Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartic protease 6

Gene

asp-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89PROSITE-ProRule annotation1
Active sitei277PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.A71

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease 6 (EC:3.4.23.-)
Gene namesi
Name:asp-6
ORF Names:F21F8.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF21F8.7 ; CE09542 ; WBGene00000219 ; asp-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000030786416 – 389Aspartic protease 6Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 106By similarity
Disulfide bondi312 ↔ 344By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO01530
PaxDbiO01530
PeptideAtlasiO01530
PRIDEiO01530

Expressioni

Gene expression databases

BgeeiWBGene00000219

Interactioni

Protein-protein interaction databases

BioGridi44250, 4 interactors
DIPiDIP-24896N
IntActiO01530, 5 interactors
MINTiO01530
STRINGi6239.F21F8.7.2

Structurei

3D structure databases

ProteinModelPortaliO01530
SMRiO01530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 384Peptidase A1PROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
InParanoidiO01530
OMAiDNSEGFW
OrthoDBiEOG091G0CWN
PhylomeDBiO01530

Family and domain databases

CDDicd05471 pepsin_like, 1 hit
Gene3Di2.40.70.10, 3 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR034164 Pepsin-like_dom
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O01530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFILLAVL GLASASVHQH KIVWRESKKM GMIRTGQYPA YLEYQRNLRA
60 70 80 90 100
VSPNVLANLP QNVNDFGDFE YLGNITIGTP DQGFIVVLDT GSSNLWIPGP
110 120 130 140 150
TCKTNCKTKS KFDSTASSTF VKNGKSWTIQ YGSGDAAGIL GQDTVRFGAK
160 170 180 190 200
GDSQLSVPTT TFGIASKISA DFKNDATDGI LGLAFTSLAV DGVVPPLINA
210 220 230 240 250
INQGILDQPL FSVWLEHRGA ANNVGGGVFT YGAIDTTNCG ALVAYQPLSS
260 270 280 290 300
ATYYQFKAAG FKLGSYSNTK TVDVISDTGT SFLGGPQSVV DGLAKAAGAT
310 320 330 340 350
YDDFNEVYFI DCAAQPGTLD ITIGTNTYSI QPVNYIVDAG NGQCLFAAFP
360 370 380
FDFGGFGPSW ILGDPFIRQY CNIYDIGNKR MGFAPSLQK
Length:389
Mass (Da):41,520
Last modified:July 1, 1997 - v1
Checksum:i38B1DC51910FBF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080569 Genomic DNA Translation: CCD64751.1
PIRiT29410
RefSeqiNP_505133.1, NM_072732.7
UniGeneiCel.18329

Genome annotation databases

EnsemblMetazoaiF21F8.7; F21F8.7; WBGene00000219
GeneIDi179209
KEGGicel:CELE_F21F8.7
UCSCiF21F8.7.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiASP6_CAEEL
AccessioniPrimary (citable) accession number: O01530
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 1, 1997
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health