TRIM38

Functionⁱ

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.1 Publication

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	16 – 63	RING-typePROSITE-ProRule annotationAdd BLAST		48
Zinc fingerⁱ	88 – 129	B box-typePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

transferase activity Source: UniProtKB-KW
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

interferon-gamma-mediated signaling pathway Source: Reactome
negative regulation of defense response to virus Source: Ensembl
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23077300
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 23077300
positive regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23077300
positive regulation of viral entry into host cell
Source: UniProtKB
Inferred from direct assayⁱ
- 18248090
positive regulation of viral genome replication Source: Ensembl
proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
protein K48-linked ubiquitination Source: Ensembl
regulation of interferon-beta production Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Immunity, Innate immunity, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300 Interferon gamma signaling
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase TRIM38 (EC:2.3.2.27) Alternative name(s): RING finger protein 15 RING-type E3 ubiquitin transferase TRIM38Curated Tripartite motif-containing protein 38 Zinc finger protein RoRet
Gene namesⁱ	Name:TRIM38 Synonyms:RNF15, RORET
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112343.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10059 TRIM38
neXtProtⁱ	NX_O00635

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10475
Open Targets More...OpenTargetsⁱ	ENSG00000112343
PharmGKBⁱ	PA35532

Polymorphism and mutation databases

BioMutaⁱ	TRIM38

BioMutaⁱ

TRIM38

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056256	1 – 465	E3 ubiquitin-protein ligase TRIM38Add BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	70	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	O00635
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00635
PaxDbⁱ	O00635
PeptideAtlas More...PeptideAtlasⁱ	O00635
PRIDEⁱ	O00635
ProteomicsDBⁱ	48005

PTM databases

iPTMnetⁱ	O00635
PhosphoSitePlusⁱ	O00635

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000112343 Expressed in 241 organ(s), highest expression level in caecum
CleanExⁱ	HS_TRIM38
ExpressionAtlasⁱ	O00635 baseline and differential
Genevisibleⁱ	O00635 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031685

HPAⁱ

HPA031685

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FLJ13057	Q53SE7	3	EBI-2130415,EBI-10172181
GC20	Q6FG85	3	EBI-2130415,EBI-10249571
GORASP2	Q9H8Y8	5	EBI-2130415,EBI-739467
HSPA2	P54652	3	EBI-2130415,EBI-356991
HSPA8	P11142	5	EBI-2130415,EBI-351896
RFC5	P40937	5	EBI-2130415,EBI-712376
SDCBP	O00560	3	EBI-2130415,EBI-727004
STXBP1	P61764	8	EBI-2130415,EBI-960169
TSPYL4	Q9UJ04	5	EBI-2130415,EBI-308511
UBE2I	Q7KZS0	5	EBI-2130415,EBI-10180829

Protein-protein interaction databases

BioGridⁱ	115738, 34 interactors
IntActⁱ	O00635, 24 interactors
Molecular INTeraction database More...MINTⁱ	O00635
STRINGⁱ	9606.ENSP00000230099

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00635
SMRⁱ	O00635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	274 – 465	B30.2/SPRYPROSITE-ProRule annotationAdd BLAST		192

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	16 – 63	RING-typePROSITE-ProRule annotationAdd BLAST		48
Zinc fingerⁱ	88 – 129	B box-typePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410ITEY Eukaryota ENOG410Y1I6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118893
HOGENOMⁱ	HOG000234133
HOVERGENⁱ	HBG001357
InParanoidⁱ	O00635
KEGG Orthology (KO) More...KOⁱ	K12014
OMAⁱ	PDTAHHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	O00635
TreeFamⁱ	TF342569

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00021 BBOX, 1 hit cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR035790 SPRY/PRY_TRIM38 IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O00635-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK 
        60         70         80         90        100
QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF 
       110        120        130        140        150
HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL 
       160        170        180        190        200
EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR 
       210        220        230        240        250
LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND 
       260        270        280        290        300
TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT 
       310        320        330        340        350
AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE 
       360        370        380        390        400
VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP 
       410        420        430        440        450
TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF 
       460 
QVYQYSPLFL PPPGD

