UniProtKB - O00634 (NET3_HUMAN)
Protein
Netrin-3
Gene
NTN3
Organism
Homo sapiens (Human)
Status
Functioni
Netrins control guidance of CNS commissural axons and peripheral motor axons.By similarity
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- axon guidance Source: UniProtKB
- dendrite development Source: GO_Central
- motor neuron axon guidance Source: GO_Central
- tissue development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O00634 |
Reactomei | R-HSA-525793, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Netrin-3Alternative name(s): Netrin-2-like protein |
Gene namesi | Name:NTN3 Synonyms:NTN2L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8030, NTN3 |
MIMi | 602349, gene |
neXtProti | NX_O00634 |
VEuPathDBi | HostDB:ENSG00000162068.1 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-KW
Golgi apparatus
- Golgi apparatus Source: Ensembl
Other locations
- basement membrane Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 4917 |
OpenTargetsi | ENSG00000162068 |
PharmGKBi | PA164724231 |
Miscellaneous databases
Pharosi | O00634, Tdark |
Genetic variation databases
BioMutai | NTN3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000017085 | 28 – 580 | Netrin-3Add BLAST | 553 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 92 ↔ 125 | By similarity | ||
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 255 ↔ 264 | By similarity | ||
Disulfide bondi | 257 ↔ 274 | By similarity | ||
Disulfide bondi | 276 ↔ 285 | By similarity | ||
Disulfide bondi | 288 ↔ 308 | By similarity | ||
Disulfide bondi | 311 ↔ 320 | By similarity | ||
Disulfide bondi | 313 ↔ 338 | By similarity | ||
Disulfide bondi | 341 ↔ 350 | By similarity | ||
Disulfide bondi | 353 ↔ 371 | By similarity | ||
Disulfide bondi | 374 ↔ 386 | By similarity | ||
Disulfide bondi | 376 ↔ 393 | By similarity | ||
Glycosylationi | 387 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 395 ↔ 404 | By similarity | ||
Disulfide bondi | 407 ↔ 421 | By similarity | ||
Disulfide bondi | 441 ↔ 514 | By similarity | ||
Disulfide bondi | 460 ↔ 577 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | O00634 |
MassIVEi | O00634 |
PaxDbi | O00634 |
PeptideAtlasi | O00634 |
PRIDEi | O00634 |
ProteomicsDBi | 48004 |
PTM databases
GlyConnecti | 1543, 1 N-Linked glycan (1 site) |
GlyGeni | O00634, 2 sites |
iPTMneti | O00634 |
PhosphoSitePlusi | O00634 |
Expressioni
Tissue specificityi
Spinal cord.1 Publication
Gene expression databases
Bgeei | ENSG00000162068, Expressed in stomach and 42 other tissues |
Genevisiblei | O00634, HS |
Organism-specific databases
HPAi | ENSG00000162068, Tissue enhanced (brain) |
Interactioni
Binary interactionsi
O00634
With | #Exp. | IntAct |
---|---|---|
DRAXIN [Q8NBI3] | 2 | EBI-10831998,EBI-10827752 |
GO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110972, 4 interactors |
IntActi | O00634, 1 interactor |
STRINGi | 9606.ENSP00000293973 |
Miscellaneous databases
RNActi | O00634, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 254 | Laminin N-terminalPROSITE-ProRule annotationAdd BLAST | 219 | |
Domaini | 255 – 308 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 311 – 371 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 374 – 421 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 441 – 577 | NTRPROSITE-ProRule annotationAdd BLAST | 137 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 500 – 502 | Cell attachment site; atypicalSequence analysis | 3 |
Keywords - Domaini
Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3512, Eukaryota |
GeneTreei | ENSGT00940000153882 |
HOGENOMi | CLU_018213_2_0_1 |
InParanoidi | O00634 |
OMAi | CKPARGN |
OrthoDBi | 858946at2759 |
PhylomeDBi | O00634 |
TreeFami | TF352481 |
Family and domain databases
Gene3Di | 2.40.50.120, 1 hit 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF00055, Laminin_N, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01248, EGF_LAM_1, 3 hits PS50027, EGF_LAM_2, 3 hits PS51117, LAMININ_NTER, 1 hit PS50189, NTR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O00634-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGWPWGLLL TAGTLFAALS PGPPAPADPC HDEGGAPRGC VPGLVNAALG
