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Entry version 169 (17 Jun 2020)
Sequence version 2 (01 Mar 2005)
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Protein

Fatty-acid amide hydrolase 1

Gene

FAAH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). Also catalyzes the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by O-aryl carbamates and alpha-keto heterocycles (PubMed:17015445). Inhibited by trifluoromethyl ketone (PubMed:9122178).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=9.7 nmol/min/mg enzyme for the hydrolysis of oleamide ((9Z)-octadecenamide)1 Publication
    2. Vmax=2.1 nmol/min/mg enzyme for the hydrolysis of N-palmitoyl ethanolamine (N-hexadecanoyl ethanolamine)1 Publication
    3. Vmax=5.6 nmol/min/mg enzyme for the hydrolysis of N-oleoyl ethanolamine (N-(9Z-octadecenoyl)-ethanolamine)1 Publication
    4. Vmax=17 nmol/min/mg enzyme for the hydrolysis of anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine)1 Publication
    5. Vmax=0.75 nmol/min/mg enzyme for the hydrolysis of N-oleoyltaurine (N-(9Z-octadecenoyl)-taurine)1 Publication

    pH dependencei

    Optimum pH is around 9.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei142Charge relay systemBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei191Substrate; via carbonyl oxygenBy similarity1
    Active sitei217Charge relay systemBy similarity1
    Binding sitei217SubstrateBy similarity1
    Active sitei241Acyl-ester intermediateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS04139-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.5.1.4 2681
    3.5.1.99 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2142753 Arachidonic acid metabolism

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    O00519

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000145

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fatty-acid amide hydrolase 1 (EC:3.5.1.993 Publications)
    Alternative name(s):
    Anandamide amidohydrolase 1
    Fatty acid ester hydrolase1 Publication (EC:3.1.1.-1 Publication)
    Oleamide hydrolase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FAAH
    Synonyms:FAAH1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000117480.15

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:3553 FAAH

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    602935 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O00519

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 403CytoplasmicBy similarityAdd BLAST374
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei404 – 433By similarityAdd BLAST30
    Topological domaini434 – 579CytoplasmicBy similarityAdd BLAST146

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2166

    MalaCards human disease database

    More...
    MalaCardsi
    FAAH
    MIMi606581 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000117480

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA27955

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    O00519 Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2243

    Drug and drug target database

    More...
    DrugBanki
    DB06894 1-DODECANOL
    DB08400 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid
    DB08385 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid
    DB00316 Acetaminophen
    DB09061 Cannabidiol
    DB12010 Fostamatinib
    DB14009 Medical Cannabis
    DB02465 Methoxy arachidonyl fluorophosphonate
    DB14011 Nabiximols
    DB00818 Propofol
    DB00599 Thiopental

    DrugCentral

    More...
    DrugCentrali
    O00519

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1400

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    FAAH

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001052641 – 579Fatty-acid amide hydrolase 1Add BLAST579

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei241PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O00519

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O00519

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    O00519

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O00519

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O00519

    PeptideAtlas

    More...
    PeptideAtlasi
    O00519

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O00519

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    47952

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O00519

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O00519

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000117480 Expressed in right lobe of thyroid gland and 190 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O00519 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O00519 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000117480 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    By similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108464, 3 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O00519, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000243167

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    O00519

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    O00519 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O00519

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni238 – 241Substrate bindingBy similarity4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the amidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1212 Eukaryota
    COG0154 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000161237

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_009600_9_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O00519

    KEGG Orthology (KO)

    More...
    KOi
    K15528

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MQPWKYD

    Database of Orthologous Groups

    More...
    OrthoDBi
    852596at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O00519

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314455

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.1300.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020556 Amidase_CS
    IPR023631 Amidase_dom
    IPR036928 AS_sf
    IPR030560 FAAH

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45847:SF3 PTHR45847:SF3, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01425 Amidase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF75304 SSF75304, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00571 AMIDASES, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    O00519-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MVQYELWAAL PGASGVALAC CFVAAAVALR WSGRRTARGA VVRARQRQRA
    60 70 80 90 100
    GLENMDRAAQ RFRLQNPDLD SEALLALPLP QLVQKLHSRE LAPEAVLFTY
    110 120 130 140 150
    VGKAWEVNKG TNCVTSYLAD CETQLSQAPR QGLLYGVPVS LKECFTYKGQ
    160 170 180 190 200
    DSTLGLSLNE GVPAECDSVV VHVLKLQGAV PFVHTNVPQS MFSYDCSNPL
    210 220 230 240 250
    FGQTVNPWKS SKSPGGSSGG EGALIGSGGS PLGLGTDIGG SIRFPSSFCG
    260 270 280 290 300
    ICGLKPTGNR LSKSGLKGCV YGQEAVRLSV GPMARDVESL ALCLRALLCE
    310 320 330 340 350
    DMFRLDPTVP PLPFREEVYT SSQPLRVGYY ETDNYTMPSP AMRRAVLETK
    360 370 380 390 400
    QSLEAAGHTL VPFLPSNIPH ALETLSTGGL FSDGGHTFLQ NFKGDFVDPC
    410 420 430 440 450
    LGDLVSILKL PQWLKGLLAF LVKPLLPRLS AFLSNMKSRS AGKLWELQHE
    460 470 480 490 500
    IEVYRKTVIA QWRALDLDVV LTPMLAPALD LNAPGRATGA VSYTMLYNCL
    510 520 530 540 550
    DFPAGVVPVT TVTAEDEAQM EHYRGYFGDI WDKMLQKGMK KSVGLPVAVQ
    560 570
    CVALPWQEEL CLRFMREVER LMTPEKQSS
    Length:579
    Mass (Da):63,066
    Last modified:March 1, 2005 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i633A92DC36940C18
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A087WYA0A0A087WYA0_HUMAN
    Fatty-acid amide hydrolase 1
    FAAH
    49Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47R → K in AAB58505 (PubMed:9122178).Curated1
    Sequence conflicti47R → K in AAD13768 (PubMed:9878243).Curated1

