NME4

Functionⁱ

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).Curated4 Publications

Catalytic activityⁱ

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactorⁱ

Mg²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	45	ATPBy similarity	1
Binding siteⁱ	93	ATPBy similarity	1
Binding siteⁱ	121	ATPBy similarity	1
Binding siteⁱ	127	ATPBy similarity	1
Binding siteⁱ	138	ATPBy similarity	1
Binding siteⁱ	148	ATPBy similarity	1
Active siteⁱ	151	Pros-phosphohistidine intermediateBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cardiolipin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 23150663
metal ion binding Source: UniProtKB-KW
nucleoside diphosphate kinase activity
Source: Reactome
Inferred from experimentⁱ
- 10799505

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

CTP biosynthetic process Source: InterPro
GTP biosynthetic process Source: InterPro
lipid transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 23150663
nucleobase-containing small molecule interconversion Source: Reactome
nucleoside metabolic process
Source: ProtInc
Traceable author statementⁱ
- 9099850
UTP biosynthetic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Lipid transport, Nucleotide metabolism, Transport
Ligand	ATP-binding, Lipid-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.4.6 2681
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Chemistry databases

SwissLipidsⁱ	SLP:000000360

SwissLipidsⁱ

SLP:000000360

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleoside diphosphate kinase, mitochondrial (EC:2.7.4.6) Short name: NDK Short name: NDP kinase, mitochondrial Alternative name(s): Nucleoside diphosphate kinase D Short name: NDPKD nm23-H4
Gene namesⁱ	Name:NME4 Synonyms:NM23D
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000103202.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7852 NME4
MIMⁱ	601818 gene
neXtProtⁱ	NX_O00746

Keywords - Cellular componentⁱ

Membrane, Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	90	R → D: Abolishes cardiolipin-containing membrane binding; decreases lipid transfer and pro-apoptotic activity; does not change phosphotransfer activity. 2 Publications		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4833
Open Targets More...OpenTargetsⁱ	ENSG00000103202
PharmGKBⁱ	PA31657

Polymorphism and mutation databases

BioMutaⁱ	NME4

BioMutaⁱ

NME4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 28	MitochondrionSequence analysisAdd BLAST		28
ChainⁱPRO_0000019432	29 – 187	Nucleoside diphosphate kinase, mitochondrialAdd BLAST		159

Proteomic databases

EPDⁱ	O00746
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00746
PaxDbⁱ	O00746
PeptideAtlas More...PeptideAtlasⁱ	O00746
PRIDEⁱ	O00746
ProteomicsDBⁱ	48013

PTM databases

iPTMnetⁱ	O00746
PhosphoSitePlusⁱ	O00746

Expressionⁱ

Tissue specificityⁱ

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000103202 Expressed in 232 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_NME4
ExpressionAtlasⁱ	O00746 baseline and differential
Genevisibleⁱ	O00746 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB045997 HPA072588

HPAⁱ

CAB045997
HPA072588

Interactionⁱ

Subunit structureⁱ

Homohexamer (PubMed:10799505). Interacts with OPA1 (PubMed:23150663). Interacts with CAPN8 (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HTT	P42858	2	EBI-744871,EBI-466029
NME1	P15531	6	EBI-744871,EBI-741141
TRIP13	Q15645	3	EBI-744871,EBI-358993

Protein-protein interaction databases

BioGridⁱ	110897, 64 interactors
IntActⁱ	O00746, 62 interactors
Molecular INTeraction database More...MINTⁱ	O00746
STRINGⁱ	9606.ENSP00000219479

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 37	Combined sources	3
Beta strandⁱ	39 – 44	Combined sources	6
Helixⁱ	46 – 50	Combined sources	5
Helixⁱ	54 – 63	Combined sources	10
Beta strandⁱ	67 – 74	Combined sources	8
Helixⁱ	78 – 84	Combined sources	7
Helixⁱ	86 – 88	Combined sources	3
Helixⁱ	94 – 101	Combined sources	8
Beta strandⁱ	106 – 113	Combined sources	8
Helixⁱ	116 – 124	Combined sources	9
Helixⁱ	129 – 131	Combined sources	3
Helixⁱ	137 – 141	Combined sources	5
Beta strandⁱ	149 – 152	Combined sources	4
Helixⁱ	156 – 166	Combined sources	11
Helixⁱ	169 – 171	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O00746
SMRⁱ	O00746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O00746

EvolutionaryTraceⁱ

O00746

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NDK family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0888 Eukaryota COG0105 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119146
HOGENOMⁱ	HOG000224564
HOVERGENⁱ	HBG000423
InParanoidⁱ	O00746
KEGG Orthology (KO) More...KOⁱ	K00940
PhylomeDBⁱ	O00746
TreeFamⁱ	TF106373

Family and domain databases

Gene3Dⁱ	3.30.70.141, 1 hit
HAMAPⁱ	MF_00451 NDP_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR034907 NDK-like_dom IPR036850 NDK-like_dom_sf IPR001564 Nucleoside_diP_kinase IPR023005 Nucleoside_diP_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00334 NDK, 1 hit
PRINTSⁱ	PR01243 NUCDPKINASE
SMARTⁱ	View protein in SMART SM00562 NDK, 1 hit
SUPFAMⁱ	SSF54919 SSF54919, 1 hit
PROSITEⁱ	View protein in PROSITE PS00469 NDP_KINASES, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00746-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ 
        60         70         80         90        100
RRLVGDVIQR FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY 
       110        120        130        140        150
MSSGPVVAMV WEGYNVVRAS RAMIGHTDSA EAAPGTIRGD FSVHISRNVI 
       160        170        180 
HASDSVEGAQ REIQLWFQSS ELVSWADGGQ HSSIHPA

Length:187

Mass (Da):20,659

Last modified:July 1, 1997 - v1

Checksum:ⁱA56FEF18A7D712D4

GO

Isoform 2 (identifier: O00746-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-70: Missing.

« Hide

        10         20         30         40         50
MKMLQAPESV LAEHYQDLRR KPFYPALIRY MSSGPVVAMV WEGYNVVRAS 
        60         70         80         90        100
RAMIGHTDSA EAAPGTIRGD FSVHISRNVI HASDSVEGAQ REIQLWFQSS 
       110 
ELVSWADGGQ HSSIHPA

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »

Length:117

Mass (Da):12,979

Checksum:ⁱ3B885B828E3C1042

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q4TT34	Q4TT34_HUMAN	Nucleoside diphosphate kinase Nucleoside diphosphate kinase, EC 2.7.4.6	NME4	195	Annotation score:
F2Z2X0	F2Z2X0_HUMAN	Nucleoside diphosphate kinase Nucleoside diphosphate kinase, EC 2.7.4.6	NME4	233	Annotation score:
A0A087WVT9	A0A087WVT9_HUMAN	Nucleoside diphosphate kinase Nucleoside diphosphate kinase, EC 2.7.4.6	NME4	153	Annotation score:
H0Y6J0	H0Y6J0_HUMAN	Nucleoside diphosphate kinase, mito... Nucleoside diphosphate kinase, mitochondrial	NME4	169	Annotation score:
A2IDC9	A2IDC9_HUMAN	Nucleoside diphosphate kinase, mito... Nucleoside diphosphate kinase, mitochondrial	NME4	37	Annotation score:
F2Z297	F2Z297_HUMAN	Nucleoside diphosphate kinase, mito... Nucleoside diphosphate kinase, mitochondrial	NME4	44	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054743	1 – 70	Missing in isoform 2. CuratedAdd BLAST		70

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y07604 mRNA Translation: CAA68877.1 BT019438 mRNA Translation: AAV38245.1 AE006463 Genomic DNA Translation: AAK61230.1 Z97634 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85818.1 CH471112 Genomic DNA Translation: EAW85819.1 CH471112 Genomic DNA Translation: EAW85820.1 BC004880 mRNA Translation: AAH04880.1 BC017067 mRNA Translation: AAH17067.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10408.1 [O00746-1] CCDS66886.1 [O00746-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273362.1, NM_001286433.1 NP_001273364.1, NM_001286435.1 NP_001273365.1, NM_001286436.1 [O00746-2] NP_001273367.1, NM_001286438.1 [O00746-2] NP_001273368.1, NM_001286439.1 [O00746-2] NP_001273369.1, NM_001286440.1 [O00746-2] NP_005000.1, NM_005009.2 [O00746-1]
UniGeneⁱ	Hs.9235

Genome annotation databases

Ensemblⁱ	ENST00000219479; ENSP00000219479; ENSG00000103202 [O00746-1] ENST00000397722; ENSP00000380834; ENSG00000103202 [O00746-2] ENST00000450036; ENSP00000389048; ENSG00000103202 [O00746-2] ENST00000620944; ENSP00000479996; ENSG00000103202 [O00746-2]
GeneIDⁱ	4833
KEGGⁱ	hsa:4833
UCSC genome browser More...UCSCⁱ	uc002cgz.4 human [O00746-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00746	Nucleoside diphosphate kinase		HUMAN		195	UniRef90_O00746
Nucleoside diphosphate kinase		PONAB		117
Nucleoside diphosphate kinase		PANTR		195
Nucleoside diphosphate kinase		MACMU		195
Nucleoside diphosphate kinase		CERAT		195
+31

Protein	Similar proteins		Species	Score	Length	Source
O00746	Nucleoside diphosphate kinase		HUMAN		195	UniRef50_O00746
Nucleoside diphosphate kinase		PONAB		117
Nucleoside diphosphate kinase		MACMU		195
Nucleoside diphosphate kinase		CERAT		195
Nucleoside diphosphate kinase		MACFA		195
+138

