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UniProtKB - O00560 (SDCB1_HUMAN)

Entry version 200 (16 Oct 2019)
Sequence version 1 (01 Jul 1997)
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Protein

Syntenin-1

Gene

SDCBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).1 Publication6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei215Phosphatidylinositol-4,5-bisphosphateCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3928664 Ephrin signaling
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00560

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00560

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		O00560 Predicted

Transport Classification Database

More...TCDBi		8.A.24.2.1 the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Melanoma differentiation-associated protein 9
Short name:
MDA-9
Pro-TGF-alpha cytoplasmic domain-interacting protein 18
Short name:
TACIP18
Scaffold protein Pbp1
Syndecan-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDCBP
Synonyms:MDA9, SYCL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10662 SDCBP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602217 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi214K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-250. 1 Publication1
Mutagenesisi215N → D: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. 1 Publication1
Mutagenesisi250K → A: Disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate. Impaired interaction with FZD7 and disruption of the cooperative binding of C-terminal peptides from FZD7 and phosphatidylinositol-4,5-bisphosphate; when associated with A-214. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6386

Open Targets

More...OpenTargetsi		ENSG00000137575

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00560

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SDCBP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001840012 – 298Syntenin-1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei46PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00560

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00560

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00560

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00560

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00560

PeptideAtlas

More...PeptideAtlasi		O00560

PRoteomics IDEntifications database

More...PRIDEi		O00560

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47974 [O00560-1]
47975 [O00560-2]
47976 [O00560-3]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O00560-1 [O00560-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00560

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00560

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O00560

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IFNG/IFN-gamma in melanoma cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137575 Expressed in 238 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00560 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00560 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB012245
HPA023840

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (By similarity).

Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA.

Interacts with NFASC and PTPRJ (By similarity).

Interacts with SDCBP2 (PubMed:11152476).

Interacts with PDCD6IP (PubMed:22660413).

Forms a complex with PDCD6IP and SDC2 (PubMed:22660413).

Interacts (via C-terminus) with TGFBR1 (PubMed:25893292). Binds to FZD7; this interaction is increased by inositol trisphosphate (IP3) (PubMed:27386966).

