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Entry version 113 (02 Jun 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Sodium channel protein

Gene
N/A
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.10.10, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBlattella germanica (German cockroach) (Blatta germanica)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6973 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraPolyneopteraDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei133 – 160HelicalUniRule annotationAdd BLAST28
Transmembranei204 – 226HelicalUniRule annotationAdd BLAST23
Transmembranei238 – 256HelicalUniRule annotationAdd BLAST19
Transmembranei262 – 284HelicalUniRule annotationAdd BLAST23
Transmembranei394 – 416HelicalUniRule annotationAdd BLAST23
Transmembranei775 – 798HelicalUniRule annotationAdd BLAST24
Transmembranei819 – 836HelicalUniRule annotationAdd BLAST18
Transmembranei848 – 872HelicalUniRule annotationAdd BLAST25
Transmembranei903 – 925HelicalUniRule annotationAdd BLAST23
Transmembranei983 – 1004HelicalUniRule annotationAdd BLAST22
Transmembranei1310 – 1329HelicalUniRule annotationAdd BLAST20
Transmembranei1341 – 1364HelicalUniRule annotationAdd BLAST24
Transmembranei1385 – 1413HelicalUniRule annotationAdd BLAST29
Transmembranei1503 – 1529HelicalUniRule annotationAdd BLAST27
Transmembranei1592 – 1610HelicalUniRule annotationAdd BLAST19
Transmembranei1622 – 1641HelicalUniRule annotationAdd BLAST20
Transmembranei1653 – 1672HelicalUniRule annotationAdd BLAST20
Transmembranei1716 – 1739HelicalUniRule annotationAdd BLAST24
Transmembranei1806 – 1829HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1846 – 1881EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 72DisorderedSequence analysisAdd BLAST32
Regioni491 – 520DisorderedSequence analysisAdd BLAST30
Regioni538 – 572DisorderedSequence analysisAdd BLAST35
Regioni1145 – 1212DisorderedSequence analysisAdd BLAST68
Regioni1970 – 2031DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili420 – 451Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi495 – 517Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi538 – 557Polar residuesSequence analysisAdd BLAST20
Compositional biasi1165 – 1194Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1195 – 1212Acidic residuesSequence analysisAdd BLAST18
Compositional biasi2016 – 2031Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048, EF_hand_dom
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O01307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDDSSSISE EERSLFRPFT RESLAAIEAR IAEEYAKQKE LEKKRAEGEV
60 70 80 90 100
RYDDEDEDEG PQPDATLEQG APIPVRMQGL FPPELASTPL EDIDPFYHNQ
110 120 130 140 150
RTFVVVSKGK DIFRFSATDA MWILDPFNPI RRVAIYILVH PLFSLFIITT
160 170 180 190 200
ILTNCIFMIM PTTPTIESTE VIFTGIYTFE SAVKVMARGF ILQPFTYLRD
210 220 230 240 250
AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA IVPGLKTIVG
260 270 280 290 300
AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KNFPINGSWG
310 320 330 340 350
ELNDENWHAF CSNNTNWYFP EGAPEVPLCG NSSGAGTCPP DYTCLQGFGE
360 370 380 390 400
NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI
410 420 430 440 450
IFLGSFYLVN LILAIVAMSY DELQKKAEEE EAAEEEALRE AEEAALAKEA
460 470 480 490 500
