UniProtKB - O00755 (WNT7A_HUMAN)
Protein Wnt-7a
WNT7A
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).
Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533).
Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).
Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity).
Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity).
Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity).
Promotes formation of synapses via its interaction with FZD5 (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- cytokine activity Source: BHF-UCL
- frizzled binding Source: GO_Central
- receptor ligand activity Source: BHF-UCL
- signaling receptor binding Source: BHF-UCL
GO - Biological processi
- angiogenesis Source: Ensembl
- asymmetric protein localization involved in cell fate determination Source: Ensembl
- axonogenesis Source: ParkinsonsUK-UCL
- canonical Wnt signaling pathway Source: BHF-UCL
- cartilage condensation Source: AgBase
- cell fate commitment Source: GO_Central
- cell proliferation in forebrain Source: BHF-UCL
- cellular response to transforming growth factor beta stimulus Source: UniProtKB
- central nervous system vasculogenesis Source: Ensembl
- cerebellar granule cell differentiation Source: Ensembl
- chondrocyte differentiation Source: AgBase
- dendritic spine morphogenesis Source: ParkinsonsUK-UCL
- dorsal/ventral pattern formation Source: Ensembl
- embryonic axis specification Source: BHF-UCL
- embryonic digit morphogenesis Source: BHF-UCL
- embryonic forelimb morphogenesis Source: BHF-UCL
- embryonic hindlimb morphogenesis Source: BHF-UCL
- establishment of cell polarity Source: Ensembl
- excitatory synapse assembly Source: ParkinsonsUK-UCL
- lens fiber cell development Source: BHF-UCL
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of neurogenesis Source: BHF-UCL
- neuron differentiation Source: GO_Central
- neurotransmitter secretion Source: Ensembl
- oviduct development Source: Ensembl
- positive regulation of cellular protein metabolic process Source: ARUK-UCL
- positive regulation of endothelial cell migration Source: Ensembl
- positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
- positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCL
- positive regulation of excitatory synapse assembly Source: ParkinsonsUK-UCL
- positive regulation of gene expression Source: Ensembl
- positive regulation of JNK cascade Source: GO_Central
- positive regulation of protein localization to presynapse Source: ParkinsonsUK-UCL
- positive regulation of synapse assembly Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- postsynapse assembly Source: ParkinsonsUK-UCL
- presynapse assembly Source: ParkinsonsUK-UCL
- regulation of axon diameter Source: Ensembl
- regulation of postsynapse organization Source: Ensembl
- regulation of presynapse assembly Source: SynGO
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to estradiol Source: Ensembl
- response to estrogen Source: Ensembl
- secondary palate development Source: BHF-UCL
- sex differentiation Source: ProtInc
- skeletal muscle satellite cell activation Source: Ensembl
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
- somatic stem cell division Source: Ensembl
- somatic stem cell population maintenance Source: Ensembl
- stem cell development Source: BHF-UCL
- synaptic vesicle recycling Source: ParkinsonsUK-UCL
- uterus morphogenesis Source: Ensembl
- Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL
- wound healing, spreading of epidermal cells Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | O00755 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | O00755 |
SIGNORi | O00755 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Wnt-7a |
Gene namesi | Name:WNT7A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12786, WNT7A |
MIMi | 601570, gene |
neXtProti | NX_O00755 |
VEuPathDBi | HostDB:ENSG00000154764 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
- Secreted 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: Reactome
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Golgi apparatus
- Golgi lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: Ensembl
- endocytic vesicle membrane Source: Reactome
- extracellular matrix Source: Ensembl
- glutamatergic synapse Source: SynGO
- presynapse Source: GOC
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Limb pelvis hypoplasia aplasia syndrome (LPHAS)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065765 | 72 | E → K in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514666EnsemblClinVar. | 1 | |
Natural variantiVAR_077340 | 102 | R → W in LPHAS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs879255548EnsemblClinVar. | 1 | |
Natural variantiVAR_064480 | 222 | R → W in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514643EnsemblClinVar. | 1 | |
