UniProtKB - O00534 (VMA5A_HUMAN)

BLAST

>sp|O00534|VMA5A_HUMAN von Willebrand factor A domain-containing protein 5A OS=Homo sapiens OX=9606 GN=VWA5A PE=2 SV=2
MVHFCGLLTLHREPVPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSA
VYSFEALVDGKKIVAELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPG
SKAAVTLKYVQELPLEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTL
SMVATIDSQHGIEKVQSNCPLSPTEYLGEDKTSAQVSLAAGHKFDRDVELLIYYNEVHTP
SVVLEMGMPNMKPGHLMGDPSAMVSFYPNIPEDQPSNTCGEFIFLMDRSGSMQSPMSSQD
TSQLRIQAAKETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLM
QADLGGTEILAPLQNIYRGPSIPGHPLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFG
IGEGTSTSLIKGIARASGGTSEFITGKDRMQSKALRTLKRSLQPVVEDVSLSWHLPPGLS
AKMLSPEQTVIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPD
VNLTIHRLAAKSLLQTKDMGLRETPASDKKDALNLSLESGVISSFTAFIAINKELNKPVQ
GPLAHRDVPRPILLGASAPLKIKCQSGFRKALHSDRPPSASQPRGELMCYKAKTFQMDDY
SLCGLISHKDQHSPGFGENHLVQLIYHQNANGSWDLNEDLAKILGMSLEEIMAAQPAELV
DSSGWATILAVIWLHSNGKDLKCEWELLERKAVAWMRAHAGSTMPSVVKAAITFLKSSVD
PAIFAF

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History
Entry version 133 (07 Nov 2018)
Sequence version 2 (12 Apr 2005)
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Protein

von Willebrand factor A domain-containing protein 5A

Gene

VWA5A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: von Willebrand factor A domain-containing protein 5A Alternative name(s): Breast cancer suppressor candidate 1 Short name: BCSC-1 Loss of heterozygosity 11 chromosomal region 2 gene A protein
Gene namesⁱ	Name:VWA5A Synonyms:BCSC1, LOH11CR2A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000110002.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6658 VWA5A
MIMⁱ	602929 gene
neXtProtⁱ	NX_O00534

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4013
Open Targets More...OpenTargetsⁱ	ENSG00000110002
PharmGKBⁱ	PA162409005

Polymorphism and mutation databases

BioMutaⁱ	VWA5A

BioMutaⁱ

VWA5A

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084411	1 – 786	von Willebrand factor A domain-containing protein 5AAdd BLAST		786

Proteomic databases

EPDⁱ	O00534
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00534
PaxDbⁱ	O00534
PeptideAtlas More...PeptideAtlasⁱ	O00534
PRIDEⁱ	O00534
ProteomicsDBⁱ	47959 47960 [O00534-2] 47961 [O00534-3] 47962 [O00534-4]

PTM databases

iPTMnetⁱ	O00534
PhosphoSitePlusⁱ	O00534

Expressionⁱ

Tissue specificityⁱ

Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000110002 Expressed in 212 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_VWA5A
ExpressionAtlasⁱ	O00534 baseline and differential
Genevisibleⁱ	O00534 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037813 HPA037814 HPA061500

HPAⁱ

HPA037813
HPA037814
HPA061500

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110197, 36 interactors
IntActⁱ	O00534, 3 interactors
STRINGⁱ	9606.ENSP00000376504

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00534
SMRⁱ	O00534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 131	VITPROSITE-ProRule annotationAdd BLAST		131
Domainⁱ	281 – 462	VWFAPROSITE-ProRule annotationAdd BLAST		182

Phylogenomic databases

eggNOGⁱ	ENOG410IG85 Eukaryota COG2304 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063006
HOGENOMⁱ	HOG000006838
InParanoidⁱ	O00534
OMAⁱ	FNVIRFD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03Q4
PhylomeDBⁱ	O00534
TreeFamⁱ	TF329720

Family and domain databases

Gene3Dⁱ	3.40.50.410, 1 hit
InterProⁱ	View protein in InterPro IPR013694 VIT IPR002035 VWF_A IPR036465 vWFA_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08487 VIT, 1 hit PF13768 VWA_3, 1 hit
SMARTⁱ	View protein in SMART SM00609 VIT, 1 hit SM00327 VWA, 1 hit
SUPFAMⁱ	SSF53300 SSF53300, 1 hit
PROSITEⁱ	View protein in PROSITE PS51468 VIT, 1 hit PS50234 VWFA, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O00534-1) [UniParc]FASTA Add to basket

