Syntenin-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytoskeletal adaptor activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9391086
• frizzled binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 18256285
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 22673509
• interleukin-5 receptor binding Source: UniProtKB <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 11498591
• phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 27386966
• protein heterodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • 11152476
• protein N-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • 15371445
• syndecan binding Source: UniProtKBInferred from physical interactionⁱ
  • 22660413

GO - Biological processⁱ

• actin cytoskeleton organization Source: UniProtKBNon-traceable author statementⁱ
  • 12037664
• chemical synaptic transmission Source: UniProtKBNon-traceable author statementⁱ
  • 9883737
• ephrin receptor signaling pathway Source: Reactome
• intracellular signal transduction Source: UniProtKBNon-traceable author statementⁱ
  • 9391086
• negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 25893292
• negative regulation of receptor internalization Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25893292
• neutrophil degranulation Source: Reactome
• positive regulation of cell growth Source: UniProtKBInferred from mutant phenotypeⁱ
  • 26539120
• positive regulation of cell migration Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25893292
  • 26539120
• positive regulation of cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 26539120
• positive regulation of epithelial to mesenchymal transition Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25893292
• positive regulation of exosomal secretion Source: UniProtKBInferred from mutant phenotypeⁱ
  • 22660413
• positive regulation of extracellular exosome assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • 22660413
• positive regulation of JNK cascade Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 18256285
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25893292
• positive regulation of phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 18256285
• positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • 25893292
• protein targeting to membrane Source: UniProtKBNon-traceable author statementⁱ
  • 10230395
• regulation of mitotic cell cycle Source: UniProtKBInferred from mutant phenotypeⁱ
  • 26539120
• substrate-dependent cell migration, cell extension Source: UniProtKBNon-traceable author statementⁱ
  • 12037664

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytoskeletal adaptor activity Source: UniProtKBNon-traceable author statementⁱ
  • 9391086
• frizzled binding Source: BHF-UCLInferred from physical interactionⁱ
  • 18256285
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 22673509
• interleukin-5 receptor binding Source: UniProtKBInferred from sequence or structural similarityⁱ
  • 11498591
• protein heterodimerization activity Source: UniProtKBInferred from physical interactionⁱ
  • 11152476
• protein N-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • 15371445
• syndecan binding Source: UniProtKBInferred from physical interactionⁱ
  • 22660413

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY 
        60         70         80         90        100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND 
       110        120        130        140        150
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV 
       160        170        180        190        200
GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT 
       210        220        230        240        250
MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK 
       260        270        280        290 
DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV   

        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY 
        60         70         80         90        100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG LVARPSSINY MVAPVTGNDV 
       110        120        130        140        150
GIRRAEIKQG IREVILCKDQ DGKIGLRLKS IDNGIFVQLV QANSPASLVG 
       160        170        180        190        200
LRFGDQVLQI NGENCAGWSS DKAHKVLKQA FGEKITMTIR DRPFERTITM 
       210        220        230        240        250
HKDSTGHVGF IFKNGKITSI VKDSSAARNG LLTEHNICEI NGQNVIGLKD 
       260        270        280        290 
SQIADILSTS GTVVTITIMP AFIFEHIIKR MAPSIMKSLM DHTIPEV    

        10         20         30         40         50
MSLYPSLEDL KAQTAFSANP ANPAILSEAS APIPHDGNLY PRLYPELSQY 
        60         70         80         90        100
MGLSLNEEEI RANVAVVSGA PLQGQLVARP SSINYMVAPV TGNDVGIRRA 
       110        120        130        140        150
EIKQGIREVI LCKDQDGKIG LRLKSIDNGI FVQLVQANSP ASLVGLRFGD 
       160        170        180        190        200
QVLQINGENC AGWSSDKAHK VLKQAFGEKI TMTIRDRPFE RTITMHKDST 
       210        220        230        240        250
GHVGFIFKNG KITSIVKDSS AARNGLLTEH NICEINGQNV IGLKDSQIAD 
       260        270        280        290 
ILSTSGTVVT ITIMPAFIFE HIIKRMAPSI MKSLMDHTIP EV         

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
2. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
4. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
5. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM