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Entry version 142 (26 Feb 2020)
Sequence version 2 (01 Oct 2001)
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Protein

G1/S-specific cyclin-E

Gene

cye-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the control of the cell cycle at the G1/S (start) transition (PubMed:12606285). In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages (PubMed:10952902, PubMed:17476329, PubMed:21558371, PubMed:21455289). In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase (PubMed:17115027). During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase (PubMed:10952902, PubMed:20005870). During hypoderm development at early larval stages, controls syncytial fate of seam cell daughter cells (PubMed:17476329). Involved in the progression of cell division in the intestinal lineage in larvae, and in particular in endoreplication, a specific growth pathway in the intestinal epithelium, required for feeding and gut development in growing larvae (PubMed:17466069). By controlling the activity of translational repressor gld-1, regulates the pool of germline stem cells and the size of the mitotic zone by preventing entry into meiosis (PubMed:21455289). In addition, repression of expression by gld-1 prevents mitosis re-entry in meiotic germline cells (PubMed:19758560).9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G1/S-specific cyclin-E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cye-1Imported
ORF Names:C37A2.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C37A2.4a ; CE24832 ; WBGene00000871 ; cye-1
C37A2.4b ; CE33761 ; WBGene00000871 ; cye-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Loss of cell division in vulval lineages as a result of lengthened intervals between cell divisons (PubMed:20005870). RNAi-mediated knockdown results in arrest prior to the 100-cell embryonic stage (PubMed:10952902). Depending on the knockdown, some animals reach adult age (PubMed:17476329). In the 1-cell embryo, persistent ruffling throughout the embryo cortex and mislocalization of par-2, which remains cytoplasmic, and par-6, which is distributed throughout the cortex. In 50 percent of embryos, the first division is symmetric. Adult mutants are sterile due to a lack of sperm and egg production (PubMed:17115027). In mutants and knockdown animals, production of 2 additional distal tip cells (DTC) is often associated with the production of an extra gonad (PubMed:17476329). In addition, gonads of knockdown animals have an abnormal mitotic zone characterized by an enlargement of the distal germ cell nuclei, a reduction in the number of mitotic germ cells, a reduction in the mitotic region length and an abnormal expression of gld-1 (PubMed:21455289).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000804581 – 524G1/S-specific cyclin-EAdd BLAST524

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O01501

PeptideAtlas

More...
PeptideAtlasi
O01501

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed dynamically in proliferating cells throughout development. Detectable in larval blast cells undergoing active proliferation that give rise to all tissue types, including germline, intestine, hypodermis, neurons, and muscle.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Ubiquitous embryonic pattern of expression declines during embryogenesis and disappears from most cells in comma-stage embryos coincident with the completion of the majority of embryonic cell divisions. Expression levels drop and become restricted and dynamic during postembryonic development (PubMed:12606285). During the development of distal tip cells, expressed asymmetrically between the daughters of the Z1.a and Z4.p cells; asymmetric expression is regulated by wrm-1, a component of the Wnt/MAPK pathway (PubMed:17476329). In the gonads, expression is restricted to the proliferating distal germline cells (PubMed:12606285, PubMed:21558371). In germline cells entering meiosis, expression is repressed by gld-1 (PubMed:21455289, PubMed:19758560).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000871 Expressed in adult organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O618473EBI-6499833,EBI-14063070

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
37847, 19 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1127 Cyclin cye-1-cdk2 complex

Protein interaction database and analysis system

More...
IntActi
O01501, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C37A2.4a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O01501

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin E subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0655 Eukaryota
ENOG410XS2J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169122

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O01501

KEGG Orthology (KO)

More...
KOi
K06626

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEESHEM

Database of Orthologous Groups

More...
OrthoDBi
993640at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O01501

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043 CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N

