Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase TRIM38

Gene

TRIM38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 63RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processImmunity, Innate immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM38 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 15
RING-type E3 ubiquitin transferase TRIM38Curated
Tripartite motif-containing protein 38
Zinc finger protein RoRet
Gene namesi
Name:TRIM38
Synonyms:RNF15, RORET
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112343.10
HGNCiHGNC:10059 TRIM38
neXtProtiNX_O00635

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10475
OpenTargetsiENSG00000112343
PharmGKBiPA35532

Polymorphism and mutation databases

BioMutaiTRIM38

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562561 – 465E3 ubiquitin-protein ligase TRIM38Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00635
MaxQBiO00635
PaxDbiO00635
PeptideAtlasiO00635
PRIDEiO00635
ProteomicsDBi48005

PTM databases

iPTMnetiO00635
PhosphoSitePlusiO00635

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000112343 Expressed in 241 organ(s), highest expression level in caecum
CleanExiHS_TRIM38
ExpressionAtlasiO00635 baseline and differential
GenevisibleiO00635 HS

Organism-specific databases

HPAiHPA031685

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115738, 33 interactors
IntActiO00635, 24 interactors
MINTiO00635
STRINGi9606.ENSP00000230099

Structurei

3D structure databases

ProteinModelPortaliO00635
SMRiO00635
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 465B30.2/SPRYPROSITE-ProRule annotationAdd BLAST192

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 63RING-typePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITEY Eukaryota
ENOG410Y1I6 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiO00635
KOiK12014
OMAiPDTAHHE
OrthoDBiEOG091G05W2
PhylomeDBiO00635
TreeFamiTF342569

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035790 SPRY/PRY_TRIM38
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK
60 70 80 90 100
QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF
110 120 130 140 150
HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL
160 170 180 190 200
EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR
210 220 230 240 250
LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND
260 270 280 290 300
TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT
310 320 330 340 350
AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE
360 370 380 390 400
VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP
410 420 430 440 450
TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF
460
QVYQYSPLFL PPPGD
Length:465
Mass (Da):53,416
Last modified:July 1, 1997 - v1
Checksum:i30A884051A2DA058
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23M → I in AAH26930 (PubMed:15489334).Curated1
Sequence conflicti411L → P in BAG36059 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013513421G → R. Corresponds to variant dbSNP:rs10317Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA Translation: AAB82084.1
U90547 mRNA Translation: AAB53425.1
AK313248 mRNA Translation: BAG36059.1
BC026930 mRNA Translation: AAH26930.1
CCDSiCCDS4568.1
RefSeqiNP_006346.1, NM_006355.4
XP_005248856.1, XM_005248799.4
XP_005248857.1, XM_005248800.4
UniGeneiHs.584851
Hs.742026

Genome annotation databases

EnsembliENST00000357085; ENSP00000349596; ENSG00000112343
GeneIDi10475
KEGGihsa:10475
UCSCiuc003nfm.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91328 Genomic DNA Translation: AAB82084.1
U90547 mRNA Translation: AAB53425.1
AK313248 mRNA Translation: BAG36059.1
BC026930 mRNA Translation: AAH26930.1
CCDSiCCDS4568.1
RefSeqiNP_006346.1, NM_006355.4
XP_005248856.1, XM_005248799.4
XP_005248857.1, XM_005248800.4
UniGeneiHs.584851
Hs.742026

3D structure databases

ProteinModelPortaliO00635
SMRiO00635
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115738, 33 interactors
IntActiO00635, 24 interactors
MINTiO00635
STRINGi9606.ENSP00000230099

PTM databases

iPTMnetiO00635
PhosphoSitePlusiO00635

Polymorphism and mutation databases

BioMutaiTRIM38

Proteomic databases

EPDiO00635
MaxQBiO00635
PaxDbiO00635
PeptideAtlasiO00635
PRIDEiO00635
ProteomicsDBi48005

Protocols and materials databases

DNASUi10475
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357085; ENSP00000349596; ENSG00000112343
GeneIDi10475
KEGGihsa:10475
UCSCiuc003nfm.5 human

Organism-specific databases

CTDi10475
DisGeNETi10475
EuPathDBiHostDB:ENSG00000112343.10
GeneCardsiTRIM38
HGNCiHGNC:10059 TRIM38
HPAiHPA031685
neXtProtiNX_O00635
OpenTargetsiENSG00000112343
PharmGKBiPA35532
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITEY Eukaryota
ENOG410Y1I6 LUCA
GeneTreeiENSGT00760000118893
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiO00635
KOiK12014
OMAiPDTAHHE
OrthoDBiEOG091G05W2
PhylomeDBiO00635
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRSiTRIM38 human
GenomeRNAii10475
PROiPR:O00635

Gene expression databases

BgeeiENSG00000112343 Expressed in 241 organ(s), highest expression level in caecum
CleanExiHS_TRIM38
ExpressionAtlasiO00635 baseline and differential
GenevisibleiO00635 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035790 SPRY/PRY_TRIM38
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI38_HUMAN
AccessioniPrimary (citable) accession number: O00635
Secondary accession number(s): B2R862
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again