FBP2

Functionⁱ

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.2 Publications

Miscellaneous

Specific for the alpha-anomer of the substrate (PubMed:22120740). The Arg-33 mutant form has been shown to act on the beta-anomer (PubMed:24086250).2 Publications

Catalytic activityⁱ

D-fructose 1,6-bisphosphate + H₂O = D-fructose 6-phosphate + phosphate.2 Publications

Cofactorⁱ

Mg²⁺2 PublicationsNote: Binds 3 Mg²⁺ ions per subunit.2 Publications

Activity regulationⁱ

Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as allosteric inhibitor. Fructose 2,6-bisphosphate acts as competitive inhibitor. Strongly inhibited by Ca²⁺.3 Publications

Kineticsⁱ

The kinetic constants are determined for the recombinant enzyme expressed in E.coli.

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	18	AMP; via carbonyl oxygen1 Publication	1
Siteⁱ	33	Important for the conversion from active R-state to inactive T-state in the presence of AMP	1
Metal bindingⁱ	69	Magnesium 1	1
Metal bindingⁱ	98	Magnesium 1	1
Metal bindingⁱ	98	Magnesium 2	1
Metal bindingⁱ	119	Magnesium 2	1
Metal bindingⁱ	119	Magnesium 3	1
Metal bindingⁱ	121	Magnesium 2; via carbonyl oxygen	1
Metal bindingⁱ	122	Magnesium 3	1
Binding siteⁱ	122	Substrate	1
Binding siteⁱ	141	AMP1 Publication	1
Binding siteⁱ	265	Substrate	1
Binding siteⁱ	275	Substrate	1
Metal bindingⁱ	281	Magnesium 3	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	28 – 32	AMP1 Publication		5
Nucleotide bindingⁱ	113 – 114	AMP1 Publication		2

GO - Molecular functionⁱ

fructose 1,6-bisphosphate 1-phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fructose 1,6-bisphosphate metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fructose 6-phosphate metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fructose metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
gluconeogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sucrose biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Allosteric enzyme, Hydrolase
Biological process	Carbohydrate metabolism, Gluconeogenesis
Ligand	Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05462-MONOMER
Reactomeⁱ	R-HSA-70263 Gluconeogenesis
SABIO-RKⁱ	O00757
UniPathwayⁱ	UPA00138

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fructose-1,6-bisphosphatase isozyme 2 (EC:3.1.3.11) Short name: FBPase 2 Alternative name(s): D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 Muscle FBPase
Gene namesⁱ	Name:FBP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130957.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3607 FBP2
MIMⁱ	603027 gene
neXtProtⁱ	NX_O00757

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	1 – 10	Missing : Greatly reduces sensitivity to inhibition by AMP and Ca(2+) and activation by Mg(2+). Decreases binding to ALDOA. 1 Publication	10
Mutagenesisⁱ	1 – 7	Missing : Greatly reduces sensitivity to inhibition by AMP and Ca(2+) and activation by Mg(2+). Decreases binding to ALDOA.	7
Mutagenesisⁱ	1 – 6	Missing : Reduces sensitivity to inhibition by AMP and Ca(2+) and activation by Mg(2+). Decreases binding to ALDOA.	6
Mutagenesisⁱ	1 – 5	Missing : Reduces sensitivity to inhibition by AMP and Ca(2+) and activation by Mg(2+). Decreases binding to ALDOA.	5
Mutagenesisⁱ	1 – 4	Missing : Slightly reduces sensitivity to inhibition by AMP and Ca(2+) and activation by Mg(2+). Decreases binding to ALDOA.	4
Mutagenesisⁱ	1 – 3	Missing : No effect on kinetic properties but decreases binding to ALDOA.	3
Mutagenesisⁱ	1 – 2	Missing : No effect on kinetic properties and interaction with ALDOA.	2
Mutagenesisⁱ	1	Missing : No effect on kinetic properties and interaction with ALDOA.	1
Mutagenesisⁱ	21	K → E: Reduces sensitivity to AMP; when associated with M-178 and C-180. 1 Publication	1
Mutagenesisⁱ	33	Q → R: Causes conformational change of N-terminal residues and decreased sensitivity towards AMP with lack of conversion to the inactive T-state in the presence of AMP.	1
Mutagenesisⁱ	70	E → Q: Greatly reduces affinity towards Ca(2+) and slightly reduces affinity towards Mg(2+). 1 Publication	1
Mutagenesisⁱ	178	T → M: Reduces sensitivity to AMP; when associated with E-21 and C-180. 1 Publication	1
Mutagenesisⁱ	180	Q → C: Reduces sensitivity to AMP; when associated with E-21 and M-178. 1 Publication	1
Mutagenesisⁱ	204 – 208	KKKGK → AAAGA or EEEGE: Almost completely abolishes nuclear localization. 1 Publication	5
Mutagenesisⁱ	204	K → E: Minor reduction in nuclear localization.	1
Mutagenesisⁱ	205	K → E: Minor reduction in nuclear localization.	1
Mutagenesisⁱ	206	K → E: Greatly reduces nuclear lozalization.	1
Mutagenesisⁱ	208	K → E: Significantly reduces nuclear localization.	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8789
Open Targets More...OpenTargetsⁱ	ENSG00000130957
PharmGKBⁱ	PA28019

