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Entry version 171 (29 Sep 2021)
Sequence version 2 (01 Oct 2001)
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Protein

NAD(P)H oxidase (H(2)O(2)-forming)

Gene

duox-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseARBA annotation
LigandCalciumARBA annotation, FADARBA annotation, Flavoprotein, NADPARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-209968, Thyroxine biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD(P)H oxidase (H(2)O(2)-forming)ARBA annotation (EC:1.6.3.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:duox-2Imported
ORF Names:CELE_F53G12.3Imported, F53G12.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F53G12.3 ; CE24999 ; WBGene00018771 ; duox-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei600 – 622HelicalSequence analysisAdd BLAST23
Transmembranei994 – 1015HelicalSequence analysisAdd BLAST22
Transmembranei1027 – 1054HelicalSequence analysisAdd BLAST28
Transmembranei1066 – 1089HelicalSequence analysisAdd BLAST24
Transmembranei1131 – 1155HelicalSequence analysisAdd BLAST25
Transmembranei1167 – 1184HelicalSequence analysisAdd BLAST18
Transmembranei1196 – 1213HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O01795

PeptideAtlas

More...
PeptideAtlasi
O01795

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00018771, Expressed in adult organism and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F53G12.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O01795

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini861 – 896EF-handInterPro annotationAdd BLAST36
Domaini1217 – 1324FAD-binding FR-typeInterPro annotationAdd BLAST108

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the peroxidase family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0039, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163963

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004482_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O01795

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLEPCVP

Database of Orthologous Groups

More...
OrthoDBi
27424at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O01795

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09820, dual_peroxidase_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl

The PANTHER Classification System

More...
PANTHERi
PTHR11972:SF175, PTHR11972:SF175, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O01795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAENFYNVN NFQSLPLEIK VQFSKETLFS ALQQEAETQR YDGWYNNLAN
60 70 80 90 100
SEWGSAGSRL HRDARSYYSD GVYSVNNSLP SARELSDILF KGESGIPNTR
110 120 130 140 150
GCTTLLAFFS QVVAYEIMQS NGVSCPLETL KIQVPLCDNV FDNECEGKTT
160 170 180 190 200
IPFYRAKYDK ATGNGLNSPR EQINERTSWI DGSFIYGTTQ PWVSALRSFK
210 220 230 240 250
QGRLAEGVPG YPPLNNPHIP LNNPAPPQVH RLMSPDRLFM LGDSRVNENP
260 270 280 290 300
GLLSFGLILF RWHNYNANQI YREHPDWTDE QIFQAARRLV IASMQKIIAY
310 320 330 340 350
DFVPGLLGED VRLSNYTKYM PHVPPGISHA FGAAAFRFPH SIVPPAMLLR
360 370 380 390 400
KRGNKCEFRT EVGGYPALRL CQNWWNAQDI VKEYSVDEII LGMASQIAER
410 420 430 440 450
DDNIVVEDLR DYIFGPMHFS RLDVVASSIM RGRDNGVPPY NELRRTFGLA
460 470 480 490 500
PKTWETMNED FYKKHTAKVE KLKELYGGNI LYLDAYVGGM LEGGENGPGE
510 520 530 540 550
MFKEIIKDQF TRIRDGDRFW FENKLNRLFT DEEVQMIHSI TLRDIIKATT
560 570 580 590 600
DIDETMLQKD VFFFKEGDPC PQPFQVNTIG LEPCAPLIQS TYWDDNDTTY
610 620 630 640 650
IYTLIGLACI PLICYSIGHY MVERRIRIGH NSACDSLTTD FSTESPKVNV
660 670 680 690 700
YKVNALEWLQ EEYIRQVRIE IENTTLTVKK PRGGILRKIR FETGQKIEVF
710 720 730 740 750
HSIPNPSAMH GPFVLLSQKN NHHLVIRLSS DRDLSKFLDQ IRQAASGINA
760 770 780 790 800
EVIIKDEENS ILLSQAITKE RRQDRLDLFF REAYAKAFND SELQDSETSF
810 820 830 840 850
DSSNDDILNE TISREELASA MGMKANNEFV KRMFAMTAKH NEDSLSFNEF
860 870 880 890 900
LTVLREFVNA PQKQKLQTLF KMCDLEGKNK VLRKDLAELV KSLNQTAGVH
910 920 930 940 950
ITESVQLRLF NDVLHKSGVS DDAEYLTCNN FDALFSEISD VQPIGLPFNR
960 970 980 990 1000
KNYNSHIKEP SCHTSFPIVD HSTPAPLSLI QRICAFLETY RQHVFIIFCF
1010 1020 1030 1040 1050
VAINIVLFFE LFWHSRYLNE DRDLRRVMGA GIAITLSSAG ALSFCMALIL
1060 1070 1080 1090 1100
LTVCRNIITL LRETVIAQYI PFDSAIAFHK IVALFTLFWS TLHTIGHCVN
1110 1120 1130 1140 1150
FYHVGTQSDR GLACLFQETF FGSDVVPTLS YWFYGTITGL TGIGLVIVMS
1160 1170 1180 1190 1200
IIYVFALPKF TRRAYHAFRL THLLNIGFYA LTILHGLPSL FGSPKFGYYV
1210 1220 1230 1240 1250
VGPIVLFVID RIIGLMQYYK SLDIAHAEIL PSDIIYIEYR RPREFEYKSG
1260 1270 1280 1290 1300
QWITVSSPSI SCTFNESHAF SIASSPQDEN MKLYIKAVGP WTWKLRSELI
1310 1320 1330 1340 1350
RSLNTGSPFP LIHMKGPYGD GNQEWMNYEV AIMVGAGIGV TPYASTLVDL
1360 1370 1380 1390 1400
VQKTSSDSFH RVRCRKVYFL WVCSSHKNFE WFVDMLKNVE NQAKPGILET
1410 1420 1430 1440 1450
HIFVTQMFHK FDLRTTMLYI CEKHFRATNS GISMFTGLHA KNHFGRPNFK
1460 1470 1480 1490 1500
AFFQFIQSEH KEQSEIGVFS CGPVNLNESI AEGCADANRQ RDAPSFAHRF