Also known as: c/f

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF 
        60         70         80         90        100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL 
       110        120        130        140        150
EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN 
       160        170        180        190        200
PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP 
       210        220        230        240        250
LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN 
       260        270        280        290        300
MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
       310        320        330        340        350
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM 
       360        370        380        390        400
EEALGRVKLM QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT 
       410        420        430        440        450
FSVIKEVRIN RQKHRCFSFG IGEGTSTSLI KGIARASGGT SEFITGKDRM 
       460        470        480        490        500
QSKALRTLKR SLQPVVEDVS LSWHLPPGLS AKMLSPEQTV IFRGQRLISY 
       510        520        530        540        550
AQLTGRMPAA ETTGEVCLKY TLQGKTFEDK VTFPLQPKPD VNLTIHRLAA 
       560        570        580        590        600
KSLLQTKDMG LRETPASDKK DALNLSLESG VISSFTAFIA INKELNKPVQ 
       610        620        630        640        650
GPLAHRDVPR PILLGASAPL KIKCQSGFRK ALHSDRPPSA SQPRGELMCY 
       660        670        680        690        700
KAKTFQMDDY SLCGLISHKD QHSPGFGENH LVQLIYHQNA NGSWDLNEDL 
       710        720        730        740        750
AKILGMSLEE IMAAQPAELV DSSGWATILA VIWLHSNGKD LKCEWELLER 
       760        770        780 
KAVAWMRAHA GSTMPSVVKA AITFLKSSVD PAIFAF

Length:786

Mass (Da):86,489

Last modified:April 12, 2005 - v2

Checksum:ⁱ4CCD27B4B6DD9BD0

Isoform 2 (identifier: O00534-2) [UniParc]FASTA Add to basket

Also known as: g

The sequence of this isoform differs from the canonical sequence as follows:
389-426: LFVFTDGEVT...FSFGIGEGTS → VFERPYTLTV...SRWTITVSVG
427-786: Missing.

« Hide

        10         20         30         40         50
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF 
        60         70         80         90        100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL 
       110        120        130        140        150
EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN 
       160        170        180        190        200
PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP 
       210        220        230        240        250
LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN 
       260        270        280        290        300
MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
       310        320        330        340        350
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM 
       360        370        380        390        400
EEALGRVKLM QADLGGTEIL APLQNIYRGP SIPGHPLQVF ERPYTLTVLL 
       410        420 
LHLSPEGNLC VIRPRHSRWT ITVSVG

Show »

Length:426

Mass (Da):47,049

Checksum:ⁱ47E0EC99F668DDC3

Isoform 3 (identifier: O00534-3) [UniParc]FASTA Add to basket

Also known as: a/d

The sequence of this isoform differs from the canonical sequence as follows:
416-786: Missing.

« Hide

        10         20         30         40         50
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF 
        60         70         80         90        100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL 
       110        120        130        140        150
EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN 
       160        170        180        190        200
PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP 
       210        220        230        240        250
LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN 
       260        270        280        290        300
MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
       310        320        330        340        350
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM 
       360        370        380        390        400
EEALGRVKLM QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT 
       410 
FSVIKEVRIN RQKHR

Show »

Length:415

Mass (Da):45,923

Checksum:ⁱEAD8C09FD28D4016

Isoform 4 (identifier: O00534-4) [UniParc]FASTA Add to basket

Also known as: b/e

The sequence of this isoform differs from the canonical sequence as follows:
265-266: SF → RT
267-786: Missing.

« Hide

        10         20         30         40         50
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF 
        60         70         80         90        100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL 
       110        120        130        140        150
EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN 
       160        170        180        190        200
PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP 
       210        220        230        240        250
LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN 
       260 
MKPGHLMGDP SAMVRT

Show »

Length:266

Mass (Da):29,235

Checksum:ⁱ7E3655E339FCF6D5

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B4DHS6	B4DHS6_HUMAN		cDNA FLJ55206, highly similar to Lo... cDNA FLJ55206, highly similar to Loss of heterozygosity 11 chromosomal region 2 gene A protein (von Willebrand factor A domain-containing protein 5A)	VWA5A	431	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059692	202	S → G. Corresponds to variant dbSNP:rs35496433Ensembl.	1
Natural variantⁱVAR_059693	205	E → K. Corresponds to variant dbSNP:rs35215239Ensembl.	1
Natural variantⁱVAR_014193	499	S → I1 PublicationCorresponds to variant dbSNP:rs2276054Ensembl.	1
Natural variantⁱVAR_014194	506	R → K1 PublicationCorresponds to variant dbSNP:rs2276053Ensembl.	1
Natural variantⁱVAR_014195	757	R → C1 PublicationCorresponds to variant dbSNP:rs117689747Ensembl.	1
Natural variantⁱVAR_014196	759	H → R1 PublicationCorresponds to variant dbSNP:rs200614108Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_013364	265 – 266	SF → RT in isoform 4. 1 Publication	2
Alternative sequenceⁱVSP_013365	267 – 786	Missing in isoform 4. 1 PublicationAdd BLAST	520
Alternative sequenceⁱVSP_013367	389 – 426	LFVFT…GEGTS → VFERPYTLTVLLLHLSPEGN LCVIRPRHSRWTITVSVG in isoform 2. 1 PublicationAdd BLAST	38
Alternative sequenceⁱVSP_013366	416 – 786	Missing in isoform 3. 3 PublicationsAdd BLAST	371
Alternative sequenceⁱVSP_013368	427 – 786	Missing in isoform 2. 1 PublicationAdd BLAST	360

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY366505 mRNA Translation: AAQ94873.1 AY366508 mRNA Translation: AAQ94876.1 AY366503 mRNA Translation: AAQ94871.1 AY366506 mRNA Translation: AAQ94874.1 AY366504 mRNA Translation: AAQ94872.1 AY366507 mRNA Translation: AAQ94875.1 AY366501 Genomic DNA Translation: AAQ94867.1 AY366501 Genomic DNA Translation: AAQ94868.1 AY366501 Genomic DNA Translation: AAQ94869.1 BT006655 mRNA Translation: AAP35301.1 BC001234 mRNA Translation: AAH01234.1 AF002672 mRNA Translation: AAB60942.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8444.1 [O00534-1] CCDS8445.1 [O00534-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001123614.1, NM_001130142.1 [O00534-1] NP_055437.2, NM_014622.4 [O00534-1] NP_938057.1, NM_198315.2 [O00534-3]
UniGeneⁱ	Hs.152944

Genome annotation databases

Ensemblⁱ	ENST00000361352; ENSP00000355070; ENSG00000110002 [O00534-3] ENST00000392748; ENSP00000376504; ENSG00000110002 [O00534-1] ENST00000449321; ENSP00000404683; ENSG00000110002 [O00534-3] ENST00000456829; ENSP00000407726; ENSG00000110002 [O00534-1]
GeneIDⁱ	4013
KEGGⁱ	hsa:4013
UCSC genome browser More...UCSCⁱ	uc001pzr.4 human [O00534-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O00534	Loss of heterozygosity, 11, chromosomal region 2, gene A, isoform CRA_b		HUMAN		786	UniRef100_O00534
cDNA FLJ55206, highly similar to Loss of heterozygosity 11 chromosomal region 2 gene A protein		HUMAN		431
Isoform 3 of von Willebrand factor A domain-containing protein 5A		HUMAN		415
UPI0005CFFD59		HUMAN		802

Protein	Similar proteins		Species	Score	Length	Source
O00534	Loss of heterozygosity, 11, chromosomal region 2, gene A, isoform CRA_b		HUMAN		786	UniRef90_O00534
von Willebrand factor A domain containing 5A		PONAB		821
Uncharacterized protein		PANPA		786
Uncharacterized protein		MACMU		786
Uncharacterized protein		COLAP		786
+38

Protein	Similar proteins		Species	Score	Length	Source
O00534	Loss of heterozygosity, 11, chromosomal region 2, gene A, isoform CRA_b		HUMAN		786	UniRef50_O00534
von Willebrand factor A domain containing 5A		PONAB		821
Uncharacterized protein		RHIBE		786
Uncharacterized protein		COLAP		786
Uncharacterized protein		MACFA		786
+189
O00534-2	Uncharacterized protein		CEREH		431	UniRef50_O00534-2
Uncharacterized protein		MYOLU		418
von Willebrand factor A domain-containing protein 5A-like protein (Fragment)		CRIGR		460
UPI00098AA525		MICMU		406
von Willebrand factor A domain-containing protein 5A		CRIGR		530
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY366505 mRNA Translation: AAQ94873.1 AY366508 mRNA Translation: AAQ94876.1 AY366503 mRNA Translation: AAQ94871.1 AY366506 mRNA Translation: AAQ94874.1 AY366504 mRNA Translation: AAQ94872.1 AY366507 mRNA Translation: AAQ94875.1 AY366501 Genomic DNA Translation: AAQ94867.1 AY366501 Genomic DNA Translation: AAQ94868.1 AY366501 Genomic DNA Translation: AAQ94869.1 BT006655 mRNA Translation: AAP35301.1 BC001234 mRNA Translation: AAH01234.1 AF002672 mRNA Translation: AAB60942.1
CCDSⁱ	CCDS8444.1 [O00534-1] CCDS8445.1 [O00534-3]
RefSeqⁱ	NP_001123614.1, NM_001130142.1 [O00534-1] NP_055437.2, NM_014622.4 [O00534-1] NP_938057.1, NM_198315.2 [O00534-3]
UniGeneⁱ	Hs.152944

3D structure databases

ProteinModelPortalⁱ	O00534
SMRⁱ	O00534
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110197, 36 interactors
IntActⁱ	O00534, 3 interactors
STRINGⁱ	9606.ENSP00000376504

PTM databases

iPTMnetⁱ	O00534
PhosphoSitePlusⁱ	O00534

Polymorphism and mutation databases

BioMutaⁱ	VWA5A

BioMutaⁱ

VWA5A

Proteomic databases

EPDⁱ	O00534
MaxQBⁱ	O00534
PaxDbⁱ	O00534
PeptideAtlasⁱ	O00534
PRIDEⁱ	O00534
ProteomicsDBⁱ	47959 47960 [O00534-2] 47961 [O00534-3] 47962 [O00534-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4013
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361352; ENSP00000355070; ENSG00000110002 [O00534-3] ENST00000392748; ENSP00000376504; ENSG00000110002 [O00534-1] ENST00000449321; ENSP00000404683; ENSG00000110002 [O00534-3] ENST00000456829; ENSP00000407726; ENSG00000110002 [O00534-1]
GeneIDⁱ	4013
KEGGⁱ	hsa:4013
UCSCⁱ	uc001pzr.4 human [O00534-1]

Organism-specific databases

CTDⁱ	4013
DisGeNETⁱ	4013
EuPathDBⁱ	HostDB:ENSG00000110002.15
GeneCardsⁱ	VWA5A
HGNCⁱ	HGNC:6658 VWA5A
HPAⁱ	HPA037813 HPA037814 HPA061500
MIMⁱ	602929 gene
neXtProtⁱ	NX_O00534
OpenTargetsⁱ	ENSG00000110002
PharmGKBⁱ	PA162409005
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IG85 Eukaryota COG2304 LUCA
GeneTreeⁱ	ENSGT00530000063006
HOGENOMⁱ	HOG000006838
InParanoidⁱ	O00534
OMAⁱ	FNVIRFD
OrthoDBⁱ	EOG091G03Q4
PhylomeDBⁱ	O00534
TreeFamⁱ	TF329720

Miscellaneous databases

ChiTaRSⁱ	VWA5A human
GenomeRNAiⁱ	4013
Protein Ontology More...PROⁱ	PR:O00534
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000110002 Expressed in 212 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_VWA5A
ExpressionAtlasⁱ	O00534 baseline and differential
Genevisibleⁱ	O00534 HS

Family and domain databases

Gene3Dⁱ	3.40.50.410, 1 hit
InterProⁱ	View protein in InterPro IPR013694 VIT IPR002035 VWF_A IPR036465 vWFA_dom_sf
Pfamⁱ	View protein in Pfam PF08487 VIT, 1 hit PF13768 VWA_3, 1 hit
SMARTⁱ	View protein in SMART SM00609 VIT, 1 hit SM00327 VWA, 1 hit
SUPFAMⁱ	SSF53300 SSF53300, 1 hit
PROSITEⁱ	View protein in PROSITE PS51468 VIT, 1 hit PS50234 VWFA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VMA5A_HUMAN
Accessionⁱ	O00534Primary (citable) accession number: O00534 Secondary accession number(s): Q6UN19, Q6UN20, Q9BVF8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	April 12, 2005
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00534 (VMA5A_HUMAN)

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von Willebrand factor A domain-containing protein 5A

VWA5A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