UniProtKB - O00507 (USP9Y_HUMAN)
Protein
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y
Gene
USP9Y
Organism
Homo sapiens (Human)
Status
Functioni
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).By similarity
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1568 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1881 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- co-SMAD binding Source: BHF-UCL
- cysteine-type endopeptidase activity Source: GO_Central
- cysteine-type peptidase activity Source: ProtInc
- thiol-dependent ubiquitin-specific protease activity Source: GO_Central
GO - Biological processi
- BMP signaling pathway Source: UniProtKB
- cell migration Source: GO_Central
- protein deubiquitination Source: UniProtKB
- spermatogenesis Source: ProtInc
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | O00507 |
Protein family/group databases
MEROPSi | C19.028 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC:3.4.19.12)Alternative name(s): Deubiquitinating enzyme FAF-Y Fat facets protein-related, Y-linked Ubiquitin thioesterase FAF-Y Ubiquitin-specific protease 9, Y chromosome Ubiquitin-specific-processing protease FAF-Y |
Gene namesi | Name:USP9Y Synonyms:DFFRY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114374.12 |
HGNCi | HGNC:12633, USP9Y |
MIMi | 400005, gene |
neXtProti | NX_O00507 |
Pathology & Biotechi
Involvement in diseasei
USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However, AZFa deletions resulting in complete loss of USP9Y have also been found in normospermic men (PubMed:19246359).1 Publication
Spermatogenic failure Y-linked 2 (SPGFY2)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry. The role of USP9Y in spermatogenesis failure is uncertain (PubMed:19246359). A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However, complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359).2 Publications
Disease descriptionA disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
Related information in OMIMOrganism-specific databases
DisGeNETi | 8287 |
GeneReviewsi | USP9Y |
MalaCardsi | USP9Y |
MIMi | 415000, phenotype |
OpenTargetsi | ENSG00000114374 |
Orphaneti | 1646, Partial chromosome Y deletion |
PharmGKBi | PA37258 |
Miscellaneous databases
Pharosi | O00507, Tbio |
Polymorphism and mutation databases
BioMutai | USP9Y |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080690 | 1 – 2555 | Probable ubiquitin carboxyl-terminal hydrolase FAF-YAdd BLAST | 2555 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 589 | PhosphoserineBy similarity | 1 | |
Modified residuei | 591 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2444 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2541 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 2548 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O00507 |
jPOSTi | O00507 |
MassIVEi | O00507 |
MaxQBi | O00507 |
PaxDbi | O00507 |
PeptideAtlasi | O00507 |
PRIDEi | O00507 |
ProteomicsDBi | 47948 [O00507-1] 47949 [O00507-2] |
PTM databases
CarbonylDBi | O00507 |
iPTMneti | O00507 |
PhosphoSitePlusi | O00507 |
Expressioni
Tissue specificityi
Widely expressed in embryonic and adult tissues.
Gene expression databases
Bgeei | ENSG00000114374, Expressed in small intestine Peyer's patch and 184 other tissues |
ExpressionAtlasi | O00507, baseline and differential |
Genevisiblei | O00507, HS |
Organism-specific databases
HPAi | ENSG00000114374, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SMAD4.
By similarityGO - Molecular functioni
- co-SMAD binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113892, 24 interactors |
IntActi | O00507, 15 interactors |
MINTi | O00507 |
Miscellaneous databases
RNActi | O00507, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1559 – 1958 | USPAdd BLAST | 400 |
Sequence similaritiesi
Belongs to the peptidase C19 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00940000155375 |
HOGENOMi | CLU_000331_1_0_1 |
InParanoidi | O00507 |
OMAi | ERMILPM |
OrthoDBi | 625455at2759 |
PhylomeDBi | O00507 |
TreeFami | TF323966 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR021905, DUF3517 IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF12030, DUF3517, 1 hit PF00443, UCH, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist.
