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UniProtKB - O00746 (NDKM_HUMAN)

Entry version 198 (23 Feb 2022)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

Nucleoside diphosphate kinase, mitochondrial

Gene

NME4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505).

Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663).

Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542).

Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086).

In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

Curated4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binding to anionic phospholipids, predominantly to cardiolipin inhibits its phosphotransfer activity.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei45ATPBy similarity1
Binding sitei93ATPBy similarity1
Binding sitei121ATPBy similarity1
Binding sitei127ATPBy similarity1
Binding sitei138ATPBy similarity1
Binding sitei148ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei151Pros-phosphohistidine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid transport, Nucleotide metabolism, Transport
LigandATP-binding, Lipid-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.4.6, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00746

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-499943, Interconversion of nucleotide di- and triphosphates

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00746

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleoside diphosphate kinase, mitochondrialCurated (EC:2.7.4.61 Publication)
Short name:
NDK
Short name:
NDP kinase, mitochondrial
Alternative name(s):
Nucleoside diphosphate kinase D
Short name:
NDPKD
nm23-H4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NME4Imported
Synonyms:NM23D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7852, NME4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601818, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00746

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000103202

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90R → D: Abolishes cardiolipin-containing membrane binding; decreases lipid transfer and pro-apoptotic activity; does not change phosphotransfer activity. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		4833

Open Targets

More...OpenTargetsi		ENSG00000103202

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31657

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00746, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NME4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001943229 – 187Nucleoside diphosphate kinase, mitochondrialAdd BLAST159

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00746

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00746

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00746

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00746

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00746

PeptideAtlas

More...PeptideAtlasi		O00746

PRoteomics IDEntifications database

More...PRIDEi		O00746

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		449
48013 [O00746-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00746

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103202, Expressed in fundus of stomach and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00746, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00746, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000103202, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer (PubMed:10799505).

Interacts with OPA1 (PubMed:23150663).

Interacts with CAPN8 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O00746
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-744871,EBI-11096309
AGT [P01019]3EBI-744871,EBI-751728
ARMC7 [Q9H6L4]3EBI-744871,EBI-742909
ATPAF2 [Q8N5M1]3EBI-744871,EBI-1166928
ATXN1 [P54253]6EBI-744871,EBI-930964
BRK1 [Q8WUW1]3EBI-744871,EBI-2837444
C14orf119 [Q9NWQ9]3EBI-744871,EBI-725606
C1orf109 [Q9NX04]3EBI-744871,EBI-8643161
CABP2 [Q9NPB3]3EBI-744871,EBI-12011224
CABP5 [Q9NP86]3EBI-744871,EBI-10311131
CCDC102B [Q68D86]3EBI-744871,EBI-10171570
CCDC57 - isoform 2 [Q2TAC2-2]5EBI-744871,EBI-10961624
CDKN2D [P55273]3EBI-744871,EBI-745859
CFAP206 [Q8IYR0]3EBI-744871,EBI-749051
CIB1 [Q99828]3EBI-744871,EBI-372594
CIB3 [Q96Q77]3EBI-744871,EBI-10292696
CIDEB [Q9UHD4]3EBI-744871,EBI-7062247
DTX2 [Q86UW9]3EBI-744871,EBI-740376
HBD [P02042]3EBI-744871,EBI-6152722
HDAC7 - isoform 6 [Q8WUI4-6]3EBI-744871,EBI-12094670
HSF2BP [O75031]3EBI-744871,EBI-7116203
HTT [P42858]20EBI-744871,EBI-466029
KLKB1 [P03952]3EBI-744871,EBI-10087153
LMO4 [P61968]3EBI-744871,EBI-2798728
LPL [P06858]3EBI-744871,EBI-715909
MKRN3 [Q13064]3EBI-744871,EBI-2340269
MLH1 [P40692]3EBI-744871,EBI-744248
NME1 [P15531]11EBI-744871,EBI-741141
NME2 [P22392]5EBI-744871,EBI-713693
NME7 [Q9Y5B8]3EBI-744871,EBI-744782
NUTF2 [P61970]3EBI-744871,EBI-591778
NXF1 [Q9UBU9]3EBI-744871,EBI-398874
PACSIN1 [Q9BY11]3EBI-744871,EBI-721769
POLR1C [O15160]5EBI-744871,EBI-1055079
PSMB1 [P20618]3EBI-744871,EBI-372273
SNCA [P37840]3EBI-744871,EBI-985879
SPG21 [Q9NZD8]3EBI-744871,EBI-742688
SUFU [Q9UMX1]3EBI-744871,EBI-740595
TARDBP [Q13148]6EBI-744871,EBI-372899
TOR1A - isoform 2 [O14656-2]3EBI-744871,EBI-25847109
TRAPPC2 - isoform 3 [P0DI81-3]3EBI-744871,EBI-11961968
TRIP13 [Q15645]4EBI-744871,EBI-358993
TSSK3 [Q96PN8]3EBI-744871,EBI-3918381
TTC19 [Q6DKK2]3EBI-744871,EBI-948354
UBL5 [Q9BZL1]3EBI-744871,EBI-607755
VHL - isoform 2 [P40337-2]3EBI-744871,EBI-12157263
ZBTB16 [Q05516]3EBI-744871,EBI-711925