Interacts with SMO (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-727004,EBI-727004
ABI2Q9NYB93EBI-727004,EBI-743598
ANKRD40Q6AI123EBI-727004,EBI-2838246
ANP32BQ926885EBI-727004,EBI-762428
APIPQ96GX95EBI-727004,EBI-359248
BCL2L15Q5TBC73EBI-727004,EBI-10247136
C11orf68Q9H3H33EBI-727004,EBI-721765
C1orf109Q9NX043EBI-727004,EBI-8643161
CADPSA2RRN73EBI-727004,EBI-10179719
CADPSQ9ULU8-43EBI-727004,EBI-10180690
CALCOCO2Q131373EBI-727004,EBI-739580
CBR3O758285EBI-727004,EBI-714504
CCDC102BQ68D863EBI-727004,EBI-10171570
CCDC36Q8IYA83EBI-727004,EBI-8638439
CDAP323205EBI-727004,EBI-9250559
CDC34P494275EBI-727004,EBI-975634
CDCP1Q9H5V85EBI-727004,EBI-1019736
CDIPTO147353EBI-727004,EBI-358858
CEP55Q53EZ45EBI-727004,EBI-747776
CGGBP1Q9UFW83EBI-727004,EBI-723153
CLK2P497603EBI-727004,EBI-750020
CLK3P497615EBI-727004,EBI-745579
CMTM5Q96DZ93EBI-727004,EBI-2548702
COX4I1P130733EBI-727004,EBI-1056574
COX4I1Q86WV23EBI-727004,EBI-10260134
CRYAAP024895EBI-727004,EBI-6875961
CT45A10P0DMU94EBI-727004,EBI-12153495
CT45A3Q8NHU07EBI-727004,EBI-8643558
CT45A5Q6NSH33EBI-727004,EBI-8635816
CUTCQ9NTM95EBI-727004,EBI-714918
DCTDP323215EBI-727004,EBI-739870
DCTPP1Q9H7733EBI-727004,EBI-723569
DDX39BQ138384EBI-727004,EBI-348622
DMC1Q145656EBI-727004,EBI-930865
DRAP1Q149194EBI-727004,EBI-712941
DTNBP1Q96EV83EBI-727004,EBI-465804
EAF1Q96JC93EBI-727004,EBI-769261
EDARADDQ8WWZ33EBI-727004,EBI-2949647
EIF1ADQ8N9N85EBI-727004,EBI-750700
EIF5A2Q9GZV45EBI-727004,EBI-748028
ELAVL1Q157173EBI-727004,EBI-374260
ENOX1Q8TC923EBI-727004,EBI-713221
ENTR1Q96C92-23EBI-727004,EBI-10178036
ERICH2A1L1623EBI-727004,EBI-2682520
FADDQ131584EBI-727004,EBI-494804
FAM118AQ9NWS63EBI-727004,EBI-8638992
FAM118BQ9BPY33EBI-727004,EBI-726822
FAM9AQ8IZU14EBI-727004,EBI-8468186
FAM9BQ8IZU05EBI-727004,EBI-10175124
FLAD1Q8NFF53EBI-727004,EBI-742815
FOXP2O154093EBI-727004,EBI-983612
FTH1Q6NZ443EBI-727004,EBI-10180219
FTLP027925EBI-727004,EBI-713279
FZD7O750844EBI-727004,EBI-746917
GPATCH11Q8N9543EBI-727004,EBI-2555378
hCG_1744368A0A024RA769EBI-727004,EBI-10180729
HEL-S-182mPV9HW603EBI-727004,EBI-10180762
HEL-S-25V9HW403EBI-727004,EBI-10330099
HMGB3O153475EBI-727004,EBI-2214136
HNRNPCP079105EBI-727004,EBI-357966
HOMEZQ8IX15-33EBI-727004,EBI-10172004
HOXA1P496395EBI-727004,EBI-740785
HPRT1P004925EBI-727004,EBI-748210
HSBP1O755069EBI-727004,EBI-748664
IKZF1Q134223EBI-727004,EBI-745305
INO80EQ8NBZ05EBI-727004,EBI-769401
KCNH1O952593EBI-727004,EBI-2909270
KCTD1Q719H95EBI-727004,EBI-9027502
KCTD6Q8NC695EBI-727004,EBI-2511344
KCTD9Q7L2735EBI-727004,EBI-4397613
KHDRBS2Q5VWX15EBI-727004,EBI-742808
KLHL12Q53G597EBI-727004,EBI-740929
KLHL2O951983EBI-727004,EBI-746999
KRTAP10-7P604093EBI-727004,EBI-10172290