The PANTHER Classification System

More...
PANTHERi
PTHR10177 PTHR10177, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00134 Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385 CYCLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954 SSF47954, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00292 CYCLINS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a1 Publication (identifier: O01501-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRKSSRTA ERVPTTQKPE RKSAILSPHD ELRERLLETA IDMKENIPQR
60 70 80 90 100
NTRNSSVGSQ KSDCSETRKR RSTKEGPAAK RHSGEKHRNG SREDSLEYIS
110 120 130 140 150
EYSDDREVGS SSSQSSRTRG QPLPAMPEEE EVFDKSSSSD NLAESEESHE
160 170 180 190 200
MVRLEERQDI EEEIEDDFDD EEEDVVNDKE EYEEIESEDE DDYPVQNEGF
210 220 230 240 250
AVTKRLMNDE HMVTAPTFLS TAKCDGIGSP TKVWSLMVKR DEIPRATRFL
260 270 280 290 300
LGNHPDMDDE KRRILIDWMM EVCESEKLHR ETFHLAVDYV DRYLESSNVE
310 320 330 340 350
CSTDNFQLVG TAALFIAAKY EEIYPPKCID FAHLTDSAFT CDNIRTMEVL
360 370 380 390 400
IVKYIGWSLG PITSIQWLST YLQLLGTGKK NKSDHYEEQN MYVPELLRSE
410 420 430 440 450
YLEMCKILDF LLFEIDSFTF SYRTIAAAVL FVNYEPTCAV EKATGFMQAQ
460 470 480 490 500
LEKVIEYVEP VCRAFAKQRQ LLDDVIPKHE SIKSDDSHNI QVYVKRSSME
510 520
PIVKSERERI QHLKARRLHP QRLF
Length:524
Mass (Da):60,586
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B16BA7E70AA5F15
GO
Isoform b1 Publication (identifier: O01501-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     100-102: Missing.

Show »
Length:521
Mass (Da):60,206
Checksum:i90CCAFAB44064ECC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007909100 – 102Missing in isoform b. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF520616 mRNA Translation: AAM78547.1
AF058331 mRNA Translation: AAC63505.1
FO080805 Genomic DNA Translation: CCD66921.1
FO080805 Genomic DNA Translation: CCD66922.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43050

NCBI Reference Sequences

More...
RefSeqi
NP_001021027.1, NM_001025856.3 [O01501-1]
NP_001021028.1, NM_001025857.2 [O01501-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C37A2.4a.1; C37A2.4a.1; WBGene00000871 [O01501-1]
C37A2.4b.1; C37A2.4b.1; WBGene00000871 [O01501-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C37A2.4

UCSC genome browser

More...
UCSCi
C37A2.4a c. elegans [O01501-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520616 mRNA Translation: AAM78547.1
AF058331 mRNA Translation: AAC63505.1
FO080805 Genomic DNA Translation: CCD66921.1
FO080805 Genomic DNA Translation: CCD66922.1
PIRiT43050
RefSeqiNP_001021027.1, NM_001025856.3 [O01501-1]
NP_001021028.1, NM_001025857.2 [O01501-2]

3D structure databases

SMRiO01501
ModBaseiSearch...

Protein-protein interaction databases

BioGridi37847, 19 interactors
ComplexPortaliCPX-1127 Cyclin cye-1-cdk2 complex
IntActiO01501, 7 interactors
STRINGi6239.C37A2.4a

Proteomic databases

PaxDbiO01501
PeptideAtlasiO01501

Genome annotation databases

EnsemblMetazoaiC37A2.4a.1; C37A2.4a.1; WBGene00000871 [O01501-1]
C37A2.4b.1; C37A2.4b.1; WBGene00000871 [O01501-2]
GeneIDi172399
KEGGicel:CELE_C37A2.4
UCSCiC37A2.4a c. elegans [O01501-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172399
WormBaseiC37A2.4a ; CE24832 ; WBGene00000871 ; cye-1
C37A2.4b ; CE33761 ; WBGene00000871 ; cye-1

Phylogenomic databases

eggNOGiKOG0655 Eukaryota
ENOG410XS2J LUCA
GeneTreeiENSGT00940000169122
InParanoidiO01501
KOiK06626
OMAiSEESHEM
OrthoDBi993640at2759
PhylomeDBiO01501

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O01501

Gene expression databases

BgeeiWBGene00000871 Expressed in adult organism and 4 other tissues

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCNE_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01501
Secondary accession number(s): O77098, Q86FL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: October 1, 2001
Last modified: February 26, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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