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Protein

C-X-C chemokine receptor type 6

Gene

CXCR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • coreceptor activity Source: ProtInc
  • C-X-C chemokine binding Source: Ensembl
  • C-X-C chemokine receptor activity Source: Ensembl
  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CDw186
G-protein coupled receptor STRL33
G-protein coupled receptor bonzo
CD_antigen: CD186
Gene namesi
Name:CXCR6
Synonyms:BONZO, STRL33, TYMSTR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172215.5
HGNCiHGNC:16647 CXCR6
MIMi605163 gene
neXtProtiNX_O00574

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 59Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini60 – 68CytoplasmicSequence analysis9
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 103ExtracellularSequence analysisAdd BLAST14
Transmembranei104 – 125Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini126 – 143CytoplasmicSequence analysisAdd BLAST18
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 187ExtracellularSequence analysisAdd BLAST23
Transmembranei188 – 215Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini216 – 231CytoplasmicSequence analysisAdd BLAST16
Transmembranei232 – 259Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini260 – 275ExtracellularSequence analysisAdd BLAST16
Transmembranei276 – 293Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini294 – 342CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10663
OpenTargetsiENSG00000172215
PharmGKBiPA38409

Chemistry databases

ChEMBLiCHEMBL5994
GuidetoPHARMACOLOGYi73

Polymorphism and mutation databases

BioMutaiCXCR6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693651 – 342C-X-C chemokine receptor type 6Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00574
PRIDEiO00574
ProteomicsDBi47984

PTM databases

iPTMnetiO00574
PhosphoSitePlusiO00574

Expressioni

Tissue specificityi

Expressed in lymphoid tissues and activated T cells.

Gene expression databases

BgeeiENSG00000172215 Expressed in 120 organ(s), highest expression level in lymph node
CleanExiHS_CXCR6
ExpressionAtlasiO00574 baseline and differential
GenevisibleiO00574 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304414

Structurei

3D structure databases

ProteinModelPortaliO00574
SMRiO00574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO00574
KOiK04191
OMAiTPFNLVK
OrthoDBiEOG091G0D3V
PhylomeDBiO00574
TreeFamiTF330966

Family and domain databases

CDDicd15173 7tmA_CXCR6, 1 hit
InterProiView protein in InterPro
IPR002235 Chemokine_CXCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF705 PTHR10489:SF705, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01105 CXCCHMKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEHDYHEDY GFSSFNDSSQ EEHQDFLQFS KVFLPCMYLV VFVCGLVGNS
60 70 80 90 100
LVLVISIFYH KLQSLTDVFL VNLPLADLVF VCTLPFWAYA GIHEWVFGQV
110 120 130 140 150
MCKSLLGIYT INFYTSMLIL TCITVDRFIV VVKATKAYNQ QAKRMTWGKV
160 170 180 190 200
TSLLIWVISL LVSLPQIIYG NVFNLDKLIC GYHDEAISTV VLATQMTLGF
210 220 230 240 250
FLPLLTMIVC YSVIIKTLLH AGGFQKHRSL KIIFLVMAVF LLTQMPFNLM
260 270 280 290 300
KFIRSTHWEY YAMTSFHYTI MVTEAIAYLR ACLNPVLYAF VSLKFRKNFW
310 320 330 340
KLVKDIGCLP YLGVSHQWKS SEDNSKTFSA SHNVEATSMF QL
Length:342
Mass (Da):39,280
Last modified:July 1, 1997 - v1
Checksum:i9FBC025556D1082E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0242533E → K1 PublicationCorresponds to variant dbSNP:rs2234355Ensembl.1
Natural variantiVAR_00350625D → A in STRL33.3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA Translation: AAB64221.1
U73529 mRNA Translation: AAB61456.1
U73531 mRNA Translation: AAB61457.1
Y13248 mRNA Translation: CAA73698.1
AF029759 Genomic DNA Translation: AAG21918.1
AY322543 Genomic DNA Translation: AAP84356.1
BC033584 mRNA Translation: AAH33584.1
CCDSiCCDS2735.1
RefSeqiNP_006555.1, NM_006564.1
XP_005264866.1, XM_005264809.2
XP_011531592.1, XM_011533290.2
XP_011531593.1, XM_011533291.2
UniGeneiHs.34526
Hs.737579

Genome annotation databases

EnsembliENST00000304552; ENSP00000304414; ENSG00000172215
ENST00000438735; ENSP00000396218; ENSG00000172215
ENST00000457814; ENSP00000396886; ENSG00000172215
ENST00000458629; ENSP00000395704; ENSG00000172215
GeneIDi10663
KEGGihsa:10663
UCSCiuc003cpc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CXC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007545 mRNA Translation: AAB64221.1
U73529 mRNA Translation: AAB61456.1
U73531 mRNA Translation: AAB61457.1
Y13248 mRNA Translation: CAA73698.1
AF029759 Genomic DNA Translation: AAG21918.1
AY322543 Genomic DNA Translation: AAP84356.1
BC033584 mRNA Translation: AAH33584.1
CCDSiCCDS2735.1
RefSeqiNP_006555.1, NM_006564.1
XP_005264866.1, XM_005264809.2
XP_011531592.1, XM_011533290.2
XP_011531593.1, XM_011533291.2
UniGeneiHs.34526
Hs.737579

3D structure databases

ProteinModelPortaliO00574
SMRiO00574
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304414

Chemistry databases

ChEMBLiCHEMBL5994
GuidetoPHARMACOLOGYi73

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO00574
PhosphoSitePlusiO00574

Polymorphism and mutation databases

BioMutaiCXCR6

Proteomic databases

PaxDbiO00574
PRIDEiO00574
ProteomicsDBi47984

Protocols and materials databases

DNASUi10663
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304552; ENSP00000304414; ENSG00000172215
ENST00000438735; ENSP00000396218; ENSG00000172215
ENST00000457814; ENSP00000396886; ENSG00000172215
ENST00000458629; ENSP00000395704; ENSG00000172215
GeneIDi10663
KEGGihsa:10663
UCSCiuc003cpc.2 human

Organism-specific databases

CTDi10663
DisGeNETi10663
EuPathDBiHostDB:ENSG00000172215.5
GeneCardsiCXCR6
HGNCiHGNC:16647 CXCR6
MIMi605163 gene
neXtProtiNX_O00574
OpenTargetsiENSG00000172215
PharmGKBiPA38409
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150843
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiO00574
KOiK04191
OMAiTPFNLVK
OrthoDBiEOG091G0D3V
PhylomeDBiO00574
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiCXCR6
GenomeRNAii10663
PROiPR:O00574
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172215 Expressed in 120 organ(s), highest expression level in lymph node
CleanExiHS_CXCR6
ExpressionAtlasiO00574 baseline and differential
GenevisibleiO00574 HS

Family and domain databases

CDDicd15173 7tmA_CXCR6, 1 hit
InterProiView protein in InterPro
IPR002235 Chemokine_CXCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF705 PTHR10489:SF705, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01105 CXCCHMKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR6_HUMAN
AccessioniPrimary (citable) accession number: O00574
Secondary accession number(s): O00575, Q9HCA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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