60 70 80 90 100
REVLASSTCG RPATRACDAS DPRRAHSPAL LTSPGGTASP LCWRSESLPR
110 120 130 140 150
APLNVTLTVP LGKAFELVFV SLRFCSAPPA SVALLKSQDH GRSWAPLGFF
160 170 180 190 200
SSHCDLDYGR LPAPANGPAG PGPEALCFPA PLAQPDGSGL LAFSMQDSSP
210 220 230 240 250
PGLDLDSSPV LQDWVTATDV RVVLTRPSTA GDPRDMEAVV PYSYAATDLQ
260 270 280 290 300
VGGRCKCNGH ASRCLLDTQG HLICDCRHGT EGPDCGRCKP FYCDRPWQRA
310 320 330 340 350
TARESHACLA CSCNGHARRC RFNMELYRLS GRRSGGVCLN CRHNTAGRHC
360 370 380 390 400
HYCREGFYRD PGRALSDRRA CRACDCHPVG AAGKTCNQTT GQCPCKDGVT
410 420 430 440 450
GLTCNRCAPG FQQSRSPVAP CVKTPIPGPT EDSSPVQPQD CDSHCKPARG
460 470 480 490 500
SYRISLKKFC KKDYAVQVAV GARGEARGAW TRFPVAVLAV FRSGEERARR
510 520 530 540 550
GSSALWVPAG DAACGCPRLL PGRRYLLLGG GPGAAAGGAG GRGPGLIAAR
560 570 580
GSLVLPWRDA WTRRLRRLQR RERRGRCSAA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050086 | 425 | P → S. Corresponds to variant dbSNP:rs34818219Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U86759 mRNA Translation: AAC51247.1 U86758 Genomic DNA Translation: AAC51246.1 |
CCDSi | CCDS10469.1 |
RefSeqi | NP_006172.1, NM_006181.2 |
Genome annotation databases
Ensembli | ENST00000293973; ENSP00000293973; ENSG00000162068 |
GeneIDi | 4917 |
KEGGi | hsa:4917 |
UCSCi | uc002cqj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U86759 mRNA Translation: AAC51247.1 U86758 Genomic DNA Translation: AAC51246.1 |
CCDSi | CCDS10469.1 |
RefSeqi | NP_006172.1, NM_006181.2 |
3D structure databases
SMRi | O00634 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110972, 4 interactors |
IntActi | O00634, 1 interactor |
STRINGi | 9606.ENSP00000293973 |
PTM databases
GlyConnecti | 1543, 1 N-Linked glycan (1 site) |
GlyGeni | O00634, 2 sites |
iPTMneti | O00634 |
PhosphoSitePlusi | O00634 |
Genetic variation databases
BioMutai | NTN3 |
Proteomic databases
jPOSTi | O00634 |
MassIVEi | O00634 |
PaxDbi | O00634 |
PeptideAtlasi | O00634 |
PRIDEi | O00634 |
ProteomicsDBi | 48004 |
Protocols and materials databases
Antibodypediai | 66015, 89 antibodies |
Genome annotation databases
Ensembli | ENST00000293973; ENSP00000293973; ENSG00000162068 |
GeneIDi | 4917 |
KEGGi | hsa:4917 |
UCSCi | uc002cqj.3, human |
Organism-specific databases
CTDi | 4917 |
DisGeNETi | 4917 |
GeneCardsi | NTN3 |
HGNCi | HGNC:8030, NTN3 |
HPAi | ENSG00000162068, Tissue enhanced (brain) |
MIMi | 602349, gene |
neXtProti | NX_O00634 |
OpenTargetsi | ENSG00000162068 |
PharmGKBi | PA164724231 |
VEuPathDBi | HostDB:ENSG00000162068.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3512, Eukaryota |
GeneTreei | ENSGT00940000153882 |
HOGENOMi | CLU_018213_2_0_1 |
InParanoidi | O00634 |
OMAi | CKPARGN |
OrthoDBi | 858946at2759 |
PhylomeDBi | O00634 |
TreeFami | TF352481 |
Enzyme and pathway databases
PathwayCommonsi | O00634 |
Reactomei | R-HSA-525793, Myogenesis |
Miscellaneous databases
BioGRID-ORCSi | 4917, 3 hits in 980 CRISPR screens |
GenomeRNAii | 4917 |
Pharosi | O00634, Tdark |
PROi | PR:O00634 |
RNActi | O00634, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162068, Expressed in stomach and 42 other tissues |
Genevisiblei | O00634, HS |
Family and domain databases
Gene3Di | 2.40.50.120, 1 hit 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR002049, Laminin_EGF IPR008211, Laminin_N IPR038684, Laminin_N_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR008993, TIMP-like_OB-fold |
Pfami | View protein in Pfam PF00053, Laminin_EGF, 3 hits PF00055, Laminin_N, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00180, EGF_Lam, 3 hits SM00136, LamNT, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 2 hits PS01248, EGF_LAM_1, 3 hits PS50027, EGF_LAM_2, 3 hits PS51117, LAMININ_NTER, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NET3_HUMAN | |
Accessioni | O00634Primary (citable) accession number: O00634 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | July 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot