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UniProtKB - O00560 (SDCB1_HUMAN)

Entry version 213 (23 Feb 2022)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

Syntenin-1

Gene

SDCBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).

Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).

In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).

Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).

In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).

May also play a role in vesicular trafficking (PubMed:11179419).

Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

1 Publication6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei215Phosphatidylinositol-4,5-bisphosphateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00560

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3928664, Ephrin signaling
R-HSA-447043, Neurofascin interactions
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5675482, Regulation of necroptotic cell death
R-HSA-6798695, Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00560

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00560

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		O00560, Predicted

Transport Classification Database

More...TCDBi		8.A.24.2.1, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Melanoma differentiation-associated protein 9
Short name:
MDA-9
Pro-TGF-alpha cytoplasmic domain-interacting protein 18
Short name:
TACIP18
Scaffold protein Pbp1
Syndecan-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDCBP
Synonyms:MDA9, SYCL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10662, SDCBP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602217, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00560

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137575

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi214K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-250. 1 Publication1
Mutagenesisi215N → D: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. 1 Publication1
Mutagenesisi250K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-214. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6386

Open Targets

More...OpenTargetsi		ENSG00000137575

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00560, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SDCBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001840012 – 298Syntenin-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei46PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00560

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00560

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00560

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00560

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00560

PeptideAtlas

More...PeptideAtlasi		O00560

PRoteomics IDEntifications database

More...PRIDEi		O00560

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47974 [O00560-1]
47975 [O00560-2]
47976 [O00560-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O00560-1 [O00560-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O00560, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00560

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00560

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O00560

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma in melanoma cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137575, Expressed in substantia nigra and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00560, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00560, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137575, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (By similarity).

Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA.

Interacts with NFASC and PTPRJ (By similarity).

Interacts with SDCBP2 (PubMed:11152476).

Interacts with PDCD6IP (PubMed:22660413).

Forms a complex with PDCD6IP and SDC2 (PubMed:22660413).

Interacts (via C-terminus) with TGFBR1 (PubMed:25893292). Binds to FZD7; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966).

