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Entry version 190 (22 Apr 2020)
Sequence version 1 (01 Jul 1997)
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Protein

Pyridoxal kinase

Gene

PDXK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for synthesis of pyridoxal-5-phosphate from vitamin B6.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+, Mg2+1 PublicationNote: Divalent metal cations. Zn2+ is more efficient than Mg2+.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=14.5 µM for pyridoxal1 Publication

    pH dependencei

    Optimum pH is 5.5-6.0.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei12SubstrateBy similarity1
    Binding sitei47SubstrateBy similarity1
    Binding sitei127SubstrateBy similarity1
    Binding sitei235SubstrateBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi186 – 187ATPBy similarity2
    Nucleotide bindingi223 – 234ATPBy similarityAdd BLAST12

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS08466-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.35 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6798695 Neutrophil degranulation
    R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    O00764

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Pyridoxal kinase (EC:2.7.1.351 Publication)
    Alternative name(s):
    Pyridoxine kinase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PDXK
    Synonyms:C21orf124, C21orf97, PKH, PNK
    ORF Names:PRED79
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8819 PDXK

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    179020 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O00764

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Neuropathy, hereditary motor and sensory, 6C, with optic atrophy (HMSN6C)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive neurologic disorder characterized by childhood onset of axonal, sensorimotor polyneuropathy affecting mainly the lower limbs, and adult-onset optic atrophy. Clinical features include progressive distal muscle weakness and atrophy, significant standing and walking difficulties, areflexia, neurogenic pain and progressive visual impairment.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083156220R → Q in HMSN6C; decreased pyridoxal kinase activity. 1 Publication1
    Natural variantiVAR_083157228A → T in HMSN6C; decreased pyridoxal kinase activity; decreased affinity for ATP; decreased affinity for pyridoxal 5'-phosphate; no effect on protein abundance. 1 Publication1

    Keywords - Diseasei

    Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    8566

    MalaCards human disease database

    More...
    MalaCardsi
    PDXK
    MIMi618511 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000160209

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33162

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    O00764 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1075181

    Drug and drug target database

    More...
    DrugBanki
    DB04776 (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
    DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
    DB04770 O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL
    DB00147 Pyridoxal
    DB00165 Pyridoxine

    DrugCentral

    More...
    DrugCentrali
    O00764

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PDXK

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133351 – 312Pyridoxal kinaseAdd BLAST312

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
    Modified residuei59PhosphoserineCombined sources1
    Modified residuei164PhosphoserineCombined sources1
    Modified residuei213PhosphoserineCombined sources1
    Modified residuei285PhosphoserineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O00764

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O00764

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    O00764

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O00764

    PeptideAtlas

    More...
    PeptideAtlasi
    O00764

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O00764

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    48024 [O00764-1]
    48025 [O00764-2]
    48026 [O00764-3]

    2D gel databases

    REPRODUCTION-2DPAGE

    More...
    REPRODUCTION-2DPAGEi
    IPI00013004
    O00764

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O00764

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    O00764

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O00764

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous (PubMed:9099727, PubMed:31187503). Isoform 3 is detected in adult testis and spermatozoa (PubMed:15154080).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000160209 Expressed in right testis and 227 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O00764 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O00764 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000160209 Tissue enhanced (testis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    Curated

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    114135, 28 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    O00764

    Protein interaction database and analysis system

    More...
    IntActi
    O00764, 10 interactors

    Molecular INTeraction database

    More...
    MINTi
    O00764

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000291565

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O00764

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    O00764 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1312
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O00764

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    O00764

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the pyridoxine kinase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2599 Eukaryota
    COG2240 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000003874

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_046496_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O00764

    KEGG Orthology (KO)

    More...
    KOi
    K00868

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CPNQLEL

    Database of Orthologous Groups

    More...
    OrthoDBi
    1091630at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O00764

