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UniProtKB - O00743 (PPP6_HUMAN)

Entry version 201 (25 May 2022)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

Serine/threonine-protein phosphatase 6 catalytic subunit

Gene

PPP6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700).

PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379).

N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194).

During mitosis, regulates spindle positioning (PubMed:27335426).

Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228).

Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation (PubMed:29053956).

Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32753499, PubMed:32474700).

CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700).

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53Manganese 1By similarity1
Metal bindingi55Manganese 1By similarity1
Metal bindingi81Manganese 1By similarity1
Metal bindingi81Manganese 2By similarity1
Metal bindingi113Manganese 2By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei114Proton donorBy similarity1
Metal bindingi163Manganese 2By similarity1
Metal bindingi237Manganese 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Immunity, Innate immunity
LigandManganese, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00743

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-171319, Telomere Extension By Telomerase
R-HSA-204005, COPII-mediated vesicle transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00743

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00743

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 catalytic subunitCurated (EC:3.1.3.163 Publications)
Short name:
PP6C1 Publication
Cleaved into the following chain:
Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP6C1 PublicationImported
Synonyms:PPP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9323, PPP6C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612725, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00743

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000119414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5537

Open Targets

More...OpenTargetsi		ENSG00000119414

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33687

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00743, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105731

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PPP6C

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004245041 – 305Serine/threonine-protein phosphatase 6 catalytic subunitAdd BLAST305
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00000588772 – 305Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processedAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00743

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00743

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00743

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00743

PeptideAtlas

More...PeptideAtlasi		O00743

PRoteomics IDEntifications database

More...PRIDEi		O00743

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48009 [O00743-1]
48010 [O00743-2]
48011 [O00743-3]

2D gel databases

USC-OGP 2-DE database

More...OGPi		O00743

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		PPP6C

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00743

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00743

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Regulated by IL2/interleukin-2 in peripheral blood T cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000119414, Expressed in oocyte and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00743, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00743, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000119414, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS) (PubMed:18186651).

Interacts with subunits PPP6R1, PPP6R2 and PPP6R3 (PubMed:16769727, PubMed:18186651).

Interacts with subunit ANKRD28 (PubMed:18186651).

Interacts with IGBP1 (PubMed:9647778).

Interacts with MAP3K7 (PubMed:17079228).

Interacts with NFKBIE (PubMed:16769727).

Interacts with TRIM14 and WRNIP1; these interactions positively regulate the RIG-I/DDX58 signaling pathway (PubMed:29053956).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111529, 185 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O00743

Database of interacting proteins

More...DIPi		DIP-27581N

Protein interaction database and analysis system

More...IntActi		O00743, 77 interactors

Molecular INTeraction database

More...MINTi		O00743

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00743, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O00743

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00743

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004962_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00743

Identification of Orthologs from Complete Genome Data

More...OMAi		CQNKYGN

Database of Orthologous Groups

More...OrthoDBi		808922at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00743

TreeFam database of animal gene trees

More...TreeFami		TF105563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.21.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR006186, Ser/Thr-sp_prot-phosphatase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00149, Metallophos, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00114, STPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00156, PP2Ac, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56300, SSF56300, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O00743-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV 
        60         70         80         90        100
CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK 
       110        120        130        140        150
AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT 
       160        170        180        190        200
VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE 
       210        220        230        240        250
DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE 
       260        270        280        290        300
KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 

TPYFL
Length:305
Mass (Da):35,144
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55E95DB6CEA7CFF4
GO
Isoform 2 (identifier: O00743-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-79: Missing.

Show »
Length:283
Mass (Da):32,532
Checksum:iC2334512732059DC
GO
Isoform 3 (identifier: O00743-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-25: K → KVSPICGLAPSGCGAPAGRPFLSPGPPPVFHFLRFLKE

Show »
Length:342
Mass (Da):38,947
Checksum:iC26CAD5C8016F112
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1S7Q5T1S7_HUMAN
Serine/threonine-protein phosphatas...
PPP6C
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61 – 64LCEL → AG in AAD45400 (PubMed:10227379).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08552855H → Y Found in patients with melanomas; decreased protein phosphatase activity, leading to increased phosphorylation of STING1. 1 Publication1
Natural variantiVAR_085529114H → Y Found in patients with melanomas; decreased protein phosphatase activity, leading to increased phosphorylation of STING1. 1 Publication1
Natural variantiVAR_085530189G → R Found in patients with melanomas; decreased protein phosphatase activity, leading to increased phosphorylation of STING1. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04115825K → KVSPICGLAPSGCGAPAGRP FLSPGPPPVFHFLRFLKE in isoform 3. 1 Publication1
Alternative sequenceiVSP_03837658 – 79Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X92972 mRNA Translation: CAA63549.1
AF035158 mRNA Translation: AAD45400.2
AK295190 mRNA Translation: BAH12005.1
AK299087 mRNA Translation: BAH12945.1
AK312332 mRNA Translation: BAG35253.1
BT019708 mRNA Translation: AAV38514.1
AL445930 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87611.1
BC006990 mRNA Translation: AAH06990.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48018.1 [O00743-3]
CCDS48019.1 [O00743-2]
CCDS6861.1 [O00743-1]