KRTAP5-9P263715EBI-727004,EBI-3958099
LDOC1O957515EBI-727004,EBI-740738
LGALS2P051627EBI-727004,EBI-7181544
LSM6P623125EBI-727004,EBI-373310
LZTFL1Q9NQ485EBI-727004,EBI-2824799
MAD2L1Q132573EBI-727004,EBI-78203
MAPRE3Q9UPY87EBI-727004,EBI-726739
MBD3O959833EBI-727004,EBI-1783068
MED4Q9NPJ63EBI-727004,EBI-394607
MID2Q9UJV3-23EBI-727004,EBI-10172526
MRFAP1L1Q96HT87EBI-727004,EBI-748896
MTUS2Q5JR593EBI-727004,EBI-742948
NADKO955445EBI-727004,EBI-743949
NAGKQ9UJ705EBI-727004,EBI-372578
NECAB2Q7Z6G3-25EBI-727004,EBI-10172876
NECTIN1Q152238EBI-727004,EBI-1771314
NKAPD1Q6ZUT19EBI-727004,EBI-3920396
NKAPD1Q6ZUT1-23EBI-727004,EBI-10180231
NOTCH2NLAQ7Z3S93EBI-727004,EBI-945833
NT5C2P499023EBI-727004,EBI-742084
OSTF1Q928823EBI-727004,EBI-1051152
PDE4DIPQ5VU433EBI-727004,EBI-1105124
PHC2Q8IXK03EBI-727004,EBI-713786
PNMA1Q8ND907EBI-727004,EBI-302345
PNMA2Q9UL425EBI-727004,EBI-302355
PRPF38AQ8NAV13EBI-727004,EBI-715374
PRPF40AO75400-23EBI-727004,EBI-5280197
PRR13Q9NZ813EBI-727004,EBI-740924
PSMC6P623337EBI-727004,EBI-357669
PSTPIP1O435863EBI-727004,EBI-1050964
PTSQ033933EBI-727004,EBI-712344
PUF60Q9UHX13EBI-727004,EBI-1053259
PYCR3Q53H965EBI-727004,EBI-2959680
RBM39Q144983EBI-727004,EBI-395290
REEP6Q96HR93EBI-727004,EBI-750345
RELQ048643EBI-727004,EBI-307352
RIC8AQ9NPQ8-43EBI-727004,EBI-9091816
RNH1P134895EBI-727004,EBI-1237106
ROPN1Q9HAT05EBI-727004,EBI-1378139
RPL22P352684EBI-727004,EBI-354533
RTN1Q16799-33EBI-727004,EBI-10180131
RUNDC3AQ59EK93EBI-727004,EBI-747225
SEPTIN3Q9UH035EBI-727004,EBI-727037
SETQ011053EBI-727004,EBI-1053182
SIAH1Q8IUQ43EBI-727004,EBI-747107
SMARCA2P515312EBI-727004,EBI-679562
SMARCA2P51531-23EBI-727004,EBI-10212306
SRCP129312EBI-727004,EBI-621482
SREK1IP1Q8N9Q25EBI-727004,EBI-10268630
SRSF11Q055193EBI-727004,EBI-1051785
SRSF7Q166295EBI-727004,EBI-398885
SSNA1O438055EBI-727004,EBI-2515299
SULT1B1O437043EBI-727004,EBI-10179062
TDO2P487758EBI-727004,EBI-743494
TEKT1Q969V43EBI-727004,EBI-10180409
TFCP2Q128003EBI-727004,EBI-717422
THG1LQ9NWX63EBI-727004,EBI-746510
TIFAQ96CG37EBI-727004,EBI-740711
TKFCQ3LXA33EBI-727004,EBI-4291069
TLE5Q081173EBI-727004,EBI-717810
TMEM239Q8WW343EBI-727004,EBI-9675724
TNFAIP8O953795EBI-727004,EBI-1049336
TNFAIP8L3Q5GJ754EBI-727004,EBI-14222571
TRAF5O004637EBI-727004,EBI-523498
TRIM27P143733EBI-727004,EBI-719493
TRIM32Q130495EBI-727004,EBI-742790
TRIM38O006353EBI-727004,EBI-2130415
TRIM54Q9BYV27EBI-727004,EBI-2130429
UBE2AP494597EBI-727004,EBI-2339348
WASHC3Q9Y3C05EBI-727004,EBI-712969
WASLO004015EBI-727004,EBI-957615
ZBTB14O438293EBI-727004,EBI-10176632
ZBTB8AQ96BR95EBI-727004,EBI-742740
ZCCHC10Q8TBK63EBI-727004,EBI-597063
ZCCHC17Q9NP647EBI-727004,EBI-746345
ZSCAN23Q3MJ624EBI-727004,EBI-5667532