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315004

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01173 pyridoxal_pyridoxamine_kinase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.1190.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013749 PM/HMP-P_kinase-1
    IPR004625 PyrdxlKinase
    IPR029056 Ribokinase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10534 PTHR10534, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08543 Phos_pyr_kin, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53613 SSF53613, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00687 pyridox_kin, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O00764-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEEECRVLSI QSHVIRGYVG NRAATFPLQV LGFEIDAVNS VQFSNHTGYA
    60 70 80 90 100
    HWKGQVLNSD ELQELYEGLR LNNMNKYDYV LTGYTRDKSF LAMVVDIVQE
    110 120 130 140 150
    LKQQNPRLVY VCDPVLGDKW DGEGSMYVPE DLLPVYKEKV VPLADIITPN
    160 170 180 190 200
    QFEAELLSGR KIHSQEEALR VMDMLHSMGP DTVVITSSDL PSPQGSNYLI
    210 220 230 240 250
    VLGSQRRRNP AGSVVMERIR MDIRKVDAVF VGTGDLFAAM LLAWTHKHPN
    260 270 280 290 300
    NLKVACEKTV STLHHVLQRT IQCAKAQAGE GVRPSPMQLE LRMVQSKRDI
    310
    EDPEIVVQAT VL
    Length:312
    Mass (Da):35,102
    Last modified:July 1, 1997 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DBDCAB5D8640569
    GO
    Isoform 2 (identifier: O00764-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-110: Missing.

    Show »
    Length:284
    Mass (Da):31,808
    Checksum:iB85FE3EFD5A6B55D
    GO
    Isoform 3 (identifier: O00764-3) [UniParc]FASTAAdd to basket
    Also known as: PKH-T

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Show »
    Length:239
    Mass (Da):26,827
    Checksum:i588E6BECD72D9640
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F2Z2Y4F2Z2Y4_HUMAN
    Pyridoxal kinase
    PDXK
    272Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A8MV33A8MV33_HUMAN
    HCG401289, isoform CRA_b
    PDXK hCG_401289
    87Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0B4J2C9A0A0B4J2C9_HUMAN
    Pyridoxal kinase
    PDXK
    162Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A8MT14A8MT14_HUMAN
    HCG401289, isoform CRA_e
    PDXK hCG_401289
    148Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_083156220R → Q in HMSN6C; decreased pyridoxal kinase activity. 1 Publication1
    Natural variantiVAR_083157228A → T in HMSN6C; decreased pyridoxal kinase activity; decreased affinity for ATP; decreased affinity for pyridoxal 5'-phosphate; no effect on protein abundance. 1 Publication1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0106711 – 73Missing in isoform 3. 1 PublicationAdd BLAST73
    Alternative sequenceiVSP_00465383 – 110Missing in isoform 2. 1 PublicationAdd BLAST28

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U89606 mRNA Translation: AAC51233.1
    AY303972 mRNA Translation: AAP73047.1
    AP001752 Genomic DNA Translation: BAA95540.1
    BC000123 mRNA Translation: AAH00123.1
    BC005825 mRNA Translation: AAH05825.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS13699.1 [O00764-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_003672.1, NM_003681.4 [O00764-1]
    XP_005261256.1, XM_005261199.2 [O00764-3]
    XP_011528062.1, XM_011529760.2 [O00764-3]
    XP_011528063.1, XM_011529761.1 [O00764-3]
    XP_016883972.1, XM_017028483.1 [O00764-3]
    XP_016883973.1, XM_017028484.1 [O00764-3]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000291565; ENSP00000291565; ENSG00000160209 [O00764-1]
    ENST00000468090; ENSP00000418359; ENSG00000160209 [O00764-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    8566

