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UniProtKB - O00534 (VMA5A_HUMAN)

Protein

von Willebrand factor A domain-containing protein 5A

Gene

VWA5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 5A
Alternative name(s):
Breast cancer suppressor candidate 1
Short name:
BCSC-1
Loss of heterozygosity 11 chromosomal region 2 gene A protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VWA5A
Synonyms:BCSC1, LOH11CR2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000110002.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:6658 VWA5A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602929 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00534

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		4013

Open Targets

More...OpenTargetsi		ENSG00000110002

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162409005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VWA5A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000844111 – 786von Willebrand factor A domain-containing protein 5AAdd BLAST786

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00534

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00534

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00534

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00534

PeptideAtlas

More...PeptideAtlasi		O00534

PRoteomics IDEntifications database

More...PRIDEi		O00534

ProteomicsDB human proteome resource

More...ProteomicsDBi		47959
47960 [O00534-2]
47961 [O00534-3]
47962 [O00534-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00534

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00534

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110002 Expressed in 212 organ(s), highest expression level in amniotic fluid

CleanEx database of gene expression profiles

More...CleanExi		HS_VWA5A

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00534 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00534 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA037813
HPA037814
HPA061500

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110197, 36 interactors

Protein interaction database and analysis system

More...IntActi		O00534, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376504

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O00534

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00534

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 131VITPROSITE-ProRule annotationAdd BLAST131
Domaini281 – 462VWFAPROSITE-ProRule annotationAdd BLAST182

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IG85 Eukaryota
COG2304 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159961

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000006838

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00534

Identification of Orthologs from Complete Genome Data

More...OMAi		FNVIRFD

Database of Orthologous Groups

More...OrthoDBi		955432at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00534

TreeFam database of animal gene trees

More...TreeFami		TF329720

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08487 VIT, 1 hit
PF13768 VWA_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O00534-1) [UniParc]FASTAAdd to basket
Also known as: c/f

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHFCGLLTL HREPVPLKSI SVSVNIYEFV AGVSATLNYE NEEKVPLEAF 
        60         70         80         90        100
FVFPMDEDSA VYSFEALVDG KKIVAELQDK MKARTNYEKA ISQGHQAFLL 
       110        120        130        140        150
EGDSSSRDVF SCNVGNLQPG SKAAVTLKYV QELPLEADGA LRFVLPAVLN 
       160        170        180        190        200
PRYQFSGSSK DSCLNVKTPI VPVEDLPYTL SMVATIDSQH GIEKVQSNCP 
       210        220        230        240        250
LSPTEYLGED KTSAQVSLAA GHKFDRDVEL LIYYNEVHTP SVVLEMGMPN 
       260        270        280        290        300
MKPGHLMGDP SAMVSFYPNI PEDQPSNTCG EFIFLMDRSG SMQSPMSSQD 
       310        320        330        340        350
TSQLRIQAAK ETLILLLKSL PIGCYFNIYG FGSSYEACFP ESVKYTQQTM 
       360        370        380        390        400
EEALGRVKLM QADLGGTEIL APLQNIYRGP SIPGHPLQLF VFTDGEVTDT 
       410        420        430        440        450
FSVIKEVRIN RQKHRCFSFG IGEGTSTSLI KGIARASGGT SEFITGKDRM 
       460        470        480        490        500
QSKALRTLKR SLQPVVEDVS LSWHLPPGLS AKMLSPEQTV IFRGQRLISY 
       510        520        530        540        550
AQLTGRMPAA ETTGEVCLKY TLQGKTFEDK VTFPLQPKPD VNLTIHRLAA 
       560        570        580        590        600
KSLLQTKDMG LRETPASDKK DALNLSLESG VISSFTAFIA INKELNKPVQ 
       610        620        630        640        650
GPLAHRDVPR PILLGASAPL KIKCQSGFRK ALHSDRPPSA SQPRGELMCY 
       660        670        680        690        700
KAKTFQMDDY SLCGLISHKD QHSPGFGENH LVQLIYHQNA NGSWDLNEDL 
       710        720        730        740        750
AKILGMSLEE IMAAQPAELV DSSGWATILA VIWLHSNGKD LKCEWELLER 
       760        770        780 
KAVAWMRAHA GSTMPSVVKA AITFLKSSVD PAIFAF
Length:786
Mass (Da):86,489
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CCD27B4B6DD9BD0
GO
Isoform 2 (identifier: O00534-2) [UniParc]FASTAAdd to basket
Also known as: g

The sequence of this isoform differs from the canonical sequence as follows:
     389-426: LFVFTDGEVT...FSFGIGEGTS → VFERPYTLTV...SRWTITVSVG
     427-786: Missing.

Show »
Length:426
Mass (Da):47,049
Checksum:i47E0EC99F668DDC3
GO
Isoform 3 (identifier: O00534-3) [UniParc]FASTAAdd to basket
Also known as: a/d

The sequence of this isoform differs from the canonical sequence as follows:
     416-786: Missing.

Show »
Length:415
Mass (Da):45,923
Checksum:iEAD8C09FD28D4016
GO
Isoform 4 (identifier: O00534-4) [UniParc]FASTAAdd to basket
Also known as: b/e

The sequence of this isoform differs from the canonical sequence as follows:
     265-266: SF → RT
     267-786: Missing.

