ACKR2

Functionⁱ

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.2 Publications

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
C-C chemokine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9364936
scavenger receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23633677

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium-mediated signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9364936
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response Source: UniProtKB-KW
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 9364936
positive regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Inflammatory response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Atypical chemokine receptor 2 Alternative name(s): C-C chemokine receptor D6 Chemokine receptor CCR-10 Chemokine receptor CCR-9 Chemokine-binding protein 2 Chemokine-binding protein D6
Gene namesⁱ	Name:ACKR2 Synonyms:CCBP2, CCR10, CMKBR9, D6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144648.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1565 ACKR2
MIMⁱ	602648 gene
neXtProtⁱ	NX_O00590

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 50	ExtracellularSequence analysisAdd BLAST	50
Transmembraneⁱ	51 – 71	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	72 – 92	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	93 – 113	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	114 – 118	ExtracellularSequence analysis	5
Transmembraneⁱ	119 – 140	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	141 – 162	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	163 – 183	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	184 – 217	ExtracellularSequence analysisAdd BLAST	34
Transmembraneⁱ	218 – 238	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	239 – 250	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	251 – 271	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	272 – 293	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	294 – 314	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	315 – 384	CytoplasmicSequence analysisAdd BLAST	70

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1238
Open Targets More...OpenTargetsⁱ	ENSG00000144648
PharmGKBⁱ	PA26139

Polymorphism and mutation databases

BioMutaⁱ	CCBP2

BioMutaⁱ

CCBP2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069219	1 – 384	Atypical chemokine receptor 2Add BLAST		384

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	19	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	117 ↔ 195	PROSITE-ProRule annotation

Post-translational modificationⁱ

Phosphorylated on serine residues in the C-terminal cytoplasmic tail.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	O00590
PeptideAtlas More...PeptideAtlasⁱ	O00590
PRIDEⁱ	O00590
ProteomicsDBⁱ	47990

PTM databases

iPTMnetⁱ	O00590
PhosphoSitePlusⁱ	O00590

Expressionⁱ

Tissue specificityⁱ

Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.3 Publications

Inductionⁱ

By interleukin-6 and interferon-gamma.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000144648 Expressed in 102 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CCBP2 HS_CCR10
ExpressionAtlasⁱ	O00590 baseline and differential
Genevisibleⁱ	O00590 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA013819 HPA073493

HPAⁱ

HPA013819
HPA073493

Interactionⁱ

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107643, 9 interactors
IntActⁱ	O00590, 6 interactors
STRINGⁱ	9606.ENSP00000273145

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00590
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	327 – 384	C-terminal cytoplasmic tailAdd BLAST		58

Domainⁱ

The C-terminal cytoplasmic tail controls its phosphorylation, stability, intracellular trafficking itinerary, and chemokine scavenging properties.

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150855
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	O00590
KEGG Orthology (KO) More...KOⁱ	K04187
OMAⁱ	LWFPYNL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FFG
PhylomeDBⁱ	O00590
TreeFamⁱ	TF330966

Family and domain databases

InterProⁱ	View protein in InterPro IPR033037 Ackr2 IPR000355 Chemokine_rcpt IPR001277 CXCR4/ACKR2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR10489:SF735 PTHR10489:SF735, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR00645 CXCCHMKINER4 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

O00590-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATASPQPL ATEDADSENS SFYYYDYLDE VAFMLCRKDA VVSFGKVFLP 
        60         70         80         90        100
VFYSLIFVLG LSGNLLLLMV LLRYVPRRRM VEIYLLNLAI SNLLFLVTLP 
       110        120        130        140        150
FWGISVAWHW VFGSFLCKMV STLYTINFYS GIFFISCMSL DKYLEIVHAQ 
       160        170        180        190        200
PYHRLRTRAK SLLLATIVWA VSLAVSIPDM VFVQTHENPK GVWNCHADFG 
       210        220        230        240        250
GHGTIWKLFL RFQQNLLGFL LPLLAMIFFY SRIGCVLVRL RPAGQGRALK 
       260        270        280        290        300
IAAALVVAFF VLWFPYNLTL FLHTLLDLQV FGNCEVSQHL DYALQVTESI 
       310        320        330        340        350
AFLHCCFSPI LYAFSSHRFR QYLKAFLAAV LGWHLAPGTA QASLSSCSES 
       360        370        380 
SILTAQEEMT GMNDLGERQS ENYPNKEDVG NKSA

