UniProtKB - O00560 (SDCB1_HUMAN)
Syntenin-1
SDCBP
Functioni
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).
Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).
In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).
In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).
May also play a role in vesicular trafficking (PubMed:11179419).
Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
1 Publication6 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 215 | Phosphatidylinositol-4,5-bisphosphateCombined sources1 Publication | 1 |
GO - Molecular functioni
- cell adhesion molecule binding Source: Ensembl
- cytoskeletal anchor activity Source: UniProtKB
- ephrin receptor binding Source: Ensembl
- frizzled binding Source: BHF-UCL
- growth factor binding Source: Ensembl
- identical protein binding Source: IntAct
- interleukin-5 receptor binding Source: UniProtKB
- neurexin family protein binding Source: Ensembl
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- syndecan binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- chemical synaptic transmission Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- negative regulation of receptor internalization Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of exosomal secretion Source: UniProtKB
- positive regulation of extracellular exosome assembly Source: UniProtKB
- positive regulation of JNK cascade Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of phosphorylation Source: BHF-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- presynapse assembly Source: Ensembl
- protein targeting to membrane Source: UniProtKB
- Ras protein signal transduction Source: Ensembl
- regulation of mitotic cell cycle Source: UniProtKB
- substrate-dependent cell migration, cell extension Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | O00560 |
Reactomei | R-HSA-3928664, Ephrin signaling R-HSA-447043, Neurofascin interactions R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-6798695, Neutrophil degranulation |
SignaLinki | O00560 |
SIGNORi | O00560 |
Protein family/group databases
MoonDBi | O00560, Predicted |
TCDBi | 8.A.24.2.1, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
Names & Taxonomyi
Protein namesi | Recommended name: Syntenin-1Alternative name(s): Melanoma differentiation-associated protein 9 Short name: MDA-9 Pro-TGF-alpha cytoplasmic domain-interacting protein 18 Short name: TACIP18 Scaffold protein Pbp1 Syndecan-binding protein 1 |
Gene namesi | Name:SDCBP Synonyms:MDA9, SYCL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10662, SDCBP |
MIMi | 602217, gene |
neXtProti | NX_O00560 |
VEuPathDBi | HostDB:ENSG00000137575 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Plasma membrane
- Cell membrane 3 Publications; Peripheral membrane protein 2 Publications
Extracellular region or secreted
- extracellular exosome 1 Publication
Nucleus
- Nucleus 1 Publication
Other locations
- focal adhesion 1 Publication
- adherens junction 1 Publication
- Melanosome 2 Publications
- Membrane raft 1 Publication
Note: Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966).4 Publications
Cytoskeleton
- cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- extracellular vesicle Source: UniProtKB
Lysosome
- azurophil granule lumen Source: Reactome
Nucleus
- nuclear membrane Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- interleukin-5 receptor complex Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB
- cytoplasm Source: BHF-UCL
- focal adhesion Source: UniProtKB-SubCell
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- membrane raft Source: UniProtKB
- synapse Source: GOC
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 214 | K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-250. 1 Publication | 1 | |
Mutagenesisi | 215 | N → D: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. 1 Publication | 1 | |
Mutagenesisi | 250 | K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-214. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6386 |
OpenTargetsi | ENSG00000137575 |
PharmGKBi | PA35592 |
Miscellaneous databases
Pharosi | O00560, Tbio |
Genetic variation databases
BioMutai | SDCBP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000184001 | 2 – 298 | Syntenin-1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 6 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O00560 |
jPOSTi | O00560 |
MassIVEi | O00560 |
MaxQBi | O00560 |
PaxDbi | O00560 |
PeptideAtlasi | O00560 |
PRIDEi | O00560 |
ProteomicsDBi | 47974 [O00560-1] 47975 [O00560-2] 47976 [O00560-3] |
TopDownProteomicsi | O00560-1 [O00560-1] |
PTM databases
GlyGeni | O00560, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O00560 |
PhosphoSitePlusi | O00560 |
SwissPalmi | O00560 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000137575, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | O00560, baseline and differential |
Genevisiblei | O00560, HS |
Organism-specific databases
HPAi | ENSG00000137575, Low tissue specificity |
Interactioni
Subunit structurei
Monomer and homodimer (By similarity).
Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA.
Interacts with NFASC and PTPRJ (By similarity).
Interacts with SDCBP2 (PubMed:11152476).
Interacts with PDCD6IP (PubMed:22660413).
Forms a complex with PDCD6IP and SDC2 (PubMed:22660413).
Interacts (via C-terminus) with TGFBR1 (PubMed:25893292). Binds to FZD7; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966).
Interacts with SMO (By similarity).
By similarity4 PublicationsBinary interactionsi
O00560
Isoform 1 [O00560-1]
With | #Exp. | IntAct |
---|---|---|
E [P59637] from Severe acute respiratory syndrome coronavirus. | 4 | EBI-9640690,EBI-25487741 |
GO - Molecular functioni
- cell adhesion molecule binding Source: Ensembl
- ephrin receptor binding Source: Ensembl
- frizzled binding Source: BHF-UCL
- growth factor binding Source: Ensembl
- identical protein binding Source: IntAct
- interleukin-5 receptor binding Source: UniProtKB
- neurexin family protein binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- syndecan binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112287, 382 interactors |
ComplexPortali | CPX-3282, Syndecan-1-syntenin-1-ALIX complex |
DIPi | DIP-42705N |
IntActi | O00560, 402 interactors |
MINTi | O00560 |
STRINGi | 9606.ENSP00000260130 |
Miscellaneous databases
RNActi | O00560, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O00560 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00560 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 193 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 198 – 273 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 60 | Interaction with PDCD6IP1 PublicationAdd BLAST | 59 | |
Regioni | 250 – 251 | phosphatidylinositol-4,5-bisphosphate-bindingCombined sources1 Publication | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 3 – 7 | LYPX(n)L motif 1By similarity | 5 | |
Motifi | 45 – 49 | LYPX(n)L motif 2By similarity | 5 | |
Motifi | 49 – 53 | LYPX(n)L motif 3By similarity | 5 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0849, Eukaryota |
GeneTreei | ENSGT00940000154502 |
InParanoidi | O00560 |
OMAi | CKDQDGR |
OrthoDBi | 1035679at2759 |
PhylomeDBi | O00560 |
TreeFami | TF327131 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR030528, SDCBP |
PANTHERi | PTHR12345:SF10, PTHR12345:SF10, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY
60 70 80 90 100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND
110 120 130 140 150
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV
160 170 180 190 200
GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT
210 220 230 240 250
MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK
260 270 280 290
DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5EA09 | G5EA09_HUMAN | Syndecan binding protein (Syntenin)... | SDCBP hCG_1787561 | 318 | Annotation score: | ||
B4DHN5 | B4DHN5_HUMAN | Syntenin-1 | SDCBP | 239 | Annotation score: | ||
E9PBU7 | E9PBU7_HUMAN | Syntenin-1 | SDCBP | 244 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | N → S in AAB51246 (PubMed:9391086).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013160 | 69 | N → S1 PublicationCorresponds to variant dbSNP:rs1127509Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038374 | 12 – 17 | Missing in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_038375 | 81 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006636 mRNA Translation: AAC52050.1 AF000652 mRNA Translation: AAB97144.1 U83463 mRNA Translation: AAB51246.1 AK300647 mRNA Translation: BAG62335.1 AK312274 mRNA Translation: BAG35204.1 AC068522 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW86814.1 BC113674 mRNA Translation: AAI13675.1 BC113676 mRNA Translation: AAI13677.1 BC143915 mRNA Translation: AAI43916.1 BC143916 mRNA Translation: AAI43917.1 |
CCDSi | CCDS47862.1 [O00560-2] CCDS47863.1 [O00560-3] CCDS6172.1 [O00560-1] |
PIRi | JC6537 |
RefSeqi | NP_001007068.1, NM_001007067.1 [O00560-1] NP_001007069.1, NM_001007068.1 [O00560-3] NP_001007070.1, NM_001007069.1 [O00560-2] NP_001007071.1, NM_001007070.1 [O00560-2] NP_005616.2, NM_005625.3 [O00560-1] |
Genome annotation databases
Ensembli | ENST00000260130; ENSP00000260130; ENSG00000137575 ENST00000413219; ENSP00000411771; ENSG00000137575 ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3] ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2] |
GeneIDi | 6386 |
KEGGi | hsa:6386 |
MANE-Selecti | ENST00000260130.9; ENSP00000260130.4; NM_005625.4; NP_005616.2 |
UCSCi | uc003xtn.3, human [O00560-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006636 mRNA Translation: AAC52050.1 AF000652 mRNA Translation: AAB97144.1 U83463 mRNA Translation: AAB51246.1 AK300647 mRNA Translation: BAG62335.1 AK312274 mRNA Translation: BAG35204.1 AC068522 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW86814.1 BC113674 mRNA Translation: AAI13675.1 BC113676 mRNA Translation: AAI13677.1 BC143915 mRNA Translation: AAI43916.1 BC143916 mRNA Translation: AAI43917.1 |
CCDSi | CCDS47862.1 [O00560-2] CCDS47863.1 [O00560-3] CCDS6172.1 [O00560-1] |
PIRi | JC6537 |
RefSeqi | NP_001007068.1, NM_001007067.1 [O00560-1] NP_001007069.1, NM_001007068.1 [O00560-3] NP_001007070.1, NM_001007069.1 [O00560-2] NP_001007071.1, NM_001007070.1 [O00560-2] NP_005616.2, NM_005625.3 [O00560-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N99 | X-ray | 1.94 | A/B | 113-273 | [»] | |
1NTE | X-ray | 1.24 | A | 197-273 | [»] | |
1OBX | X-ray | 1.35 | A | 197-270 | [»] | |
1OBY | X-ray | 1.85 | A/B | 197-270 | [»] | |
1OBZ | X-ray | 1.69 | A/B | 113-273 | [»] | |
1R6J | X-ray | 0.73 | A | 197-273 | [»] | |
1V1T | X-ray | 1.80 | A/B | 113-273 | [»] | |
1W9E | X-ray | 1.56 | A/B | 113-273 | [»] | |
1W9O | X-ray | 2.25 | A/B | 113-273 | [»] | |
1W9Q | X-ray | 1.70 | A/B | 113-273 | [»] | |
1YBO | X-ray | 2.30 | A/B | 113-273 | [»] | |
4Z33 | X-ray | 2.45 | A/B | 111-275 | [»] | |
6R9H | X-ray | 2.00 | A/B/C/D | 113-273 | [»] | |
6RLC | X-ray | 2.20 | A/B/C/D | 113-273 | [»] | |
SMRi | O00560 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112287, 382 interactors |
ComplexPortali | CPX-3282, Syndecan-1-syntenin-1-ALIX complex |
DIPi | DIP-42705N |
IntActi | O00560, 402 interactors |
MINTi | O00560 |
STRINGi | 9606.ENSP00000260130 |
Protein family/group databases
MoonDBi | O00560, Predicted |
TCDBi | 8.A.24.2.1, the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family |
PTM databases
GlyGeni | O00560, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O00560 |
PhosphoSitePlusi | O00560 |
SwissPalmi | O00560 |
Genetic variation databases
BioMutai | SDCBP |
Proteomic databases
EPDi | O00560 |
jPOSTi | O00560 |
MassIVEi | O00560 |
MaxQBi | O00560 |
PaxDbi | O00560 |
PeptideAtlasi | O00560 |
PRIDEi | O00560 |
ProteomicsDBi | 47974 [O00560-1] 47975 [O00560-2] 47976 [O00560-3] |
TopDownProteomicsi | O00560-1 [O00560-1] |
Protocols and materials databases
Antibodypediai | 3216, 529 antibodies from 38 providers |
DNASUi | 6386 |
Genome annotation databases
Ensembli | ENST00000260130; ENSP00000260130; ENSG00000137575 ENST00000413219; ENSP00000411771; ENSG00000137575 ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3] ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2] |
GeneIDi | 6386 |
KEGGi | hsa:6386 |
MANE-Selecti | ENST00000260130.9; ENSP00000260130.4; NM_005625.4; NP_005616.2 |
UCSCi | uc003xtn.3, human [O00560-1] |
Organism-specific databases
CTDi | 6386 |
DisGeNETi | 6386 |
GeneCardsi | SDCBP |
HGNCi | HGNC:10662, SDCBP |
HPAi | ENSG00000137575, Low tissue specificity |
MIMi | 602217, gene |
neXtProti | NX_O00560 |
OpenTargetsi | ENSG00000137575 |
PharmGKBi | PA35592 |
VEuPathDBi | HostDB:ENSG00000137575 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0849, Eukaryota |
GeneTreei | ENSGT00940000154502 |
InParanoidi | O00560 |
OMAi | CKDQDGR |
OrthoDBi | 1035679at2759 |
PhylomeDBi | O00560 |
TreeFami | TF327131 |
Enzyme and pathway databases
PathwayCommonsi | O00560 |
Reactomei | R-HSA-3928664, Ephrin signaling R-HSA-447043, Neurofascin interactions R-HSA-5213460, RIPK1-mediated regulated necrosis R-HSA-5675482, Regulation of necroptotic cell death R-HSA-6798695, Neutrophil degranulation |
SignaLinki | O00560 |
SIGNORi | O00560 |
Miscellaneous databases
BioGRID-ORCSi | 6386, 13 hits in 1047 CRISPR screens |
ChiTaRSi | SDCBP, human |
EvolutionaryTracei | O00560 |
GeneWikii | SDCBP |
GenomeRNAii | 6386 |
Pharosi | O00560, Tbio |
PROi | PR:O00560 |
RNActi | O00560, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137575, Expressed in substantia nigra and 250 other tissues |
ExpressionAtlasi | O00560, baseline and differential |
Genevisiblei | O00560, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR030528, SDCBP |
PANTHERi | PTHR12345:SF10, PTHR12345:SF10, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 2 hits |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SDCB1_HUMAN | |
Accessioni | O00560Primary (citable) accession number: O00560 Secondary accession number(s): B2R5Q7 Q14CP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | July 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references