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Entry version 183 (12 Aug 2020)
Sequence version 3 (01 Oct 2002)
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Protein

Serine/threonine-protein kinase mrck-1

Gene

mrck-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation (PubMed:19675126). Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation (PubMed:25743393).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei112ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei207Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi89 – 97ATPPROSITE-ProRule annotation9
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri957 – 1007Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O01583

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase mrck-1Curated (EC:2.7.11.1By similarity)
Alternative name(s):
Myotonic dystrophy kinase-related CDC42-binding kinase homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mrck-1Imported
ORF Names:K08B12.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
K08B12.5 ; CE30818 ; WBGene00006437 ; mrck-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Normal adult development, but progeny arrest at either the L1 stage or during embryogenesis (PubMed:19675126). RNAi-mediated knockdown causes excretory canal truncation, abnormal lumen and cyst formation. In addition, causes a reduced distribution of Golgi and ER components along the excretory canal length and a decrease in cdc-42 activation (PubMed:25743393).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004323831 – 1592Serine/threonine-protein kinase mrck-1Add BLAST1592

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O01583

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O01583

PeptideAtlas

More...
PeptideAtlasi
O01583

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic and L4 larval seam cells and in embryonic dorsal and ventral epidermal cells. Also expressed in the pharynx throughout development and in sublateral nerve cords in the L4 larva.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006437, Expressed in material anatomical entity and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O01583, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-25790N

STRING: functional protein association networks

More...
STRINGi
6239.K08B12.5.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O01583

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 351Protein kinasePROSITE-ProRule annotationAdd BLAST269
Domaini352 – 426AGC-kinase C-terminalSequence analysisAdd BLAST75
Domaini1026 – 1154PHPROSITE-ProRule annotationAdd BLAST129
Domaini1181 – 1479CNHPROSITE-ProRule annotationAdd BLAST299
Domaini1544 – 1557CRIBPROSITE-ProRule annotationAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili444 – 782Sequence analysisAdd BLAST339
Coiled coili811 – 871Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi516 – 519Poly-GlnSequence analysis4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri957 – 1007Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0612, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203642

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_140_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O01583

Identification of Orthologs from Complete Genome Data

More...
OMAi
STERMGW

Database of Orthologous Groups

More...
OrthoDBi
759391at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O01583

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR001180, CNH_dom
IPR000095, CRIB_dom
IPR011009, Kinase-like_dom_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00036, CNH, 1 hit
SM00285, PBD, 1 hit
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50219, CNH, 1 hit
PS50108, CRIB, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O01583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPPPDDSA PVRLKTLENI YMDGPSKKPE ALSFETLIDS LICLYDECCN
60 70 80 90 100
STLRKEKCIA EFVESVKTVI SKAKKLRLSR DDFEVLKVIG KGAFGEVAVV
110 120 130 140 150
RMRGVGEIYA MKILNKWEMV KRAETACFRE ERDVLVYGDR RWITNLHYAF
160 170 180 190 200
QDEKNLYFVM DYYIGGDMLT LLSKFVDHIP ESMAKFYIAE MVLAIDSLHR
210 220 230 240 250
LGYVHRDVKP DNVLLDMQGH IRLADFGSCL RILADGSVAS NVAVGTPDYI
260 270 280 290 300
SPEILRAMED GRGRYGKECD WWSLGICMYE MLYGTTPFYS ERLVDTYGKI
310 320 330 340 350
MSHQDMLDFP DDEIDWVVSE EAKDLIRQLI CSSDVRFGRN GLSDFQLHPF
360 370 380 390 400
FEGIDWNTIR DSNPPYVPEV SSPEDTSNFD VDVCEDDFTP CLQETQPPRV
410 420 430 440 450
LAAFTGNHLP FVGFSYTHGS LLSDARSLTD EIRAIAQRCQ GDAELMEKSV
460 470 480 490 500
DGFMVELENE KAELVQKLKE AQTIIAQHVA ENPRSEEDRN YESTIAQLKD
510 520 530 540 550
EIQILNKRLE DEALAQQQQK PKDEIVAESE KKLKELKERN KQLVMEKSEI
560 570 580 590 600
QRELDNINDH LDQVLVEKAT VVQQRDDMQA ELADVGDSLL TEKDSVKRLQ
610 620 630 640 650
DEAEKAKKQV ADFEEKLKEI ETEKIALIKK QEEVTIEARK SVETDDHLSE
660 670 680 690 700
EVVAAKNTIA SLQATNEERE TEIKKLKQRM DEERASHTAQ SEQEMKQLEA
710 720 730 740 750
HYERAQKMLQ DNVEQMNVEN RGLRDEIEKL SQQMAALPRG GLNEQQLHEI
760 770 780 790 800
FNWVSEEKAT REEMENLTRK ITGEVESLKN NSPLTTSNYI QNTPSGWGSR
810 820 830 840 850
RMNNVARKDG LDLQRQLQAE IDAKLKLKAE LKNSQEQYLT SAARLDDTEK
860 870 880 890 900
RMASLMREVA MLKQQKNIEN SSDSAFSSTM GRGDLMISMN NDYEMSNSSL
910 920 930 940 950
MRQEMISRQS TPSYENAILL HDHQVPKRVD DLRYKQKPMK TASGIFSPVS
960 970 980 990 1000
ISAMERGHNF ERMKIKTPTK CGHCTSILIG LDRQGLFCQS CQYACHVSCA
1010 1020 1030 1040 1050
ERVSQSCPVP EEERRPLGID PTRGVGTAYE GLVKTPRAGG VRKGWQTAYV
1060 1070 1080 1090 1100
VVCDFKLYLY DCTVDRQNKM QDVKNEIRLV LDMRDPDFTV CGVSEADVIH
1110 1120 1130 1140 1150
AQKGDIPKIF RVTTTQILNS SSEYSSSSKF YTLFMAETEE EKRKWVVALS
1160 1170 1180 1190 1200
ELKTLLRRSK LADRKAFLVK EVFDVTTLPS IRVAQCCAII DRSKIVIGFS
1210 1220 1230 1240 1250
DHGLYCIEIS RQLLIPVGGE KENKQRCVET VEYDEAEQLL MMIVGPAKDR
1260 1270 1280 1290 1300
HVRIVPSAAL DGRDLKWIKV NDTKGCHLLA VGTNNPGGRA GFFAVAFKKS
1310 1320 1330 1340 1350
VTIFQIDRSE KRHKKWKDLA MPGTPQSIAI FNGRLYVGFS HSFRSWSLVG
1360 1370 1380 1390 1400
VDSSPVGSGD ASGAVLQHIS LVNMEDTSLQ FLNQQTSYEA KLIVNVPGSP
1410 1420 1430 1440 1450
DEYLLVFNMI GLYVNEMGRR SRLPEVMFPT QAKYFAYHEP YLCVFSENEV
1460 1470 1480 1490 1500
DIFNVTLAEW VQTINLRSAK PLSGDGILST CLCNDSPIFV LLQNVLQDQD
1510 1520 1530 1540 1550
SIEVPVNLAS GSTDGRKVTR RKFTFRTIGK DDRSASERRS HIQISTPSDF
1560 1570 1580 1590
MHIVHMGPAP VMELQQNFID LQSNHSHTSS DKDSLNRSVN ND
Length:1,592
Mass (Da):180,744
Last modified:October 1, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF909FA8F5C9C876C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AUZ7A0A0K3AUZ7_CAEEL
Non-specific serine/threonine prote...
mrck-1 CELE_K08B12.5, K08B12.5
1,590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AS73A0A0K3AS73_CAEEL
Non-specific serine/threonine prote...
mrck-1 CELE_K08B12.5, K08B12.5
1,310Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AVQ9A0A0K3AVQ9_CAEEL
Non-specific serine/threonine prote...
mrck-1 CELE_K08B12.5, K08B12.5
1,312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0K3AY02A0A0K3AY02_CAEEL
Myotonic dystrophy-Related, Cdc42-b...
mrck-1 CELE_K08B12.5, K08B12.5
913Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO081273 Genomic DNA Translation: CCD70382.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T25808

NCBI Reference Sequences

More...
RefSeqi
NP_504599.2, NM_072198.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K08B12.5a.1; K08B12.5a.1; WBGene00006437
K08B12.5a.2; K08B12.5a.2; WBGene00006437

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179013

UCSC genome browser

More...
UCSCi
K08B12.5.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081273 Genomic DNA Translation: CCD70382.1
PIRiT25808
RefSeqiNP_504599.2, NM_072198.5

3D structure databases

SMRiO01583
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-25790N
STRINGi6239.K08B12.5.2

Proteomic databases

EPDiO01583
PaxDbiO01583
PeptideAtlasiO01583

Genome annotation databases

EnsemblMetazoaiK08B12.5a.1; K08B12.5a.1; WBGene00006437
K08B12.5a.2; K08B12.5a.2; WBGene00006437
GeneIDi179013
UCSCiK08B12.5.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
179013
WormBaseiK08B12.5 ; CE30818 ; WBGene00006437 ; mrck-1

Phylogenomic databases

eggNOGiKOG0612, Eukaryota
GeneTreeiENSGT00990000203642
HOGENOMiCLU_000288_140_3_1
InParanoidiO01583
OMAiSTERMGW
OrthoDBi759391at2759
PhylomeDBiO01583

Enzyme and pathway databases

SignaLinkiO01583

Miscellaneous databases

Protein Ontology

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PROi
PR:O01583

Gene expression databases

BgeeiWBGene00006437, Expressed in material anatomical entity and 5 other tissues
ExpressionAtlasiO01583, baseline and differential

Family and domain databases

CDDicd00029, C1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR001180, CNH_dom
IPR000095, CRIB_dom
IPR011009, Kinase-like_dom_sf
IPR002219, PE/DAG-bd
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00780, CNH, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00036, CNH, 1 hit
SM00285, PBD, 1 hit
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50219, CNH, 1 hit
PS50108, CRIB, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRCK_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01583
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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