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110897, 181 interactors

Protein interaction database and analysis system

More...IntActi		O00746, 120 interactors

Molecular INTeraction database

More...MINTi		O00746

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219479

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00746, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00746

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NDK family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0888, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_060216_6_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00746

Identification of Orthologs from Complete Genome Data

More...OMAi		WADEGHH

Database of Orthologous Groups

More...OrthoDBi		1334716at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00746

TreeFam database of animal gene trees

More...TreeFami		TF106373

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.141, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00451, NDP_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR034907, NDK-like_dom
IPR036850, NDK-like_dom_sf
IPR001564, Nucleoside_diP_kinase
IPR023005, Nucleoside_diP_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00334, NDK, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01243, NUCDPKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00562, NDK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54919, SSF54919, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00469, NDP_KINASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGLFWRSAL RGLRCGPRAP GPSLLVRHGS GGPSWTRERT LVAVKPDGVQ 
        60         70         80         90        100
RRLVGDVIQR FERRGFTLVG MKMLQAPESV LAEHYQDLRR KPFYPALIRY 
       110        120        130        140        150
MSSGPVVAMV WEGYNVVRAS RAMIGHTDSA EAAPGTIRGD FSVHISRNVI 
       160        170        180 
HASDSVEGAQ REIQLWFQSS ELVSWADGGQ HSSIHPA
Length:187
Mass (Da):20,659
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA56FEF18A7D712D4
GO
Isoform 2 (identifier: O00746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:117
Mass (Da):12,979
Checksum:i3B885B828E3C1042
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4TT34Q4TT34_HUMAN
Nucleoside diphosphate kinase
NME4
195Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2X0F2Z2X0_HUMAN
Nucleoside diphosphate kinase
NME4
233Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVT9A0A087WVT9_HUMAN
Nucleoside diphosphate kinase
NME4
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2IDC9A2IDC9_HUMAN
Nucleoside diphosphate kinase, mito...
NME4
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6J0H0Y6J0_HUMAN
Nucleoside diphosphate kinase, mito...
NME4
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z297F2Z297_HUMAN
Nucleoside diphosphate kinase, mito...
NME4
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547431 – 70Missing in isoform 2. CuratedAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y07604 mRNA Translation: CAA68877.1
BT019438 mRNA Translation: AAV38245.1
AE006463 Genomic DNA Translation: AAK61230.1
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85818.1
CH471112 Genomic DNA Translation: EAW85819.1
CH471112 Genomic DNA Translation: EAW85820.1
BC004880 mRNA Translation: AAH04880.1
BC017067 mRNA Translation: AAH17067.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10408.1 [O00746-1]
CCDS66886.1 [O00746-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273362.1, NM_001286433.1
NP_001273364.1, NM_001286435.1
NP_001273365.1, NM_001286436.1 [O00746-2]
NP_001273367.1, NM_001286438.1 [O00746-2]
NP_001273368.1, NM_001286439.1 [O00746-2]
NP_001273369.1, NM_001286440.1 [O00746-2]
NP_005000.1, NM_005009.2 [O00746-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219479; ENSP00000219479; ENSG00000103202
ENST00000397722; ENSP00000380834; ENSG00000103202 [O00746-2]
ENST00000450036; ENSP00000389048; ENSG00000103202 [O00746-2]
ENST00000620944; ENSP00000479996; ENSG00000103202 [O00746-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4833