    <p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIMi:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence.3 Publications

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013563129P → T Polymorphism associated with susceptibility to drug abuse; the mutant enzyme is more sensitive to proteolytic degradation; displays reduced cellular expression probably due to a post-translational mechanism preceding productive folding. 6 PublicationsCorresponds to variant dbSNP:rs324420EnsemblClinVar.1
    Natural variantiVAR_035704345A → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772931153Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U82535 mRNA Translation: AAB58505.1
    AF098019 AF098018 Genomic DNA Translation: AAD13768.1
    AY842444 Genomic DNA Translation: AAV88095.1
    AL122001 Genomic DNA No translation available.
    CH471059 Genomic DNA Translation: EAX06912.1
    CH471059 Genomic DNA Translation: EAX06919.1
    BC093632 mRNA Translation: AAH93632.1
    BC110404 mRNA Translation: AAI10405.1
    BC111941 mRNA Translation: AAI11942.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS535.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001432.2, NM_001441.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000243167; ENSP00000243167; ENSG00000117480

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2166

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2166

    UCSC genome browser

    More...
    UCSCi
    uc001cpu.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U82535 mRNA Translation: AAB58505.1
    AF098019 AF098018 Genomic DNA Translation: AAD13768.1
    AY842444 Genomic DNA Translation: AAV88095.1
    AL122001 Genomic DNA No translation available.
    CH471059 Genomic DNA Translation: EAX06912.1
    CH471059 Genomic DNA Translation: EAX06919.1
    BC093632 mRNA Translation: AAH93632.1
    BC110404 mRNA Translation: AAI10405.1
    BC111941 mRNA Translation: AAI11942.1
    CCDSiCCDS535.1
    RefSeqiNP_001432.2, NM_001441.2

    3D structure databases

    SMRiO00519
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi108464, 3 interactors
    IntActiO00519, 4 interactors
    STRINGi9606.ENSP00000243167

    Chemistry databases

    BindingDBiO00519
    ChEMBLiCHEMBL2243
    DrugBankiDB06894 1-DODECANOL
    DB08400 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid
    DB08385 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid
    DB00316 Acetaminophen
    DB09061 Cannabidiol
    DB12010 Fostamatinib
    DB14009 Medical Cannabis
    DB02465 Methoxy arachidonyl fluorophosphonate
    DB14011 Nabiximols
    DB00818 Propofol
    DB00599 Thiopental
    DrugCentraliO00519
    GuidetoPHARMACOLOGYi1400
    SwissLipidsiSLP:000000145

    PTM databases

    iPTMnetiO00519
    PhosphoSitePlusiO00519

    Polymorphism and mutation databases

    BioMutaiFAAH

    Proteomic databases

    EPDiO00519
    jPOSTiO00519
    MassIVEiO00519
    MaxQBiO00519
    PaxDbiO00519
    PeptideAtlasiO00519
    PRIDEiO00519
    ProteomicsDBi47952

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    1478 370 antibodies

    Genome annotation databases

    EnsembliENST00000243167; ENSP00000243167; ENSG00000117480
    GeneIDi2166
    KEGGihsa:2166
    UCSCiuc001cpu.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2166
    DisGeNETi2166
    EuPathDBiHostDB:ENSG00000117480.15

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    FAAH
    HGNCiHGNC:3553 FAAH
    HPAiENSG00000117480 Low tissue specificity
    MalaCardsiFAAH
    MIMi602935 gene
    606581 phenotype
    neXtProtiNX_O00519
    OpenTargetsiENSG00000117480
    PharmGKBiPA27955

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1212 Eukaryota
    COG0154 LUCA
    GeneTreeiENSGT00940000161237
    HOGENOMiCLU_009600_9_3_1
    InParanoidiO00519
    KOiK15528
    OMAiMQPWKYD
    OrthoDBi852596at2759
    PhylomeDBiO00519
    TreeFamiTF314455

    Enzyme and pathway databases

    BioCyciMetaCyc:HS04139-MONOMER
    BRENDAi3.5.1.4 2681
    3.5.1.99 2681
    ReactomeiR-HSA-2142753 Arachidonic acid metabolism
    SIGNORiO00519

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    2166 6 hits in 785 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    FAAH human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2166
    PharosiO00519 Tchem

    Protein Ontology

    More...
    PROi
    PR:O00519
    RNActiO00519 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000117480 Expressed in right lobe of thyroid gland and 190 other tissues
    ExpressionAtlasiO00519 baseline and differential
    GenevisibleiO00519 HS

    Family and domain databases

    Gene3Di3.90.1300.10, 1 hit
    InterProiView protein in InterPro
    IPR020556 Amidase_CS
    IPR023631 Amidase_dom
    IPR036928 AS_sf
    IPR030560 FAAH
    PANTHERiPTHR45847:SF3 PTHR45847:SF3, 1 hit
    PfamiView protein in Pfam
    PF01425 Amidase, 1 hit
    SUPFAMiSSF75304 SSF75304, 1 hit
    PROSITEiView protein in PROSITE
    PS00571 AMIDASES, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAAH1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00519
    Secondary accession number(s): D3DQ19, Q52M86, Q5TDF8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: March 1, 2005
    Last modified: June 17, 2020
    This is version 169 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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