Protein Wnt-7a

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor ligand activity Source: BHF-UCLInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins."
    Caricasole A., Ferraro T., Iacovelli L., Barletta E., Caruso A., Melchiorri D., Terstappen G.C., Nicoletti F.
    J. Biol. Chem. 278:37024-37031(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• asymmetric protein localization involved in cell fate determination Source: Ensembl
• axonogenesis Source: ParkinsonsUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins."
    Caricasole A., Ferraro T., Iacovelli L., Barletta E., Caruso A., Melchiorri D., Terstappen G.C., Nicoletti F.
    J. Biol. Chem. 278:37024-37031(2003) [PubMed] [Europe PMC] [Abstract]
  • "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing."
    Lyu J., Joo C.K.
    J Biol Chem 280:21653-21660(2005) [PubMed] [Europe PMC] [Abstract]
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• cartilage condensation Source: AgBaseInferred from direct assayⁱ
  • "BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway."
    Jin E.J., Lee S.Y., Choi Y.A., Jung J.C., Bang O.S., Kang S.S.
    Mol Cells 22:353-359(2006) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell proliferation in forebrain Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2."
    Viti J., Gulacsi A., Lillien L.
    J Neurosci 23:5919-5927(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells."
    Zhou S., Eid K., Glowacki J.
    J Bone Miner Res 19:463-470(2004) [PubMed] [Europe PMC] [Abstract]
• central nervous system vasculogenesis Source: Ensembl
• cerebellar granule cell differentiation Source: Ensembl
• chondrocyte differentiation Source: AgBaseInferred from direct assayⁱ
  • "BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway."
    Jin E.J., Lee S.Y., Choi Y.A., Jung J.C., Bang O.S., Kang S.S.
    Mol Cells 22:353-359(2006) [PubMed] [Europe PMC] [Abstract]
• dendritic spine morphogenesis Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc Natl Acad Sci U S A 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]
• dorsal/ventral pattern formation Source: Ensembl
• embryonic axis specification Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.9

    "Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome."
    Woods C.G., Stricker S., Seemann P., Stern R., Cox J., Sherridan E., Roberts E., Springell K., Scott S., Karbani G., Sharif S.M., Toomes C., Bond J., Kumar D., Al-Gazali L., Mundlos S.
    Am. J. Hum. Genet. 79:402-408(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT FUHRS THR-109, VARIANT LPHAS CYS-292, CHARACTERIZATION OF VARIANT FUHRS THR-109, CHARACTERIZATION OF VARIANT LPHAS CYS-292, INVOLVEMENT IN FUHRS, INVOLVEMENT IN LPHAS, FUNCTION.
• embryonic digit morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome."
    Woods C.G., Stricker S., Seemann P., Stern R., Cox J., Sherridan E., Roberts E., Springell K., Scott S., Karbani G., Sharif S.M., Toomes C., Bond J., Kumar D., Al-Gazali L., Mundlos S.
    Am. J. Hum. Genet. 79:402-408(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT FUHRS THR-109, VARIANT LPHAS CYS-292, CHARACTERIZATION OF VARIANT FUHRS THR-109, CHARACTERIZATION OF VARIANT LPHAS CYS-292, INVOLVEMENT IN FUHRS, INVOLVEMENT IN LPHAS, FUNCTION.
• embryonic forelimb morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome."
    Woods C.G., Stricker S., Seemann P., Stern R., Cox J., Sherridan E., Roberts E., Springell K., Scott S., Karbani G., Sharif S.M., Toomes C., Bond J., Kumar D., Al-Gazali L., Mundlos S.
    Am. J. Hum. Genet. 79:402-408(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT FUHRS THR-109, VARIANT LPHAS CYS-292, CHARACTERIZATION OF VARIANT FUHRS THR-109, CHARACTERIZATION OF VARIANT LPHAS CYS-292, INVOLVEMENT IN FUHRS, INVOLVEMENT IN LPHAS, FUNCTION.
• embryonic hindlimb morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • Ref.9

    "Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome."
    Woods C.G., Stricker S., Seemann P., Stern R., Cox J., Sherridan E., Roberts E., Springell K., Scott S., Karbani G., Sharif S.M., Toomes C., Bond J., Kumar D., Al-Gazali L., Mundlos S.
    Am. J. Hum. Genet. 79:402-408(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT FUHRS THR-109, VARIANT LPHAS CYS-292, CHARACTERIZATION OF VARIANT FUHRS THR-109, CHARACTERIZATION OF VARIANT LPHAS CYS-292, INVOLVEMENT IN FUHRS, INVOLVEMENT IN LPHAS, FUNCTION.
• establishment of cell polarity Source: Ensembl
• excitatory synapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• lens fiber cell development Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Expression patterns of Wnt genes during development of an anterior part of the chicken eye."
    Fokina V.M., Frolova E.I.
    Dev. Dyn. 235:496-505(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of neurogenesis Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2."
    Viti J., Gulacsi A., Lillien L.
    J Neurosci 23:5919-5927(2003) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter secretion Source: Ensembl
• oviduct development Source: Ensembl
• positive regulation of cellular protein metabolic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells."
    Caruso A., Motolese M., Iacovelli L., Caraci F., Copani A., Nicoletti F., Terstappen G.C., Gaviraghi G., Caricasole A.
    J Neurochem 98:364-371(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell migration Source: Ensembl
• positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing."
    Lyu J., Joo C.K.
    J Biol Chem 280:21653-21660(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of excitatory postsynaptic potential Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc Natl Acad Sci U S A 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of excitatory synapse assembly Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • "Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca^2⁺/Calmodulin-dependent protein kinase II."
    Ciani L., Boyle K.A., Dickins E., Sahores M., Anane D., Lopes D.M., Gibb A.J., Salinas P.C.
    Proc Natl Acad Sci U S A 108:10732-10737(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of JNK cascade Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein localization to presynapse Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synapse assembly Source: BHF-UCLInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing."
    Lyu J., Joo C.K.
    J Biol Chem 280:21653-21660(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins."
    Caricasole A., Ferraro T., Iacovelli L., Barletta E., Caruso A., Melchiorri D., Terstappen G.C., Nicoletti F.
    J. Biol. Chem. 278:37024-37031(2003) [PubMed] [Europe PMC] [Abstract]
• postsynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• presynapse assembly Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases."
    Purro S.A., Galli S., Salinas P.C.
    J Mol Cell Biol 6:75-80(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of axon diameter Source: Ensembl
• regulation of postsynapse organization Source: Ensembl
• regulation of presynapse assembly Source: SynGOInferred from direct assayⁱ
  • "Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis."
    Sahores M., Gibb A., Salinas P.C.
    Development 137:2215-2225(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: Ensembl
• response to estradiol Source: Ensembl
• response to estrogen Source: Ensembl
• secondary palate development Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate."
    Chiquet B.T., Blanton S.H., Burt A., Ma D., Stal S., Mulliken J.B., Hecht J.T.
    Hum Mol Genet 17:2212-2218(2008) [PubMed] [Europe PMC] [Abstract]
• sex differentiation Source: ProtIncTraceable author statementⁱ
  • "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a."
    Parr B.A., McMahon A.P.
    Nature 395:707-710(1998) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle satellite cell activation Source: Ensembl
• skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
• somatic stem cell division Source: Ensembl
• somatic stem cell population maintenance Source: Ensembl
• stem cell development Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2."
    Viti J., Gulacsi A., Lillien L.
    J Neurosci 23:5919-5927(2003) [PubMed] [Europe PMC] [Abstract]
• synaptic vesicle recycling Source: ParkinsonsUK-UCLTraceable author statementⁱ
  • "The importance of Wnt signalling for neurodegeneration in Parkinson's disease."
    Berwick D.C., Harvey K.
    Biochem Soc Trans 40:1123-1128(2012) [PubMed] [Europe PMC] [Abstract]
• uterus morphogenesis Source: Ensembl
• Wnt signaling pathway Source: Reactome
• Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing."
    Lyu J., Joo C.K.
    J Biol Chem 280:21653-21660(2005) [PubMed] [Europe PMC] [Abstract]
• wound healing, spreading of epidermal cells Source: BHF-UCLInferred from direct assayⁱ
  • "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing."
    Lyu J., Joo C.K.
    J Biol Chem 280:21653-21660(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCLInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• frizzled binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor ligand activity Source: BHF-UCLInferred from direct assayⁱ
  • "Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation."
    Davis E.K., Zou Y., Ghosh A.
    Neural Dev 3:32-32(2008) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins."
    Caricasole A., Ferraro T., Iacovelli L., Barletta E., Caruso A., Melchiorri D., Terstappen G.C., Nicoletti F.
    J. Biol. Chem. 278:37024-37031(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA 
        60         70         80         90        100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG 
       110        120        130        140        150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG 
       160        170        180        190        200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC 
       210        220        230        240        250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT 
       260        270        280        290        300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 
       310        320        330        340 
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK  

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families