Polymorphism and mutation databases

BioMutaⁱ	FBP2

BioMutaⁱ

FBP2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200504	1 – 339	Fructose-1,6-bisphosphatase isozyme 2Add BLAST		339

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	216	PhosphotyrosineBy similarity		1
Modified residueⁱ	219	PhosphotyrosineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O00757
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00757
PaxDbⁱ	O00757
PeptideAtlas More...PeptideAtlasⁱ	O00757
PRIDEⁱ	O00757
ProteomicsDBⁱ	48020

PTM databases

DEPODⁱ	O00757
iPTMnetⁱ	O00757
PhosphoSitePlusⁱ	O00757
SwissPalmⁱ	O00757

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000130957 Expressed in 93 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_FBP2
Genevisibleⁱ	O00757 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012513 HPA055286

HPAⁱ

HPA012513
HPA055286

Interactionⁱ

Subunit structureⁱ

Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca²⁺. Interacts with alpha-actinin and F-actin.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-719781,EBI-719781
FBP1	P09467	14	EBI-719781,EBI-712740

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114317, 3 interactors
IntActⁱ	O00757, 20 interactors
Molecular INTeraction database More...MINTⁱ	O00757
STRINGⁱ	9606.ENSP00000364486

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	14 – 24	Combined sources	11
Helixⁱ	30 – 50	Combined sources	21
Turnⁱ	51 – 54	Combined sources	4
Turnⁱ	58 – 61	Combined sources	4
Beta strandⁱ	70 – 72	Combined sources	3
Helixⁱ	74 – 87	Combined sources	14
Turnⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 97	Combined sources	6
Helixⁱ	108 – 110	Combined sources	3
Beta strandⁱ	111 – 122	Combined sources	12
Helixⁱ	124 – 126	Combined sources	3
Turnⁱ	127 – 130	Combined sources	4
Beta strandⁱ	133 – 141	Combined sources	9
Helixⁱ	150 – 153	Combined sources	4
Helixⁱ	157 – 159	Combined sources	3
Beta strandⁱ	161 – 180	Combined sources	20
Beta strandⁱ	182 – 188	Combined sources	7
Turnⁱ	189 – 192	Combined sources	4
Beta strandⁱ	193 – 201	Combined sources	9
Beta strandⁱ	208 – 211	Combined sources	4
Helixⁱ	214 – 219	Combined sources	6
Helixⁱ	222 – 232	Combined sources	11
Beta strandⁱ	235 – 237	Combined sources	3
Helixⁱ	249 – 259	Combined sources	11
Beta strandⁱ	262 – 265	Combined sources	4
Beta strandⁱ	268 – 270	Combined sources	3
Beta strandⁱ	275 – 277	Combined sources	3
Turnⁱ	278 – 281	Combined sources	4
Helixⁱ	282 – 291	Combined sources	10
Beta strandⁱ	295 – 297	Combined sources	3
Beta strandⁱ	299 – 302	Combined sources	4
Helixⁱ	303 – 305	Combined sources	3
Beta strandⁱ	317 – 321	Combined sources	5
Helixⁱ	322 – 335	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	O00757
SMRⁱ	O00757
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

