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Protein

C-C motif chemokine 22

Gene

CCL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 22
Alternative name(s):
CC chemokine STCP-1
MDC(1-69)
Macrophage-derived chemokine
Small-inducible cytokine A22
Stimulated T-cell chemotactic protein 1
Cleaved into the following 3 chains:
Gene namesi
Name:CCL22
Synonyms:MDC, SCYA22
ORF Names:A-152E5.1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102962.4
HGNCiHGNC:10621 CCL22
MIMi602957 gene
neXtProtiNX_O00626

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6367
OpenTargetsiENSG00000102962
PharmGKBiPA35553

Polymorphism and mutation databases

BioMutaiCCL22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000000522425 – 93C-C motif chemokine 22Add BLAST69
ChainiPRO_000000522527 – 93MDC(3-69)Add BLAST67
ChainiPRO_000000522629 – 93MDC(5-69)Add BLAST65
ChainiPRO_000000522731 – 93MDC(7-69)Add BLAST63

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 60By similarity
Disulfide bondi37 ↔ 76By similarity

Post-translational modificationi

The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO00626
PeptideAtlasiO00626
PRIDEiO00626
ProteomicsDBi48000

PTM databases

iPTMnetiO00626
PhosphoSitePlusiO00626

Miscellaneous databases

PMAP-CutDBiB2R4W2

Expressioni

Tissue specificityi

Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis.1 Publication

Gene expression databases

BgeeiENSG00000102962 Expressed in 90 organ(s), highest expression level in heart right ventricle
CleanExiHS_CCL22
GenevisibleiO00626 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112270, 40 interactors
DIPiDIP-5849N
IntActiO00626, 6 interactors
MINTiO00626
STRINGi9606.ENSP00000219235

Structurei

3D structure databases

ProteinModelPortaliO00626
SMRiO00626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J20K Eukaryota
ENOG41113E8 LUCA
GeneTreeiENSGT00530000064374
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO00626
KOiK21095
OMAiDREICAD
OrthoDBiEOG091G13Z3
PhylomeDBiO00626
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR030598 CCL22
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF102 PTHR12015:SF102, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV
60 70 80 90
KHFYWTSDSC PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ
Length:93
Mass (Da):10,625
Last modified:November 2, 2010 - v2
Checksum:i641FCE999586A7D2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0551172D → A6 PublicationsCorresponds to variant dbSNP:rs4359426Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA Translation: AAB53372.1
U83171 mRNA Translation: AAB58360.1
EF064764 Genomic DNA Translation: ABK41947.1
AK311970 mRNA Translation: BAG34909.1
AC004382 Genomic DNA Translation: AAC24306.1
AC009052 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82918.1
BC027952 mRNA Translation: AAH27952.1
CCDSiCCDS10778.1
RefSeqiNP_002981.2, NM_002990.4
XP_016879020.1, XM_017023531.1
UniGeneiHs.534347

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962
GeneIDi6367
KEGGihsa:6367
UCSCiuc002elh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL22 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83239 mRNA Translation: AAB53372.1
U83171 mRNA Translation: AAB58360.1
EF064764 Genomic DNA Translation: ABK41947.1
AK311970 mRNA Translation: BAG34909.1
AC004382 Genomic DNA Translation: AAC24306.1
AC009052 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82918.1
BC027952 mRNA Translation: AAH27952.1
CCDSiCCDS10778.1
RefSeqiNP_002981.2, NM_002990.4
XP_016879020.1, XM_017023531.1
UniGeneiHs.534347

3D structure databases

ProteinModelPortaliO00626
SMRiO00626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112270, 40 interactors
DIPiDIP-5849N
IntActiO00626, 6 interactors
MINTiO00626
STRINGi9606.ENSP00000219235

PTM databases

iPTMnetiO00626
PhosphoSitePlusiO00626

Polymorphism and mutation databases

BioMutaiCCL22

Proteomic databases

PaxDbiO00626
PeptideAtlasiO00626
PRIDEiO00626
ProteomicsDBi48000

Protocols and materials databases

DNASUi6367
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219235; ENSP00000219235; ENSG00000102962
GeneIDi6367
KEGGihsa:6367
UCSCiuc002elh.4 human

Organism-specific databases

CTDi6367
DisGeNETi6367
EuPathDBiHostDB:ENSG00000102962.4
GeneCardsiCCL22
H-InvDBiHIX0013071
HGNCiHGNC:10621 CCL22
MIMi602957 gene
neXtProtiNX_O00626
OpenTargetsiENSG00000102962
PharmGKBiPA35553
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J20K Eukaryota
ENOG41113E8 LUCA
GeneTreeiENSGT00530000064374
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO00626
KOiK21095
OMAiDREICAD
OrthoDBiEOG091G13Z3
PhylomeDBiO00626
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

ChiTaRSiCCL22 human
GeneWikiiCCL22
GenomeRNAii6367
PMAP-CutDBiB2R4W2
PROiPR:O00626
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102962 Expressed in 90 organ(s), highest expression level in heart right ventricle
CleanExiHS_CCL22
GenevisibleiO00626 HS

Family and domain databases

InterProiView protein in InterPro
IPR030598 CCL22
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF102 PTHR12015:SF102, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL22_HUMAN
AccessioniPrimary (citable) accession number: O00626
Secondary accession number(s): A0N0Q6, B2R4W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2010
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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