UniProtKB - O00635 (TRI38_HUMAN)
Protein
E3 ubiquitin-protein ligase TRIM38
Gene
TRIM38
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.1 Publication
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 63 | RING-typePROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: GO_Central
- interferon-gamma-mediated signaling pathway Source: Reactome
- negative regulation of defense response to virus Source: Ensembl
- positive regulation of autophagy Source: GO_Central
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of viral entry into host cell Source: UniProtKB
- positive regulation of viral genome replication Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
- protein K48-linked ubiquitination Source: Ensembl
- protein polyubiquitination Source: GO_Central
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of interferon-beta production Source: Ensembl
- regulation of protein localization Source: GO_Central
- regulation of viral entry into host cell Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Immunity, Innate immunity, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O00635 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase TRIM38 (EC:2.3.2.27)Alternative name(s): RING finger protein 15 RING-type E3 ubiquitin transferase TRIM38Curated Tripartite motif-containing protein 38 Zinc finger protein RoRet |
Gene namesi | Name:TRIM38 Synonyms:RNF15, RORET |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112343.10 |
HGNCi | HGNC:10059, TRIM38 |
neXtProti | NX_O00635 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10475 |
OpenTargetsi | ENSG00000112343 |
PharmGKBi | PA35532 |
Miscellaneous databases
Pharosi | O00635, Tbio |
Polymorphism and mutation databases
BioMutai | TRIM38 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056256 | 1 – 465 | E3 ubiquitin-protein ligase TRIM38Add BLAST | 465 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 70 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O00635 |
jPOSTi | O00635 |
MassIVEi | O00635 |
MaxQBi | O00635 |
PaxDbi | O00635 |
PeptideAtlasi | O00635 |
PRIDEi | O00635 |
ProteomicsDBi | 48005 |
PTM databases
iPTMneti | O00635 |
PhosphoSitePlusi | O00635 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000112343, Expressed in caecum and 250 other tissues |
ExpressionAtlasi | O00635, baseline and differential |
Genevisiblei | O00635, HS |
Organism-specific databases
HPAi | ENSG00000112343, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsO00635
GO - Molecular functioni
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 115738, 42 interactors |
IntActi | O00635, 23 interactors |
MINTi | O00635 |
STRINGi | 9606.ENSP00000349596 |
Miscellaneous databases
RNActi | O00635, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 274 – 465 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 192 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 63 | RING-typePROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 88 – 129 | B box-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160468 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | O00635 |
OMAi | MLRRYQV |
OrthoDBi | 423686at2759 |
PhylomeDBi | O00635 |
TreeFami | TF342569 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit cd15815, SPRY_PRY_TRIM38, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR035790, SPRY/PRY_TRIM38 IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O00635-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK
60 70 80 90 100
QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF
110 120 130 140 150
HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL
160 170 180 190 200
EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR
210 220 230 240 250
LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND
260 270 280 290 300
TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT
310 320 330 340 350
AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE
360 370 380 390 400
VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP
410 420 430 440 450
TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF
460
QVYQYSPLFL PPPGD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | M → I in AAH26930 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 411 | L → P in BAG36059 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013513 | 421 | G → R. Corresponds to variant dbSNP:rs10317Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91328 Genomic DNA Translation: AAB82084.1 U90547 mRNA Translation: AAB53425.1 AK313248 mRNA Translation: BAG36059.1 BC026930 mRNA Translation: AAH26930.1 |
CCDSi | CCDS4568.1 |
RefSeqi | NP_006346.1, NM_006355.4 XP_005248856.1, XM_005248799.4 XP_005248857.1, XM_005248800.4 |
Genome annotation databases
Ensembli | ENST00000357085; ENSP00000349596; ENSG00000112343 |
GeneIDi | 10475 |
KEGGi | hsa:10475 |
UCSCi | uc003nfm.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U91328 Genomic DNA Translation: AAB82084.1 U90547 mRNA Translation: AAB53425.1 AK313248 mRNA Translation: BAG36059.1 BC026930 mRNA Translation: AAH26930.1 |
CCDSi | CCDS4568.1 |
RefSeqi | NP_006346.1, NM_006355.4 XP_005248856.1, XM_005248799.4 XP_005248857.1, XM_005248800.4 |
3D structure databases
SMRi | O00635 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115738, 42 interactors |
IntActi | O00635, 23 interactors |
MINTi | O00635 |
STRINGi | 9606.ENSP00000349596 |
PTM databases
iPTMneti | O00635 |
PhosphoSitePlusi | O00635 |
Polymorphism and mutation databases
BioMutai | TRIM38 |
Proteomic databases
EPDi | O00635 |
jPOSTi | O00635 |
MassIVEi | O00635 |
MaxQBi | O00635 |
PaxDbi | O00635 |
PeptideAtlasi | O00635 |
PRIDEi | O00635 |
ProteomicsDBi | 48005 |
Protocols and materials databases
Antibodypediai | 10788, 475 antibodies |
DNASUi | 10475 |
Genome annotation databases
Ensembli | ENST00000357085; ENSP00000349596; ENSG00000112343 |
GeneIDi | 10475 |
KEGGi | hsa:10475 |
UCSCi | uc003nfm.5, human |
Organism-specific databases
CTDi | 10475 |
DisGeNETi | 10475 |
EuPathDBi | HostDB:ENSG00000112343.10 |
GeneCardsi | TRIM38 |
HGNCi | HGNC:10059, TRIM38 |
HPAi | ENSG00000112343, Low tissue specificity |
neXtProti | NX_O00635 |
OpenTargetsi | ENSG00000112343 |
PharmGKBi | PA35532 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160468 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | O00635 |
OMAi | MLRRYQV |
OrthoDBi | 423686at2759 |
PhylomeDBi | O00635 |
TreeFami | TF342569 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | O00635 |
Reactomei | R-HSA-877300, Interferon gamma signaling |
Miscellaneous databases
BioGRID-ORCSi | 10475, 6 hits in 841 CRISPR screens |
ChiTaRSi | TRIM38, human |
GenomeRNAii | 10475 |
Pharosi | O00635, Tbio |
PROi | PR:O00635 |
RNActi | O00635, protein |
Gene expression databases
Bgeei | ENSG00000112343, Expressed in caecum and 250 other tissues |
ExpressionAtlasi | O00635, baseline and differential |
Genevisiblei | O00635, HS |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit cd15815, SPRY_PRY_TRIM38, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR035790, SPRY/PRY_TRIM38 IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI38_HUMAN | |
Accessioni | O00635Primary (citable) accession number: O00635 Secondary accession number(s): B2R862 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 6, 2002 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PATHWAY comments
Index of metabolic and biosynthesis pathways - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations