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Protein

Sarcolipin

Gene

SLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity).By similarity2 Publications

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • enzyme inhibitor activity Source: BHF-UCL

GO - Biological processi

  • calcium ion transport Source: UniProtKB
  • negative regulation of calcium ion binding Source: BHF-UCL
  • negative regulation of calcium ion import Source: BHF-UCL
  • negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
  • negative regulation of catalytic activity Source: BHF-UCL
  • negative regulation of protein complex disassembly Source: BHF-UCL
  • positive regulation of protein depolymerization Source: BHF-UCL
  • regulation of calcium ion transport Source: UniProtKB
  • regulation of calcium-transporting ATPase activity Source: UniProtKB
  • regulation of relaxation of muscle Source: UniProtKB
  • sarcoplasmic reticulum calcium ion transport Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi1.A.50.2.1 the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sarcolipin
Gene namesi
Name:SLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170290.3
HGNCiHGNC:11089 SLN
MIMi602203 gene
neXtProtiNX_O00631

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7Cytoplasmic1 Publication7
Transmembranei8 – 26HelicalAdd BLAST19
Topological domaini27 – 31Lumenal1 Publication5

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6588
OpenTargetsiENSG00000170290
PharmGKBiPA35942

Polymorphism and mutation databases

BioMutaiSLN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000458981 – 31SarcolipinAdd BLAST31

Proteomic databases

PaxDbiO00631
PRIDEiO00631
ProteomicsDBi48003

PTM databases

iPTMnetiO00631
PhosphoSitePlusiO00631

Expressioni

Gene expression databases

BgeeiENSG00000170290
CleanExiHS_SLN
ExpressionAtlasiO00631 baseline and differential
GenevisibleiO00631 HS

Organism-specific databases

HPAiCAB011628

Interactioni

Subunit structurei

Interacts with calcium ATPase ATP2A1/SERCA1.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi112474, 8 interactors
CORUMiO00631
DIPiDIP-61731N
IntActiO00631, 4 interactors
STRINGi9606.ENSP00000304707

Structurei

Secondary structure

131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Helixi9 – 25Combined sources17

3D structure databases

ProteinModelPortaliO00631
SMRiO00631
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00631

Family & Domainsi

Sequence similaritiesi

Belongs to the sarcolipin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JIZ8 Eukaryota
ENOG411147S LUCA
GeneTreeiENSGT00860000133954
HOGENOMiHOG000142457
InParanoidiO00631
KOiK22642
OrthoDBiEOG091G1CUE
PhylomeDBiO00631

Family and domain databases

InterProiView protein in InterPro
IPR008028 Sarcolipin
PANTHERiPTHR17358 PTHR17358, 1 hit
PfamiView protein in Pfam
PF05366 Sarcolipin, 1 hit

Sequencei

Sequence statusi: Complete.

O00631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MGINTRELFL NFTIVLITVI LMWLLVRSYQ Y
Length:31
Mass (Da):3,762
Last modified:July 1, 1997 - v1
Checksum:i9B245D9ACD26C58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96094 mRNA Translation: AAB86981.1
U96093 Genomic DNA Translation: AAB86980.1
AK312097 mRNA Translation: BAG35033.1
CR450290 mRNA Translation: CAG29286.1
BC094685 mRNA Translation: AAH94685.1
BC104150 mRNA Translation: AAI04151.1
BC104185 mRNA Translation: AAI04186.1
BC113930 mRNA Translation: AAI13931.1
BC113987 mRNA Translation: AAI13988.1
CCDSiCCDS31667.1
RefSeqiNP_003054.1, NM_003063.2
UniGeneiHs.334629

Genome annotation databases

EnsembliENST00000305991; ENSP00000304707; ENSG00000170290
ENST00000525934; ENSP00000434189; ENSG00000170290
ENST00000531293; ENSP00000435380; ENSG00000170290
GeneIDi6588
KEGGihsa:6588
UCSCiuc001pjp.4 human

Similar proteinsi

Entry informationi

Entry nameiSARCO_HUMAN
AccessioniPrimary (citable) accession number: O00631
Secondary accession number(s): Q6ICV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 18, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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