Interacts with SMO (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

O00560
With#Exp.IntAct
ABI2 [Q9NYB9]5EBI-727004,EBI-743598
ANKRD33 - isoform 1 [Q7Z3H0-1]3EBI-727004,EBI-16746154
ANKRD36B - isoform 4 [Q8N2N9-4]3EBI-727004,EBI-12170453
ANKRD40 [Q6AI12]3EBI-727004,EBI-2838246
ANP32B [Q92688]6EBI-727004,EBI-762428
APIP [Q96GX9]5EBI-727004,EBI-359248
ARFIP2 [P53365]3EBI-727004,EBI-638194
ARL6IP1 [Q15041]3EBI-727004,EBI-714543
ATXN1 [P54253]6EBI-727004,EBI-930964
BCL2L15 [Q5TBC7]3EBI-727004,EBI-10247136
BEND7 - isoform 2 [Q8N7W2-2]3EBI-727004,EBI-10181188
C11orf68 [Q9H3H3]3EBI-727004,EBI-721765
C11orf68 - isoform 3 [Q9H3H3-3]3EBI-727004,EBI-12002214
C1orf109 [Q9NX04]3EBI-727004,EBI-8643161
C2CD2L [O14523]3EBI-727004,EBI-12822627
CABP5 [Q9NP86]3EBI-727004,EBI-10311131
CADPS [A2RRN7]3EBI-727004,EBI-10179719
CADPS - isoform 4 [Q9ULU8-4]3EBI-727004,EBI-10180690
CALCOCO2 [Q13137]3EBI-727004,EBI-739580
CAV2 [P51636]3EBI-727004,EBI-603607
CBR3 [O75828]8EBI-727004,EBI-714504
CCDC102B [Q68D86]3EBI-727004,EBI-10171570
CCDC106 [Q9BWC9]3EBI-727004,EBI-711501
CDA [P32320]6EBI-727004,EBI-9250559
CDC34 [P49427]6EBI-727004,EBI-975634
CDCP1 [Q9H5V8]6EBI-727004,EBI-1019736
CDIPT [O14735]3EBI-727004,EBI-358858
CDKN2D [P55273]3EBI-727004,EBI-745859
CEP55 [Q53EZ4]6EBI-727004,EBI-747776
CEP85 - isoform 3 [Q6P2H3-3]3EBI-727004,EBI-12368239
CGGBP1 [Q9UFW8]3EBI-727004,EBI-723153
CHIC2 [Q9UKJ5]3EBI-727004,EBI-741528
CHMP1A [Q9HD42]3EBI-727004,EBI-1057156
CLK2 [P49760]3EBI-727004,EBI-750020
CLK3 [P49761]6EBI-727004,EBI-745579
CMTM5 [Q96DZ9]3EBI-727004,EBI-2548702
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-727004,EBI-11522780
COX4I1 [P13073]4EBI-727004,EBI-1056574
COX4I1 [Q86WV2]3EBI-727004,EBI-10260134
CRX [O43186]3EBI-727004,EBI-748171
CRYAA [P02489]7EBI-727004,EBI-6875961
CT45A1 [Q5HYN5]3EBI-727004,EBI-12051833
CT45A10 [P0DMU9]6EBI-727004,EBI-12153495
CT45A3 [Q8NHU0]9EBI-727004,EBI-8643558
CT45A5 [Q6NSH3]3EBI-727004,EBI-8635816
CTBP2 - isoform 3 [P56545-3]3EBI-727004,EBI-10171902
CTDSP1 [Q9GZU7]3EBI-727004,EBI-751587
CUTC [Q9NTM9]6EBI-727004,EBI-714918
CYHR1 - isoform 3 [Q6ZMK1-3]3EBI-727004,EBI-11997340
DCTD [P32321]6EBI-727004,EBI-739870
DCTPP1 [Q9H773]3EBI-727004,EBI-723569
DDX39B [Q13838]3EBI-727004,EBI-348622
DERL3 [Q96Q80]3EBI-727004,EBI-12831318
DMC1 [Q14565]7EBI-727004,EBI-930865
DMWD [G5E9A7]3EBI-727004,EBI-10976677
DNM2 [P50570]3EBI-727004,EBI-346547
DRAP1 [Q14919]5EBI-727004,EBI-712941
DTNBP1 [Q96EV8]3EBI-727004,EBI-465804
DYNLT1 [P63172]3EBI-727004,EBI-1176455
EAF1 [Q96JC9]3EBI-727004,EBI-769261
EDARADD [Q8WWZ3]3EBI-727004,EBI-2949647
EIF1AD [Q8N9N8]6EBI-727004,EBI-750700
EIF5A [P63241]3EBI-727004,EBI-373150
EIF5A2 [Q9GZV4]6EBI-727004,EBI-748028
ELAVL1 [Q15717]3EBI-727004,EBI-374260
EMILIN3 [Q9NT22]3EBI-727004,EBI-3197883
ENOX1 [Q8TC92]3EBI-727004,EBI-713221
ENTR1 - isoform 2 [Q96C92-2]3EBI-727004,EBI-10178036
ERICH2 [A1L162]3EBI-727004,EBI-2682520
EXOSC4 [Q9NPD3]3EBI-727004,EBI-371823
FADD [Q13158]6EBI-727004,EBI-494804
FAM118A [Q9NWS6]3EBI-727004,EBI-8638992
FAM118B [Q9BPY3]3EBI-727004,EBI-726822
FAM9A [Q8IZU1]3EBI-727004,EBI-8468186
FAM9B [Q8IZU0]6EBI-727004,EBI-10175124
FHL3 [Q13643]3EBI-727004,EBI-741101
FHL5 [Q5TD97]3EBI-727004,EBI-750641
FLAD1 [Q8NFF5]4EBI-727004,EBI-742815
FOXP2 [O15409]3EBI-727004,EBI-983612
FTH1 [Q6NZ44]3EBI-727004,EBI-10180219
FTL [P02792]6EBI-727004,EBI-713279
FZD7 [O75084]4EBI-727004,EBI-746917
GET4 [Q7L5D6]3EBI-727004,EBI-711823
GGPS1 [O95749]3EBI-727004,EBI-10179283
GKAP1 [Q5VSY0]3EBI-727004,EBI-743722
GOLT1B [Q9Y3E0]3EBI-727004,EBI-4402607
GPATCH11 [Q8N954]3EBI-727004,EBI-2555378
GPATCH11 - isoform 2 [Q8N954-2]3EBI-727004,EBI-12178961
GRXCR1 [A8MXD5]3EBI-727004,EBI-5235612
GSC2 [O15499]3EBI-727004,EBI-19954058
GSG1 - isoform 3 [Q2KHT4-3]3EBI-727004,EBI-12951679
hCG_1744368 [A0A024RA76]5EBI-727004,EBI-10180729
HEL-S-182mP [V9HW60]3EBI-727004,EBI-10180762
HEL-S-25 [V9HW40]3EBI-727004,EBI-10330099
HEXIM2 [Q96MH2]3EBI-727004,EBI-5460660
HHAT [Q5VTY9]3EBI-727004,EBI-12951255
HMBOX1 [Q6NT76]3EBI-727004,EBI-2549423
HMGB3 [O15347]7EBI-727004,EBI-2214136
HNRNPC [P07910]6EBI-727004,EBI-357966
HOMER3 [Q9NSC5]5EBI-727004,EBI-748420
HOMEZ - isoform 2 [Q8IX15-3]3EBI-727004,EBI-10172004
HOXA1 [P49639]6EBI-727004,EBI-740785
HOXA7 [P31268]3EBI-727004,EBI-3910421
HPRT1 [P00492]7EBI-727004,EBI-748210
HSBP1 [O75506]8EBI-727004,EBI-748664
HSF2BP [O75031]3EBI-727004,EBI-7116203
HTT [P42858]12EBI-727004,EBI-466029
HUS1 [O60921]3EBI-727004,EBI-1056174
ID3 [Q02535]3EBI-727004,EBI-1387094
IGFBP6 [P24592]3EBI-727004,EBI-947015
IHO1 [Q8IYA8]3EBI-727004,EBI-8638439
IKZF1 [Q13422]3EBI-727004,EBI-745305
IL5RA [Q01344]2EBI-727004,EBI-1759442
INO80E [Q8NBZ0]6EBI-727004,EBI-769401
KATNBL1 [Q9H079]3EBI-727004,EBI-715394
KCNH1 [O95259]3EBI-727004,EBI-2909270
KCNJ2 [P63252]3EBI-727004,EBI-703457
KCTD1 [Q719H9]6EBI-727004,EBI-9027502
KCTD6 [Q8NC69]6EBI-727004,EBI-2511344
KCTD9 [Q7L273]6EBI-727004,EBI-4397613
KHDRBS2 [Q5VWX1]6EBI-727004,EBI-742808
KIF1B - isoform 2 [O60333-2]3EBI-727004,EBI-10975473
KLHL12 [Q53G59]8EBI-727004,EBI-740929
KLHL2 [O95198]3EBI-727004,EBI-746999
KRT14 [P02533]3EBI-727004,EBI-702178
KRTAP1-5 [Q9BYS1]3EBI-727004,EBI-11741292
KRTAP10-7 [P60409]3EBI-727004,EBI-10172290
KRTAP5-9 [P26371]6EBI-727004,EBI-3958099
LDB2 [O43679]3EBI-727004,EBI-2865580
LDHB [P07195]3EBI-727004,EBI-358748
LDOC1 [O95751]6EBI-727004,EBI-740738
LEPROTL1 [O95214]3EBI-727004,EBI-750776
LGALS2 [P05162]9EBI-727004,EBI-7181544
LSM6 [P62312]6EBI-727004,EBI-373310
LURAP1L [Q8IV03]3EBI-727004,EBI-12898559
LZTFL1 [Q9NQ48]6EBI-727004,EBI-2824799
MAD2L1 [Q13257]3EBI-727004,EBI-78203
MAPK9 [P45984]3EBI-727004,EBI-713568
MAPRE3 [Q9UPY8]6EBI-727004,EBI-726739
MATN4 - isoform 2 [O95460-2]3EBI-727004,EBI-12072296
MBD3 [O95983]3EBI-727004,EBI-1783068
MED4 [Q9NPJ6]3EBI-727004,EBI-394607
MEOX1 [P50221]3EBI-727004,EBI-2864512
MEOX2 [Q6FHY5]3EBI-727004,EBI-16439278
MGLL [A0A0C4DFN3]3EBI-727004,EBI-12866138
MID2 - isoform 2 [Q9UJV3-2]3EBI-727004,EBI-10172526
MINDY3 [Q9H8M7]3EBI-727004,EBI-724928
MKRN1 [Q9UHC7]3EBI-727004,EBI-373524
MMTAG2 [Q9BU76]3EBI-727004,EBI-742459
MOBP - isoform 3 [Q13875-3]3EBI-727004,EBI-12013470
MRFAP1 [Q9Y605]3EBI-727004,EBI-995714
MRFAP1L1 [Q96HT8]8EBI-727004,EBI-748896
MTUS2 [Q5JR59]3EBI-727004,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]3EBI-727004,EBI-11522433
MYLIP [Q8WY64]3EBI-727004,EBI-6952711
N4BP3 [O15049]3EBI-727004,EBI-2512055
NADK [O95544]7EBI-727004,EBI-743949
NAGK [Q9UJ70]5EBI-727004,EBI-372578
NAGK - isoform 2 [Q9UJ70-2]3EBI-727004,EBI-11526455
NAPB [Q9H115]3EBI-727004,EBI-3921185
NECAB2 - isoform 2 [Q7Z6G3-2]5EBI-727004,EBI-10172876
NECTIN1 [Q15223]8EBI-727004,EBI-1771314
NKAPD1 [Q6ZUT1]8EBI-727004,EBI-3920396
NKAPD1 - isoform 2 [Q6ZUT1-2]3EBI-727004,EBI-10180231
NOTCH2NLA [Q7Z3S9]3EBI-727004,EBI-945833
NT5C2 [P49902]3EBI-727004,EBI-742084
OCM [P0CE72]3EBI-727004,EBI-11955379
ODAM [A1E959]3EBI-727004,EBI-5774125
OPTN [Q96CV9]3EBI-727004,EBI-748974
OSTF1 [Q92882]3EBI-727004,EBI-1051152
PCBD1 [P61457]3EBI-727004,EBI-740475
PCYT1A [P49585]3EBI-727004,EBI-2563309
PDE4DIP [Q5VU43]4EBI-727004,EBI-1105124
PDE4DIP - isoform 2 [Q5VU43-2]4EBI-727004,EBI-9640281
PDE9A - isoform PDE9A2 [O76083-2]3EBI-727004,EBI-11524542
PDLIM4 [P50479]3EBI-727004,EBI-372861
PDZK1IP1 [Q13113]3EBI-727004,EBI-716063
PFDN5 [Q99471]3EBI-727004,EBI-357275
PHC2 [Q8IXK0]3EBI-727004,EBI-713786
PHF11 [Q9UIL8]3EBI-727004,EBI-2861403
PIH1D2 [Q8WWB5]3EBI-727004,EBI-10232538
PNMA1 [Q8ND90]8EBI-727004,EBI-302345
PNMA2 [Q9UL42]7EBI-727004,EBI-302355
POLR2J [P52435]3EBI-727004,EBI-394753
POLR3K [Q9Y2Y1]3EBI-727004,EBI-11023785
PRPF38A [Q8NAV1]3EBI-727004,EBI-715374
PRPF40A - isoform 2 [O75400-2]3EBI-727004,EBI-5280197
PRR13 [Q9NZ81]3EBI-727004,EBI-740924
PSMB3 [P49720]3EBI-727004,EBI-603340
PSMC6 [P62333]6EBI-727004,EBI-357669
PSME2 [Q9UL46]3EBI-727004,EBI-741630
PSTPIP1 [O43586]3EBI-727004,EBI-1050964
PTS [Q03393]4EBI-727004,EBI-712344
PUF60 [Q9UHX1]3EBI-727004,EBI-1053259
PYCR3 [Q53H96]8EBI-727004,EBI-2959680
RALY [Q53GL6]3EBI-727004,EBI-9512693
RBM39 [Q14498]3EBI-727004,EBI-395290
REEP6 [Q96HR9]3EBI-727004,EBI-750345
REEP6 - isoform 2 [Q96HR9-2]3EBI-727004,EBI-14065960
REL [Q04864]3EBI-727004,EBI-307352
RIC8A - isoform 4 [Q9NPQ8-4]3EBI-727004,EBI-9091816
RNF11 [Q9Y3C5]3EBI-727004,EBI-396669
RNH1 [P13489]8EBI-727004,EBI-1237106
ROPN1 [Q9HAT0]6EBI-727004,EBI-1378139
RP9 [Q8TA86]5EBI-727004,EBI-630339
RPIA [P49247]3EBI-727004,EBI-744831
RPL22 [P35268]5EBI-727004,EBI-354533
RPRD1A - isoform 2 [Q96P16-3]3EBI-727004,EBI-12840198
RPRM [Q9NS64]3EBI-727004,EBI-1052363
RPS26 [P62854]3EBI-727004,EBI-353438
RRM2 [P31350]3EBI-727004,EBI-2339245
RRS1 [Q15050]3EBI-727004,EBI-749186
RTL8B [Q17RB0]3EBI-727004,EBI-10238588
RTN1 - isoform RTN1-C [Q16799-3]3EBI-727004,EBI-10180131
RUNDC3A [Q59EK9]3EBI-727004,EBI-747225
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-727004,EBI-11957366
S100B [P04271]3EBI-727004,EBI-458391
SCG3 [Q8WXD2]3EBI-727004,EBI-12162999
SCML1 - isoform 2 [Q9UN30-2]3EBI-727004,EBI-12137487
itself7EBI-727004,EBI-727004
SEPTIN1 [Q8WYJ6]3EBI-727004,EBI-693002
SEPTIN3 [Q9UH03]6EBI-727004,EBI-727037
SET [Q01105]3EBI-727004,EBI-1053182
SET - isoform 2 [Q01105-2]3EBI-727004,EBI-7481343
SFT2D1 [Q8WV19]3EBI-727004,EBI-2854842
SIAH1 [Q8IUQ4]3EBI-727004,EBI-747107
SLC50A1 [Q9BRV3]3EBI-727004,EBI-8634123
SMARCA2 [P51531]2EBI-727004,EBI-679562
SMARCA2 - isoform Short [P51531-2]3EBI-727004,EBI-10212306
SNCA [P37840]3EBI-727004,EBI-985879
SNRPA [P09012]3EBI-727004,EBI-607085
SNX1 [Q13596]3EBI-727004,EBI-2822329
SPANXN3 [Q5MJ09]3EBI-727004,EBI-12037215
SPRED1 [Q7Z699]3EBI-727004,EBI-5235340
SRC [P12931]2EBI-727004,EBI-621482
SREK1IP1 [Q8N9Q2]6EBI-727004,EBI-10268630
SRSF11 [Q05519]3EBI-727004,EBI-1051785
SRSF11 - isoform 2 [Q05519-2]3EBI-727004,EBI-11975029
SRSF3 [P84103]3EBI-727004,EBI-372557
SRSF7 [Q16629]6EBI-727004,EBI-398885
SSC5D [A1L4H1]3EBI-727004,EBI-10172867
SSNA1 [O43805]6EBI-727004,EBI-2515299
SUB1 [P53999]3EBI-727004,EBI-998260
SULT1B1 [O43704]3EBI-727004,EBI-10179062
SYNGR1 - isoform 1B [O43759-2]3EBI-727004,EBI-12187159
SYPL1 [Q16563]3EBI-727004,EBI-2800683
SYS1 [Q8N2H4]3EBI-727004,EBI-13075176
TCF21 [O43680]3EBI-727004,EBI-723267
TCF4 - isoform SEF2-1D [P15884-3]3EBI-727004,EBI-13636688
TDO2 [P48775]7EBI-727004,EBI-743494
TEKT1 [Q969V4]3EBI-727004,EBI-10180409
TFCP2 [Q12800]3EBI-727004,EBI-717422
THG1L [Q9NWX6]3EBI-727004,EBI-746510
TIFA [Q96CG3]8EBI-727004,EBI-740711
TKFC [Q3LXA3]3EBI-727004,EBI-4291069
TLE5 [Q08117]3EBI-727004,EBI-717810
TMCO2 [Q7Z6W1]3EBI-727004,EBI-12807858
TMEM17 [Q86X19]3EBI-727004,EBI-11343485
TMEM239 [Q8WW34]3EBI-727004,EBI-9675724
TMEM239 - isoform 2 [Q8WW34-2]3EBI-727004,EBI-11528917
TNFAIP8 [O95379]6EBI-727004,EBI-1049336
TNFAIP8L3 [Q5GJ75]3EBI-727004,EBI-14222571
TNKS [O95271]5EBI-727004,EBI-1105254
TRAF5 [O00463]8EBI-727004,EBI-523498
TRIM27 [P14373]3EBI-727004,EBI-719493
TRIM32 [Q13049]7EBI-727004,EBI-742790
TRIM38 [O00635]3EBI-727004,EBI-2130415
TRIM54 [Q9BYV2]6EBI-727004,EBI-2130429
TRIP13 [Q15645]3EBI-727004,EBI-358993
TSC1 [Q86WV8]3EBI-727004,EBI-12806590
TSN [Q15631]3EBI-727004,EBI-1044160
TUSC5 [A5PKU2]3EBI-727004,EBI-11988865
UBB [P0CG47]3EBI-727004,EBI-413034
UBE2A [P49459]9EBI-727004,EBI-2339348
UBE2K [P61086]3EBI-727004,EBI-473850
UBE2R2 [Q712K3]3EBI-727004,EBI-2340879
VAPB [O95292]3EBI-727004,EBI-1188298
WASHC3 [Q9Y3C0]6EBI-727004,EBI-712969
WASL [O00401]6EBI-727004,EBI-957615
WFS1 [O76024]3EBI-727004,EBI-720609
YIF1A [O95070]3EBI-727004,EBI-2799703
ZBTB14 [O43829]3EBI-727004,EBI-10176632
ZBTB8A [Q96BR9]6EBI-727004,EBI-742740
ZCCHC10 [Q8TBK6]3EBI-727004,EBI-597063
ZCCHC17 [Q9NP64]8EBI-727004,EBI-746345
ZMYND12 [Q9H0C1]3EBI-727004,EBI-12030590
ZNF343 [Q6P1L6]3EBI-727004,EBI-10252492
ZNF485 [Q8NCK3]3EBI-727004,EBI-12901093
ZNF660 [Q6AZW8]3EBI-727004,EBI-12376497
ZNF768 [Q9H5H4]3EBI-727004,EBI-1210580
ZRANB1 [Q9UGI0]3EBI-727004,EBI-527853
ZSCAN23 [Q3MJ62]3EBI-727004,EBI-5667532
Isoform 1 [O00560-1]
With#Exp.IntAct
E [P59637] from Severe acute respiratory syndrome coronavirus.4EBI-9640690,EBI-25487741

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112287, 382 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3282, Syndecan-1-syntenin-1-ALIX complex

Database of interacting proteins

More...DIPi		DIP-42705N

Protein interaction database and analysis system

More...IntActi		O00560, 402 interactors

Molecular INTeraction database

More...MINTi		O00560

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000260130

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00560, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00560

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00560

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 193PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini198 – 273PDZ 2PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 60Interaction with PDCD6IP1 PublicationAdd BLAST59
Regioni250 – 251phosphatidylinositol-4,5-bisphosphate-bindingCombined sources1 Publication2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 7LYPX(n)L motif 1By similarity5
Motifi45 – 49LYPX(n)L motif 2By similarity5
Motifi49 – 53LYPX(n)L motif 3By similarity5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0849, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154502

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00560

Identification of Orthologs from Complete Genome Data

More...OMAi		CKDQDGR

Database of Orthologous Groups

More...OrthoDBi		1035679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00560

TreeFam database of animal gene trees

More...TreeFami		TF327131

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030528, SDCBP

The PANTHER Classification System

More...PANTHERi		PTHR12345:SF10, PTHR12345:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY 
        60         70         80         90        100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND 
       110        120        130        140        150
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV 
       160        170        180        190        200
GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT 
       210        220        230        240        250
MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK 
       260        270        280        290 
DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV
Length:298
Mass (Da):32,444
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i574E1349F86F949F
GO
Isoform 2 (identifier: O00560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Show »
Length:297
Mass (Da):32,316
Checksum:i67FED210EFB6EEF6
GO
Isoform 3 (identifier: O00560-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.

Show »
Length:292
Mass (Da):31,762
Checksum:i004BFE46AC4D9FBA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA09G5EA09_HUMAN
Syndecan binding protein (Syntenin)...
SDCBP hCG_1787561
318Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHN5B4DHN5_HUMAN
Syntenin-1
SDCBP
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBU7E9PBU7_HUMAN
Syntenin-1
SDCBP
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62N → S in AAB51246 (PubMed:9391086).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01316069N → S1 PublicationCorresponds to variant dbSNP:rs1127509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03837412 – 17Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_03837581Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006636 mRNA Translation: AAC52050.1
AF000652 mRNA Translation: AAB97144.1
U83463 mRNA Translation: AAB51246.1
AK300647 mRNA Translation: BAG62335.1
AK312274 mRNA Translation: BAG35204.1
AC068522 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86814.1
BC113674 mRNA Translation: AAI13675.1
BC113676 mRNA Translation: AAI13677.1
BC143915 mRNA Translation: AAI43916.1
BC143916 mRNA Translation: AAI43917.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47862.1 [O00560-2]
CCDS47863.1 [O00560-3]
CCDS6172.1 [O00560-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC6537

NCBI Reference Sequences

More...RefSeqi		NP_001007068.1, NM_001007067.1 [O00560-1]
NP_001007069.1, NM_001007068.1 [O00560-3]
NP_001007070.1, NM_001007069.1 [O00560-2]
NP_001007071.1, NM_001007070.1 [O00560-2]
NP_005616.2, NM_005625.3 [O00560-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260130; ENSP00000260130; ENSG00000137575
ENST00000413219; ENSP00000411771; ENSG00000137575
ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6386

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000260130.9; ENSP00000260130.4; NM_005625.4; NP_005616.2

UCSC genome browser

More...UCSCi		uc003xtn.3, human [O00560-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006636 mRNA Translation: AAC52050.1
AF000652 mRNA Translation: AAB97144.1
U83463 mRNA Translation: AAB51246.1
AK300647 mRNA Translation: BAG62335.1
AK312274 mRNA Translation: BAG35204.1
AC068522 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86814.1
BC113674 mRNA Translation: AAI13675.1
BC113676 mRNA Translation: AAI13677.1
BC143915 mRNA Translation: AAI43916.1
BC143916 mRNA Translation: AAI43917.1
CCDSiCCDS47862.1 [O00560-2]
CCDS47863.1 [O00560-3]
CCDS6172.1 [O00560-1]
PIRiJC6537
RefSeqiNP_001007068.1, NM_001007067.1 [O00560-1]
NP_001007069.1, NM_001007068.1 [O00560-3]
NP_001007070.1, NM_001007069.1 [O00560-2]
NP_001007071.1, NM_001007070.1 [O00560-2]
NP_005616.2, NM_005625.3 [O00560-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N99X-ray1.94A/B113-273[»]
1NTEX-ray1.24A197-273[»]
1OBXX-ray1.35A197-270[»]
1OBYX-ray1.85A/B197-270[»]
1OBZX-ray1.69A/B113-273[»]
1R6JX-ray0.73A197-273[»]
1V1TX-ray1.80A/B113-273[»]
1W9EX-ray1.56A/B113-273[»]
1W9OX-ray2.25A/B113-273[»]
1W9QX-ray1.70A/B113-273[»]
1YBOX-ray2.30A/B113-273[»]
4Z33X-ray2.45A/B111-275[»]
6R9HX-ray2.00A/B/C/D113-273[»]
6RLCX-ray2.20A/B/C/D113-273[»]
SMRiO00560
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112287, 382 interactors
ComplexPortaliCPX-3282, Syndecan-1-syntenin-1-ALIX complex
DIPiDIP-42705N
IntActiO00560, 402 interactors
MINTiO00560
STRINGi9606.ENSP00000260130

Protein family/group databases

MoonDBiO00560, Predicted
TCDBi8.A.24.2.1, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

GlyGeniO00560, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO00560
PhosphoSitePlusiO00560
SwissPalmiO00560

Genetic variation databases

BioMutaiSDCBP

Proteomic databases

EPDiO00560
jPOSTiO00560
MassIVEiO00560
MaxQBiO00560
PaxDbiO00560
PeptideAtlasiO00560
PRIDEiO00560
ProteomicsDBi47974 [O00560-1]
47975 [O00560-2]
47976 [O00560-3]
TopDownProteomicsiO00560-1 [O00560-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3216, 529 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		6386

Genome annotation databases

EnsembliENST00000260130; ENSP00000260130; ENSG00000137575
ENST00000413219; ENSP00000411771; ENSG00000137575
ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2]
GeneIDi6386
KEGGihsa:6386
MANE-SelectiENST00000260130.9; ENSP00000260130.4; NM_005625.4; NP_005616.2
UCSCiuc003xtn.3, human [O00560-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6386
DisGeNETi6386

GeneCards: human genes, protein and diseases

More...GeneCardsi		SDCBP
HGNCiHGNC:10662, SDCBP
HPAiENSG00000137575, Low tissue specificity
MIMi602217, gene
neXtProtiNX_O00560
OpenTargetsiENSG00000137575
PharmGKBiPA35592
VEuPathDBiHostDB:ENSG00000137575

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0849, Eukaryota
GeneTreeiENSGT00940000154502
InParanoidiO00560
OMAiCKDQDGR
OrthoDBi1035679at2759
PhylomeDBiO00560
TreeFamiTF327131

Enzyme and pathway databases

PathwayCommonsiO00560
ReactomeiR-HSA-3928664, Ephrin signaling
R-HSA-447043, Neurofascin interactions
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5675482, Regulation of necroptotic cell death
R-HSA-6798695, Neutrophil degranulation
SignaLinkiO00560
SIGNORiO00560

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6386, 13 hits in 1047 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SDCBP, human
EvolutionaryTraceiO00560

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SDCBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6386
PharosiO00560, Tbio

Protein Ontology

More...PROi		PR:O00560
RNActiO00560, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137575, Expressed in substantia nigra and 250 other tissues
ExpressionAtlasiO00560, baseline and differential
GenevisibleiO00560, HS

Family and domain databases

Gene3Di2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR030528, SDCBP
PANTHERiPTHR12345:SF10, PTHR12345:SF10, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 2 hits
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SUPFAMiSSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDCB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00560
Secondary accession number(s): B2R5Q7
, B4DUH3, B7ZLN2, O00173, O43391, Q14CP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 1, 1997
Last modified: February 23, 2022
This is version 213 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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