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y07604 mRNA Translation: CAA68877.1 BT019438 mRNA Translation: AAV38245.1 AE006463 Genomic DNA Translation: AAK61230.1 Z97634 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85818.1 CH471112 Genomic DNA Translation: EAW85819.1 CH471112 Genomic DNA Translation: EAW85820.1 BC004880 mRNA Translation: AAH04880.1 BC017067 mRNA Translation: AAH17067.1
CCDSⁱ	CCDS10408.1 [O00746-1] CCDS66886.1 [O00746-2]
RefSeqⁱ	NP_001273362.1, NM_001286433.1 NP_001273364.1, NM_001286435.1 NP_001273365.1, NM_001286436.1 [O00746-2] NP_001273367.1, NM_001286438.1 [O00746-2] NP_001273368.1, NM_001286439.1 [O00746-2] NP_001273369.1, NM_001286440.1 [O00746-2] NP_005000.1, NM_005009.2 [O00746-1]
UniGeneⁱ	Hs.9235

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EHW	X-ray	2.40	A/B	33-175	[»]
ProteinModelPortalⁱ	O00746
SMRⁱ	O00746
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110897, 64 interactors
IntActⁱ	O00746, 62 interactors
MINTⁱ	O00746
STRINGⁱ	9606.ENSP00000219479

Chemistry databases

SwissLipidsⁱ	SLP:000000360

SwissLipidsⁱ

SLP:000000360

PTM databases

iPTMnetⁱ	O00746
PhosphoSitePlusⁱ	O00746

Polymorphism and mutation databases

BioMutaⁱ	NME4

BioMutaⁱ

NME4

Proteomic databases

EPDⁱ	O00746
MaxQBⁱ	O00746
PaxDbⁱ	O00746
PeptideAtlasⁱ	O00746
PRIDEⁱ	O00746
ProteomicsDBⁱ	48013

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4833
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000219479; ENSP00000219479; ENSG00000103202 [O00746-1] ENST00000397722; ENSP00000380834; ENSG00000103202 [O00746-2] ENST00000450036; ENSP00000389048; ENSG00000103202 [O00746-2] ENST00000620944; ENSP00000479996; ENSG00000103202 [O00746-2]
GeneIDⁱ	4833
KEGGⁱ	hsa:4833
UCSCⁱ	uc002cgz.4 human [O00746-1]

Organism-specific databases

CTDⁱ	4833
DisGeNETⁱ	4833
EuPathDBⁱ	HostDB:ENSG00000103202.12
GeneCardsⁱ	NME4
H-InvDBⁱ	HIX0012647
HGNCⁱ	HGNC:7852 NME4
HPAⁱ	CAB045997 HPA072588
MIMⁱ	601818 gene
neXtProtⁱ	NX_O00746
OpenTargetsⁱ	ENSG00000103202
PharmGKBⁱ	PA31657
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0888 Eukaryota COG0105 LUCA
GeneTreeⁱ	ENSGT00760000119146
HOGENOMⁱ	HOG000224564
HOVERGENⁱ	HBG000423
InParanoidⁱ	O00746
KOⁱ	K00940
PhylomeDBⁱ	O00746
TreeFamⁱ	TF106373

Enzyme and pathway databases

BRENDAⁱ	2.7.4.6 2681
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRSⁱ	NME4 human
EvolutionaryTraceⁱ	O00746
GeneWikiⁱ	NME4
GenomeRNAiⁱ	4833
Protein Ontology More...PROⁱ	PR:O00746
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000103202 Expressed in 232 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_NME4
ExpressionAtlasⁱ	O00746 baseline and differential
Genevisibleⁱ	O00746 HS

Family and domain databases

Gene3Dⁱ	3.30.70.141, 1 hit
HAMAPⁱ	MF_00451 NDP_kinase, 1 hit
InterProⁱ	View protein in InterPro IPR034907 NDK-like_dom IPR036850 NDK-like_dom_sf IPR001564 Nucleoside_diP_kinase IPR023005 Nucleoside_diP_kinase_AS
Pfamⁱ	View protein in Pfam PF00334 NDK, 1 hit
PRINTSⁱ	PR01243 NUCDPKINASE
SMARTⁱ	View protein in SMART SM00562 NDK, 1 hit
SUPFAMⁱ	SSF54919 SSF54919, 1 hit
PROSITEⁱ	View protein in PROSITE PS00469 NDP_KINASES, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDKM_HUMAN
Accessionⁱ	O00746Primary (citable) accession number: O00746 Secondary accession number(s): A2IDD0, Q5U0M9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00746 (NDKM_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Nucleoside diphosphate kinase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