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Protein

Protein CYR61

Gene

CYR61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.1 Publication

GO - Molecular functioni

  • extracellular matrix binding Source: Ensembl
  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: InterPro
  • integrin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding, Heparin-binding
Biological processCell adhesion, Chemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name:
IBP-10
Short name:
IGF-binding protein 10
Short name:
IGFBP-10
Protein GIG1
Gene namesi
Name:CYR61
Synonyms:CCN1, GIG1, IGFBP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142871.15
HGNCiHGNC:2654 CYR61
MIMi602369 gene
neXtProtiNX_O00622

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3491
OpenTargetsiENSG00000142871
PharmGKBiPA27126

Polymorphism and mutation databases

BioMutaiCYR61

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001439825 – 381Protein CYR61Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Phosphoserine; by FAM20C1 Publication1
Disulfide bondi286 ↔ 323By similarity
Disulfide bondi303 ↔ 337By similarity
Disulfide bondi314 ↔ 353By similarity
Disulfide bondi317 ↔ 355By similarity
Disulfide bondi322 ↔ 359By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO00622
PaxDbiO00622
PeptideAtlasiO00622
PRIDEiO00622
ProteomicsDBi47995

PTM databases

iPTMnetiO00622
PhosphoSitePlusiO00622

Miscellaneous databases

PMAP-CutDBiO00622

Expressioni

Gene expression databases

BgeeiENSG00000142871 Expressed in 232 organ(s), highest expression level in thyroid gland
CleanExiHS_CYR61
ExpressionAtlasiO00622 baseline and differential
GenevisibleiO00622 HS

Organism-specific databases

HPAiHPA029853

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109712, 10 interactors
CORUMiO00622
IntActiO00622, 9 interactors
STRINGi9606.ENSP00000398736

Structurei

3D structure databases

ProteinModelPortaliO00622
SMRiO00622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST70
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini228 – 273TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini286 – 360CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 315Heparin-bindingBy similarityAdd BLAST37

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY0 Eukaryota
ENOG41119KZ LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO00622
KOiK06829
OMAiFTYAGCS
OrthoDBiEOG091G0SQP
PhylomeDBiO00622
TreeFamiTF326070

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00622-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRIARALA LVVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC
60 70 80 90 100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC
110 120 130 140 150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL
160 170 180 190 200
VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA
210 220 230 240 250
VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR
260 270 280 290 300
VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY
310 320 330 340 350
AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI
360 370 380
QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D
Length:381
Mass (Da):42,027
Last modified:July 1, 1997 - v1
Checksum:iFC0BD39C078CA0B1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165E → Q in CAA72167 (PubMed:9536281).Curated1
Sequence conflicti210L → I in AAB84227 (Ref. 5) Curated1
Sequence conflicti220L → R in AAB84227 (Ref. 5) Curated1
Sequence conflicti369F → L in AAG59863 (PubMed:11810026).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018934334R → W1 PublicationCorresponds to variant dbSNP:rs9658587Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62015 mRNA Translation: AAB58319.1
Y11307 mRNA Translation: CAA72167.1
Y12084 mRNA Translation: CAA72802.1
AF003594 mRNA Translation: AAB61240.1
AF031385 mRNA Translation: AAB84227.1
Z98053 mRNA Translation: CAB10848.1
AF307860 Genomic DNA Translation: AAG59863.1
AY443495 Genomic DNA Translation: AAR05446.1
BC001271 mRNA Translation: AAH01271.1
BC009199 mRNA Translation: AAH09199.1
BC016952 mRNA Translation: AAH16952.1
CCDSiCCDS706.1
RefSeqiNP_001545.2, NM_001554.4
UniGeneiHs.8867

Genome annotation databases

EnsembliENST00000451137; ENSP00000398736; ENSG00000142871
GeneIDi3491
KEGGihsa:3491

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62015 mRNA Translation: AAB58319.1
Y11307 mRNA Translation: CAA72167.1
Y12084 mRNA Translation: CAA72802.1
AF003594 mRNA Translation: AAB61240.1
AF031385 mRNA Translation: AAB84227.1
Z98053 mRNA Translation: CAB10848.1
AF307860 Genomic DNA Translation: AAG59863.1
AY443495 Genomic DNA Translation: AAR05446.1
BC001271 mRNA Translation: AAH01271.1
BC009199 mRNA Translation: AAH09199.1
BC016952 mRNA Translation: AAH16952.1
CCDSiCCDS706.1
RefSeqiNP_001545.2, NM_001554.4
UniGeneiHs.8867

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0ZX-ray2.20X/Y24-29[»]
4D11X-ray2.85L/O/P/X/Z24-29[»]
ProteinModelPortaliO00622
SMRiO00622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109712, 10 interactors
CORUMiO00622
IntActiO00622, 9 interactors
STRINGi9606.ENSP00000398736

PTM databases

iPTMnetiO00622
PhosphoSitePlusiO00622

Polymorphism and mutation databases

BioMutaiCYR61

Proteomic databases

EPDiO00622
PaxDbiO00622
PeptideAtlasiO00622
PRIDEiO00622
ProteomicsDBi47995

Protocols and materials databases

DNASUi3491
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451137; ENSP00000398736; ENSG00000142871
GeneIDi3491
KEGGihsa:3491

Organism-specific databases

CTDi3491
DisGeNETi3491
EuPathDBiHostDB:ENSG00000142871.15
GeneCardsiCYR61
HGNCiHGNC:2654 CYR61
HPAiHPA029853
MIMi602369 gene
neXtProtiNX_O00622
OpenTargetsiENSG00000142871
PharmGKBiPA27126
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIY0 Eukaryota
ENOG41119KZ LUCA
GeneTreeiENSGT00760000119225
HOGENOMiHOG000231462
HOVERGENiHBG000635
InParanoidiO00622
KOiK06829
OMAiFTYAGCS
OrthoDBiEOG091G0SQP
PhylomeDBiO00622
TreeFamiTF326070

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiCYR61 human
GeneWikiiCYR61
GenomeRNAii3491
PMAP-CutDBiO00622
PROiPR:O00622
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142871 Expressed in 232 organ(s), highest expression level in thyroid gland
CleanExiHS_CYR61
ExpressionAtlasiO00622 baseline and differential
GenevisibleiO00622 HS

Family and domain databases

Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYR61_HUMAN
AccessioniPrimary (citable) accession number: O00622
Secondary accession number(s): O14934, O43775, Q9BZL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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