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Entry version 124 (08 May 2019)
Sequence version 4 (01 Mar 2004)
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Protein
Submitted name:

PhosphatidylInositol Glycan anchor biosynthesis class O

Gene

pigo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mannose-ethanolamine phosphotransferase activity Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PhosphatidylInositol Glycan anchor biosynthesis class OImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pigo-1Imported
ORF Names:C27A12.9Imported, CELE_C27A12.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C27A12.9 ; CE36272 ; WBGene00016159 ; pigo-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 27HelicalSequence analysisAdd BLAST22
Transmembranei591 – 612HelicalSequence analysisAdd BLAST22
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Transmembranei693 – 720HelicalSequence analysisAdd BLAST28
Transmembranei727 – 749HelicalSequence analysisAdd BLAST23
Transmembranei769 – 791HelicalSequence analysisAdd BLAST23
Transmembranei812 – 829HelicalSequence analysisAdd BLAST18
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O01966

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O01966

PeptideAtlas

More...
PeptideAtlasi
O01966

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00016159 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C27A12.9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2126 Eukaryota
COG1524 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00910000144278

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O01966

KEGG Orthology (KO)

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KOi
K05288

Identification of Orthologs from Complete Genome Data

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OMAi
CEATIFS

Database of Orthologous Groups

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OrthoDBi
848878at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O01966

Family and domain databases

Conserved Domains Database

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CDDi
cd16023 GPI_EPT_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR002591 Phosphodiest/P_Trfase
IPR037675 PIG-O_N
IPR039524 PIGO/GPI13

The PANTHER Classification System

More...
PANTHERi
PTHR23071 PTHR23071, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01663 Phosphodiest, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53649 SSF53649, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O01966-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSIIRILLV SINILLALFI FQNGFLLKRQ EILSKSSCSD AHAQPGQTCW
60 70 80 90 100
MKQQYQRVIL ILVDALRYDF LIPIDENTKK SKEEWYYRGQ MKNIEKLVKS
110 120 130 140 150
GNVSIGTLLA DPPTTTLQRL KALTTGTLPT FIDAGDNFSP DAVISEDSFV
160 170 180 190 200
YQAAQLGKNV TLLGDDTWLS LFPNQFSKTA AYDSFDINDL NTVDDKIAPI
210 220 230 240 250
LQDEMLNSNS SIIIAHFLGV DHCGHKFGPS HPVMADTLRK MDRIIGQTIE
260 270 280 290 300
TMKSDDHGMT STGDHGGESE NEIRAGILVH SKKHQIILPE RPIHQIDIVP
310 320 330 340 350
TISLLMGLPI PFSNLGTVIT QLFTRDLWEI AVGMNYEQVK RFAETYAAQK
360 370 380 390 400
NFGELHSHTI RDSNTMEEQL DTMSRIQTLL RVSWTQFDDA YINAGIFSLV
410 420 430 440 450
EAIMFLITNE VMSLEWIIYR TGCGLLQAAL LTDKTDSDGS ARTLLLMTLA
460 470 480 490 500
VSCLSSIISM CHKALQIRIS IKSMLSAKVI GPILVIIHSI SLFSNSYVVY
510 520 530 540 550
EAQVVRYFLQ SLVTLVFLEK LRSTALRPRK PFKLNFLWKF VNQDQNLIIF
560 570 580 590 600
TLIMVGLRSE PIFHRCREEE VGCDTYYPSR QAGSLTRDAQ VVRLLFALGS
610 620 630 640 650
LAVANLSVFK YYGLRDTKSQ IESNSKRSSE TIRILSATSW LHIAIIVLHS
660 670 680 690 700
VFASLTHDVS RANLSAHSLS VISLICAVLA WREGNSAICA HFLLMPVYIL
710 720 730 740 750
FGDGLIPAII IFIAVSVLIA EFVSREFIAS TIALLIPLGF YHLGHSPVIS
760 770 780 790 800
SIPWNAAFVG IPGGTALRVL PALFVLFHLN FSAISSIFVI SSESESSQKM
810 820 830 840 850
SAPNTAWTLT ETLVLMTIRA TLTCLVSSIH RRHLMVWKIF APKFIFECIL
860 870 880
TIVFIFSANF FLIYRQFFGE KFKNSEAKIN KLH
Length:883
Mass (Da):98,903
Last modified:March 1, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BB25E734BBB405D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD61207.1

Protein sequence database of the Protein Information Resource

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PIRi
A87794

NCBI Reference Sequences

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RefSeqi
NP_491750.3, NM_059349.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C27A12.9; C27A12.9; WBGene00016159

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172285

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C27A12.9

UCSC genome browser

More...
UCSCi
C27A12.9 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD61207.1
PIRiA87794
RefSeqiNP_491750.3, NM_059349.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C27A12.9

Proteomic databases

EPDiO01966
PaxDbiO01966
PeptideAtlasiO01966

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC27A12.9; C27A12.9; WBGene00016159
GeneIDi172285
KEGGicel:CELE_C27A12.9
UCSCiC27A12.9 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172285
WormBaseiC27A12.9 ; CE36272 ; WBGene00016159 ; pigo-1

Phylogenomic databases

eggNOGiKOG2126 Eukaryota
COG1524 LUCA
GeneTreeiENSGT00910000144278
InParanoidiO01966
KOiK05288
OMAiCEATIFS
OrthoDBi848878at2759
PhylomeDBiO01966

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O01966

Gene expression databases

BgeeiWBGene00016159 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

CDDicd16023 GPI_EPT_3, 1 hit
Gene3Di3.40.720.10, 1 hit
InterProiView protein in InterPro
IPR017850 Alkaline_phosphatase_core_sf
IPR002591 Phosphodiest/P_Trfase
IPR037675 PIG-O_N
IPR039524 PIGO/GPI13
PANTHERiPTHR23071 PTHR23071, 1 hit
PfamiView protein in Pfam
PF01663 Phosphodiest, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO01966_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01966
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: March 1, 2004
Last modified: May 8, 2019
This is version 124 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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