KKLRQADKLA AQELAAAQEL AGANLAKSPS GSSSRSYELF INQKDGNNDN
510 520 530 540 550
KRENMSIRSE GGDSISEHKG RVGANGTAIR KVSAASLSLP GSPFNHRRGS
560 570 580 590 600
QGSHHFTIRN GRGRFVGPPG GDRKPLVLST YLDAQEHLPY ADDSNAVTPM
610 620 630 640 650
SEENGAIVVP VYYASLGSRH SSYTSHASRI SYTSHGDLLG AGNKSQTKIN
660 670 680 690 700
QLRARSVRNN PSQVPNSTPY MNASADSDDG AVKAKHTDNP FIEQMQQTTI
710 720 730 740 750
VDMNDVMVLN DIIEQAAGQQ SRASEHGVSI YYFPTDEDDE GPTVKEKVLA
760 770 780 790 800
ICMRGIDIFC VWDCCWLWLK FQEYVALLVF DPFVELFITL CIVVNTLFMA
810 820 830 840 850
LDHHDMNKDM DKALKSGNYF FTATFAIEAT LKLIAMSPKY YFQEGWNIFD
860 870 880 890 900
FIIVALSLLE LGLEGVQGLS VLRSFRLLRV FKLAKSWPTL NLLISIMGRT
910 920 930 940 950
VGALGNLTFV LCIIIFIFAV MGMQLFGKNY YDNVERFPDG DMPRWNFTDF
960 970 980 990 1000
MHSFMIVFRV LCGEWIESMW DCMLVGDWSC IPFFLATVVI GNFVVLNLFL
1010 1020 1030 1040 1050
ALLLSNFGSS NLSAPTADNE TNKIAEAFER FSRFFNWIKR SALNVAKMLR
1060 1070 1080 1090 1100
AKLTNQISDQ TPDAHERDTD LDLTADEILA DGIVYRDKKS PKEQTQLEVA
1110 1120 1130 1140 1150
IGDGMEFTIH GDLKNKLKKD KLMMNSTKVI GNSLNHKDNR IESGDYLHNR
1160 1170 1180 1190 1200
QDEDTLSTGS YGSHKNRPYK DDSHKGSAET MDGEEKKDAS KEDLDQEGEG
1210 1220 1230 1240 1250
EEDGEGEGPL EEDMVLDAGT EDVMMSEYPA DCCPDHCYKR FPFLAGDEDS
1260 1270 1280 1290 1300
PFWQGWGNLR LKTFQLIENK YFETAVITMI LLSSLALALE DVHLPHRPIL
1310 1320 1330 1340 1350
QDILYYMDRI FTVIFFIEML IKWLALGFKK YFTNAWCWLD FIIVMVSLIN
1360 1370 1380 1390 1400
FVASLVGAGG IQAFKTMRTL RALRPLRAMS RMQGMRVVVN ALVQAIPSIF
1410 1420 1430 1440 1450
NVLLVCLIFW LIFAIMGVQL FAGKYHKCVD SNSTTLSHEI IPDRNACIAE
1460 1470 1480 1490 1500
NYTWENSPMN FDHVGKAYLC LFQVATFKGW IQIMNDAIDS RELHKQPIRE
1510 1520 1530 1540 1550
TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED
1560 1570 1580 1590 1600
QKKYYNAMKK MGSKKPLKAI PRPKWRPQAI VFEICTDKKF DMIIMLFIGF
1610 1620 1630 1640 1650
NMLTMTLDHY QQSKQFSDVL DYLNMIFIVI FSSECLMKIF ALRYHYFKEP
1660 1670 1680 1690 1700
WNLFDFVVVI LSILGLVLSD IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA
1710 1720 1730 1740 1750
KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM HVRDKGGLDD
1760 1770 1780 1790 1800
VYNFKTFGQS MILLFQMSTS AGWDGVLDGI MNEEDCNKPN SEIGYPGDCG
1810 1820 1830 1840 1850
SATVGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM
1860 1870 1880 1890 1900
YYEIWQQFDP DGTQYIRYDQ LSDFLDVLEP PLQIHKPNKY KIVSMDIPIC
1910 1920 1930 1940 1950
KGDLMFCVDI LDALTKDFFA RKGNPIEESA ELGEVQPGRP DEVGYEPVSS
1960 1970 1980 1990 2000
TLWRQREEYC ARLIQNAWRK HKQQRQGAPG EDSDEAGDDP ELQDRHQTAV
2010 2020 2030
LVESDGFVTK NGHRVVIHSR SPSVTSRSTD V
Length:2,031
Mass (Da):229,998
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F0821181EFF5AF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U73584 mRNA Translation: AAC47484.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73584 mRNA Translation: AAC47484.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.1.10.10, the voltage-gated ion channel (vic) superfamily

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048, EF_hand_dom
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO01307_BLAGE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01307
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 2, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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