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Entry version 131 (02 Jun 2021)
Sequence version 1 (01 Jul 1997)
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Protein
Submitted name:

Rho-GAP domain-containing protein

Gene

rga-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho-GAP domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rga-3Imported
ORF Names:CELE_K09H11.3Imported, K09H11.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
K09H11.3 ; CE12052 ; WBGene00019600 ; rga-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O01585

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O01585

PeptideAtlas

More...
PeptideAtlasi
O01585

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019600, Expressed in adult organism and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
O01585, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K09H11.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O01585

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 271Rho-GAPInterPro annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni341 – 458DisorderedSequence analysisAdd BLAST118
Regioni550 – 598DisorderedSequence analysisAdd BLAST49
Regioni719 – 754DisorderedSequence analysisAdd BLAST36
Regioni800 – 819DisorderedSequence analysisAdd BLAST20
Regioni837 – 858DisorderedSequence analysisAdd BLAST22
Regioni906 – 956DisorderedSequence analysisAdd BLAST51
Regioni1058 – 1085DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi341 – 360Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi375 – 401Polar residuesSequence analysisAdd BLAST27
Compositional biasi420 – 458Polar residuesSequence analysisAdd BLAST39
Compositional biasi550 – 577Polar residuesSequence analysisAdd BLAST28
Compositional biasi801 – 815Pro residuesSequence analysisAdd BLAST15
Compositional biasi906 – 925Polar residuesSequence analysisAdd BLAST20
Compositional biasi934 – 956Polar residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1453, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_281342_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O01585

Database of Orthologous Groups

More...
OrthoDBi
355465at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15670, PTHR15670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O01585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHNDFRVVT SSSVYRKGST TSGVIAGAGP RPNKFSYTLG EVCSTNVTLD
60 70 80 90 100
VNVGTGWTRI RLKEVPKFIV NAFNIISKHG MDTDGIFRKE GNSVRLNRAE
110 120 130 140 150
VQAIYKGQRD IPNDYSVIDV CTMVKRFLRD LKPPLLDSEE CRARLLKKAC
160 170 180 190 200
QARISDGFLM TRDEMADVFY MEDRTIEQQT PLLSDAHAST LGYVMRQLNR
210 220 230 240 250
IAAHSEQHKM SIENLAIVFI GSVFGDGIHD SKKTPQLRRG SKEDILAQKR
260 270 280 290 300
HEMNVNTAAV KLLITNANLI GVRRDPYVTS NAMLRSSSAM PRCMSSGYET
310 320 330 340 350
LSDADCLSAQ TASLQRREPG PSTPLTIHRR DSEAVHKIVT ARKKGEQDSK
360 370 380 390 400
KKRSASFLPS FRDLKHRFSN MKRTKSPSPE RLTTGHTAEP SKLTDICSLN
410 420 430 440 450
LHTDPHQDPL IHRKKVARNE STTMSTGSTA SGRQSRSHQN RRGNTNATPR
460 470 480 490 500
NNGSGKSTIS TMFESEQILS SGALRRLSAS DRNTDAMRFA KQIMSNEQMN
510 520 530 540 550
VAEFLLSEHQ RNRESKIRKR NTVILGEKPR SNGVKLTNRR HTAPISNRLR
560 570 580 590 600
RNRPNTVGAS LPHRNDSFLN NGSSMEEKEN QADCETDDTL DATNNVDQSE
610 620 630 640 650
WLLEQKALEA RSRREGRKNK AAPMRHISTG SMLVLNGSMA VESTSMLKAE
660 670 680 690 700
PLVMDSLKEE SPQSPQKTPK VVLRKDLDNL KKMKKFCDIA TSPMVMDTPT
710 720 730 740 750
KLSHENGHAW VGTKQVVSVT RTPSLSRRRS RAHLSYSKAT ESPLDKPSEV
760 770 780 790 800
RRESSSLMSP LLKHVTMTNN SAPSQVITSS PRTNLTPRSH TLSPLAVKIK
810 820 830 840 850
RSTPPPIPPH SPPHLTPGKS EVSLDALDDM KRISISDGSR RIPTSPSHPR
860 870 880 890 900
MPKTFSPKLP IRSVSIDNRF EFPVAAAGEP EEPSTQFKLP QLPMPKKMNR
910 920 930 940 950
SGISPLARQA HSSKSTLSVP NRSNLRETKS IEETPTALRS APAQASYQGS
960 970 980 990 1000
SNQMSPRSSD YFEFGKYTNA LRSATDEFAL PSRKASVESR PSVAILRNNN
1010 1020 1030 1040 1050
CGLVRSRVNH FQEIEHLQRV ETSMSGRLSA MSQSSLRSND PFSDRFSDVS
1060 1070 1080
DLRNAAFSES TDSAISTPTA TPTTSRVSND AGQYF
Length:1,085
Mass (Da):120,642
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97D192F9387F4084
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD67874.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G89056

NCBI Reference Sequences

More...
RefSeqi
NP_504503.1, NM_072102.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K09H11.3.1; K09H11.3.1; WBGene00019600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178961

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K09H11.3

UCSC genome browser

More...
UCSCi
K09H11.3, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD67874.1
PIRiG89056
RefSeqiNP_504503.1, NM_072102.3

3D structure databases

SMRiO01585
ModBaseiSearch...

Protein-protein interaction databases

IntActiO01585, 3 interactors
STRINGi6239.K09H11.3

Proteomic databases

EPDiO01585
PaxDbiO01585
PeptideAtlasiO01585

Genome annotation databases

EnsemblMetazoaiK09H11.3.1; K09H11.3.1; WBGene00019600
GeneIDi178961
KEGGicel:CELE_K09H11.3
UCSCiK09H11.3, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178961
WormBaseiK09H11.3 ; CE12052 ; WBGene00019600 ; rga-3

Phylogenomic databases

eggNOGiKOG1453, Eukaryota
GeneTreeiENSGT00940000155312
HOGENOMiCLU_281342_0_0_1
InParanoidiO01585
OrthoDBi355465at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O01585

Gene expression databases

BgeeiWBGene00019600, Expressed in adult organism and 6 other tissues

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PANTHERiPTHR15670, PTHR15670, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO01585_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01585
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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