Length:384

Mass (Da):43,443

Last modified:May 2, 2002 - v2

Checksum:ⁱ464C5703C1DE9A6A

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

V9GZ70	V9GZ70_HUMAN	Atypical chemokine receptor 2 Atypical chemokine receptor 2	ACKR2	142	Annotation score:
V9GYX0	V9GYX0_HUMAN	Atypical chemokine receptor 2 Atypical chemokine receptor 2	ACKR2	170	Annotation score:
V9GYB7	V9GYB7_HUMAN	Atypical chemokine receptor 2 Atypical chemokine receptor 2	ACKR2	233	Annotation score:
V9GYM0	V9GYM0_HUMAN	Atypical chemokine receptor 2 Atypical chemokine receptor 2	ACKR2	124	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17	S → A in AAB97728 (PubMed:9364936).Curated	1
Sequence conflictⁱ	161	S → N in AAB97728 (PubMed:9364936).Curated	1
Sequence conflictⁱ	356	Q → L in AAB97728 (PubMed:9364936).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049379	41	V → A. Corresponds to variant dbSNP:rs2228467Ensembl.	1
Natural variantⁱVAR_049380	248	A → V. Corresponds to variant dbSNP:rs2228469Ensembl.	1
Natural variantⁱVAR_049381	311	L → V. Corresponds to variant dbSNP:rs6779520Ensembl.	1
Natural variantⁱVAR_024252	373	Y → S1 PublicationCorresponds to variant dbSNP:rs2228468Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U94888 mRNA Translation: AAB97728.1 Y12815 mRNA Translation: CAA73346.1 AY262687 Genomic DNA Translation: AAP20651.1 BT006800 mRNA Translation: AAP35446.1 AK313561 mRNA Translation: BAG36335.1 BC008816 mRNA Translation: AAH08816.1 BC011631 mRNA Translation: AAH11631.1 BC020558 mRNA Translation: AAH20558.1 BC101629 mRNA Translation: AAI01630.1 BC112045 mRNA Translation: AAI12046.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2706.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001287.2, NM_001296.4
UniGeneⁱ	Hs.146346

Genome annotation databases

Ensemblⁱ	ENST00000422265; ENSP00000416996; ENSG00000144648 ENST00000442925; ENSP00000396150; ENSG00000144648
GeneIDⁱ	1238
KEGGⁱ	hsa:1238
UCSC genome browser More...UCSCⁱ	uc003cme.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00590	Chemokine binding protein 2, isoform CRA_a		HUMAN		384	UniRef100_O00590
Atypical chemokine receptor 2 (Fragment)		HUMAN		170
Atypical chemokine receptor 2 (Fragment)		HUMAN		142
Atypical chemokine receptor 2 (Fragment)		HUMAN		233
Atypical chemokine receptor 2 (Fragment)		HUMAN		124

Protein	Similar proteins		Species	Score	Length	Source
O00590	Chemokine binding protein 2, isoform CRA_a		HUMAN		384	UniRef90_O00590
Uncharacterized protein		COLAP		384
Atypical chemokine receptor 2		MACMU		384
Uncharacterized protein		MACFA		384
Uncharacterized protein		MACNE		384
+12

Protein	Similar proteins		Species	Score	Length	Source
O00590	Chemokine binding protein 2, isoform CRA_a		HUMAN		384	UniRef50_O00590
Atypical chemokine receptor 2		MACMU		384
Uncharacterized protein		MACFA		384
Uncharacterized protein		MACNE		384
Uncharacterized protein		GORGO		384
+122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U94888 mRNA Translation: AAB97728.1 Y12815 mRNA Translation: CAA73346.1 AY262687 Genomic DNA Translation: AAP20651.1 BT006800 mRNA Translation: AAP35446.1 AK313561 mRNA Translation: BAG36335.1 BC008816 mRNA Translation: AAH08816.1 BC011631 mRNA Translation: AAH11631.1 BC020558 mRNA Translation: AAH20558.1 BC101629 mRNA Translation: AAI01630.1 BC112045 mRNA Translation: AAI12046.1
CCDSⁱ	CCDS2706.1
RefSeqⁱ	NP_001287.2, NM_001296.4
UniGeneⁱ	Hs.146346

3D structure databases

ProteinModelPortalⁱ	O00590
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107643, 9 interactors
IntActⁱ	O00590, 6 interactors
STRINGⁱ	9606.ENSP00000273145

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O00590
PhosphoSitePlusⁱ	O00590

Polymorphism and mutation databases

BioMutaⁱ	CCBP2

BioMutaⁱ

CCBP2

Proteomic databases

PaxDbⁱ	O00590
PeptideAtlasⁱ	O00590
PRIDEⁱ	O00590
ProteomicsDBⁱ	47990

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1238
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000422265; ENSP00000416996; ENSG00000144648 ENST00000442925; ENSP00000396150; ENSG00000144648
GeneIDⁱ	1238
KEGGⁱ	hsa:1238
UCSCⁱ	uc003cme.4 human

Organism-specific databases

CTDⁱ	1238
DisGeNETⁱ	1238
EuPathDBⁱ	HostDB:ENSG00000144648.15
GeneCardsⁱ	ACKR2
HGNCⁱ	HGNC:1565 ACKR2
HPAⁱ	HPA013819 HPA073493
MIMⁱ	602648 gene
neXtProtⁱ	NX_O00590
OpenTargetsⁱ	ENSG00000144648
PharmGKBⁱ	PA26139
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00930000150855
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	O00590
KOⁱ	K04187
OMAⁱ	LWFPYNL
OrthoDBⁱ	EOG091G0FFG
PhylomeDBⁱ	O00590
TreeFamⁱ	TF330966

Miscellaneous databases

GeneWikiⁱ	CCBP2
GenomeRNAiⁱ	1238
Protein Ontology More...PROⁱ	PR:O00590
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144648 Expressed in 102 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CCBP2 HS_CCR10
ExpressionAtlasⁱ	O00590 baseline and differential
Genevisibleⁱ	O00590 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033037 Ackr2 IPR000355 Chemokine_rcpt IPR001277 CXCR4/ACKR2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR10489:SF735 PTHR10489:SF735, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR00645 CXCCHMKINER4 PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACKR2_HUMAN
Accessionⁱ	O00590Primary (citable) accession number: O00590 Secondary accession number(s): B2R8Y8 , O00537, Q53YA1, Q86UN9, Q96A02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
	Last sequence update:	May 2, 2002
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - O00590 (ACKR2_HUMAN)

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Atypical chemokine receptor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Cytoskeleton

Cytosol

Endosome

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