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Protein

30 kDa salivary gland allergen Aed a 3

Gene

AAEL010235

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
30 kDa salivary gland allergen Aed a 3
Alternative name(s):
Allergen: Aed a 3
Gene namesi
ORF Names:AAEL010235
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3054 Aed a 3.0101
5 Aed a 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002067620 – 27330 kDa salivary gland allergen Aed a 3Add BLAST254

Expressioni

Tissue specificityi

Adult female salivary gland.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiO01949, 2 interactors
MINTiO01949

Structurei

3D structure databases

ProteinModelPortaliO01949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 146Glu-richAdd BLAST123

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiO01949
OMAiHIQSEYL
OrthoDBiEOG091G0SV9

Family and domain databases

InterProiView protein in InterPro
IPR017262 Salivary_gland_allergen_Aed3
PIRSFiPIRSF037682 Salivary_gland_allergen_Aed3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: O01949-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPLVKLFLL FCLVGIVLSR PMPEDEEPVA EGGDDDASGE SEGEEETTDD
60 70 80 90 100
AGGDGGEEEN EGEEHAGDKD AGGEDTGKEE NTGHDDAGEE DAGEEDAGEE
110 120 130 140 150
DAGEEDAGEE DAEKEEGEKE DAGDDAGSDD GEEDSTGGDE GEDNAEDSKG
160 170 180 190 200
SEKNDPADTY RQVVALLDKD TKVDHIQSEY LRSALNNDLQ SEVRVPVVEA
210 220 230 240 250
IGRIGDYSKI QGCFKSMGKD VKKVISEEEK KFKSCMSKKK SEYQCSEDSF
260 270
AAAKSKLSPI TSKIKSCVSS KGR
Length:273
Mass (Da):29,155
Last modified:July 22, 2008 - v2
Checksum:iC827EFA0FE76E721
GO
Isoform 1 (identifier: O01949-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-44: Missing.
     85-94: Missing.

Show »
Length:253
Mass (Da):27,189
Checksum:i6D2F6069E547D01C
GO
Isoform 3 (identifier: O01949-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-44: Missing.
     85-89: Missing.

Show »
Length:258
Mass (Da):27,691
Checksum:iD0D8AF65DCFE1581
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69K → E in AAB58417 (Ref. 1) Curated1
Sequence conflicti69K → E in ABF18125 (PubMed:17204158).Curated1
Sequence conflicti143D → A in AAB58417 (Ref. 1) Curated1
Sequence conflicti143D → A in ABF18125 (PubMed:17204158).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03468535 – 44Missing in isoform 1 and isoform 3. 2 Publications10
Alternative sequenceiVSP_03468685 – 94Missing in isoform 1. 1 Publication10
Alternative sequenceiVSP_03468785 – 89Missing in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001927 mRNA Translation: AAB58417.1
DQ440089 mRNA Translation: ABF18122.1
DQ440092 mRNA Translation: ABF18125.1
CH477649 Genomic DNA Translation: EAT37812.1
RefSeqiXP_001660691.1, XM_001660641.1
UniGeneiAae.1631

Genome annotation databases

EnsemblMetazoaiAAEL010235-RA; AAEL010235-PA; AAEL010235 [O01949-1]
GeneIDi5580040
KEGGiaag:5580040

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALL3_AEDAE
AccessioniPrimary (citable) accession number: O01949
Secondary accession number(s): Q1HRK2, Q1HRK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 22, 2008
Last modified: March 28, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries

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