Natural variantiVAR_030674 | 292 | R → C in LPHAS; results in a loss of function mutation with some residual activity. 2 PublicationsCorresponds to variant dbSNP:rs104893835EnsemblClinVar. | 1 |
Fuhrmann syndrome (FUHRS)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030673 | 109 | A → T in FUHRS; retains activity that is significant but not comparable to wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs104893832EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 206 | S → A: Does not affect interaction with RECK. 1 Publication | 1 | |
Mutagenesisi | 241 | V → A in 4A; abolished interaction with RECK; when associated with 251-A-A-252 and A-262. 1 Publication | 1 | |
Mutagenesisi | 251 – 252 | FL → AA in 4A; abolished interaction with RECK; when associated with A-241 and A-262. 1 Publication | 2 | |
Mutagenesisi | 262 | K → A in 4A; abolished interaction with RECK; when associated with A-241 and 251-A-A-252. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7476 |
MalaCardsi | WNT7A |
MIMi | 228930, phenotype 276820, phenotype |
OpenTargetsi | ENSG00000154764 |
Orphaneti | 2854, Fuhrmann syndrome 2879, Phocomelia, Schinzel type |
PharmGKBi | PA37387 |
Miscellaneous databases
Pharosi | O00755, Tbio |
Genetic variation databases
BioMutai | WNT7A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000041442 | 32 – 349 | Protein Wnt-7aAdd BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 84 | By similarity | ||
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 123 ↔ 131 | By similarity | ||
Glycosylationi | 127 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 133 ↔ 152 | By similarity | ||
Disulfide bondi | 200 ↔ 214 | By similarity | ||
Disulfide bondi | 202 ↔ 209 | By similarity | ||
Lipidationi | 206 | O-palmitoleoyl serine; by PORCN1 Publication | 1 | |
Disulfide bondi | 278 ↔ 309 | By similarity | ||
Disulfide bondi | 294 ↔ 304 | By similarity | ||
Glycosylationi | 295 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 308 ↔ 348 | By similarity | ||
Disulfide bondi | 324 ↔ 339 | By similarity | ||
Disulfide bondi | 326 ↔ 336 | By similarity | ||
Disulfide bondi | 331 ↔ 332 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, LipoproteinProteomic databases
jPOSTi | O00755 |
MassIVEi | O00755 |
MaxQBi | O00755 |
PaxDbi | O00755 |
PeptideAtlasi | O00755 |
PRIDEi | O00755 |
ProteomicsDBi | 48019 |
TopDownProteomicsi | O00755 |
PTM databases
GlyGeni | O00755, 3 sites |
iPTMneti | O00755 |
PhosphoSitePlusi | O00755 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000154764, Expressed in epithelium of bronchus and 74 other tissues |
Genevisiblei | O00755, HS |
Organism-specific databases
HPAi | ENSG00000154764, Tissue enhanced (brain, gallbladder, placenta) |
Interactioni
Subunit structurei
Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).
Interacts with FZD5 (By similarity).
Interacts with PORCN (By similarity).
Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (PubMed:30026314).
By similarity2 PublicationsBinary interactionsi
O00755
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- frizzled binding Source: GO_Central
- receptor ligand activity Source: BHF-UCL
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113313, 37 interactors |
DIPi | DIP-61511N |
IntActi | O00755, 37 interactors |
MINTi | O00755 |
STRINGi | 9606.ENSP00000285018 |
Miscellaneous databases
RNActi | O00755, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 238 – 266 | Disordered linker1 PublicationAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158523 |
HOGENOMi | CLU_033039_1_4_1 |
InParanoidi | O00755 |
OMAi | IVYLRIG |
OrthoDBi | 745245at2759 |
PhylomeDBi | O00755 |
TreeFami | TF105310 |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR013300, Wnt7 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01891, WNT7PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA
60 70 80 90 100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG
110 120 130 140 150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG
160 170 180 190 200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC
210 220 230 240 250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT
260 270 280 290 300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ
310 320 330 340
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | R → L in AAC51319 (PubMed:9161407).Curated | 1 | |
Sequence conflicti | 14 | L → F in BAA82509 (PubMed:8893824).Curated | 1 | |
Sequence conflicti | 20 | Y → C in AAC51319 (PubMed:9161407).Curated | 1 | |
Sequence conflicti | 35 | S → T in AAC51319 (PubMed:9161407).Curated | 1 | |
Sequence conflicti | 103 – 104 | EA → DG in AAC51319 (PubMed:9161407).Curated | 2 | |
Sequence conflicti | 125 | Q → H in AAC51319 (PubMed:9161407).Curated | 1 | |
Sequence conflicti | 280 | E → G no nucleotide entry (PubMed:8168088).Curated | 1 | |
Sequence conflicti | 329 | H → Q in BAA82509 (PubMed:8893824).Curated | 1 | |
Sequence conflicti | 338 | T → K in BAA82509 (PubMed:8893824).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065765 | 72 | E → K in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514666EnsemblClinVar. | 1 | |
Natural variantiVAR_077340 | 102 | R → W in LPHAS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs879255548EnsemblClinVar. | 1 | |
Natural variantiVAR_030673 | 109 | A → T in FUHRS; retains activity that is significant but not comparable to wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs104893832EnsemblClinVar. | 1 | |
Natural variantiVAR_064480 | 222 | R → W in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514643EnsemblClinVar. | 1 | |
Natural variantiVAR_030674 | 292 | R → C in LPHAS; results in a loss of function mutation with some residual activity. 2 PublicationsCorresponds to variant dbSNP:rs104893835EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U53476 mRNA Translation: AAC51319.1 D83175 mRNA Translation: BAA82509.1 CH471055 Genomic DNA Translation: EAW64173.1 BC008811 mRNA Translation: AAH08811.1 |
CCDSi | CCDS2616.1 |
RefSeqi | NP_004616.2, NM_004625.3 |
Genome annotation databases
Ensembli | ENST00000285018; ENSP00000285018; ENSG00000154764 |
GeneIDi | 7476 |
KEGGi | hsa:7476 |
MANE-Selecti | ENST00000285018.5; ENSP00000285018.4; NM_004625.4; NP_004616.2 |
UCSCi | uc003bye.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U53476 mRNA Translation: AAC51319.1 D83175 mRNA Translation: BAA82509.1 CH471055 Genomic DNA Translation: EAW64173.1 BC008811 mRNA Translation: AAH08811.1 |
CCDSi | CCDS2616.1 |
RefSeqi | NP_004616.2, NM_004625.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UZQ | X-ray | 1.50 | B | 202-209 | [»] | |
SMRi | O00755 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113313, 37 interactors |
DIPi | DIP-61511N |
IntActi | O00755, 37 interactors |
MINTi | O00755 |
STRINGi | 9606.ENSP00000285018 |
PTM databases
GlyGeni | O00755, 3 sites |
iPTMneti | O00755 |
PhosphoSitePlusi | O00755 |
Genetic variation databases
BioMutai | WNT7A |
Proteomic databases
jPOSTi | O00755 |
MassIVEi | O00755 |
MaxQBi | O00755 |
PaxDbi | O00755 |
PeptideAtlasi | O00755 |
PRIDEi | O00755 |
ProteomicsDBi | 48019 |
TopDownProteomicsi | O00755 |
Protocols and materials databases
Antibodypediai | 2520, 209 antibodies from 30 providers |
DNASUi | 7476 |
Genome annotation databases
Ensembli | ENST00000285018; ENSP00000285018; ENSG00000154764 |
GeneIDi | 7476 |
KEGGi | hsa:7476 |
MANE-Selecti | ENST00000285018.5; ENSP00000285018.4; NM_004625.4; NP_004616.2 |
UCSCi | uc003bye.2, human |
Organism-specific databases
CTDi | 7476 |
DisGeNETi | 7476 |
GeneCardsi | WNT7A |
HGNCi | HGNC:12786, WNT7A |
HPAi | ENSG00000154764, Tissue enhanced (brain, gallbladder, placenta) |
MalaCardsi | WNT7A |
MIMi | 228930, phenotype 276820, phenotype 601570, gene |
neXtProti | NX_O00755 |
OpenTargetsi | ENSG00000154764 |
Orphaneti | 2854, Fuhrmann syndrome 2879, Phocomelia, Schinzel type |
PharmGKBi | PA37387 |
VEuPathDBi | HostDB:ENSG00000154764 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3913, Eukaryota |
GeneTreei | ENSGT00940000158523 |
HOGENOMi | CLU_033039_1_4_1 |
InParanoidi | O00755 |
OMAi | IVYLRIG |
OrthoDBi | 745245at2759 |
PhylomeDBi | O00755 |
TreeFami | TF105310 |
Enzyme and pathway databases
PathwayCommonsi | O00755 |
Reactomei | R-HSA-3238698, WNT ligand biogenesis and trafficking R-HSA-373080, Class B/2 (Secretin family receptors) |
SignaLinki | O00755 |
SIGNORi | O00755 |
Miscellaneous databases
BioGRID-ORCSi | 7476, 4 hits in 1027 CRISPR screens |
GeneWikii | WNT7A |
GenomeRNAii | 7476 |
Pharosi | O00755, Tbio |
PROi | PR:O00755 |
RNActi | O00755, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154764, Expressed in epithelium of bronchus and 74 other tissues |
Genevisiblei | O00755, HS |
Family and domain databases
Gene3Di | 3.30.2460.20, 1 hit |
InterProi | View protein in InterPro IPR005817, Wnt IPR013300, Wnt7 IPR043158, Wnt_C IPR018161, Wnt_CS |
PANTHERi | PTHR12027, PTHR12027, 1 hit |
Pfami | View protein in Pfam PF00110, wnt, 1 hit |
PRINTSi | PR01891, WNT7PROTEIN PR01349, WNTPROTEIN |
SMARTi | View protein in SMART SM00097, WNT1, 1 hit |
PROSITEi | View protein in PROSITE PS00246, WNT1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WNT7A_HUMAN | |
Accessioni | O00755Primary (citable) accession number: O00755 Secondary accession number(s): Q96H90, Q9Y560 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 17, 2007 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families