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Protein

Uroplakin-2

Gene

UPK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).By similarity

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • multicellular organism development Source: ProtInc

Protein family/group databases

TCDBi8.A.90.1.1 the uroplakin 2/3 (upk2/3) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uroplakin-2
Short name:
UP2
Alternative name(s):
Uroplakin II
Short name:
UPII
Gene namesi
Name:UPK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110375.2
HGNCiHGNC:12579 UPK2
MIMi611558 gene
neXtProtiNX_O00526

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini85 – 155LumenalSequence analysisAdd BLAST71
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 184CytoplasmicSequence analysis8

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7379
OpenTargetsiENSG00000110375
PharmGKBiPA37211

Polymorphism and mutation databases

BioMutaiUPK2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000002263026 – 84By similarityAdd BLAST59
ChainiPRO_000002263185 – 184Uroplakin-2Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiO00526
PaxDbiO00526
PeptideAtlasiO00526
PRIDEiO00526
ProteomicsDBi47956
TopDownProteomicsiO00526

PTM databases

iPTMnetiO00526
PhosphoSitePlusiO00526

Expressioni

Tissue specificityi

Expressed in ureter.1 Publication

Gene expression databases

BgeeiENSG00000110375 Expressed in 55 organ(s), highest expression level in urinary bladder
CleanExiHS_UPK2
GenevisibleiO00526 HS

Organism-specific databases

HPAiHPA043312
HPA061106

Interactioni

Subunit structurei

Interacts with uroplakin-1a (UPK1A).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10179682,EBI-749265

Protein-protein interaction databases

BioGridi113225, 42 interactors
IntActiO00526, 28 interactors
STRINGi9606.ENSP00000264031

Structurei

3D structure databases

ProteinModelPortaliO00526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uroplakin-2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8ZD Eukaryota
ENOG4111EC7 LUCA
GeneTreeiENSGT00390000006115
HOGENOMiHOG000132917
HOVERGENiHBG016837
InParanoidiO00526
OMAiPRRNMES
OrthoDBiEOG091G0SKR
PhylomeDBiO00526
TreeFamiTF337797

Family and domain databases

CDDicd09967 UP_II, 1 hit
InterProiView protein in InterPro
IPR009952 Uroplakin-2
PANTHERiPTHR17573 PTHR17573, 1 hit
PfamiView protein in Pfam
PF07353 Uroplakin_II, 1 hit
PIRSFiPIRSF016439 Uroplakin_II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022112 Uroplakin_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00526-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP
60 70 80 90 100
CHLTGGNATL MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR
110 120 130 140 150
LSAYQVTNLV PGTKFYISYL VKKGTATESS REIPMSTLPR RNMESIGLGM
160 170 180
ARTGGMVVIT VLLSVAMFLL VLGFIIALAL GSRK
Length:184
Mass (Da):19,438
Last modified:May 30, 2000 - v2
Checksum:i83D963F06050A585
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149G → A in AAB58416 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05147347A → S. Corresponds to variant dbSNP:rs3886020Ensembl.1
Natural variantiVAR_062246160T → M. Corresponds to variant dbSNP:rs45530531Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13645 mRNA Translation: CAA73996.1
AB078607 Genomic DNA Translation: BAB84089.1
AY455312 mRNA Translation: AAR19396.1
EF445028 Genomic DNA Translation: ACA06070.1
BC113900 mRNA Translation: AAI13901.1
AF000562 mRNA Translation: AAB58416.1
CCDSiCCDS8404.1
PIRiT09609
RefSeqiNP_006751.1, NM_006760.3
UniGeneiHs.379613

Genome annotation databases

EnsembliENST00000264031; ENSP00000264031; ENSG00000110375
GeneIDi7379
KEGGihsa:7379
UCSCiuc001puh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13645 mRNA Translation: CAA73996.1
AB078607 Genomic DNA Translation: BAB84089.1
AY455312 mRNA Translation: AAR19396.1
EF445028 Genomic DNA Translation: ACA06070.1
BC113900 mRNA Translation: AAI13901.1
AF000562 mRNA Translation: AAB58416.1
CCDSiCCDS8404.1
PIRiT09609
RefSeqiNP_006751.1, NM_006760.3
UniGeneiHs.379613

3D structure databases

ProteinModelPortaliO00526
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113225, 42 interactors
IntActiO00526, 28 interactors
STRINGi9606.ENSP00000264031

Protein family/group databases

TCDBi8.A.90.1.1 the uroplakin 2/3 (upk2/3) family

PTM databases

iPTMnetiO00526
PhosphoSitePlusiO00526

Polymorphism and mutation databases

BioMutaiUPK2

Proteomic databases

MaxQBiO00526
PaxDbiO00526
PeptideAtlasiO00526
PRIDEiO00526
ProteomicsDBi47956
TopDownProteomicsiO00526

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264031; ENSP00000264031; ENSG00000110375
GeneIDi7379
KEGGihsa:7379
UCSCiuc001puh.4 human

Organism-specific databases

CTDi7379
DisGeNETi7379
EuPathDBiHostDB:ENSG00000110375.2
GeneCardsiUPK2
HGNCiHGNC:12579 UPK2
HPAiHPA043312
HPA061106
MIMi611558 gene
neXtProtiNX_O00526
OpenTargetsiENSG00000110375
PharmGKBiPA37211
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8ZD Eukaryota
ENOG4111EC7 LUCA
GeneTreeiENSGT00390000006115
HOGENOMiHOG000132917
HOVERGENiHBG016837
InParanoidiO00526
OMAiPRRNMES
OrthoDBiEOG091G0SKR
PhylomeDBiO00526
TreeFamiTF337797

Miscellaneous databases

GeneWikiiUPK2
GenomeRNAii7379
PROiPR:O00526
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110375 Expressed in 55 organ(s), highest expression level in urinary bladder
CleanExiHS_UPK2
GenevisibleiO00526 HS

Family and domain databases

CDDicd09967 UP_II, 1 hit
InterProiView protein in InterPro
IPR009952 Uroplakin-2
PANTHERiPTHR17573 PTHR17573, 1 hit
PfamiView protein in Pfam
PF07353 Uroplakin_II, 1 hit
PIRSFiPIRSF016439 Uroplakin_II, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022112 Uroplakin_II, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPK2_HUMAN
AccessioniPrimary (citable) accession number: O00526
Secondary accession number(s): B0YJ92, O00457, Q53YV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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