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000219479.7; ENSP00000219479.2; NM_005009.3; NP_005000.1

UCSC genome browser

More...UCSCi		uc002cgz.4, human [O00746-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07604 mRNA Translation: CAA68877.1
BT019438 mRNA Translation: AAV38245.1
AE006463 Genomic DNA Translation: AAK61230.1
Z97634 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85818.1
CH471112 Genomic DNA Translation: EAW85819.1
CH471112 Genomic DNA Translation: EAW85820.1
BC004880 mRNA Translation: AAH04880.1
BC017067 mRNA Translation: AAH17067.1
CCDSiCCDS10408.1 [O00746-1]
CCDS66886.1 [O00746-2]
RefSeqiNP_001273362.1, NM_001286433.1
NP_001273364.1, NM_001286435.1
NP_001273365.1, NM_001286436.1 [O00746-2]
NP_001273367.1, NM_001286438.1 [O00746-2]
NP_001273368.1, NM_001286439.1 [O00746-2]
NP_001273369.1, NM_001286440.1 [O00746-2]
NP_005000.1, NM_005009.2 [O00746-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHWX-ray2.40A/B33-175[»]
SMRiO00746
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110897, 181 interactors
IntActiO00746, 120 interactors
MINTiO00746
STRINGi9606.ENSP00000219479

Chemistry databases

SwissLipidsiSLP:000000360

PTM databases

iPTMnetiO00746
PhosphoSitePlusiO00746

Genetic variation databases

BioMutaiNME4

Proteomic databases

EPDiO00746
jPOSTiO00746
MassIVEiO00746
MaxQBiO00746
PaxDbiO00746
PeptideAtlasiO00746
PRIDEiO00746
ProteomicsDBi449
48013 [O00746-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34896, 380 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		4833

Genome annotation databases

EnsembliENST00000219479; ENSP00000219479; ENSG00000103202
ENST00000397722; ENSP00000380834; ENSG00000103202 [O00746-2]
ENST00000450036; ENSP00000389048; ENSG00000103202 [O00746-2]
ENST00000620944; ENSP00000479996; ENSG00000103202 [O00746-2]
GeneIDi4833
KEGGihsa:4833
MANE-SelectiENST00000219479.7; ENSP00000219479.2; NM_005009.3; NP_005000.1
UCSCiuc002cgz.4, human [O00746-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4833
DisGeNETi4833

GeneCards: human genes, protein and diseases

More...GeneCardsi		NME4
HGNCiHGNC:7852, NME4
HPAiENSG00000103202, Low tissue specificity
MIMi601818, gene
neXtProtiNX_O00746
OpenTargetsiENSG00000103202
PharmGKBiPA31657
VEuPathDBiHostDB:ENSG00000103202

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0888, Eukaryota
GeneTreeiENSGT00940000160286
HOGENOMiCLU_060216_6_3_1
InParanoidiO00746
OMAiWADEGHH
OrthoDBi1334716at2759
PhylomeDBiO00746
TreeFamiTF106373

Enzyme and pathway databases

BRENDAi2.7.4.6, 2681
PathwayCommonsiO00746
ReactomeiR-HSA-499943, Interconversion of nucleotide di- and triphosphates
SignaLinkiO00746

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4833, 5 hits in 1045 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NME4, human
EvolutionaryTraceiO00746

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NME4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4833
PharosiO00746, Tbio

Protein Ontology

More...PROi		PR:O00746
RNActiO00746, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103202, Expressed in fundus of stomach and 245 other tissues
ExpressionAtlasiO00746, baseline and differential
GenevisibleiO00746, HS

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451, NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907, NDK-like_dom
IPR036850, NDK-like_dom_sf
IPR001564, Nucleoside_diP_kinase
IPR023005, Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334, NDK, 1 hit
PRINTSiPR01243, NUCDPKINASE
SMARTiView protein in SMART
SM00562, NDK, 1 hit
SUPFAMiSSF54919, SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469, NDP_KINASES, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDKM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00746
Secondary accession number(s): A2IDD0, Q5U0M9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: February 23, 2022
This is version 198 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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