This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform Long (identifier: O00507-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTAITHGSPV GGNDSQGQVL DGQSQHLFQQ NQTSSPDSSN ENSVATPPPE
60 70 80 90 100
EQGQGDAPPQ HEDEEPAFPH TELANLDDMI NRPRWVVPVL PKGELEVLLE
110 120 130 140 150
AAIDLSVKGL DVKSEACQRF FRDGLTISFT KILMDEAVSG WKFEIHRCII
160 170 180 190 200
NNTHRLVELC VAKLSQDWFP LLELLAMALN PHCKFHIYNG TRPCELISSN
210 220 230 240 250
AQLPEDELFA RSSDPRSPKG WLVDLINKFG TLNGFQILHD RFFNGSALNI
260 270 280 290 300
QIIAALIKPF GQCYEFLSQH TLKKYFIPVI EIVPHLLENL TDEELKKEAK
310 320 330 340 350
NEAKNDALSM IIKSLKNLAS RISGQDETIK NLEIFRLKMI LRLLQISSFN
360 370 380 390 400
GKMNALNEIN KVISSVSYYT HRHSNPEEEE WLTAERMAEW IQQNNILSIV
410 420 430 440 450
LQDSLHQPQY VEKLEKILRF VIKEKALTLQ DLDNIWAAQA GKHEAIVKNV
460 470 480 490 500
HDLLAKLAWD FSPGQLDHLF DCFKASWTNA SKKQREKLLE LIRRLAEDDK
510 520 530 540 550
DGVMAHKVLN LLWNLAQSDD VPVDIMDLAL SAHIKILDYS CSQDRDAQKI
560 570 580 590 600
QWIDHFIEEL RTNDKWVIPA LKQIREICSL FGEASQNLSQ TQRSPHIFYR
610 620 630 640 650
HDLINQLQQN HALVTLVAEN LATYMNSIRL YAGDHEDYDP QTVRLGSRYS
660 670 680 690 700
HVQEVQERLN FLRFLLKDGQ LWLCAPQAKQ IWKCLAENAV YLCDREACFK
710 720 730 740 750
WYSKLMGDEP DLDPDINKDF FESNVLQLDP SLLTENGMKC FERFFKAVNC
760 770 780 790 800
RERKLIAKRR SYMMDDLELI GLDYLWRVVI QSSDEIANRA IDLLKEIYTN
810 820 830 840 850
LGPRLKANQV VIHEDFIQSC FDRLKASYDT LCVFDGDKNS INCARQEAIR
860 870 880 890 900
MVRVLTVIKE YINECDSDYH KERMILPMSR AFRGKHLSLI VRFPNQGRQV
910 920 930 940 950
DELDIWSHTN DTIGSVRRCI VNRIKANVAH KKIELFVGGE LIDSEDDRKL
960 970 980 990 1000
IGQLNLKDKS LITAKLTQIN FNMPSSPDSS SDSSTASPGN HRNHYNDGPN
1010 1020 1030 1040 1050
LEVESCLPGV IMSVHPRYIS FLWQVADLGS NLNMPPLRDG ARVLMKLMPP
1060 1070 1080 1090 1100
DRTAVEKLRA VCLDHAKLGE GKLSPPLDSL FFGPSASQVL YLTEVVYALL
1110 1120 1130 1140 1150
MPAGVPLTDG SSDFQVHFLK SGGLPLVLSM LIRNNFLPNT DMETRRGAYL
1160 1170 1180 1190 1200
NALKIAKLLL TAIGYGHVRA VAEACQPVVD GTDPITQINQ VTHDQAVVLQ
1210 1220 1230 1240 1250
SALQSIPNPS SECVLRNESI LLAQEISNEA SRYMPDICVI RAIQKIIWAS
1260 1270 1280 1290 1300
ACGALGLVFS PNEEITKIYQ MTTNGSNKLE VEDEQVCCEA LEVMTLCFAL
1310 1320 1330 1340 1350
LPTALDALSK EKAWQTFIID LLLHCPSKTV RQLAQEQFFL MCTRCCMGHR
1360 1370 1380 1390 1400
PLLFFITLLF TILGSTAREK GKYSGDYFTL LRHLLNYAYN GNINIPNAEV
1410 1420 1430 1440 1450
LLVSEIDWLK RIRDNVKNTG ETGVEEPILE GHLGVTKELL AFQTSEKKYH
1460 1470 1480 1490 1500
FGCEKGGANL IKELIDDFIF PASKVYLQYL RSGELPAEQA IPVCSSPVTI
1510 1520 1530 1540 1550
NAGFELLVAL AIGCVRNLKQ IVDCLTEMYY MGTAITTCEA LTEWEYLPPV
1560 1570 1580 1590 1600
GPRPPKGFVG LKNAGATCYM NSVIQQLYMI PSIRNSILAI EGTGSDLHDD
1610 1620 1630 1640 1650
MFGDEKQDSE SNVDPRDDVF GYPHQFEDKP ALSKTEDRKE YNIGVLRHLQ
1660 1670 1680 1690 1700
VIFGHLAASQ LQYYVPRGFW KQFRLWGEPV NLREQHDALE FFNSLVDSLD
1710 1720 1730 1740 1750
EALKALGHPA ILSKVLGGSF ADQKICQGCP HRYECEESFT TLNVDIRNHQ
1760 1770 1780 1790 1800
NLLDSLEQYI KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPRVLAIQLK
1810 1820 1830 1840 1850
RFDYDWEREC AIKFNDYFEF PRELDMGPYT VAGVANLERD NVNSENELIE
1860 1870 1880 1890 1900
QKEQSDNETA GGTKYRLVGV LVHSGQASGG HYYSYIIQRN GKDDQTDHWY
1910 1920 1930 1940 1950
KFDDGDVTEC KMDDDEEMKN QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA
1960 1970 1980 1990 2000
YILFYEQMDM IDEDDEMIRY ISELTIARPH QIIMSPAIER SVRKQNVKFM
2010 2020 2030 2040 2050
HNRLQYSLEY FQFVKKLLTC NGVYLNPAPG QDYLLPEAEE ITMISIQLAA
2060 2070 2080 2090 2100
RFLFTTGFHT KKIVRGPASD WYDALCVLLR HSKNVRFWFT HNVLFNVSNR
2110 2120 2130 2140 2150
FSEYLLECPS AEVRGAFAKL IVFIAHFSLQ DGSCPSPFAS PGPSSQACDN
