PEX7

Functionⁱ

Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11931631
peroxisome matrix targeting signal-2 binding
Source: UniProtKB
Inferred from direct assayⁱ
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11931631

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endochondral ossification Source: Ensembl
ether lipid biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12522768
- 9090383
fatty acid beta-oxidation Source: Ensembl
neuron migration Source: Ensembl
peroxisome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10022913
protein import into peroxisome matrix
Source: MGI
Inferred from direct assayⁱ
- 9090381
protein targeting to peroxisome Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9033241 Peroxisomal protein import
SignaLinkⁱ	O00628
SIGNORⁱ	O00628

Protein family/group databases

TCDBⁱ	3.A.20.1.1 the peroxisomal protein importer (ppi) family

TCDBⁱ

3.A.20.1.1 the peroxisomal protein importer (ppi) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisomal targeting signal 2 receptor Short name: PTS2 receptor Alternative name(s): Peroxin-7
Gene namesⁱ	Name:PEX7 Synonyms:PTS2R
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112357.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8860 PEX7
MIMⁱ	601757 gene
neXtProtⁱ	NX_O00628

Keywords - Cellular componentⁱ

Cytoplasm, Peroxisome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Peroxisome biogenesis disorder complementation group 11 (PBD-CG11)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).

Rhizomelic chondrodysplasia punctata 1 (RCDP1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA peroxisome biogenesis disorder. It is characterized by severely disturbed endochondral bone formation, rhizomelic shortening of femur and humerus, vertebral disorders, dwarfism, cataract, cutaneous lesions, facial dysmorphism, and severe mental retardation with spasticity.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_007725	217	G → R in RCDP1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121909152EnsemblClinVar.		1
Natural variantⁱVAR_007726	218	A → V in RCDP1. 1 PublicationCorresponds to variant dbSNP:rs121909151EnsemblClinVar.		1

Peroxisome biogenesis disorder 9B (PBD9B)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA peroxisome biogenesis disorder with unusually mild clinical and biochemical manifestations. Affected individuals manifest a variable phenotype similar to, and in some cases indistinguishable from, classic Refsum disease. Variable features include ocular abnormalities, sensorimotor neuropathy, ichthyosis, deafness, chondrodysplasia punctata without rhizomelia or growth failure.

Keywords - Diseaseⁱ

Cataract, Deafness, Disease mutation, Ichthyosis, Peroxisome biogenesis disorder, Retinitis pigmentosa, Rhizomelic chondrodysplasia punctata

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5191
GeneReviewsⁱ	PEX7
MalaCards human disease database More...MalaCardsⁱ	PEX7
MIMⁱ	215100 phenotype 614879 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000112357
Orphanetⁱ	773 Refsum disease 309789 Rhizomelic chondrodysplasia punctata type 1
PharmGKBⁱ	PA33202

Polymorphism and mutation databases

BioMutaⁱ	PEX7

BioMutaⁱ

PEX7

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051116	1 – 323	Peroxisomal targeting signal 2 receptorAdd BLAST		323

Proteomic databases

EPDⁱ	O00628
PaxDbⁱ	O00628
PeptideAtlas More...PeptideAtlasⁱ	O00628
PRIDEⁱ	O00628
ProteomicsDBⁱ	48001

PTM databases

iPTMnetⁱ	O00628
PhosphoSitePlusⁱ	O00628

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highest expression in pancreas, skeletal muscle and heart.

Gene expression databases

Bgeeⁱ	ENSG00000112357 Expressed in 211 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_PEX7
ExpressionAtlasⁱ	O00628 baseline and differential
Genevisibleⁱ	O00628 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049202

HPAⁱ

HPA049202

Interactionⁱ

Subunit structureⁱ

Interacts with PEX5.

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11931631
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11931631

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111214, 30 interactors
IntActⁱ	O00628, 4 interactors
Molecular INTeraction database More...MINTⁱ	O00628
STRINGⁱ	9606.ENSP00000315680

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	65 – 96	WD 1Add BLAST	32
Repeatⁱ	109 – 141	WD 2Add BLAST	33
Repeatⁱ	153 – 184	WD 3Add BLAST	32
Repeatⁱ	196 – 227	WD 4Add BLAST	32
Repeatⁱ	240 – 271	WD 5Add BLAST	32
Repeatⁱ	284 – 315	WD 6Add BLAST	32

Sequence similaritiesⁱ

Belongs to the WD repeat peroxin-7 family.Curated

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0277 Eukaryota ENOG410XNVU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149080
HOGENOMⁱ	HOG000204332
HOVERGENⁱ	HBG003354
InParanoidⁱ	O00628
KEGG Orthology (KO) More...KOⁱ	K13341
OMAⁱ	NYDFTTR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C6L
PhylomeDBⁱ	O00628
TreeFamⁱ	TF323220

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O00628-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAVCGGAAR MLRTPGRHGY AAEFSPYLPG RLACATAQHY GIAGCGTLLI 
        60         70         80         90        100
LDPDEAGLRL FRSFDWNDGL FDVTWSENNE HVLITCSGDG SLQLWDTAKA 
       110        120        130        140        150
AGPLQVYKEH AQEVYSVDWS QTRGEQLVVS GSWDQTVKLW DPTVGKSLCT 
       160        170        180        190        200
FRGHESIIYS TIWSPHIPGC FASASGDQTL RIWDVKAAGV RIVIPAHQAE 
       210        220        230        240        250
ILSCDWCKYN ENLLVTGAVD CSLRGWDLRN VRQPVFELLG HTYAIRRVKF 
       260        270        280        290        300
SPFHASVLAS CSYDFTVRFW NFSKPDSLLE TVEHHTEFTC GLDFSLQSPT 
       310        320 
QVADCSWDET IKIYDPACLT IPA

Length:323

Mass (Da):35,892

Last modified:July 1, 1997 - v1

Checksum:ⁱD405387F7F14B432

GO

Isoform 2 (identifier: O00628-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
250-323: FSPFHASVLA...YDPACLTIPA → MESCPVTQTRSQLTATSAFWVQAVLLPQPTE

« Hide

        10         20         30         40         50
MSAVCGGAAR MLRTPGRHGY AAEFSPYLPG RLACATAQHY GIAGCGTLLI 
        60         70         80         90        100
LDPDEAGLRL FRSFDWNDGL FDVTWSENNE HVLITCSGDG SLQLWDTAKA 
       110        120        130        140        150
AGPLQVYKEH AQEVYSVDWS QTRGEQLVVS GSWDQTVKLW DPTVGKSLCT 
       160        170        180        190        200
FRGHESIIYS TIWSPHIPGC FASASGDQTL RIWDVKAAGV RIVIPAHQAE 
       210        220        230        240        250
ILSCDWCKYN ENLLVTGAVD CSLRGWDLRN VRQPVFELLG HTYAIRRVKM 
       260        270        280
ESCPVTQTRS QLTATSAFWV QAVLLPQPTE

Note: No experimental confirmation available.

Show »

Length:280

Mass (Da):30,947

Checksum:ⁱCCE69B17EE2571BA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5TDQ5	Q5TDQ5_HUMAN		Peroxisomal targeting signal 2 rece... Peroxisomal targeting signal 2 receptor	PEX7	122	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_016810	14	T → P in PBD9B. 1 PublicationCorresponds to variant dbSNP:rs61753233EnsemblClinVar.	1
Natural variantⁱVAR_007725	217	G → R in RCDP1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121909152EnsemblClinVar.	1
Natural variantⁱVAR_007726	218	A → V in RCDP1. 1 PublicationCorresponds to variant dbSNP:rs121909151EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056393	250 – 323	FSPFH…LTIPA → MESCPVTQTRSQLTATSAFW VQAVLLPQPTE in isoform 2. 1 PublicationAdd BLAST		74

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U88871 mRNA Translation: AAC51238.1 U76560 mRNA Translation: AAB50556.1 AF180814 AF180813 Genomic DNA Translation: AAF37350.1 AL121933 Genomic DNA No translation available. AL357082 Genomic DNA No translation available. AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47941.1 BC006268 mRNA Translation: AAH06268.1 BC031606 mRNA Translation: AAH31606.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5180.1 [O00628-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000279.1, NM_000288.3 [O00628-1]
UniGeneⁱ	Hs.280932

Genome annotation databases

Ensemblⁱ	ENST00000318471; ENSP00000315680; ENSG00000112357 [O00628-1] ENST00000541292; ENSP00000441004; ENSG00000112357 [O00628-2]
GeneIDⁱ	5191
KEGGⁱ	hsa:5191
UCSC genome browser More...UCSCⁱ	uc063rtk.1 human [O00628-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00628	PEX7 protein		HUMAN		323	UniRef100_O00628

Protein	Similar proteins		Species	Score	Length	Source
O00628	Peroxisomal targeting signal 2 receptor		MOUSE		318	UniRef90_O00628
Peroxisomal targeting signal 2 receptor		CRIGR		318
PEX7 protein		HUMAN		323
Uncharacterized protein		AOTNA		397
Uncharacterized protein		PANPA		325
+92
O00628-2	PEX7 isoform 2		PANTR		280	UniRef90_O00628-2
Uncharacterized protein		CALJA		280
Uncharacterized protein		Cebus capucinus imitator		280
PEX7 isoform 1		PONAB		280
Uncharacterized protein		CERAT		280
+10

