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Protein

Ladinin-1

Gene

LAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anchoring filament protein which is a component of the basement membrane zone.By similarity

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • structural molecule activity Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Ladinin-1
Short name:
Lad-1
Alternative name(s):
Linear IgA disease antigen
Short name:
LADA
Gene namesi
Name:LAD1
Synonyms:LAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159166.13
HGNCiHGNC:6472 LAD1
MIMi602314 gene
neXtProtiNX_O00515

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3898
OpenTargetsiENSG00000159166
PharmGKBiPA30263

Polymorphism and mutation databases

BioMutaiLAD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843491 – 517Ladinin-1Add BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei78PhosphoserineBy similarity1
Modified residuei121PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei356PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1
Modified residuei424Omega-N-methylarginineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO00515
MaxQBiO00515
PaxDbiO00515
PeptideAtlasiO00515
PRIDEiO00515
ProteomicsDBi47951

PTM databases

iPTMnetiO00515
PhosphoSitePlusiO00515

Expressioni

Gene expression databases

BgeeiENSG00000159166 Expressed in 164 organ(s), highest expression level in esophagus mucosa
CleanExiHS_LAD1
ExpressionAtlasiO00515 baseline and differential
GenevisibleiO00515 HS

Organism-specific databases

HPAiHPA007256
HPA028732

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110095, 4 interactors
IntActiO00515, 5 interactors
MINTiO00515
STRINGi9606.ENSP00000375829

Structurei

3D structure databases

ProteinModelPortaliO00515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati203 – 205SEK 13
Repeati209 – 211SEK 23
Repeati215 – 217SEK 33
Repeati221 – 223SEK 43
Repeati227 – 229SEK 53
Repeati239 – 241SEK 63
Repeati257 – 259SEK 73
Repeati269 – 271SEK 83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 2718 X SEK repeatsAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 35Poly-Arg8

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIRJ Eukaryota
ENOG410YZPA LUCA
GeneTreeiENSGT00390000005256
HOGENOMiHOG000113274
HOVERGENiHBG006240
InParanoidiO00515
PhylomeDBiO00515
TreeFamiTF335896

Family and domain databases

InterProiView protein in InterPro
IPR017404 Ladinin_1
PANTHERiPTHR12392 PTHR12392, 3 hits
PIRSFiPIRSF038144 Ladinin_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O00515-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVSRKDWSA LSSLARQRTL EDEEEQERER RRRHRNLSST TDDEAPRLSQ
60 70 80 90 100
NGDRQASASE RLPSVEEAEV PKPLPPASKD EDEDIQSILR TRQERRQRRQ
110 120 130 140 150
VVEAAQAPIQ ERLEAEEGRN SLSPVQATQK PLVSKKELEI PPRRRLSREQ
160 170 180 190 200
RGPWALEEES LVGREPEERK KGVPEKSPVL EKSSMPKKTA PEKSLVSDKT
210 220 230 240 250
SISEKVLASE KTSLSEKIAV SEKRNSSEKK SVLEKTSVSE KSLAPGMALG
260 270 280 290 300
SGRRLVSEKA SIFEKALASE KSPTADAKPA PKRATASEQP LAQEPPASGG
310 320 330 340 350
SPATTKEQRG RALPGKNLPS LAKQGASDPP TVASRLPPVT LQVKIPSKEE
360 370 380 390 400
EADMSSPTQR TYSSSLKRSS PRTISFRMKP KKENSETTLT RSASMKLPDN
410 420 430 440 450
TVKLGEKLER YHTAIRRSES VKSRGLPCTE LFVAPVGVAS KRHLFEKELA
460 470 480 490 500
GQSRAEPASS RKENLRLSGV VTSRLNLWIS RTQESGDQDP QEAQKASSAT
510
ERTQWGQKSD SSLDAEV
Length:517
Mass (Da):57,131
Last modified:September 23, 2008 - v2
Checksum:i622E81B9412A924B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDI4E9PDI4_HUMAN
Ladinin-1
LAD1
531Annotation score:
H0Y901H0Y901_HUMAN
Ladinin-1
LAD1
192Annotation score:
A0A0J9YYF6A0A0J9YYF6_HUMAN
Ladinin-1
LAD1
183Annotation score:
A0A0J9YVY2A0A0J9YVY2_HUMAN
Ladinin-1
LAD1
178Annotation score:
A0A0J9YW63A0A0J9YW63_HUMAN
Ladinin-1
LAD1
188Annotation score:

Sequence cautioni

The sequence AAD10849 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04653956A → S. Corresponds to variant dbSNP:rs3738281Ensembl.1
Natural variantiVAR_046540155A → P2 PublicationsCorresponds to variant dbSNP:rs1128316Ensembl.1
Natural variantiVAR_046541243L → P. Corresponds to variant dbSNP:rs12088790Ensembl.1
Natural variantiVAR_046542279P → Q. Corresponds to variant dbSNP:rs11805972Ensembl.1
Natural variantiVAR_046543323K → E. Corresponds to variant dbSNP:rs4128458Ensembl.1
Natural variantiVAR_046544503T → S. Corresponds to variant dbSNP:rs2275866Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42408 mRNA Translation: AAB58817.1
U58994 Genomic DNA Translation: AAD10849.1 Sequence problems.
AK313388 mRNA Translation: BAG36186.1
BC009742 mRNA Translation: AAH09742.1
CCDSiCCDS1410.1
RefSeqiNP_005549.2, NM_005558.3
UniGeneiHs.519035

Genome annotation databases

EnsembliENST00000391967; ENSP00000375829; ENSG00000159166
GeneIDi3898
KEGGihsa:3898
UCSCiuc001gwm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42408 mRNA Translation: AAB58817.1
U58994 Genomic DNA Translation: AAD10849.1 Sequence problems.
AK313388 mRNA Translation: BAG36186.1
BC009742 mRNA Translation: AAH09742.1
CCDSiCCDS1410.1
RefSeqiNP_005549.2, NM_005558.3
UniGeneiHs.519035

3D structure databases

ProteinModelPortaliO00515
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110095, 4 interactors
IntActiO00515, 5 interactors
MINTiO00515
STRINGi9606.ENSP00000375829

PTM databases

iPTMnetiO00515
PhosphoSitePlusiO00515

Polymorphism and mutation databases

BioMutaiLAD1

Proteomic databases

EPDiO00515
MaxQBiO00515
PaxDbiO00515
PeptideAtlasiO00515
PRIDEiO00515
ProteomicsDBi47951

Protocols and materials databases

DNASUi3898
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391967; ENSP00000375829; ENSG00000159166
GeneIDi3898
KEGGihsa:3898
UCSCiuc001gwm.4 human

Organism-specific databases

CTDi3898
DisGeNETi3898
EuPathDBiHostDB:ENSG00000159166.13
GeneCardsiLAD1
HGNCiHGNC:6472 LAD1
HPAiHPA007256
HPA028732
MIMi602314 gene
neXtProtiNX_O00515
OpenTargetsiENSG00000159166
PharmGKBiPA30263
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRJ Eukaryota
ENOG410YZPA LUCA
GeneTreeiENSGT00390000005256
HOGENOMiHOG000113274
HOVERGENiHBG006240
InParanoidiO00515
PhylomeDBiO00515
TreeFamiTF335896

Miscellaneous databases

ChiTaRSiLAD1 human
GeneWikiiLAD1
GenomeRNAii3898
PROiPR:O00515
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159166 Expressed in 164 organ(s), highest expression level in esophagus mucosa
CleanExiHS_LAD1
ExpressionAtlasiO00515 baseline and differential
GenevisibleiO00515 HS

Family and domain databases

InterProiView protein in InterPro
IPR017404 Ladinin_1
PANTHERiPTHR12392 PTHR12392, 3 hits
PIRSFiPIRSF038144 Ladinin_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAD1_HUMAN
AccessioniPrimary (citable) accession number: O00515
Secondary accession number(s): O95614, Q96GD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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