UniProtKB - O01393 (UNC9_CAEEL)
Protein
Innexin unc-9
Gene
unc-9
Organism
Caenorhabditis elegans
Status
Functioni
Structural component of gap junctions (PubMed:27015090, PubMed:33238150). Plays a role in maintaining gap junction activity to promote locomotion (PubMed:33238150).2 Publications
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- gap junction channel activity Source: WormBase
- gap junction hemi-channel activity Source: UniProtKB
GO - Biological processi
- ion transmembrane transport Source: WormBase
- positive regulation of locomotion Source: UniProtKB
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Innexin unc-9Alternative name(s): Uncoordinated protein 9 |
Gene namesi | Name:unc-9Imported ORF Names:R12H7.1Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R12H7.1a ; CE28246 ; WBGene00006749 ; unc-9 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation
Other locations
- gap junction 2 Publications
Note: Co-localizes with unc-1 at the gap junctions formed between PLM and other neurons.1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell-cell junction Source: WormBase
- gap junction Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 282 – 302 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Gap junction, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208518 | 1 – 386 | Innexin unc-9Add BLAST | 386 |
Proteomic databases
EPDi | O01393 |
PaxDbi | O01393 |
PeptideAtlasi | O01393 |
Expressioni
Tissue specificityi
Expressed in PLM neurons (at protein level). Expressed in the nerve ring (PubMed:33238150).2 Publications
Gene expression databases
Bgeei | WBGene00006749, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | O01393, baseline and differential |
Interactioni
Subunit structurei
GO - Molecular functioni
- actin filament binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 46346, 4 interactors |
STRINGi | 6239.R12H7.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the pannexin family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSWG, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | O01393 |
OMAi | WFVLMRV |
OrthoDBi | 738314at2759 |
PhylomeDBi | O01393 |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 2 hits |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O01393-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSMLLYYFAS AVKSIQFHVD DDIIDKLNYY YTTAIITVFA ILVSAKQYVG
60 70 80 90 100
FPIQCWVPAT FTEPMEQYTE NYCWVQNTYF LPLHDYIPHN YAERENRQIG
110 120 130 140 150
YYQWVPFVLA LEALLFYVPT IVWRLLSWQS GIHVQSLVQM ACDSRLLDLE
160 170 180 190 200
SRNRALQTIA TNVEEALHVK HQVMSGNRLK LLNLIICTRS SGAAVTFLYI
210 220 230 240 250
SVKILYTVNI VGQIFLLNTF LGNRSKWYGL QVLNDLMNGR EWEESGHFPR
260 270 280 290 300
VTLCDFEVKV LGNVHRHTVQ CVLMINMFNE KIFLFLWFWY FLLAGATLCS
310 320 330 340 350
LFYWIYISVV PSRQLNFVGK YLTGIEGYKM VDSQSLRRFV FHFLRQDGVF
360 370 380
LLRMVATHAG ELPCYELAKT LWNNYCDNKE GKMHDV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1C3NSM1 | A0A1C3NSM1_CAEEL | Innexin | unc-9 inx, CELE_R12H7.1, R12H7.1 | 322 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U93195 mRNA Translation: AAB51534.1 BX284606 Genomic DNA Translation: CAB61030.2 |
RefSeqi | NP_741917.1, NM_171790.3 |
Genome annotation databases
EnsemblMetazoai | R12H7.1a.1; R12H7.1a.1; WBGene00006749 |
GeneIDi | 181443 |
KEGGi | cel:CELE_R12H7.1 |
UCSCi | R12H7.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U93195 mRNA Translation: AAB51534.1 BX284606 Genomic DNA Translation: CAB61030.2 |
RefSeqi | NP_741917.1, NM_171790.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 46346, 4 interactors |
STRINGi | 6239.R12H7.1 |
Proteomic databases
EPDi | O01393 |
PaxDbi | O01393 |
PeptideAtlasi | O01393 |
Genome annotation databases
EnsemblMetazoai | R12H7.1a.1; R12H7.1a.1; WBGene00006749 |
GeneIDi | 181443 |
KEGGi | cel:CELE_R12H7.1 |
UCSCi | R12H7.1, c. elegans |
Organism-specific databases
CTDi | 181443 |
WormBasei | R12H7.1a ; CE28246 ; WBGene00006749 ; unc-9 |
Phylogenomic databases
eggNOGi | ENOG502QSWG, Eukaryota |
HOGENOMi | CLU_035763_0_1_1 |
InParanoidi | O01393 |
OMAi | WFVLMRV |
OrthoDBi | 738314at2759 |
PhylomeDBi | O01393 |
Miscellaneous databases
PROi | PR:O01393 |
Gene expression databases
Bgeei | WBGene00006749, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | O01393, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000990, Innexin |
PANTHERi | PTHR11893, PTHR11893, 2 hits |
Pfami | View protein in Pfam PF00876, Innexin, 1 hit |
PRINTSi | PR01262, INNEXIN |
PROSITEi | View protein in PROSITE PS51013, PANNEXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UNC9_CAEEL | |
Accessioni | O01393Primary (citable) accession number: O01393 Secondary accession number(s): Q9NAN6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | July 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families