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UniProtKB - O00584 (RNT2_HUMAN)

Entry version 166 (13 Nov 2019)
Sequence version 2 (01 Nov 1999)
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Protein

Ribonuclease T2

Gene

RNASET2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • RNA + H(2)O = an (RNA fragment)-3'-nucleoside-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment).PROSITE-ProRule annotation EC:4.6.1.19

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Zn2+ and Cu2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei65PROSITE-ProRule annotation1
Active sitei114By similarity1
Active sitei118PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Lyase, Nuclease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease T2 (EC:4.6.1.19PROSITE-ProRule annotation)
Alternative name(s):
Ribonuclease 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASET2
Synonyms:RNASE6PL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21686 RNASET2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612944 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00584

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukoencephalopathy, cystic, without megalencephaly (LCWM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063596184C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs121918137EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		8635

MalaCards human disease database

More...MalaCardsi		RNASET2
MIMi612951 phenotype

Open Targets

More...OpenTargetsi		ENSG00000026297

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		85136 Cystic leukoencephalopathy without megalencephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394541

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00584

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNASET2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003098725 – 256Ribonuclease T2Add BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 551 Publication
Disulfide bondi75 ↔ 1211 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi106N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi184 ↔ 2411 Publication
Disulfide bondi202 ↔ 2131 Publication
Glycosylationi212N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00584

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00584

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00584

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00584

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00584

PeptideAtlas

More...PeptideAtlasi		O00584

PRoteomics IDEntifications database

More...PRIDEi		O00584

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47985 [O00584-1]
47986 [O00584-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1719

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00584

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00584

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O00584

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000026297 Expressed in 232 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00584 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00584 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA029013
HPA066509

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114188, 12 interactors

Protein interaction database and analysis system

More...IntActi		O00584, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000426455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00584

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNase T2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1642 Eukaryota
ENOG4111M7G LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00640000091563

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00584

KEGG Orthology (KO)

More...KOi		K01166

Database of Orthologous Groups

More...OrthoDBi		994722at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00584

TreeFam database of animal gene trees

More...TreeFami		TF315063

Family and domain databases

Conserved Domains Database

More...CDDi		cd01061 RNase_T2_euk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033697 Ribonuclease_T2_eukaryotic
IPR001568 RNase_T2-like
IPR036430 RNase_T2-like_sf
IPR018188 RNase_T2_His_AS_1
IPR033130 RNase_T2_His_AS_2

The PANTHER Classification System

More...PANTHERi		PTHR11240 PTHR11240, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00445 Ribonuclease_T2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55895 SSF55895, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00530 RNASE_T2_1, 1 hit
PS00531 RNASE_T2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00584-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK 
        60         70         80         90        100
IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV 
       110        120        130        140        150
IHSFPNRSRF WKHEWEKHGT CAAQVDALNS QKKYFGRSLE LYRELDLNSV 
       160        170        180        190        200
LLKLGIKPSI NYYQVADFKD ALARVYGVIP KIQCLPPSQD EEVQTIGQIE 
       210        220        230        240        250
LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV CEDGPVFYPP 

PKKTKH
Length:256
Mass (Da):29,481
Last modified:November 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C8BB08B8ED853EB
GO
Isoform 2 (identifier: O00584-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-121: DLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTC → KNWMEITDSSLPSPSTLPIINIFYSVLHLLQLMN
     122-256: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:121
Mass (Da):14,000
Checksum:i984FAD634B7286E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHI9D6RHI9_HUMAN
Ribonuclease T2
RNASET2
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZM2A0A087WZM2_HUMAN
Ribonuclease T2
RNASET2
306Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQ64J3QQ64_HUMAN
Ribonuclease T2
RNASET2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWI1A0A087WWI1_HUMAN
Ribonuclease T2
RNASET2
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REQ6D6REQ6_HUMAN
Ribonuclease T2
RNASET2 hCG_15018
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063596184C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs121918137EnsemblClinVar.1
Natural variantiVAR_013004236R → W. Corresponds to variant dbSNP:rs11159EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00840588 – 121DLLPE…KHGTC → KNWMEITDSSLPSPSTLPII NIFYSVLHLLQLMN in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_008406122 – 256Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U85625 mRNA Translation: AAC51363.2
AJ419865 mRNA Translation: CAD12030.1
AJ419866 mRNA Translation: CAD12031.1
AK315467 mRNA Translation: BAG37854.1
AL133458 Genomic DNA No translation available.
AL159163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47512.1
CH471051 Genomic DNA Translation: EAW47513.1
CH471051 Genomic DNA Translation: EAW47514.1
BC001660 mRNA Translation: AAH01660.1
BC001819 mRNA Translation: AAH01819.1
BC039713 mRNA Translation: AAH39713.1
BC051912 mRNA Translation: AAH51912.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5295.1 [O00584-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S78046

NCBI Reference Sequences

More...RefSeqi		NP_003721.2, NM_003730.4 [O00584-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000421787; ENSP00000390833; ENSG00000026297 [O00584-2]
ENST00000476238; ENSP00000422846; ENSG00000026297 [O00584-1]
ENST00000508775; ENSP00000426455; ENSG00000026297 [O00584-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8635

UCSC genome browser

More...UCSCi		uc003qve.4 human [O00584-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85625 mRNA Translation: AAC51363.2
AJ419865 mRNA Translation: CAD12030.1
AJ419866 mRNA Translation: CAD12031.1
AK315467 mRNA Translation: BAG37854.1
AL133458 Genomic DNA No translation available.
AL159163 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47512.1
CH471051 Genomic DNA Translation: EAW47513.1
CH471051 Genomic DNA Translation: EAW47514.1
BC001660 mRNA Translation: AAH01660.1
BC001819 mRNA Translation: AAH01819.1
BC039713 mRNA Translation: AAH39713.1
BC051912 mRNA Translation: AAH51912.1
CCDSiCCDS5295.1 [O00584-1]
PIRiS78046
RefSeqiNP_003721.2, NM_003730.4 [O00584-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T0OX-ray1.59A25-256[»]
SMRiO00584
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114188, 12 interactors
IntActiO00584, 7 interactors
STRINGi9606.ENSP00000426455

PTM databases

GlyConnecti1719
iPTMnetiO00584
PhosphoSitePlusiO00584
SwissPalmiO00584

Polymorphism and mutation databases

BioMutaiRNASET2

Proteomic databases

EPDiO00584
jPOSTiO00584
MassIVEiO00584
MaxQBiO00584
PaxDbiO00584
PeptideAtlasiO00584
PRIDEiO00584
ProteomicsDBi47985 [O00584-1]
47986 [O00584-2]

Genome annotation databases

EnsembliENST00000421787; ENSP00000390833; ENSG00000026297 [O00584-2]
ENST00000476238; ENSP00000422846; ENSG00000026297 [O00584-1]
ENST00000508775; ENSP00000426455; ENSG00000026297 [O00584-1]
GeneIDi8635
KEGGihsa:8635
UCSCiuc003qve.4 human [O00584-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8635
DisGeNETi8635

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNASET2
HGNCiHGNC:21686 RNASET2
HPAiHPA029013
HPA066509
MalaCardsiRNASET2
MIMi612944 gene
612951 phenotype
neXtProtiNX_O00584
OpenTargetsiENSG00000026297
Orphaneti85136 Cystic leukoencephalopathy without megalencephaly
PharmGKBiPA128394541

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1642 Eukaryota
ENOG4111M7G LUCA
GeneTreeiENSGT00640000091563
InParanoidiO00584
KOiK01166
OrthoDBi994722at2759
PhylomeDBiO00584
TreeFamiTF315063

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNASET2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RNASET2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8635
PharosiO00584

Protein Ontology

More...PROi		PR:O00584

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000026297 Expressed in 232 organ(s), highest expression level in endometrium
ExpressionAtlasiO00584 baseline and differential
GenevisibleiO00584 HS

Family and domain databases

CDDicd01061 RNase_T2_euk, 1 hit
Gene3Di3.90.730.10, 1 hit
InterProiView protein in InterPro
IPR033697 Ribonuclease_T2_eukaryotic
IPR001568 RNase_T2-like
IPR036430 RNase_T2-like_sf
IPR018188 RNase_T2_His_AS_1
IPR033130 RNase_T2_His_AS_2
PANTHERiPTHR11240 PTHR11240, 1 hit
PfamiView protein in Pfam
PF00445 Ribonuclease_T2, 1 hit
SUPFAMiSSF55895 SSF55895, 1 hit
PROSITEiView protein in PROSITE
PS00530 RNASE_T2_1, 1 hit
PS00531 RNASE_T2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00584
Secondary accession number(s): B2RDA7
, E1P5C3, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: November 1, 1999
Last modified: November 13, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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