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Entry version 186 (16 Oct 2019)
Sequence version 2 (06 Jun 2002)
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Protein

Acyl-CoA desaturase

Gene

SCD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+1 Publication1 PublicationNote: Expected to bind 2 Fe2+ ions per subunit, instead of the Zn2+ ions seen in the 3D-structure.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei75Substrate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi120Iron 11 Publication1
Metal bindingi125Iron 11 Publication1
Binding sitei148Substrate1 Publication1
Binding sitei155Substrate1 Publication1
Binding sitei156Substrate1 Publication1
Metal bindingi157Iron 11 Publication1
Metal bindingi160Iron 21 Publication1
Metal bindingi161Iron 11 Publication1
Binding sitei188Substrate1 Publication1
Binding sitei189Substrate1 Publication1
Binding sitei262Substrate1 Publication1
Metal bindingi269Iron 21 Publication1
Metal bindingi298Iron 21 Publication1
Metal bindingi301Iron 11 Publication1
Metal bindingi302Iron 21 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.19.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-75105 Fatty acyl-CoA biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00767

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000465

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-CoA desaturase (EC:1.14.19.13 Publications)
Alternative name(s):
Delta(9)-desaturase
Short name:
Delta-9 desaturase
Fatty acid desaturase
Stearoyl-CoA desaturase1 Publication
Short name:
hSCD11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10571 SCD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604031 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00767

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 72Cytoplasmic1 PublicationAdd BLAST72
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93Helical1 PublicationAdd BLAST21
Topological domaini94 – 97Lumenal1 Publication4
Transmembranei98 – 118Helical1 PublicationAdd BLAST21
Topological domaini119 – 217Cytoplasmic1 PublicationAdd BLAST99
Transmembranei218 – 237Helical1 PublicationAdd BLAST20
Topological domaini238 – 241Lumenal1 Publication4
Transmembranei242 – 263Helical1 PublicationAdd BLAST22
Topological domaini264 – 359Cytoplasmic1 PublicationAdd BLAST96

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6319

Open Targets

More...
OpenTargetsi
ENSG00000099194

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O00767

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5555

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCD

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001853951 – 359Acyl-CoA desaturaseAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei198PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00767

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00767

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O00767

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00767

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00767

PeptideAtlas

More...
PeptideAtlasi
O00767

PRoteomics IDEntifications database

More...
PRIDEi
O00767

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48027

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O00767

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00767

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00767

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00767

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099194 Expressed in 237 organ(s), highest expression level in adipose tissue of abdominal region

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00767 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012107
HPA063921

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May self-associate and form homodimers.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A0A142I5B93EBI-2684237,EBI-20625235From Zika virus (isolate ZIKV/Human/Cambodia/FSS13025/2010).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112225, 26 interactors

Protein interaction database and analysis system

More...
IntActi
O00767, 47 interactors

Molecular INTeraction database

More...
MINTi
O00767

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359380

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00767

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi120 – 125Histidine box-1Curated6
Motifi157 – 161Histidine box-2Curated5
Motifi298 – 302Histidine box-3Curated5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The histidine box domains are involved in binding the catalytic metal ions.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1600 Eukaryota
COG1398 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00767

KEGG Orthology (KO)

More...
KOi
K00507

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHWLFGS

Database of Orthologous Groups

More...
OrthoDBi
971318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00767

TreeFam database of animal gene trees

More...
TreeFami
TF313251

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03505 Delta9-FADS-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015876 Acyl-CoA_DS
IPR001522 FADS-1_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11351 PTHR11351, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00075 FACDDSATRASE

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00476 FATTY_ACID_DESATUR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O00767-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAHLLQDDI SSSYTTTTTI TAPPSRVLQN GGDKLETMPL YLEDDIRPDI
60 70 80 90 100
KDDIYDPTYK DKEGPSPKVE YVWRNIILMS LLHLGALYGI TLIPTCKFYT
110 120 130 140 150
WLWGVFYYFV SALGITAGAH RLWSHRSYKA RLPLRLFLII ANTMAFQNDV
160 170 180 190 200
YEWARDHRAH HKFSETHADP HNSRRGFFFS HVGWLLVRKH PAVKEKGSTL
210 220 230 240 250
DLSDLEAEKL VMFQRRYYKP GLLMMCFILP TLVPWYFWGE TFQNSVFVAT
260 270 280 290 300
FLRYAVVLNA TWLVNSAAHL FGYRPYDKNI SPRENILVSL GAVGEGFHNY
310 320 330 340 350
HHSFPYDYSA SEYRWHINFT TFFIDCMAAL GLAYDRKKVS KAAILARIKR

TGDGNYKSG
Length:359
Mass (Da):41,523
Last modified:June 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED56A63DBD850F05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5L → M in AAB30631 (PubMed:7909540).Curated1
Sequence conflicti8D → E in AAB30631 (PubMed:7909540).Curated1
Sequence conflicti25 – 26SR → PG in CAA73998 (Ref. 1) Curated2
Sequence conflicti25 – 26SR → PG in AAB30631 (PubMed:7909540).Curated2
Sequence conflicti237F → C in AAB30631 (PubMed:7909540).Curated1
Sequence conflicti269H → L in BAD96582 (Ref. 5) Curated1
Sequence conflicti320T → N in CAA73998 (Ref. 1) Curated1
Sequence conflicti326C → W in CAA73998 (Ref. 1) Curated1
Sequence conflicti333A → T in CAA73998 (Ref. 1) Curated1
Sequence conflicti356 – 359Missing in AAH05807 (PubMed:15489334).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025994224M → L4 PublicationsCorresponds to variant dbSNP:rs2234970Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y13647 mRNA Translation: CAA73998.1
AF097514 mRNA Translation: AAD29870.1
AB032261 mRNA Translation: BAA93510.1
AK312312 mRNA Translation: BAG35237.1
AK222862 mRNA Translation: BAD96582.1
AL139819 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49829.1
CH471066 Genomic DNA Translation: EAW49830.1
BC005807 mRNA Translation: AAH05807.1
BC062303 mRNA Translation: AAH62303.1
AF320307 Genomic DNA Translation: AAK54510.1
S70284 mRNA Translation: AAB30631.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7493.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I54779

NCBI Reference Sequences

More...
RefSeqi
NP_005054.3, NM_005063.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370355; ENSP00000359380; ENSG00000099194

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6319

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6319

UCSC genome browser

More...
UCSCi
uc001kqy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13647 mRNA Translation: CAA73998.1
AF097514 mRNA Translation: AAD29870.1
AB032261 mRNA Translation: BAA93510.1
AK312312 mRNA Translation: BAG35237.1
AK222862 mRNA Translation: BAD96582.1
AL139819 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49829.1
CH471066 Genomic DNA Translation: EAW49830.1
BC005807 mRNA Translation: AAH05807.1
BC062303 mRNA Translation: AAH62303.1
AF320307 Genomic DNA Translation: AAK54510.1
S70284 mRNA Translation: AAB30631.1
CCDSiCCDS7493.1
PIRiI54779
RefSeqiNP_005054.3, NM_005063.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZYOX-ray3.25A45-359[»]
SMRiO00767
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112225, 26 interactors
IntActiO00767, 47 interactors
MINTiO00767
STRINGi9606.ENSP00000359380

Chemistry databases

BindingDBiO00767
ChEMBLiCHEMBL5555
SwissLipidsiSLP:000000465

PTM databases

iPTMnetiO00767
PhosphoSitePlusiO00767
SwissPalmiO00767

Polymorphism and mutation databases

BioMutaiSCD

Proteomic databases

EPDiO00767
jPOSTiO00767
MassIVEiO00767
MaxQBiO00767
PaxDbiO00767
PeptideAtlasiO00767
PRIDEiO00767
ProteomicsDBi48027
TopDownProteomicsiO00767

Genome annotation databases

EnsembliENST00000370355; ENSP00000359380; ENSG00000099194
GeneIDi6319
KEGGihsa:6319
UCSCiuc001kqy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6319
DisGeNETi6319

GeneCards: human genes, protein and diseases

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GeneCardsi
SCD
HGNCiHGNC:10571 SCD
HPAiHPA012107
HPA063921
MIMi604031 gene
neXtProtiNX_O00767
OpenTargetsiENSG00000099194
PharmGKBiPA34984

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1600 Eukaryota
COG1398 LUCA
GeneTreeiENSGT00940000154908
InParanoidiO00767
KOiK00507
OMAiLHWLFGS
OrthoDBi971318at2759
PhylomeDBiO00767
TreeFamiTF313251

Enzyme and pathway databases

BRENDAi1.14.19.1 2681
ReactomeiR-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-75105 Fatty acyl-CoA biosynthesis
SIGNORiO00767

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCD human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Stearoyl-CoA_desaturase-1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6319
PharosiO00767

Protein Ontology

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PROi
PR:O00767

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099194 Expressed in 237 organ(s), highest expression level in adipose tissue of abdominal region
GenevisibleiO00767 HS

Family and domain databases

CDDicd03505 Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876 Acyl-CoA_DS
IPR001522 FADS-1_CS
PANTHERiPTHR11351 PTHR11351, 1 hit
PRINTSiPR00075 FACDDSATRASE
PROSITEiView protein in PROSITE
PS00476 FATTY_ACID_DESATUR_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00767
Secondary accession number(s): B2R5U0
, D3DR68, Q16150, Q53GR9, Q5W037, Q5W038, Q6GSS4, Q96KF6, Q9BS07, Q9Y695
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: October 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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