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:8566

    UCSC genome browser

    More...
    UCSCi
    uc002zdn.4 human [O00764-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U89606 mRNA Translation: AAC51233.1
    AY303972 mRNA Translation: AAP73047.1
    AP001752 Genomic DNA Translation: BAA95540.1
    BC000123 mRNA Translation: AAH00123.1
    BC005825 mRNA Translation: AAH05825.1
    CCDSiCCDS13699.1 [O00764-1]
    RefSeqiNP_003672.1, NM_003681.4 [O00764-1]
    XP_005261256.1, XM_005261199.2 [O00764-3]
    XP_011528062.1, XM_011529760.2 [O00764-3]
    XP_011528063.1, XM_011529761.1 [O00764-3]
    XP_016883972.1, XM_017028483.1 [O00764-3]
    XP_016883973.1, XM_017028484.1 [O00764-3]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2AJPX-ray2.50A/B6-312[»]
    2F7KX-ray2.80A/B1-312[»]
    2YXTX-ray2.00A/B1-312[»]
    2YXUX-ray2.20A/B1-312[»]
    3FHXX-ray2.50A/B1-312[»]
    3FHYX-ray2.30A/B1-312[»]
    3KEUX-ray2.10A/B1-312[»]
    4EN4X-ray2.15A/B1-312[»]
    4EOHX-ray2.10A/B1-312[»]
    SMRiO00764
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi114135, 28 interactors
    CORUMiO00764
    IntActiO00764, 10 interactors
    MINTiO00764
    STRINGi9606.ENSP00000291565

    Chemistry databases

    BindingDBiO00764
    ChEMBLiCHEMBL1075181
    DrugBankiDB04776 (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
    DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
    DB04770 O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL
    DB00147 Pyridoxal
    DB00165 Pyridoxine
    DrugCentraliO00764

    PTM databases

    iPTMnetiO00764
    MetOSiteiO00764
    PhosphoSitePlusiO00764

    Polymorphism and mutation databases

    BioMutaiPDXK

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00013004
    O00764

    Proteomic databases

    EPDiO00764
    jPOSTiO00764
    MassIVEiO00764
    PaxDbiO00764
    PeptideAtlasiO00764
    PRIDEiO00764
    ProteomicsDBi48024 [O00764-1]
    48025 [O00764-2]
    48026 [O00764-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    24020 328 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    8566

    Genome annotation databases

    EnsembliENST00000291565; ENSP00000291565; ENSG00000160209 [O00764-1]
    ENST00000468090; ENSP00000418359; ENSG00000160209 [O00764-2]
    GeneIDi8566
    KEGGihsa:8566
    UCSCiuc002zdn.4 human [O00764-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    8566
    DisGeNETi8566

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PDXK
    HGNCiHGNC:8819 PDXK
    HPAiENSG00000160209 Tissue enhanced (testis)
    MalaCardsiPDXK
    MIMi179020 gene
    618511 phenotype
    neXtProtiNX_O00764
    OpenTargetsiENSG00000160209
    PharmGKBiPA33162

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2599 Eukaryota
    COG2240 LUCA
    GeneTreeiENSGT00390000003874
    HOGENOMiCLU_046496_1_1_1
    InParanoidiO00764
    KOiK00868
    OMAiCPNQLEL
    OrthoDBi1091630at2759
    PhylomeDBiO00764
    TreeFamiTF315004

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08466-MONOMER
    BRENDAi2.7.1.35 2681
    ReactomeiR-HSA-6798695 Neutrophil degranulation
    R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate
    SABIO-RKiO00764

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PDXK human
    EvolutionaryTraceiO00764

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PDXK

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    8566
    PharosiO00764 Tbio

    Protein Ontology

    More...
    PROi
    PR:O00764
    RNActiO00764 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000160209 Expressed in right testis and 227 other tissues
    ExpressionAtlasiO00764 baseline and differential
    GenevisibleiO00764 HS

    Family and domain databases

    CDDicd01173 pyridoxal_pyridoxamine_kinase, 1 hit
    Gene3Di3.40.1190.20, 1 hit
    InterProiView protein in InterPro
    IPR013749 PM/HMP-P_kinase-1
    IPR004625 PyrdxlKinase
    IPR029056 Ribokinase-like
    PANTHERiPTHR10534 PTHR10534, 1 hit
    PfamiView protein in Pfam
    PF08543 Phos_pyr_kin, 1 hit
    SUPFAMiSSF53613 SSF53613, 1 hit
    TIGRFAMsiTIGR00687 pyridox_kin, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDXK_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00764
    Secondary accession number(s): Q7Z2Y0, Q9BS02
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: April 22, 2020
    This is version 190 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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