2160 2170 2180 2190 2200
LSLSDHLLRA TLNLLRREVS EHGHHLQQYF NLFVMYANLG VAEKTQLLKL
2210 2220 2230 2240 2250
NVPATFMLVS LDEGPGPPIK YQYAELGKLY SVVSQLIRCC NVSSTMQSSI
2260 2270 2280 2290 2300
NGNPPLPNPF GDLNLSQPIM PIQQNVLDIL FVRTSYVKKI IEDCSNSEDT
2310 2320 2330 2340 2350
IKLLRFCSWE NPQFSSTVLS ELLWQVAYSY TYELRPYLDL LFQILLIEDS
2360 2370 2380 2390 2400
WQTHRIHNAL KGIPDDRDGL FDTIQRSKNH YQKRAYQCIK CMVALFSSCP
2410 2420 2430 2440 2450
VAYQILQGNG DLKRKWTWAV EWLGDELERR PYTGNPQYSY NNWSPPVQSN
2460 2470 2480 2490 2500
ETANGYFLER SHSARMTLAK ACELCPEEEP DDQDAPDEHE PSPSEDAPLY
2510 2520 2530 2540 2550
PHSPASQYQQ NNHVHGQPYT GPAAHHLNNP QKTGQRTQEN YEGNEEVSSP
QMKDQ
Isoform Short (identifier: O00507-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
2071-2555: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C2M9 | H7C2M9_HUMAN | Probable ubiquitin carboxyl-termina... | USP9Y | 237 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 206 | D → E in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 206 | D → E in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 282 | I → M in AAC51833 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 524 | D → Y in AAC51833 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 542 | S → A in AAC51833 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 666 | L → V in AAC51833 (PubMed:9381176).Curated | 1 | |
Sequence conflicti | 883 | R → C in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 883 | R → C in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 907 | S → F in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 907 | S → F in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 946 | D → N in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 946 | D → N in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1002 | E → K in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1002 | E → K in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1017 | R → K in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1017 | R → K in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1025 – 1027 | VAD → FAN in CAA73940 (PubMed:9384609).Curated | 3 | |
Sequence conflicti | 1025 – 1027 | VAD → FAN in CAA73941 (PubMed:9384609).Curated | 3 | |
Sequence conflicti | 1038 – 1039 | RD → KN in CAA73940 (PubMed:9384609).Curated | 2 | |
Sequence conflicti | 1038 – 1039 | RD → KN in CAA73941 (PubMed:9384609).Curated | 2 | |
Sequence conflicti | 1067 | K → N in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1067 | K → N in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1258 | V → F in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1258 | V → F in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1733 | Y → F in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1733 | Y → F in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1953 | L → P in CAA73940 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 1953 | L → P in CAA73941 (PubMed:9384609).Curated | 1 | |
Sequence conflicti | 2086 | R → G in AAC51833 (PubMed:9381176).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055350 | 65 | E → D. Corresponds to variant dbSNP:rs7067496Ensembl. | 1 | |
Natural variantiVAR_055351 | 211 | R → C. Corresponds to variant dbSNP:rs2032596Ensembl. | 1 | |
Natural variantiVAR_029328 | 1035 | P → S. Corresponds to variant dbSNP:rs20319Ensembl. | 1 | |
Natural variantiVAR_016194 | 1060 | A → T1 PublicationCorresponds to variant dbSNP:rs20320Ensembl. | 1 | |