Length:465

Mass (Da):53,416

Last modified:July 1, 1997 - v1

Checksum:ⁱ30A884051A2DA058

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	23	M → I in AAH26930 (PubMed:15489334).Curated		1
Sequence conflictⁱ	411	L → P in BAG36059 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_013513	421	G → R. Corresponds to variant dbSNP:rs10317Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91328 Genomic DNA Translation: AAB82084.1 U90547 mRNA Translation: AAB53425.1 AK313248 mRNA Translation: BAG36059.1 BC026930 mRNA Translation: AAH26930.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4568.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006346.1, NM_006355.4 XP_005248856.1, XM_005248799.4 XP_005248857.1, XM_005248800.4
UniGeneⁱ	Hs.584851 Hs.742026

Genome annotation databases

Ensemblⁱ	ENST00000357085; ENSP00000349596; ENSG00000112343
GeneIDⁱ	10475
KEGGⁱ	hsa:10475
UCSC genome browser More...UCSCⁱ	uc003nfm.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O00635	Tripartite motif-containing 38, isoform CRA_a		HUMAN		465	UniRef100_O00635

Protein	Similar proteins		Species	Score	Length	Source
O00635	Tripartite motif-containing 38, isoform CRA_a		HUMAN		465	UniRef90_O00635
Uncharacterized protein		PAPAN		468
Tripartite motif-containing protein 38 (Fragment)		MACMU		272
Uncharacterized protein		COLAP		465
Uncharacterized protein		NOMLE		465
+18

Protein	Similar proteins		Species	Score	Length	Source
O00635	E3 ubiquitin-protein ligase TRIM38		BOVIN		460	UniRef50_O00635
Tripartite motif-containing 38, isoform CRA_a		HUMAN		465
Uncharacterized protein		PAPAN		468
Tripartite motif-containing protein 38 (Fragment)		MACMU		272
Tripartite motif containing 38		GORGO		465
+147

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U91328 Genomic DNA Translation: AAB82084.1 U90547 mRNA Translation: AAB53425.1 AK313248 mRNA Translation: BAG36059.1 BC026930 mRNA Translation: AAH26930.1
CCDSⁱ	CCDS4568.1
RefSeqⁱ	NP_006346.1, NM_006355.4 XP_005248856.1, XM_005248799.4 XP_005248857.1, XM_005248800.4
UniGeneⁱ	Hs.584851 Hs.742026

3D structure databases

ProteinModelPortalⁱ	O00635
SMRⁱ	O00635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115738, 34 interactors
IntActⁱ	O00635, 24 interactors
MINTⁱ	O00635
STRINGⁱ	9606.ENSP00000230099

PTM databases

iPTMnetⁱ	O00635
PhosphoSitePlusⁱ	O00635

Polymorphism and mutation databases

BioMutaⁱ	TRIM38

BioMutaⁱ

TRIM38

Proteomic databases

EPDⁱ	O00635
MaxQBⁱ	O00635
PaxDbⁱ	O00635
PeptideAtlasⁱ	O00635
PRIDEⁱ	O00635
ProteomicsDBⁱ	48005

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10475
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357085; ENSP00000349596; ENSG00000112343
GeneIDⁱ	10475
KEGGⁱ	hsa:10475
UCSCⁱ	uc003nfm.5 human

Organism-specific databases

CTDⁱ	10475
DisGeNETⁱ	10475
EuPathDBⁱ	HostDB:ENSG00000112343.10
GeneCardsⁱ	TRIM38
HGNCⁱ	HGNC:10059 TRIM38
HPAⁱ	HPA031685
neXtProtⁱ	NX_O00635
OpenTargetsⁱ	ENSG00000112343
PharmGKBⁱ	PA35532
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ITEY Eukaryota ENOG410Y1I6 LUCA
GeneTreeⁱ	ENSGT00760000118893
HOGENOMⁱ	HOG000234133
HOVERGENⁱ	HBG001357
InParanoidⁱ	O00635
KOⁱ	K12014
OMAⁱ	PDTAHHE
OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	O00635
TreeFamⁱ	TF342569

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSⁱ	TRIM38 human
GenomeRNAiⁱ	10475
Protein Ontology More...PROⁱ	PR:O00635

Gene expression databases

Bgeeⁱ	ENSG00000112343 Expressed in 241 organ(s), highest expression level in caecum
CleanExⁱ	HS_TRIM38
ExpressionAtlasⁱ	O00635 baseline and differential
Genevisibleⁱ	O00635 HS

Family and domain databases

CDDⁱ	cd00021 BBOX, 1 hit cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR035790 SPRY/PRY_TRIM38 IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRI38_HUMAN
Accessionⁱ	O00635Primary (citable) accession number: O00635 Secondary accession number(s): B2R862
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - O00635 (TRI38_HUMAN)

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E3 ubiquitin-protein ligase TRIM38

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