RNASET2

Functionⁱ

Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.By similarity3 Publications

Activity regulationⁱ

Inhibited by Zn²⁺ and Cu²⁺.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	65	By similarity	1
Active siteⁱ	114	By similarity	1
Active siteⁱ	118	By similarity	1

GO - Molecular functionⁱ

endoribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ribonuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22735700
ribonuclease T2 activity Source: InterPro
RNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neutrophil degranulation Source: Reactome
RNA catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 22735700

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Endonuclease, Hydrolase, Nuclease

Molecular function

Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribonuclease T2 (EC:3.1.27.-) Alternative name(s): Ribonuclease 6
Gene namesⁱ	Name:RNASET2 Synonyms:RNASE6PL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000026297.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21686 RNASET2
MIMⁱ	612944 gene
neXtProtⁱ	NX_O00584

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Lysosome, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leukoencephalopathy, cystic, without megalencephaly (LCWM)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8635
MalaCards human disease database More...MalaCardsⁱ	RNASET2
MIMⁱ	612951 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000026297
Orphanetⁱ	85136 Cystic leukoencephalopathy without megalencephaly
PharmGKBⁱ	PA128394541

Polymorphism and mutation databases

BioMutaⁱ	RNASET2

BioMutaⁱ

RNASET2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_0000030987	25 – 256	Ribonuclease T2Add BLAST		232

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	48 ↔ 55	1 Publication
Disulfide bondⁱ	75 ↔ 121	1 Publication
Glycosylationⁱ	76	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	184 ↔ 241	1 Publication
Disulfide bondⁱ	202 ↔ 213	1 Publication
Glycosylationⁱ	212	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O00584
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00584
PaxDbⁱ	O00584
PeptideAtlas More...PeptideAtlasⁱ	O00584
PRIDEⁱ	O00584
ProteomicsDBⁱ	47985 47986 [O00584-2]

PTM databases

GlyConnectⁱ	1719
iPTMnetⁱ	O00584
PhosphoSitePlusⁱ	O00584
SwissPalmⁱ	O00584

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000026297 Expressed in 232 organ(s), highest expression level in endometrium
CleanExⁱ	HS_RNASET2
ExpressionAtlasⁱ	O00584 baseline and differential
Genevisibleⁱ	O00584 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029013 HPA066509

HPAⁱ

HPA029013
HPA066509

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114188, 12 interactors
IntActⁱ	O00584, 5 interactors
STRINGⁱ	9606.ENSP00000422846

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	36 – 42	Combined sources	7
Helixⁱ	44 – 47	Combined sources	4
Beta strandⁱ	50 – 52	Combined sources	3
Helixⁱ	53 – 55	Combined sources	3
Beta strandⁱ	63 – 71	Combined sources	9
Helixⁱ	83 – 89	Combined sources	7
Helixⁱ	90 – 96	Combined sources	7
Helixⁱ	108 – 117	Combined sources	10
Helixⁱ	119 – 122	Combined sources	4
Helixⁱ	126 – 128	Combined sources	3
Helixⁱ	131 – 145	Combined sources	15
Helixⁱ	147 – 153	Combined sources	7
Helixⁱ	165 – 176	Combined sources	12
Beta strandⁱ	181 – 185	Combined sources	5
Beta strandⁱ	195 – 204	Combined sources	10
Turnⁱ	205 – 207	Combined sources	3
Beta strandⁱ	243 – 247	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	O00584
SMRⁱ	O00584
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the RNase T2 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1642 Eukaryota ENOG4111M7G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00640000091563
HOVERGENⁱ	HBG050037
InParanoidⁱ	O00584
KEGG Orthology (KO) More...KOⁱ	K01166
PhylomeDBⁱ	O00584
TreeFamⁱ	TF315063

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01061 RNase_T2_euk, 1 hit
Gene3Dⁱ	3.90.730.10, 1 hit
InterProⁱ	View protein in InterPro IPR033697 Ribonuclease_T2_eukaryotic IPR001568 RNase_T2-like IPR036430 RNase_T2-like_sf IPR018188 RNase_T2_His_AS_1 IPR033130 RNase_T2_His_AS_2
PANTHERⁱ	PTHR11240 PTHR11240, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00445 Ribonuclease_T2, 1 hit
SUPFAMⁱ	SSF55895 SSF55895, 1 hit
PROSITEⁱ	View protein in PROSITE PS00530 RNASE_T2_1, 1 hit PS00531 RNASE_T2_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00584-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK 
        60         70         80         90        100
IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV 
       110        120        130        140        150
IHSFPNRSRF WKHEWEKHGT CAAQVDALNS QKKYFGRSLE LYRELDLNSV 
       160        170        180        190        200
LLKLGIKPSI NYYQVADFKD ALARVYGVIP KIQCLPPSQD EEVQTIGQIE 
       210        220        230        240        250
LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV CEDGPVFYPP 

PKKTKH

Length:256

Mass (Da):29,481

Last modified:November 1, 1999 - v2

Checksum:ⁱ7C8BB08B8ED853EB

GO

Isoform 2 (identifier: O00584-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
88-121: DLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTC → KNWMEITDSSLPSPSTLPIINIFYSVLHLLQLMN
122-256: Missing.

« Hide

        10         20         30         40         50
MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK 
        60         70         80         90        100
IQNDCRDPPD YWTIHGLWPD KSEGCNRSWP FNLEEIKKNW MEITDSSLPS 
       110        120 
PSTLPIINIF YSVLHLLQLM N

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:121

Mass (Da):14,000

Checksum:ⁱ984FAD634B7286E8

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WZM2	A0A087WZM2_HUMAN	Ribonuclease T2 Ribonuclease T2	RNASET2	306	Annotation score:
J3QQ64	J3QQ64_HUMAN	Ribonuclease T2 Ribonuclease T2	RNASET2	71	Annotation score:
D6RHI9	D6RHI9_HUMAN	Ribonuclease T2 Ribonuclease T2	RNASET2	253	Annotation score:
A0A087WWI1	A0A087WWI1_HUMAN	Ribonuclease T2 Ribonuclease T2	RNASET2	238	Annotation score:
D6REQ6	D6REQ6_HUMAN	Ribonuclease T2, isoform CRA_c Ribonuclease T2, isoform CRA_c	RNASET2 hCG_15018	218	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063596	184	C → R in LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum. 2 PublicationsCorresponds to variant dbSNP:rs121918137EnsemblClinVar.		1
Natural variantⁱVAR_013004	236	R → W. Corresponds to variant dbSNP:rs11159EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_008405	88 – 121	DLLPE…KHGTC → KNWMEITDSSLPSPSTLPII NIFYSVLHLLQLMN in isoform 2. 1 PublicationAdd BLAST		34
Alternative sequenceⁱVSP_008406	122 – 256	Missing in isoform 2. 1 PublicationAdd BLAST		135

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85625 mRNA Translation: AAC51363.2 AJ419865 mRNA Translation: CAD12030.1 AJ419866 mRNA Translation: CAD12031.1 AK315467 mRNA Translation: BAG37854.1 AL133458 Genomic DNA No translation available. AL159163 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47512.1 CH471051 Genomic DNA Translation: EAW47513.1 CH471051 Genomic DNA Translation: EAW47514.1 BC001660 mRNA Translation: AAH01660.1 BC001819 mRNA Translation: AAH01819.1 BC039713 mRNA Translation: AAH39713.1 BC051912 mRNA Translation: AAH51912.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5295.1 [O00584-1]
PIRⁱ	S78046
NCBI Reference Sequences More...RefSeqⁱ	NP_003721.2, NM_003730.4 [O00584-1]
UniGeneⁱ	Hs.529989

Genome annotation databases

Ensemblⁱ	ENST00000421787; ENSP00000390833; ENSG00000026297 [O00584-2] ENST00000476238; ENSP00000422846; ENSG00000026297 [O00584-1] ENST00000508775; ENSP00000426455; ENSG00000026297 [O00584-1]
GeneIDⁱ	8635
KEGGⁱ	hsa:8635
UCSC genome browser More...UCSCⁱ	uc003qve.4 human [O00584-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00584	Ribonuclease T2 (Fragment)		HUMAN		253	UniRef100_O00584
Ribonuclease T2, isoform CRA_c		HUMAN		218

Protein	Similar proteins		Species	Score	Length	Source
O00584	Ribonuclease T2 (Fragment)		HUMAN		253	UniRef90_O00584
Uncharacterized protein		CERAT		297
Uncharacterized protein		NOMLE		256
Ribonuclease T2		MACMU		256
Uncharacterized protein		MACFA		256
+21

Protein	Similar proteins		Species	Score	Length	Source
O00584	Ribonuclease T2 (Fragment)		HUMAN		253	UniRef50_O00584
Uncharacterized protein		CERAT		297
Uncharacterized protein		COLAP		256
Macaca fascicularis brain cDNA clone: QflA-16109, similar to human ribonuclease T2 (RNASET2), mRNA, RefSeq: NM_003730.3		MACFA		256
Ribonuclease T2		PANTR		256
+75

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U85625 mRNA Translation: AAC51363.2 AJ419865 mRNA Translation: CAD12030.1 AJ419866 mRNA Translation: CAD12031.1 AK315467 mRNA Translation: BAG37854.1 AL133458 Genomic DNA No translation available. AL159163 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47512.1 CH471051 Genomic DNA Translation: EAW47513.1 CH471051 Genomic DNA Translation: EAW47514.1 BC001660 mRNA Translation: AAH01660.1 BC001819 mRNA Translation: AAH01819.1 BC039713 mRNA Translation: AAH39713.1 BC051912 mRNA Translation: AAH51912.1
CCDSⁱ	CCDS5295.1 [O00584-1]
PIRⁱ	S78046
RefSeqⁱ	NP_003721.2, NM_003730.4 [O00584-1]
UniGeneⁱ	Hs.529989

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3T0O	X-ray	1.59	A	25-256	[»]
ProteinModelPortalⁱ	O00584
SMRⁱ	O00584
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114188, 12 interactors
IntActⁱ	O00584, 5 interactors
STRINGⁱ	9606.ENSP00000422846

PTM databases

GlyConnectⁱ	1719
iPTMnetⁱ	O00584
PhosphoSitePlusⁱ	O00584
SwissPalmⁱ	O00584

Polymorphism and mutation databases

BioMutaⁱ	RNASET2

BioMutaⁱ

RNASET2

Proteomic databases

EPDⁱ	O00584
MaxQBⁱ	O00584
PaxDbⁱ	O00584
PeptideAtlasⁱ	O00584
PRIDEⁱ	O00584
ProteomicsDBⁱ	47985 47986 [O00584-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000421787; ENSP00000390833; ENSG00000026297 [O00584-2] ENST00000476238; ENSP00000422846; ENSG00000026297 [O00584-1] ENST00000508775; ENSP00000426455; ENSG00000026297 [O00584-1]
GeneIDⁱ	8635
KEGGⁱ	hsa:8635
UCSCⁱ	uc003qve.4 human [O00584-1]

Organism-specific databases

CTDⁱ	8635
DisGeNETⁱ	8635
EuPathDBⁱ	HostDB:ENSG00000026297.15
GeneCardsⁱ	RNASET2
HGNCⁱ	HGNC:21686 RNASET2
HPAⁱ	HPA029013 HPA066509
MalaCardsⁱ	RNASET2
MIMⁱ	612944 gene 612951 phenotype
neXtProtⁱ	NX_O00584
OpenTargetsⁱ	ENSG00000026297
Orphanetⁱ	85136 Cystic leukoencephalopathy without megalencephaly
PharmGKBⁱ	PA128394541
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1642 Eukaryota ENOG4111M7G LUCA
GeneTreeⁱ	ENSGT00640000091563
HOVERGENⁱ	HBG050037
InParanoidⁱ	O00584
KOⁱ	K01166
PhylomeDBⁱ	O00584
TreeFamⁱ	TF315063

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	RNASET2 human
GeneWikiⁱ	RNASET2
GenomeRNAiⁱ	8635
Protein Ontology More...PROⁱ	PR:O00584
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000026297 Expressed in 232 organ(s), highest expression level in endometrium
CleanExⁱ	HS_RNASET2
ExpressionAtlasⁱ	O00584 baseline and differential
Genevisibleⁱ	O00584 HS

Family and domain databases

CDDⁱ	cd01061 RNase_T2_euk, 1 hit
Gene3Dⁱ	3.90.730.10, 1 hit
InterProⁱ	View protein in InterPro IPR033697 Ribonuclease_T2_eukaryotic IPR001568 RNase_T2-like IPR036430 RNase_T2-like_sf IPR018188 RNase_T2_His_AS_1 IPR033130 RNase_T2_His_AS_2
PANTHERⁱ	PTHR11240 PTHR11240, 1 hit
Pfamⁱ	View protein in Pfam PF00445 Ribonuclease_T2, 1 hit
SUPFAMⁱ	SSF55895 SSF55895, 1 hit
PROSITEⁱ	View protein in PROSITE PS00530 RNASE_T2_1, 1 hit PS00531 RNASE_T2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RNT2_HUMAN
Accessionⁱ	O00584Primary (citable) accession number: O00584 Secondary accession number(s): B2RDA7 , E1P5C3, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - O00584 (RNT2_HUMAN)

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Ribonuclease T2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Lysosome

Endoplasmic reticulum

Extracellular region or secreted

Lysosome

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