ETF
Length:1,503
Mass (Da):171,593
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB429705C221711DF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD71702.1

NCBI Reference Sequences

More...
RefSeqi
NP_490684.1, NM_058283.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F53G12.3.1; F53G12.3.1; WBGene00018771

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
186188

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F53G12.3

UCSC genome browser

More...
UCSCi
F53G12.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD71702.1
RefSeqiNP_490684.1, NM_058283.1

3D structure databases

SMRiO01795
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F53G12.3

Proteomic databases

PaxDbiO01795
PeptideAtlasiO01795

Genome annotation databases

EnsemblMetazoaiF53G12.3.1; F53G12.3.1; WBGene00018771
GeneIDi186188
KEGGicel:CELE_F53G12.3
UCSCiF53G12.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
186188
WormBaseiF53G12.3 ; CE24999 ; WBGene00018771 ; duox-2

Phylogenomic databases

eggNOGiKOG0039, Eukaryota
GeneTreeiENSGT00940000163963
HOGENOMiCLU_004482_1_0_1
InParanoidiO01795
OMAiMLEPCVP
OrthoDBi27424at2759
PhylomeDBiO01795

Enzyme and pathway databases

ReactomeiR-CEL-209968, Thyroxine biosynthesis

Gene expression databases

BgeeiWBGene00018771, Expressed in adult organism and 2 other tissues

Family and domain databases

CDDicd09820, dual_peroxidase_like, 1 hit
Gene3Di1.10.640.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR029595, DUOX1/Duox
IPR034821, DUOX_peroxidase
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR013112, FAD-bd_8
IPR017927, FAD-bd_FR_type
IPR013130, Fe3_Rdtase_TM_dom
IPR013121, Fe_red_NAD-bd_6
IPR039261, FNR_nucleotide-bd
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR017938, Riboflavin_synthase-like_b-brl
PANTHERiPTHR11972:SF175, PTHR11972:SF175, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF08022, FAD_binding_8, 1 hit
PF01794, Ferric_reduct, 1 hit
PF08030, NAD_binding_6, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48113, SSF48113, 1 hit
SSF52343, SSF52343, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit
PS51384, FAD_FR, 1 hit
PS50292, PEROXIDASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO01795_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01795
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: October 1, 2001
Last modified: September 29, 2021
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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