Natural variantiVAR_055352 | 1705 | A → S. Corresponds to variant dbSNP:rs2032606Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005272 | 2071 – 2555 | Missing in isoform Short. CuratedAdd BLAST | 485 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000986 mRNA Translation: AAC51833.1 Y13618 mRNA Translation: CAA73940.1 Y13619 mRNA Translation: CAA73941.1 AC002531 Genomic DNA No translation available. |
CCDSi | CCDS14781.1 [O00507-1] |
RefSeqi | NP_004645.2, NM_004654.3 [O00507-1] |
Genome annotation databases
Ensembli | ENST00000338981; ENSP00000342812; ENSG00000114374 [O00507-1] ENST00000651177; ENSP00000498372; ENSG00000114374 [O00507-1] |
GeneIDi | 8287 |
KEGGi | hsa:8287 |
UCSCi | uc004fst.2, human [O00507-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000986 mRNA Translation: AAC51833.1 Y13618 mRNA Translation: CAA73940.1 Y13619 mRNA Translation: CAA73941.1 AC002531 Genomic DNA No translation available. |
CCDSi | CCDS14781.1 [O00507-1] |
RefSeqi | NP_004645.2, NM_004654.3 [O00507-1] |
3D structure databases
SMRi | O00507 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113892, 24 interactors |
IntActi | O00507, 15 interactors |
MINTi | O00507 |
Protein family/group databases
MEROPSi | C19.028 |
PTM databases
CarbonylDBi | O00507 |
iPTMneti | O00507 |
PhosphoSitePlusi | O00507 |
Polymorphism and mutation databases
BioMutai | USP9Y |
Proteomic databases
EPDi | O00507 |
jPOSTi | O00507 |
MassIVEi | O00507 |
MaxQBi | O00507 |
PaxDbi | O00507 |
PeptideAtlasi | O00507 |
PRIDEi | O00507 |
ProteomicsDBi | 47948 [O00507-1] 47949 [O00507-2] |
Protocols and materials databases
Antibodypediai | 21866, 35 antibodies |
Genome annotation databases
Ensembli | ENST00000338981; ENSP00000342812; ENSG00000114374 [O00507-1] ENST00000651177; ENSP00000498372; ENSG00000114374 [O00507-1] |
GeneIDi | 8287 |
KEGGi | hsa:8287 |
UCSCi | uc004fst.2, human [O00507-1] |
Organism-specific databases
CTDi | 8287 |
DisGeNETi | 8287 |
EuPathDBi | HostDB:ENSG00000114374.12 |
GeneCardsi | TTTY15 USP9Y |
GeneReviewsi | USP9Y |
HGNCi | HGNC:12633, USP9Y |
HPAi | ENSG00000114374, Low tissue specificity |
MalaCardsi | USP9Y |
MIMi | 400005, gene 415000, phenotype |
neXtProti | NX_O00507 |
OpenTargetsi | ENSG00000114374 |
Orphaneti | 1646, Partial chromosome Y deletion |
PharmGKBi | PA37258 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155375 |
HOGENOMi | CLU_000331_1_0_1 |
InParanoidi | O00507 |
OMAi | ERMILPM |
OrthoDBi | 625455at2759 |
PhylomeDBi | O00507 |
TreeFami | TF323966 |
Enzyme and pathway databases
PathwayCommonsi | O00507 |
Miscellaneous databases
BioGRID-ORCSi | 8287, 3 hits in 474 CRISPR screens |
ChiTaRSi | USP9Y, human |
GeneWikii | USP9Y |
GenomeRNAii | 8287 |
Pharosi | O00507, Tbio |
PROi | PR:O00507 |
RNActi | O00507, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114374, Expressed in small intestine Peyer's patch and 184 other tissues |
ExpressionAtlasi | O00507, baseline and differential |
Genevisiblei | O00507, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR021905, DUF3517 IPR038765, Papain-like_cys_pep_sf IPR001394, Peptidase_C19_UCH IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF12030, DUF3517, 1 hit PF00443, UCH, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | USP9Y_HUMAN | |
Accessioni | O00507Primary (citable) accession number: O00507 Secondary accession number(s): O14601 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome Y
Human chromosome Y: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries