAST66
Regioni1622 – 1649DisorderedSequence analysisAdd BLAST28
Regioni1672 – 1754DisorderedSequence analysisAdd BLAST83
Regioni1768 – 1826DisorderedSequence analysisAdd BLAST59
Regioni1867 – 1911DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 29PolyampholyteSequence analysisAdd BLAST22
Compositional biasi758 – 778PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1622 – 1647PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1672 – 1718PolarSequence analysisAdd BLAST47
Compositional biasi1768 – 1823PolarSequence analysisAdd BLAST56
Compositional biasi1885 – 1911PolarSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL
PR01630, LVDCCALPHA1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O02038-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFDVQVKQSD GETERQGKWE SRPSEDDDDS IPFENSSPQY DWDDNDLTSG
60 70 80 90 100
KDQDDEKNLA LLATQKMATS TYPTKKTKKQ PGAGQNLRPK RALFCLTLDN
110 120 130 140 150
PVRSAAITIV DWKPFDFFIL ASIFANCAAL AAYEPLPAGD MTSTNQDLEV
160 170 180 190 200
AEYFFLAVFA IEGLLKIIAY GFILHPGAYL RNGWNILDFS IVVIGFASMI
210 220 230 240 250
FEEYLKSGFD VKALRAFRVL RPLRLVSGVP SLQVVMNSIV KAMLPLFHIA
260 270 280 290 300
LLVVFVIIIY AIIGVELFTG KLHQTCYDNI TNLPASSEPK PCSTTTSYGR
310 320 330 340 350
QCPSGSICKN NWEGPNYGIT NFDNVALAAL TVFQCTTLEG WTDVLYDINN
360 370 380 390 400
VSGGGWPWIY FVTLITFGSF FVLNLILGVL SGEFAKEKAR QTKSGEFHKI
410 420 430 440 450
REKHMLDDAV KGYLDWINQA SDIENVTVTQ EGAVEPGDST SERKLSSRRA
460 470 480 490 500
SGISHASSGI YNIAAPNPLT TKERIEKNLT KFHHRLRRQC RGIVKSQTFY
510 520 530 540 550
WMVIIAVFLN SLVLAVEHYD QPDYITMFLD RANYFFLGLF TFEMLLKIYC
560 570 580 590 600
LGIYGYLNSL FNRFDCLVVL SSLLEVAITV PTGWPPIGIS VLRCVRLLRI
610 620 630 640 650
FKVTRYWESL SNLVQSLVNS IKSIGSLLLL LSLFILIFSL LGMQIFGGRF
660 670 680 690 700
NLDEQAPPRT NFDSFWRSLI TVFQILTGED WNAVMYVGIQ SWGGIKNPSS
710 720 730 740 750
IIAIIYFVAL VIVGNYILLN VFLAIAVDNL ADAENMTKVN EEEKRKKKDA
760 770 780 790 800
KLMKKLARKK MDSLDSAEGK KETTESITDG SKDPLSGSEG PEDVELGNPK
810 820 830 840 850
SKNGTLRHMG ETTSTEMSEG KEARIRPLRL SELNLLKDIP DPMPPESSFF
860 870 880 890 900
IFSANNKLRY LCYRLAVNKI FINSILVLII MSSVALAAED PIGRDVLRNK
910 920 930 940 950
ILGYFDIFFT AMFTFEVTVK MIAFGVILHK RSFCRSFFNQ LDLVIVAVSW
960 970 980 990 1000
AAIMLSRGSA TSVVRILRVL RVLRPLRAIN RAKGLKHVVQ CVFLAIKSIG
1010 1020 1030 1040 1050
NIMIVTLLFQ FLFAVIGIQL FKGTFFYCTD RSKMTAEECK GTFNSYPEVN
1060 1070 1080 1090 1100
LANPVVAART WEKHTFRFDN VFQAYLSLFV VMTFEGWPSI LEHSIDSTTV
1110 1120 1130 1140 1150
NQGPKFNNRP FVAIYYVIYI IIIAFFMINI FVGFVIVTFQ NEGEEEFADC
1160 1170 1180 1190 1200
ELDKNQRKCV EYVLTVKPTY RFVPRKRFQY HIWRVVTSRL FEYMIFGFIL
1210 1220 1230 1240 1250
GNTIVLAAQY HNASKLYERV LDGFNIGFTA VFLLECVLKL MAFNAKNYFR
1260 1270 1280 1290 1300
DPWNIFDFVI VVGSIADIII GEISKDGGIK VNFFRLFRAL RLVKLLSQGD
1310 1320 1330 1340 1350
GIRTLLWTFM KSFQALPFVG LLILLLFFIY AVIGMQVFGT IRLDSGTVIN
1360 1370 1380 1390 1400
SNNNFQTFPQ ALIVLFRSAT GENWQQIMMA CVNSESVKCE VDPSKTCGTD
1410 1420 1430 1440 1450
FAYLYFMSFY MICSFLIINL FVAVIMDNFD YLTRDWSILG AHHLEEYVRI
1460 1470 1480 1490 1500
WAEYDPEASG RMKHVDIVSM LKRIEPPLGF GKCCPHREAC KRLVSMNMMM
1510 1520 1530 1540 1550
NNDGTVDFHA TLFALVRTSL NIKKPDATET ILHANNELRG ILKHLWPRTN
1560 1570 1580 1590 1600
ENLFDKLIPP PDYAEGITVG KFYATFLIQE YFRKFKKKRQ EERKKKNADS
1610 1620 1630 1640 1650
TVALKAGLRT LQELGPKIKR AISGDLMEEG TKEEEEKEKE PNKRHSFMAG
1660 1670 1680 1690 1700
LRKGIISSFA GDKKRNSYYN ALQDTPKQTP KQTPTSSVSH LAAPNTQGKR
1710 1720 1730 1740 1750
ISLPSLQTKT NSSQDNIPRG ALHEGPSIMQ RLSPRLKRKG QRPKSTPFEI
1760 1770 1780 1790 1800
IHHDSDDLAL PQIVLSSQSD VSNPSSKDRD NSRSSTPQHA SSIPGADLNS
1810 1820 1830 1840 1850
NLLDSNLGPR RSRSSSTSSL VGQALAHEGV PQDEAILRTV QKELSDSLNI
1860 1870 1880 1890 1900
SESQLEGAAR NIIYDFEKES GTSIPPPEAA PPQEQPNAEQ LSPYNDNNDN
1910
RSSRPDRTSY L
Length:1,911
Mass (Da):215,698
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43D29A672436A8C3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U93075 mRNA Translation: AAC63050.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43048

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93075 mRNA Translation: AAC63050.1
PIRiT43048

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.1.11.14, the voltage-gated ion channel (vic) superfamily

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 2 hits
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO02038_CYACP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O02038
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: April 7, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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