NCBI Reference Sequences

More...RefSeqi		NP_001116827.1, NM_001123355.1 [O00743-3]
NP_001116841.1, NM_001123369.1 [O00743-2]
NP_002712.1, NM_002721.4 [O00743-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373547.9; ENSP00000362648.4; ENSG00000119414.12
ENST00000415905.5; ENSP00000411744.1; ENSG00000119414.12 [O00743-2]
ENST00000451402.5; ENSP00000392147.1; ENSG00000119414.12 [O00743-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5537

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5537

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000373547.9; ENSP00000362648.4; NM_002721.5; NP_002712.1

UCSC genome browser

More...UCSCi		uc004bpg.5, human [O00743-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92972 mRNA Translation: CAA63549.1
AF035158 mRNA Translation: AAD45400.2
AK295190 mRNA Translation: BAH12005.1
AK299087 mRNA Translation: BAH12945.1
AK312332 mRNA Translation: BAG35253.1
BT019708 mRNA Translation: AAV38514.1
AL445930 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87611.1
BC006990 mRNA Translation: AAH06990.1
CCDSiCCDS48018.1 [O00743-3]
CCDS48019.1 [O00743-2]
CCDS6861.1 [O00743-1]
RefSeqiNP_001116827.1, NM_001123355.1 [O00743-3]
NP_001116841.1, NM_001123369.1 [O00743-2]
NP_002712.1, NM_002721.4 [O00743-1]

3D structure databases

AlphaFoldDBiO00743
SMRiO00743
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi111529, 185 interactors
CORUMiO00743
DIPiDIP-27581N
IntActiO00743, 77 interactors
MINTiO00743

Chemistry databases

ChEMBLiCHEMBL4105731

PTM databases

DEPODiPPP6C
iPTMnetiO00743
PhosphoSitePlusiO00743

Genetic variation databases

BioMutaiPPP6C

2D gel databases

OGPiO00743

Proteomic databases

EPDiO00743
jPOSTiO00743
MassIVEiO00743
MaxQBiO00743
PeptideAtlasiO00743
PRIDEiO00743
ProteomicsDBi48009 [O00743-1]
48010 [O00743-2]
48011 [O00743-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30522, 291 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		5537

Genome annotation databases

EnsembliENST00000373547.9; ENSP00000362648.4; ENSG00000119414.12
ENST00000415905.5; ENSP00000411744.1; ENSG00000119414.12 [O00743-2]
ENST00000451402.5; ENSP00000392147.1; ENSG00000119414.12 [O00743-3]
GeneIDi5537
KEGGihsa:5537
MANE-SelectiENST00000373547.9; ENSP00000362648.4; NM_002721.5; NP_002712.1
UCSCiuc004bpg.5, human [O00743-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5537
DisGeNETi5537

GeneCards: human genes, protein and diseases

More...GeneCardsi		PPP6C
HGNCiHGNC:9323, PPP6C
HPAiENSG00000119414, Low tissue specificity
MIMi612725, gene
neXtProtiNX_O00743
OpenTargetsiENSG00000119414
PharmGKBiPA33687
VEuPathDBiHostDB:ENSG00000119414

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00550000074961
HOGENOMiCLU_004962_8_1_1
InParanoidiO00743
OMAiCQNKYGN
OrthoDBi808922at2759
PhylomeDBiO00743
TreeFamiTF105563

Enzyme and pathway databases

PathwayCommonsiO00743
ReactomeiR-HSA-171319, Telomere Extension By Telomerase
R-HSA-204005, COPII-mediated vesicle transport
SignaLinkiO00743
SIGNORiO00743

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5537, 432 hits in 1093 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PPP6C, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PPP6C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5537
PharosiO00743, Tbio

Protein Ontology

More...PROi		PR:O00743
RNActiO00743, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000119414, Expressed in oocyte and 250 other tissues
ExpressionAtlasiO00743, baseline and differential
GenevisibleiO00743, HS

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843, Calcineurin-like_PHP_ApaH
IPR029052, Metallo-depent_PP-like
IPR006186, Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149, Metallophos, 1 hit
PRINTSiPR00114, STPHPHTASE
SMARTiView protein in SMART
SM00156, PP2Ac, 1 hit
SUPFAMiSSF56300, SSF56300, 1 hit
PROSITEiView protein in PROSITE
PS00125, SER_THR_PHOSPHATASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00743
Secondary accession number(s): B2R5V6
, B7Z2W9, B7Z5K9, Q5U0A2, Q9UIC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 25, 2022
This is version 201 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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