Show »
Length:266
Mass (Da):29,235
Checksum:i7E3655E339FCF6D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DHS6B4DHS6_HUMAN
cDNA FLJ55206, highly similar to Lo...
VWA5A
431Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059692202S → G. Corresponds to variant dbSNP:rs35496433Ensembl.1
Natural variantiVAR_059693205E → K. Corresponds to variant dbSNP:rs35215239Ensembl.1
Natural variantiVAR_014193499S → I1 PublicationCorresponds to variant dbSNP:rs2276054Ensembl.1
Natural variantiVAR_014194506R → K1 PublicationCorresponds to variant dbSNP:rs2276053Ensembl.1
Natural variantiVAR_014195757R → C1 PublicationCorresponds to variant dbSNP:rs117689747Ensembl.1
Natural variantiVAR_014196759H → R1 PublicationCorresponds to variant dbSNP:rs200614108Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013364265 – 266SF → RT in isoform 4. 1 Publication2
Alternative sequenceiVSP_013365267 – 786Missing in isoform 4. 1 PublicationAdd BLAST520
Alternative sequenceiVSP_013367389 – 426LFVFT…GEGTS → VFERPYTLTVLLLHLSPEGN LCVIRPRHSRWTITVSVG in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_013366416 – 786Missing in isoform 3. 3 PublicationsAdd BLAST371
Alternative sequenceiVSP_013368427 – 786Missing in isoform 2. 1 PublicationAdd BLAST360

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY366505 mRNA Translation: AAQ94873.1
AY366508 mRNA Translation: AAQ94876.1
AY366503 mRNA Translation: AAQ94871.1
AY366506 mRNA Translation: AAQ94874.1
AY366504 mRNA Translation: AAQ94872.1
AY366507 mRNA Translation: AAQ94875.1
AY366501 Genomic DNA Translation: AAQ94867.1
AY366501 Genomic DNA Translation: AAQ94868.1
AY366501 Genomic DNA Translation: AAQ94869.1
BT006655 mRNA Translation: AAP35301.1
BC001234 mRNA Translation: AAH01234.1
AF002672 mRNA Translation: AAB60942.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS8444.1 [O00534-1]
CCDS8445.1 [O00534-3]

NCBI Reference Sequences

More...RefSeqi		NP_001123614.1, NM_001130142.1 [O00534-1]
NP_055437.2, NM_014622.4 [O00534-1]
NP_938057.1, NM_198315.2 [O00534-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.152944

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361352; ENSP00000355070; ENSG00000110002 [O00534-3]
ENST00000392748; ENSP00000376504; ENSG00000110002 [O00534-1]
ENST00000449321; ENSP00000404683; ENSG00000110002 [O00534-3]
ENST00000456829; ENSP00000407726; ENSG00000110002 [O00534-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4013

UCSC genome browser

More...UCSCi		uc001pzr.4 human [O00534-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366505 mRNA Translation: AAQ94873.1
AY366508 mRNA Translation: AAQ94876.1
AY366503 mRNA Translation: AAQ94871.1
AY366506 mRNA Translation: AAQ94874.1
AY366504 mRNA Translation: AAQ94872.1
AY366507 mRNA Translation: AAQ94875.1
AY366501 Genomic DNA Translation: AAQ94867.1
AY366501 Genomic DNA Translation: AAQ94868.1
AY366501 Genomic DNA Translation: AAQ94869.1
BT006655 mRNA Translation: AAP35301.1
BC001234 mRNA Translation: AAH01234.1
AF002672 mRNA Translation: AAB60942.1
CCDSiCCDS8444.1 [O00534-1]
CCDS8445.1 [O00534-3]
RefSeqiNP_001123614.1, NM_001130142.1 [O00534-1]
NP_055437.2, NM_014622.4 [O00534-1]
NP_938057.1, NM_198315.2 [O00534-3]
UniGeneiHs.152944

3D structure databases

ProteinModelPortaliO00534
SMRiO00534
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110197, 36 interactors
IntActiO00534, 3 interactors
STRINGi9606.ENSP00000376504

PTM databases

iPTMnetiO00534
PhosphoSitePlusiO00534

Polymorphism and mutation databases

BioMutaiVWA5A

Proteomic databases

EPDiO00534
jPOSTiO00534
MaxQBiO00534
PaxDbiO00534
PeptideAtlasiO00534
PRIDEiO00534
ProteomicsDBi47959
47960 [O00534-2]
47961 [O00534-3]
47962 [O00534-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4013
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361352; ENSP00000355070; ENSG00000110002 [O00534-3]
ENST00000392748; ENSP00000376504; ENSG00000110002 [O00534-1]
ENST00000449321; ENSP00000404683; ENSG00000110002 [O00534-3]
ENST00000456829; ENSP00000407726; ENSG00000110002 [O00534-1]
GeneIDi4013
KEGGihsa:4013
UCSCiuc001pzr.4 human [O00534-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4013
DisGeNETi4013
EuPathDBiHostDB:ENSG00000110002.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		VWA5A
HGNCiHGNC:6658 VWA5A
HPAiHPA037813
HPA037814
HPA061500
MIMi602929 gene
neXtProtiNX_O00534
OpenTargetsiENSG00000110002
PharmGKBiPA162409005

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IG85 Eukaryota
COG2304 LUCA
GeneTreeiENSGT00940000159961
HOGENOMiHOG000006838
InParanoidiO00534
OMAiFNVIRFD
OrthoDBi955432at2759
PhylomeDBiO00534
TreeFamiTF329720

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VWA5A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4013

Protein Ontology

More...PROi		PR:O00534

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000110002 Expressed in 212 organ(s), highest expression level in amniotic fluid
CleanExiHS_VWA5A
ExpressionAtlasiO00534 baseline and differential
GenevisibleiO00534 HS

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013694 VIT
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF08487 VIT, 1 hit
PF13768 VWA_3, 1 hit
SMARTiView protein in SMART
SM00609 VIT, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS51468 VIT, 1 hit
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVMA5A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00534
Secondary accession number(s): Q6UN19, Q6UN20, Q9BVF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: April 12, 2005
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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