O00757

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	3 – 10	Important for interaction with ALDOA1 Publication	8
Regionⁱ	213 – 216	Substrate binding	4
Regionⁱ	245 – 249	Substrate binding	5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	204 – 208	Nuclear localization signal1 Publication		5

Sequence similaritiesⁱ

Belongs to the FBPase class 1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1458 Eukaryota COG0158 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015513
HOGENOMⁱ	HOG000191265
HOVERGENⁱ	HBG005627
InParanoidⁱ	O00757
KEGG Orthology (KO) More...KOⁱ	K03841
OMAⁱ	HEKSECY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AZP
PhylomeDBⁱ	O00757
TreeFamⁱ	TF314824

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00354 FBPase, 1 hit
HAMAPⁱ	MF_01855 FBPase_class1, 1 hit
InterProⁱ	View protein in InterPro IPR000146 FBPase_class-1 IPR033391 FBPase_N IPR028343 FBPtase IPR020548 Fructose_bisphosphatase_AS
PANTHERⁱ	PTHR11556 PTHR11556, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00316 FBPase, 1 hit
PIRSFⁱ	PIRSF500210 FBPtase, 1 hit PIRSF000904 FBPtase_SBPase, 1 hit
PRINTSⁱ	PR00115 F16BPHPHTASE
PROSITEⁱ	View protein in PROSITE PS00124 FBPASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O00757-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR 
        60         70         80         90        100
KAGLAHLYGI AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN 
       110        120        130        140        150
KDAIITAKEK RGKYVVCFDP LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE 
       160        170        180        190        200
KDALQCGRNI VAAGYALYGS ATLVALSTGQ GVDLFMLDPA LGEFVLVEKD 
       210        220        230        240        250
VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP YGARYVGSMV 
       260        270        280        290        300
ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT 
       310        320        330 
QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS

Length:339

Mass (Da):36,743

Last modified:September 27, 2005 - v2

Checksum:ⁱ196B06D744710BC4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024448	86	V → L2 PublicationsCorresponds to variant dbSNP:rs573212Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10812 mRNA Translation: CAA71772.1 CR536483 mRNA Translation: CAG38722.1 AL161728 Genomic DNA No translation available. BC113632 mRNA Translation: AAI13633.1 BC117477 mRNA Translation: AAI17478.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6711.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003828.2, NM_003837.3
UniGeneⁱ	Hs.61255

Genome annotation databases

Ensemblⁱ	ENST00000375337; ENSP00000364486; ENSG00000130957
GeneIDⁱ	8789
KEGGⁱ	hsa:8789
UCSC genome browser More...UCSCⁱ	uc004auv.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00757	Fructose-1,6-bisphosphatase isozyme 2		BOVIN		339	UniRef90_O00757
Fructose-1,6-bisphosphatase isozyme 2		RABIT		339
Fructose-1,6-bisphosphatase isozyme 2		MYODS		387
fructose-1,6-bisphosphatase isozyme 2		BALAS		340
Fructose-1,6-bisphosphatase isozyme 2 (Fragment)		ESCRO		111
+86

Protein	Similar proteins		Species	Score	Length	Source
O00757	Fructose-1,6-bisphosphatase 1	)	HUMAN		338	UniRef50_P09467
Fructose-1,6-bisphosphatase 1	)	RABIT		338
Fructose-1,6-bisphosphatase 1	)	PIG		338
Fructose-1,6-bisphosphatase 1		RAT		363
Fructose-1,6-bisphosphatase 1		MOUSE		338
+852

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10812 mRNA Translation: CAA71772.1 CR536483 mRNA Translation: CAG38722.1 AL161728 Genomic DNA No translation available. BC113632 mRNA Translation: AAI13633.1 BC117477 mRNA Translation: AAI17478.1
CCDSⁱ	CCDS6711.1
RefSeqⁱ	NP_003828.2, NM_003837.3
UniGeneⁱ	Hs.61255

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3IFA	X-ray	1.93	A/B/C/D	2-339	[»]
	3IFC	X-ray	1.97	A/B/C/D	2-339	[»]
	4HE0	X-ray	2.69	A	2-339	[»]
	4HE1	X-ray	2.23	A	2-339	[»]
	4HE2	X-ray	1.60	A	2-339	[»]
	5ET5	X-ray	1.67	A	2-339	[»]
	5ET6	X-ray	1.84	A/B/C/D	2-339	[»]
	5ET7	X-ray	2.99	A/B/C/D	2-339	[»]
	5ET8	X-ray	1.92	A	2-339	[»]
	5K54	X-ray	1.72	A	2-339	[»]
	5K55	X-ray	1.98	A	2-339	[»]
	5K56	X-ray	2.20	A	2-339	[»]
	5L0A	X-ray	2.30	A	2-339	[»]
ProteinModelPortalⁱ	O00757
SMRⁱ	O00757
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114317, 3 interactors
IntActⁱ	O00757, 20 interactors
MINTⁱ	O00757
STRINGⁱ	9606.ENSP00000364486

PTM databases

DEPODⁱ	O00757
iPTMnetⁱ	O00757
PhosphoSitePlusⁱ	O00757
SwissPalmⁱ	O00757

Polymorphism and mutation databases

BioMutaⁱ	FBP2

BioMutaⁱ

FBP2

Proteomic databases

EPDⁱ	O00757
MaxQBⁱ	O00757
PaxDbⁱ	O00757
PeptideAtlasⁱ	O00757
PRIDEⁱ	O00757
ProteomicsDBⁱ	48020

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8789
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375337; ENSP00000364486; ENSG00000130957
GeneIDⁱ	8789
KEGGⁱ	hsa:8789
UCSCⁱ	uc004auv.5 human

Organism-specific databases

CTDⁱ	8789
DisGeNETⁱ	8789
EuPathDBⁱ	HostDB:ENSG00000130957.4
GeneCardsⁱ	FBP2
HGNCⁱ	HGNC:3607 FBP2
HPAⁱ	HPA012513 HPA055286
MIMⁱ	603027 gene
neXtProtⁱ	NX_O00757
OpenTargetsⁱ	ENSG00000130957
PharmGKBⁱ	PA28019
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1458 Eukaryota COG0158 LUCA
GeneTreeⁱ	ENSGT00390000015513
HOGENOMⁱ	HOG000191265
HOVERGENⁱ	HBG005627
InParanoidⁱ	O00757
KOⁱ	K03841
OMAⁱ	HEKSECY
OrthoDBⁱ	EOG091G0AZP
PhylomeDBⁱ	O00757
TreeFamⁱ	TF314824

Enzyme and pathway databases

UniPathwayⁱ	UPA00138
BioCycⁱ	MetaCyc:HS05462-MONOMER
Reactomeⁱ	R-HSA-70263 Gluconeogenesis
SABIO-RKⁱ	O00757

Miscellaneous databases

EvolutionaryTraceⁱ	O00757
GenomeRNAiⁱ	8789
Protein Ontology More...PROⁱ	PR:O00757
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130957 Expressed in 93 organ(s), highest expression level in muscle of leg
CleanExⁱ	HS_FBP2
Genevisibleⁱ	O00757 HS

Family and domain databases

CDDⁱ	cd00354 FBPase, 1 hit
HAMAPⁱ	MF_01855 FBPase_class1, 1 hit
InterProⁱ	View protein in InterPro IPR000146 FBPase_class-1 IPR033391 FBPase_N IPR028343 FBPtase IPR020548 Fructose_bisphosphatase_AS
PANTHERⁱ	PTHR11556 PTHR11556, 1 hit
Pfamⁱ	View protein in Pfam PF00316 FBPase, 1 hit
PIRSFⁱ	PIRSF500210 FBPtase, 1 hit PIRSF000904 FBPtase_SBPase, 1 hit
PRINTSⁱ	PR00115 F16BPHPHTASE
PROSITEⁱ	View protein in PROSITE PS00124 FBPASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F16P2_HUMAN
Accessionⁱ	O00757Primary (citable) accession number: O00757 Secondary accession number(s): Q17R39, Q6FI53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 27, 2005
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00757 (F16P2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Fructose-1,6-bisphosphatase isozyme 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

Kineticsⁱ

Pathwayⁱ: gluconeogenesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