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Protein

Gamma-aminobutyric acid receptor subunit pi

Gene

GABRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit pi
Alternative name(s):
GABA(A) receptor subunit pi
Gene namesi
Name:GABRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000094755.16
HGNCiHGNC:4089 GABRP
MIMi602729 gene
neXtProtiNX_O00591

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 242ExtracellularSequence analysisAdd BLAST226
Transmembranei243 – 266HelicalSequence analysisAdd BLAST24
Transmembranei270 – 292HelicalSequence analysisAdd BLAST23
Transmembranei305 – 327HelicalSequence analysisAdd BLAST23
Topological domaini328 – 416CytoplasmicSequence analysisAdd BLAST89
Transmembranei417 – 438HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2568
OpenTargetsiENSG00000094755
PharmGKBiPA28503

Chemistry databases

ChEMBLiCHEMBL2093872
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

Polymorphism and mutation databases

BioMutaiGABRP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000049217 – 440Gamma-aminobutyric acid receptor subunit piAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 174By similarity
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO00591
PaxDbiO00591
PeptideAtlasiO00591
PRIDEiO00591
ProteomicsDBi47991

PTM databases

iPTMnetiO00591
PhosphoSitePlusiO00591

Expressioni

Tissue specificityi

Most abundant in the uterus, also expressed in lung, thymus and prostate.

Gene expression databases

BgeeiENSG00000094755 Expressed in 112 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_GABRP
ExpressionAtlasiO00591 baseline and differential
GenevisibleiO00591 HS

Organism-specific databases

HPAiCAB014883

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and epsilon. A sixth class of subunit: Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.

Protein-protein interaction databases

STRINGi9606.ENSP00000265294

Structurei

3D structure databases

ProteinModelPortaliO00591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiO00591
KOiK05189
OMAiNDVEFSW
OrthoDBiEOG091G0805
PhylomeDBiO00591
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008100 GABAAp_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF33 PTHR18945:SF33, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01724 GABAARPI
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O00591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYSLHLAFV CLSLFTERMC IQGSQFNVEV GRSDKLSLPG FENLTAGYNK
60 70 80 90 100
FLRPNFGGEP VQIALTLDIA SISSISESNM DYTATIYLRQ RWMDQRLVFE
110 120 130 140 150
GNKSFTLDAR LVEFLWVPDT YIVESKKSFL HEVTVGNRLI RLFSNGTVLY
160 170 180 190 200
ALRITTTVAC NMDLSKYPMD TQTCKLQLES WGYDGNDVEF TWLRGNDSVR
210 220 230 240 250
GLEHLRLAQY TIERYFTLVT RSQQETGNYT RLVLQFELRR NVLYFILETY
260 270 280 290 300
VPSTFLVVLS WVSFWISLDS VPARTCIGVT TVLSMTTLMI GSRTSLPNTN
310 320 330 340 350
CFIKAIDVYL GICFSFVFGA LLEYAVAHYS SLQQMAAKDR GTTKEVEEVS
360 370 380 390 400
ITNIINSSIS SFKRKISFAS IEISSDNVDY SDLTMKTSDK FKFVFREKMG
410 420 430 440
RIVDYFTIQN PSNVDHYSKL LFPLIFMLAN VFYWAYYMYF
Length:440
Mass (Da):50,640
Last modified:July 1, 1997 - v1
Checksum:i92CA66C264560718
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EWG0E7EWG0_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
289Annotation score:
E5RI57E5RI57_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
349Annotation score:
E5RGF7E5RGF7_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
189Annotation score:
E5RG98E5RG98_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
171Annotation score:
E5RK74E5RK74_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
92Annotation score:
E5RHF6E5RHF6_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
52Annotation score:
E5RHU0E5RHU0_HUMAN
Gamma-aminobutyric acid receptor su...
GABRP
59Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020323391F → L1 PublicationCorresponds to variant dbSNP:rs1063310Ensembl.1
Natural variantiVAR_036034416H → R in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95367 mRNA Translation: AAC51357.1
AF009702
, AF009694, AF009695, AF009696, AF009697, AF009698, AF009699, AF009700, AF009701 Genomic DNA Translation: AAC24194.1
AK292901 mRNA Translation: BAF85590.1
CH471062 Genomic DNA Translation: EAW61467.1
CH471062 Genomic DNA Translation: EAW61468.1
BC074810 mRNA Translation: AAH74810.1
BC074865 mRNA Translation: AAH74865.1
BC109105 mRNA Translation: AAI09106.1
BC109106 mRNA Translation: AAI09107.1
CCDSiCCDS4375.1
RefSeqiNP_001278914.1, NM_001291985.1
NP_055026.1, NM_014211.2
UniGeneiHs.26225

Genome annotation databases

EnsembliENST00000265294; ENSP00000265294; ENSG00000094755
ENST00000518525; ENSP00000430100; ENSG00000094755
GeneIDi2568
KEGGihsa:2568
UCSCiuc003mau.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95367 mRNA Translation: AAC51357.1
AF009702
, AF009694, AF009695, AF009696, AF009697, AF009698, AF009699, AF009700, AF009701 Genomic DNA Translation: AAC24194.1
AK292901 mRNA Translation: BAF85590.1
CH471062 Genomic DNA Translation: EAW61467.1
CH471062 Genomic DNA Translation: EAW61468.1
BC074810 mRNA Translation: AAH74810.1
BC074865 mRNA Translation: AAH74865.1
BC109105 mRNA Translation: AAI09106.1
BC109106 mRNA Translation: AAI09107.1
CCDSiCCDS4375.1
RefSeqiNP_001278914.1, NM_001291985.1
NP_055026.1, NM_014211.2
UniGeneiHs.26225

3D structure databases

ProteinModelPortaliO00591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265294

Chemistry databases

ChEMBLiCHEMBL2093872
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

PTM databases

iPTMnetiO00591
PhosphoSitePlusiO00591

Polymorphism and mutation databases

BioMutaiGABRP

Proteomic databases

MaxQBiO00591
PaxDbiO00591
PeptideAtlasiO00591
PRIDEiO00591
ProteomicsDBi47991

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265294; ENSP00000265294; ENSG00000094755
ENST00000518525; ENSP00000430100; ENSG00000094755
GeneIDi2568
KEGGihsa:2568
UCSCiuc003mau.4 human

Organism-specific databases

CTDi2568
DisGeNETi2568
EuPathDBiHostDB:ENSG00000094755.16
GeneCardsiGABRP
HGNCiHGNC:4089 GABRP
HPAiCAB014883
MIMi602729 gene
neXtProtiNX_O00591
OpenTargetsiENSG00000094755
PharmGKBiPA28503
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiO00591
KOiK05189
OMAiNDVEFSW
OrthoDBiEOG091G0805
PhylomeDBiO00591
TreeFamiTF315453

Miscellaneous databases

ChiTaRSiGABRP human
GeneWikiiGABRP
GenomeRNAii2568
PROiPR:O00591
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000094755 Expressed in 112 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_GABRP
ExpressionAtlasiO00591 baseline and differential
GenevisibleiO00591 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008100 GABAAp_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PTHR18945:SF33 PTHR18945:SF33, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01724 GABAARPI
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBRP_HUMAN
AccessioniPrimary (citable) accession number: O00591
Secondary accession number(s): A8KA36, D3DQL2, Q32MJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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