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112287, 222 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3282 Syndecan-1-syntenin-1-ALIX complex

Database of interacting proteins

More...DIPi		DIP-42705N

Protein interaction database and analysis system

More...IntActi		O00560, 406 interactors

Molecular INTeraction database

More...MINTi		O00560

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000260130

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00560

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00560

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini114 – 193PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini198 – 273PDZ 2PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 60Interaction with PDCD6IP1 PublicationAdd BLAST59
Regioni250 – 251phosphatidylinositol-4,5-bisphosphate-bindingCombined sources1 Publication2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 7LYPX(n)L motif 1By similarity5
Motifi45 – 49LYPX(n)L motif 2By similarity5
Motifi49 – 53LYPX(n)L motif 3By similarity5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IEB7 Eukaryota
ENOG410YNPQ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231604

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00560

KEGG Orthology (KO)

More...KOi		K17254

Database of Orthologous Groups

More...OrthoDBi		1035679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00560

TreeFam database of animal gene trees

More...TreeFami		TF327131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR030528 SDCBP

The PANTHER Classification System

More...PANTHERi		PTHR12345:SF10 PTHR12345:SF10, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595 PDZ, 1 hit
PF17820 PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228 PDZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156 SSF50156, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106 PDZ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY 
        60         70         80         90        100
PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND 
       110        120        130        140        150
VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV 
       160        170        180        190        200
GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT 
       210        220        230        240        250
MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK 
       260        270        280        290 
DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV
Length:298
Mass (Da):32,444
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i574E1349F86F949F
GO
Isoform 2 (identifier: O00560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Missing.

Show »
Length:297
Mass (Da):32,316
Checksum:i67FED210EFB6EEF6
GO
Isoform 3 (identifier: O00560-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.

Show »
Length:292
Mass (Da):31,762
Checksum:i004BFE46AC4D9FBA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EA09G5EA09_HUMAN
Syndecan binding protein (Syntenin)...
SDCBP hCG_1787561
318Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DHN5B4DHN5_HUMAN
Syntenin-1
SDCBP
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PBU7E9PBU7_HUMAN
Syntenin-1
SDCBP
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62N → S in AAB51246 (PubMed:9391086).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01316069N → S1 PublicationCorresponds to variant dbSNP:rs1127509Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03837412 – 17Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_03837581Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006636 mRNA Translation: AAC52050.1
AF000652 mRNA Translation: AAB97144.1
U83463 mRNA Translation: AAB51246.1
AK300647 mRNA Translation: BAG62335.1
AK312274 mRNA Translation: BAG35204.1
AC068522 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86814.1
BC113674 mRNA Translation: AAI13675.1
BC113676 mRNA Translation: AAI13677.1
BC143915 mRNA Translation: AAI43916.1
BC143916 mRNA Translation: AAI43917.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47862.1 [O00560-2]
CCDS47863.1 [O00560-3]
CCDS6172.1 [O00560-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JC6537

NCBI Reference Sequences

More...RefSeqi		NP_001007068.1, NM_001007067.1 [O00560-1]
NP_001007069.1, NM_001007068.1 [O00560-3]
NP_001007070.1, NM_001007069.1 [O00560-2]
NP_001007071.1, NM_001007070.1 [O00560-2]
NP_005616.2, NM_005625.3 [O00560-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000260130; ENSP00000260130; ENSG00000137575 [O00560-1]
ENST00000413219; ENSP00000411771; ENSG00000137575 [O00560-1]
ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6386

UCSC genome browser

More...UCSCi		uc003xtn.3 human [O00560-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006636 mRNA Translation: AAC52050.1
AF000652 mRNA Translation: AAB97144.1
U83463 mRNA Translation: AAB51246.1
AK300647 mRNA Translation: BAG62335.1
AK312274 mRNA Translation: BAG35204.1
AC068522 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86814.1
BC113674 mRNA Translation: AAI13675.1
BC113676 mRNA Translation: AAI13677.1
BC143915 mRNA Translation: AAI43916.1
BC143916 mRNA Translation: AAI43917.1
CCDSiCCDS47862.1 [O00560-2]
CCDS47863.1 [O00560-3]
CCDS6172.1 [O00560-1]
PIRiJC6537
RefSeqiNP_001007068.1, NM_001007067.1 [O00560-1]
NP_001007069.1, NM_001007068.1 [O00560-3]
NP_001007070.1, NM_001007069.1 [O00560-2]
NP_001007071.1, NM_001007070.1 [O00560-2]
NP_005616.2, NM_005625.3 [O00560-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N99X-ray1.94A/B113-273[»]
1NTEX-ray1.24A197-273[»]
1OBXX-ray1.35A197-270[»]
1OBYX-ray1.85A/B197-270[»]
1OBZX-ray1.69A/B113-273[»]
1R6JX-ray0.73A197-273[»]
1V1TX-ray1.80A/B113-273[»]
1W9EX-ray1.56A/B113-273[»]
1W9OX-ray2.25A/B113-273[»]
1W9QX-ray1.70A/B113-273[»]
1YBOX-ray2.30A/B113-273[»]
4Z33X-ray2.45A/B111-275[»]
SMRiO00560
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112287, 222 interactors
ComplexPortaliCPX-3282 Syndecan-1-syntenin-1-ALIX complex
DIPiDIP-42705N
IntActiO00560, 406 interactors
MINTiO00560
STRINGi9606.ENSP00000260130

Protein family/group databases

MoonDBiO00560 Predicted
TCDBi8.A.24.2.1 the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

iPTMnetiO00560
PhosphoSitePlusiO00560
SwissPalmiO00560

Polymorphism and mutation databases

BioMutaiSDCBP

Proteomic databases

EPDiO00560
jPOSTiO00560
MassIVEiO00560
MaxQBiO00560
PaxDbiO00560
PeptideAtlasiO00560
PRIDEiO00560
ProteomicsDBi47974 [O00560-1]
47975 [O00560-2]
47976 [O00560-3]
TopDownProteomicsiO00560-1 [O00560-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6386

Genome annotation databases

EnsembliENST00000260130; ENSP00000260130; ENSG00000137575 [O00560-1]
ENST00000413219; ENSP00000411771; ENSG00000137575 [O00560-1]
ENST00000424270; ENSP00000395351; ENSG00000137575 [O00560-3]
ENST00000447182; ENSP00000409288; ENSG00000137575 [O00560-2]
GeneIDi6386
KEGGihsa:6386
UCSCiuc003xtn.3 human [O00560-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6386
DisGeNETi6386

GeneCards: human genes, protein and diseases

More...GeneCardsi		SDCBP
HGNCiHGNC:10662 SDCBP
HPAiCAB012245
HPA023840
MIMi602217 gene
neXtProtiNX_O00560
OpenTargetsiENSG00000137575
PharmGKBiPA35592

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IEB7 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00940000154502
HOGENOMiHOG000231604
InParanoidiO00560
KOiK17254
OrthoDBi1035679at2759
PhylomeDBiO00560
TreeFamiTF327131

Enzyme and pathway databases

ReactomeiR-HSA-3928664 Ephrin signaling
R-HSA-447043 Neurofascin interactions
R-HSA-6798695 Neutrophil degranulation
SignaLinkiO00560
SIGNORiO00560

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SDCBP human
EvolutionaryTraceiO00560

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SDCBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6386
PharosiO00560

Protein Ontology

More...PROi		PR:O00560

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137575 Expressed in 238 organ(s), highest expression level in blood
ExpressionAtlasiO00560 baseline and differential
GenevisibleiO00560 HS

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR030528 SDCBP
PANTHERiPTHR12345:SF10 PTHR12345:SF10, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PF17820 PDZ_6, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDCB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00560
Secondary accession number(s): B2R5Q7
, B4DUH3, B7ZLN2, O00173, O43391, Q14CP2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: July 1, 1997
Last modified: October 16, 2019
This is version 200 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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