Protein	Similar proteins		Species	Score	Length	Source
O00628	Peroxisomal targeting signal 2 receptor		MOUSE		318	UniRef50_O00628
Peroxisomal targeting signal 2 receptor		CRIGR		318
PEX7 protein		HUMAN		323
Uncharacterized protein		AOTNA		397
Uncharacterized protein		PANPA		325
+123
O00628-2	Uncharacterized protein		RHIBE		280	UniRef50_O00628-2
PEX7 isoform 2		PANTR		280
Uncharacterized protein		PAPAN		280
Uncharacterized protein		MANLE		236
Uncharacterized protein		CALJA		280
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U88871 mRNA Translation: AAC51238.1 U76560 mRNA Translation: AAB50556.1 AF180814 AF180813 Genomic DNA Translation: AAF37350.1 AL121933 Genomic DNA No translation available. AL357082 Genomic DNA No translation available. AL365223 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47941.1 BC006268 mRNA Translation: AAH06268.1 BC031606 mRNA Translation: AAH31606.1
CCDSⁱ	CCDS5180.1 [O00628-1]
RefSeqⁱ	NP_000279.1, NM_000288.3 [O00628-1]
UniGeneⁱ	Hs.280932

3D structure databases

ProteinModelPortalⁱ	O00628
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111214, 30 interactors
IntActⁱ	O00628, 4 interactors
MINTⁱ	O00628
STRINGⁱ	9606.ENSP00000315680

Protein family/group databases

TCDBⁱ	3.A.20.1.1 the peroxisomal protein importer (ppi) family

TCDBⁱ

3.A.20.1.1 the peroxisomal protein importer (ppi) family

PTM databases

iPTMnetⁱ	O00628
PhosphoSitePlusⁱ	O00628

Polymorphism and mutation databases

BioMutaⁱ	PEX7

BioMutaⁱ

PEX7

Proteomic databases

EPDⁱ	O00628
PaxDbⁱ	O00628
PeptideAtlasⁱ	O00628
PRIDEⁱ	O00628
ProteomicsDBⁱ	48001

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5191
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000318471; ENSP00000315680; ENSG00000112357 [O00628-1] ENST00000541292; ENSP00000441004; ENSG00000112357 [O00628-2]
GeneIDⁱ	5191
KEGGⁱ	hsa:5191
UCSCⁱ	uc063rtk.1 human [O00628-1]

Organism-specific databases

CTDⁱ	5191
DisGeNETⁱ	5191
EuPathDBⁱ	HostDB:ENSG00000112357.12
GeneCardsⁱ	PEX7
GeneReviewsⁱ	PEX7
HGNCⁱ	HGNC:8860 PEX7
HPAⁱ	HPA049202
MalaCardsⁱ	PEX7
MIMⁱ	215100 phenotype 601757 gene 614879 phenotype
neXtProtⁱ	NX_O00628
OpenTargetsⁱ	ENSG00000112357
Orphanetⁱ	773 Refsum disease 309789 Rhizomelic chondrodysplasia punctata type 1
PharmGKBⁱ	PA33202
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0277 Eukaryota ENOG410XNVU LUCA
GeneTreeⁱ	ENSGT00920000149080
HOGENOMⁱ	HOG000204332
HOVERGENⁱ	HBG003354
InParanoidⁱ	O00628
KOⁱ	K13341
OMAⁱ	NYDFTTR
OrthoDBⁱ	EOG091G0C6L
PhylomeDBⁱ	O00628
TreeFamⁱ	TF323220

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9033241 Peroxisomal protein import
SignaLinkⁱ	O00628
SIGNORⁱ	O00628

Miscellaneous databases

ChiTaRSⁱ	PEX7 human
GenomeRNAiⁱ	5191
Protein Ontology More...PROⁱ	PR:O00628
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112357 Expressed in 211 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_PEX7
ExpressionAtlasⁱ	O00628 baseline and differential
Genevisibleⁱ	O00628 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 4 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 6 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 4 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PEX7_HUMAN
Accessionⁱ	O00628Primary (citable) accession number: O00628 Secondary accession number(s): C0H5X6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - O00628 (PEX7_HUMAN)

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Peroxisomal targeting signal 2 receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

Other locations

Cytosol

Peroxisome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Peroxisome biogenesis disorder complementation group 11 (PBD-CG11)

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