WNT7A

Functionⁱ

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes (By similarity). Required for normal neural stem cell proliferation in the hippocampus dentate gyrus (By similarity). Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation (By similarity). Promotes formation of synapses via its interaction with FZD5 (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18986540
frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
receptor ligand activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18986540
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12857724

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: Ensembl
asymmetric protein localization involved in cell fate determination Source: Ensembl
axonogenesis
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
cartilage condensation
Source: AgBase
Inferred from direct assayⁱ
- 17202865
cell fate commitment
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell proliferation in forebrain
Source: BHF-UCL
Inferred from direct assayⁱ
- 12843296
cellular response to transforming growth factor beta stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 15040835
central nervous system vasculogenesis Source: Ensembl
cerebellar granule cell differentiation Source: Ensembl
chondrocyte differentiation
Source: AgBase
Inferred from direct assayⁱ
- 17202865
dendritic spine morphogenesis
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21670302
dorsal/ventral pattern formation Source: Ensembl
embryonic axis specification
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16826533
embryonic digit morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16826533
embryonic forelimb morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16826533
embryonic hindlimb morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16826533
establishment of cell polarity Source: Ensembl
excitatory synapse assembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
lens fiber cell development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16258938
negative regulation of apoptotic process Source: Ensembl
negative regulation of neurogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 12843296
neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurotransmitter secretion Source: Ensembl
oviduct development Source: Ensembl
positive regulation of cellular protein metabolic process
Source: ARUK-UCL
Inferred from direct assayⁱ
- 16805831
positive regulation of endothelial cell migration Source: Ensembl
positive regulation of epithelial cell proliferation involved in wound healing
Source: BHF-UCL
Inferred from direct assayⁱ
- 15802269
positive regulation of excitatory postsynaptic potential
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21670302
positive regulation of excitatory synapse assembly
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 21670302
positive regulation of JNK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of protein localization to presynapse
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
positive regulation of synapse assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 18986540
positive regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 15802269
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12857724
postsynapse assembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
presynapse assembly
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 24449494
regulation of axon diameter Source: Ensembl
regulation of postsynapse organization Source: Ensembl
regulation of presynapse assembly
Source: SynGO
Inferred from direct assayⁱ
- 20530549
regulation of synaptic vesicle exocytosis Source: Ensembl
response to estradiol Source: Ensembl
response to estrogen Source: Ensembl
secondary palate development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18413325
sex differentiation
Source: ProtInc
Traceable author statementⁱ
- 9790192
skeletal muscle satellite cell activation Source: Ensembl
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
somatic stem cell division Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
stem cell development
Source: BHF-UCL
Inferred from direct assayⁱ
- 12843296
synaptic vesicle recycling
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 22988876
uterus morphogenesis Source: Ensembl
Wnt signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Wnt signaling pathway, planar cell polarity pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 15802269
wound healing, spreading of epidermal cells
Source: BHF-UCL
Inferred from direct assayⁱ
- 15802269

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Wnt signaling pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-373080 Class B/2 (Secretin family receptors)
SignaLinkⁱ	O00755
SIGNORⁱ	O00755

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein Wnt-7a
Gene namesⁱ	Name:WNT7A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154764.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12786 WNT7A
MIMⁱ	601570 gene
neXtProtⁱ	NX_O00755

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Limb pelvis hypoplasia aplasia syndrome (LPHAS)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present.

Fuhrmann syndrome (FUHRS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionDistinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030673	109	A → T in FUHRS; retains activity that is significant but not comparable to wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs104893832EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	206	S → A: Does not affect interaction with RECK. 1 Publication	1
Mutagenesisⁱ	241	V → A in 4A; abolished interaction with RECK; when associated with 251-A-A-252 and A-262. 1 Publication	1
Mutagenesisⁱ	251 – 252	FL → AA in 4A; abolished interaction with RECK; when associated with A-241 and A-262. 1 Publication	2
Mutagenesisⁱ	262	K → A in 4A; abolished interaction with RECK; when associated with A-241 and 251-A-A-252. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7476
MalaCards human disease database More...MalaCardsⁱ	WNT7A
MIMⁱ	228930 phenotype 276820 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000154764
Orphanetⁱ	2854 Fuhrmann syndrome 2879 Phocomelia, Schinzel type
PharmGKBⁱ	PA37387

Polymorphism and mutation databases

BioMutaⁱ	WNT7A

BioMutaⁱ

WNT7A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	Sequence analysisAdd BLAST		31
ChainⁱPRO_0000041442	32 – 349	Protein Wnt-7aAdd BLAST		318

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	73 ↔ 84	By similarity
Glycosylationⁱ	83	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	123 ↔ 131	By similarity
Glycosylationⁱ	127	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	133 ↔ 152	By similarity
Disulfide bondⁱ	200 ↔ 214	By similarity
Disulfide bondⁱ	202 ↔ 209	By similarity
Lipidationⁱ	206	O-palmitoleoyl serine; by PORCN1 Publication	1
Disulfide bondⁱ	294 ↔ 309	By similarity
Glycosylationⁱ	295	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	324 ↔ 339	By similarity
Disulfide bondⁱ	326 ↔ 336	By similarity
Disulfide bondⁱ	331 ↔ 332	By similarity

Post-translational modificationⁱ

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00755
PaxDbⁱ	O00755
PeptideAtlas More...PeptideAtlasⁱ	O00755
PRIDEⁱ	O00755
ProteomicsDBⁱ	48019
TopDownProteomicsⁱ	O00755

PTM databases

iPTMnetⁱ	O00755
PhosphoSitePlusⁱ	O00755

Expressionⁱ

Tissue specificityⁱ

Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.

Gene expression databases

Bgeeⁱ	ENSG00000154764 Expressed in 49 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_WNT7A
Genevisibleⁱ	O00755 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025894 HPA015719

HPAⁱ

CAB025894
HPA015719

Interactionⁱ

Subunit structureⁱ

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD5 (By similarity). Interacts with PORCN (By similarity). Interacts (via intrinsically disordered linker region) with RECK; interaction with RECK confers ligand selectivity for Wnt7 in brain endothelial cells and allows these cells to selectively respond to Wnt7 (PubMed:30026314).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
WIF1	Q9Y5W5	3	EBI-727198,EBI-3922719

With

Entry

#Exp.

IntAct

Notes

WIF1

Q9Y5W5

3

EBI-727198,EBI-3922719

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18986540
frizzled binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
receptor ligand activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18986540
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12857724

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113313, 31 interactors
Database of interacting proteins More...DIPⁱ	DIP-61511N
IntActⁱ	O00755, 3 interactors
Molecular INTeraction database More...MINTⁱ	O00755
STRINGⁱ	9606.ENSP00000285018

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00755
SMRⁱ	O00755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	238 – 266	Intrinsically disordered linker1 PublicationAdd BLAST		29

Domainⁱ

The intrinsically disordered linker region is required for recognition by RECK in brain endothelial cells.1 Publication

Sequence similaritiesⁱ

Belongs to the Wnt family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039528
HOVERGENⁱ	HBG001595
InParanoidⁱ	O00755
KEGG Orthology (KO) More...KOⁱ	K00572
OMAⁱ	KNMRLEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OFF
PhylomeDBⁱ	O00755
TreeFamⁱ	TF105310

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR013300 Wnt7 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01891 WNT7PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

O00755-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA 
        60         70         80         90        100
ICQSRPDAII VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG 
       110        120        130        140        150
SREAAFTYAI IAAGVAHAIT AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG 
       160        170        180        190        200
GCSADIRYGI GFAKVFVDAR EIKQNARTLM NLHNNEAGRK ILEENMKLEC 
       210        220        230        240        250
KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP VRASRNKRPT 
       260        270        280        290        300
FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 
       310        320        330        340 
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK

Length:349

Mass (Da):39,005

Last modified:April 17, 2007 - v2

Checksum:ⁱ259EF506CFCD7AB0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	R → L in AAC51319 (PubMed:9161407).Curated	1
Sequence conflictⁱ	14	L → F in BAA82509 (PubMed:8893824).Curated	1
Sequence conflictⁱ	20	Y → C in AAC51319 (PubMed:9161407).Curated	1
Sequence conflictⁱ	35	S → T in AAC51319 (PubMed:9161407).Curated	1
Sequence conflictⁱ	103 – 104	EA → DG in AAC51319 (PubMed:9161407).Curated	2
Sequence conflictⁱ	125	Q → H in AAC51319 (PubMed:9161407).Curated	1
Sequence conflictⁱ	280	E → G no nucleotide entry (PubMed:8168088).Curated	1
Sequence conflictⁱ	329	H → Q in BAA82509 (PubMed:8893824).Curated	1
Sequence conflictⁱ	338	T → K in BAA82509 (PubMed:8893824).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065765	72	E → K in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514666EnsemblClinVar.	1
Natural variantⁱVAR_077340	102	R → W in LPHAS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs879255548EnsemblClinVar.	1
Natural variantⁱVAR_030673	109	A → T in FUHRS; retains activity that is significant but not comparable to wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs104893832EnsemblClinVar.	1
Natural variantⁱVAR_064480	222	R → W in LPHAS. 1 PublicationCorresponds to variant dbSNP:rs397514643EnsemblClinVar.	1
Natural variantⁱVAR_030674	292	R → C in LPHAS; results in a loss of function mutation with some residual activity. 2 PublicationsCorresponds to variant dbSNP:rs104893835EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U53476 mRNA Translation: AAC51319.1 D83175 mRNA Translation: BAA82509.1 CH471055 Genomic DNA Translation: EAW64173.1 BC008811 mRNA Translation: AAH08811.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2616.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004616.2, NM_004625.3
UniGeneⁱ	Hs.72290

Genome annotation databases

Ensemblⁱ	ENST00000285018; ENSP00000285018; ENSG00000154764
GeneIDⁱ	7476
KEGGⁱ	hsa:7476
UCSC genome browser More...UCSCⁱ	uc003bye.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00755	Protein Wnt-7a		CALJA		349	UniRef100_O00755
Protein Wnt-7a		AOTTR		349
Protein Wnt-7a		GORGO		349
Protein Wnt-7a		PANTR		349
Protein Wnt-7a		PONPY		349
+13

Protein	Similar proteins		Species	Score	Length	Source
O00755	Protein Wnt-7a		CALJA		349	UniRef90_O00755
Protein Wnt-7a		AOTTR		349
Protein Wnt-7a		GORGO		349
Protein Wnt-7a		PANTR		349
Protein Wnt-7a		PONPY		349
+86

Protein	Similar proteins		Species	Score	Length	Source
O00755	Protein Wnt-7a		CALJA		349	UniRef50_O00755
Protein Wnt-7a		AOTTR		349
Protein Wnt-7a		GORGO		349
Protein Wnt-7a		PANTR		349
Protein Wnt-7a		PONPY		349
+256

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U53476 mRNA Translation: AAC51319.1 D83175 mRNA Translation: BAA82509.1 CH471055 Genomic DNA Translation: EAW64173.1 BC008811 mRNA Translation: AAH08811.1
CCDSⁱ	CCDS2616.1
RefSeqⁱ	NP_004616.2, NM_004625.3
UniGeneⁱ	Hs.72290

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4UZQ	X-ray	1.50	B	202-209	[»]
ProteinModelPortalⁱ	O00755
SMRⁱ	O00755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113313, 31 interactors
DIPⁱ	DIP-61511N
IntActⁱ	O00755, 3 interactors
MINTⁱ	O00755
STRINGⁱ	9606.ENSP00000285018

PTM databases

iPTMnetⁱ	O00755
PhosphoSitePlusⁱ	O00755

Polymorphism and mutation databases

BioMutaⁱ	WNT7A

BioMutaⁱ

WNT7A

Proteomic databases

MaxQBⁱ	O00755
PaxDbⁱ	O00755
PeptideAtlasⁱ	O00755
PRIDEⁱ	O00755
ProteomicsDBⁱ	48019
TopDownProteomicsⁱ	O00755

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7476
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000285018; ENSP00000285018; ENSG00000154764
GeneIDⁱ	7476
KEGGⁱ	hsa:7476
UCSCⁱ	uc003bye.2 human

Organism-specific databases

CTDⁱ	7476
DisGeNETⁱ	7476
EuPathDBⁱ	HostDB:ENSG00000154764.5
GeneCardsⁱ	WNT7A
HGNCⁱ	HGNC:12786 WNT7A
HPAⁱ	CAB025894 HPA015719
MalaCardsⁱ	WNT7A
MIMⁱ	228930 phenotype 276820 phenotype 601570 gene
neXtProtⁱ	NX_O00755
OpenTargetsⁱ	ENSG00000154764
Orphanetⁱ	2854 Fuhrmann syndrome 2879 Phocomelia, Schinzel type
PharmGKBⁱ	PA37387
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
GeneTreeⁱ	ENSGT00760000118943
HOGENOMⁱ	HOG000039528
HOVERGENⁱ	HBG001595
InParanoidⁱ	O00755
KOⁱ	K00572
OMAⁱ	KNMRLEC
OrthoDBⁱ	EOG091G0OFF
PhylomeDBⁱ	O00755
TreeFamⁱ	TF105310

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-373080 Class B/2 (Secretin family receptors)
SignaLinkⁱ	O00755
SIGNORⁱ	O00755

Miscellaneous databases

ChiTaRSⁱ	WNT7A human
GeneWikiⁱ	WNT7A
GenomeRNAiⁱ	7476
Protein Ontology More...PROⁱ	PR:O00755
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154764 Expressed in 49 organ(s), highest expression level in epithelium of bronchus
CleanExⁱ	HS_WNT7A
Genevisibleⁱ	O00755 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR013300 Wnt7 IPR018161 Wnt_CS
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01891 WNT7PROTEIN PR01349 WNTPROTEIN
SMARTⁱ	View protein in SMART SM00097 WNT1, 1 hit
PROSITEⁱ	View protein in PROSITE PS00246 WNT1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WNT7A_HUMAN
Accessionⁱ	O00755Primary (citable) accession number: O00755 Secondary accession number(s): Q96H90, Q9Y560
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	April 17, 2007
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00755 (WNT7A_HUMAN)

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Protein Wnt-7a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