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Protein

Probable ubiquitin carboxyl-terminal hydrolase FAF-Y

Gene

USP9Y

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1568NucleophilePROSITE-ProRule annotation1
Active sitei1881Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • co-SMAD binding Source: BHF-UCL
  • cysteine-type endopeptidase activity Source: GO_Central
  • cysteine-type peptidase activity Source: ProtInc
  • thiol-dependent ubiquitin-specific protease activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C19.028

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme FAF-Y
Fat facets protein-related, Y-linked
Ubiquitin thioesterase FAF-Y
Ubiquitin-specific protease 9, Y chromosome
Ubiquitin-specific-processing protease FAF-Y
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP9Y
Synonyms:DFFRY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome Y

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000114374.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12633 USP9Y

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
400005 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00507

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

USP9Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. However, AZFa deletions resulting in complete loss of USP9Y have also been found in normospermic men (PubMed:19246359).1 Publication
Spermatogenic failure Y-linked 2 (SPGFY2)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry. The role of USP9Y in spermatogenesis failure is uncertain (PubMed:19246359). A 4-bp deletion in a splice-donor site, causing exon skipping and protein truncation has been observed in non-obstructive azoospermia (PubMed:10581029). However, complete USP9Y deletion has been detected in individuals with no spermatogenic defects (PubMed:19246359).2 Publications
Disease descriptionA disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
See also OMIM:415000

Organism-specific databases

DisGeNET

More...
DisGeNETi
8287

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
USP9Y

MalaCards human disease database

More...
MalaCardsi
USP9Y
MIMi415000 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000114374

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1646 Partial chromosome Y deletion

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37258

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP9Y

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806901 – 2555Probable ubiquitin carboxyl-terminal hydrolase FAF-YAdd BLAST2555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei589PhosphoserineBy similarity1
Modified residuei591PhosphothreonineBy similarity1
Modified residuei2444PhosphoserineBy similarity1
Modified residuei2541PhosphotyrosineBy similarity1
Modified residuei2548PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00507

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00507

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00507

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00507

PeptideAtlas

More...
PeptideAtlasi
O00507

PRoteomics IDEntifications database

More...
PRIDEi
O00507

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47948
47949 [O00507-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
O00507

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00507

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00507

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in embryonic and adult tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114374 Expressed in 174 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

More...
CleanExi
HS_USP10
HS_USP9Y

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00507 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00507 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057687

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113892, 18 interactors

Protein interaction database and analysis system

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IntActi
O00507, 7 interactors

Molecular INTeraction database

More...
MINTi
O00507

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342812

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00507

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00507

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1559 – 1958USPAdd BLAST400

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1866 Eukaryota
COG5077 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155375

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231283

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG073749

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00507

KEGG Orthology (KO)

More...
KOi
K11840

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERMILPM

Database of Orthologous Groups

More...
OrthoDBi
1016440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00507

TreeFam database of animal gene trees

More...
TreeFami
TF323966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: O00507-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAITHGSPV GGNDSQGQVL DGQSQHLFQQ NQTSSPDSSN ENSVATPPPE
60 70 80 90 100
EQGQGDAPPQ HEDEEPAFPH TELANLDDMI NRPRWVVPVL PKGELEVLLE
110 120 130 140 150
AAIDLSVKGL DVKSEACQRF FRDGLTISFT KILMDEAVSG WKFEIHRCII
160 170 180 190 200
NNTHRLVELC VAKLSQDWFP LLELLAMALN PHCKFHIYNG TRPCELISSN
210 220 230 240 250
AQLPEDELFA RSSDPRSPKG WLVDLINKFG TLNGFQILHD RFFNGSALNI
260 270 280 290 300
QIIAALIKPF GQCYEFLSQH TLKKYFIPVI EIVPHLLENL TDEELKKEAK
310 320 330 340 350
NEAKNDALSM IIKSLKNLAS RISGQDETIK NLEIFRLKMI LRLLQISSFN
360 370 380 390 400
GKMNALNEIN KVISSVSYYT HRHSNPEEEE WLTAERMAEW IQQNNILSIV
410 420 430 440 450
LQDSLHQPQY VEKLEKILRF VIKEKALTLQ DLDNIWAAQA GKHEAIVKNV
460 470 480 490 500
HDLLAKLAWD FSPGQLDHLF DCFKASWTNA SKKQREKLLE LIRRLAEDDK
510 520 530 540 550
DGVMAHKVLN LLWNLAQSDD VPVDIMDLAL SAHIKILDYS CSQDRDAQKI
560 570 580 590 600
QWIDHFIEEL RTNDKWVIPA LKQIREICSL FGEASQNLSQ TQRSPHIFYR
610 620 630 640 650
HDLINQLQQN HALVTLVAEN LATYMNSIRL YAGDHEDYDP QTVRLGSRYS
660 670 680 690 700
HVQEVQERLN FLRFLLKDGQ LWLCAPQAKQ IWKCLAENAV YLCDREACFK
710 720 730 740 750
WYSKLMGDEP DLDPDINKDF FESNVLQLDP SLLTENGMKC FERFFKAVNC
760 770 780 790 800
RERKLIAKRR SYMMDDLELI GLDYLWRVVI QSSDEIANRA IDLLKEIYTN
810 820 830 840 850
LGPRLKANQV VIHEDFIQSC FDRLKASYDT LCVFDGDKNS INCARQEAIR
860 870 880 890 900
MVRVLTVIKE YINECDSDYH KERMILPMSR AFRGKHLSLI VRFPNQGRQV
910 920 930 940 950
DELDIWSHTN DTIGSVRRCI VNRIKANVAH KKIELFVGGE LIDSEDDRKL
960 970 980 990 1000
IGQLNLKDKS LITAKLTQIN FNMPSSPDSS SDSSTASPGN HRNHYNDGPN
1010 1020 1030 1040 1050
LEVESCLPGV IMSVHPRYIS FLWQVADLGS NLNMPPLRDG ARVLMKLMPP
1060 1070 1080 1090 1100
DRTAVEKLRA VCLDHAKLGE GKLSPPLDSL FFGPSASQVL YLTEVVYALL
1110 1120 1130 1140 1150
MPAGVPLTDG SSDFQVHFLK SGGLPLVLSM LIRNNFLPNT DMETRRGAYL
1160 1170 1180 1190 1200
NALKIAKLLL TAIGYGHVRA VAEACQPVVD GTDPITQINQ VTHDQAVVLQ
1210 1220 1230 1240 1250
SALQSIPNPS SECVLRNESI LLAQEISNEA SRYMPDICVI RAIQKIIWAS
1260 1270 1280 1290 1300
ACGALGLVFS PNEEITKIYQ MTTNGSNKLE VEDEQVCCEA LEVMTLCFAL
1310 1320 1330 1340 1350
LPTALDALSK EKAWQTFIID LLLHCPSKTV RQLAQEQFFL MCTRCCMGHR
1360 1370 1380 1390 1400
PLLFFITLLF TILGSTAREK GKYSGDYFTL LRHLLNYAYN GNINIPNAEV
1410 1420 1430 1440 1450
LLVSEIDWLK RIRDNVKNTG ETGVEEPILE GHLGVTKELL AFQTSEKKYH
1460 1470 1480 1490 1500
FGCEKGGANL IKELIDDFIF PASKVYLQYL RSGELPAEQA IPVCSSPVTI
1510 1520 1530 1540 1550
NAGFELLVAL AIGCVRNLKQ IVDCLTEMYY MGTAITTCEA LTEWEYLPPV
1560 1570 1580 1590 1600
GPRPPKGFVG LKNAGATCYM NSVIQQLYMI PSIRNSILAI EGTGSDLHDD
1610 1620 1630 1640 1650
MFGDEKQDSE SNVDPRDDVF GYPHQFEDKP ALSKTEDRKE YNIGVLRHLQ
1660 1670 1680 1690 1700
VIFGHLAASQ LQYYVPRGFW KQFRLWGEPV NLREQHDALE FFNSLVDSLD
1710 1720 1730 1740 1750
EALKALGHPA ILSKVLGGSF ADQKICQGCP HRYECEESFT TLNVDIRNHQ
1760 1770 1780 1790 1800
NLLDSLEQYI KGDLLEGANA YHCEKCDKKV DTVKRLLIKK LPRVLAIQLK
1810 1820 1830 1840 1850
RFDYDWEREC AIKFNDYFEF PRELDMGPYT VAGVANLERD NVNSENELIE
1860 1870 1880 1890 1900
QKEQSDNETA GGTKYRLVGV LVHSGQASGG HYYSYIIQRN GKDDQTDHWY
1910 1920 1930 1940 1950
KFDDGDVTEC KMDDDEEMKN QCFGGEYMGE VFDHMMKRMS YRRQKRWWNA
1960 1970 1980 1990 2000
YILFYEQMDM IDEDDEMIRY ISELTIARPH QIIMSPAIER SVRKQNVKFM
2010 2020 2030 2040 2050
HNRLQYSLEY FQFVKKLLTC NGVYLNPAPG QDYLLPEAEE ITMISIQLAA
2060 2070 2080 2090 2100
RFLFTTGFHT KKIVRGPASD WYDALCVLLR HSKNVRFWFT HNVLFNVSNR
2110 2120 2130 2140 2150
FSEYLLECPS AEVRGAFAKL IVFIAHFSLQ DGSCPSPFAS PGPSSQACDN
2160 2170 2180 2190 2200
LSLSDHLLRA TLNLLRREVS EHGHHLQQYF NLFVMYANLG VAEKTQLLKL
2210 2220 2230 2240 2250
NVPATFMLVS LDEGPGPPIK YQYAELGKLY SVVSQLIRCC NVSSTMQSSI
2260 2270 2280 2290 2300
NGNPPLPNPF GDLNLSQPIM PIQQNVLDIL FVRTSYVKKI IEDCSNSEDT
2310 2320 2330 2340 2350
IKLLRFCSWE NPQFSSTVLS ELLWQVAYSY TYELRPYLDL LFQILLIEDS
2360 2370 2380 2390 2400
WQTHRIHNAL KGIPDDRDGL FDTIQRSKNH YQKRAYQCIK CMVALFSSCP
2410 2420 2430 2440 2450
VAYQILQGNG DLKRKWTWAV EWLGDELERR PYTGNPQYSY NNWSPPVQSN
2460 2470 2480 2490 2500
ETANGYFLER SHSARMTLAK ACELCPEEEP DDQDAPDEHE PSPSEDAPLY
2510 2520 2530 2540 2550
PHSPASQYQQ NNHVHGQPYT GPAAHHLNNP QKTGQRTQEN YEGNEEVSSP

QMKDQ
Length:2,555
Mass (Da):291,077
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i421D47D5899F4415
GO
Isoform Short (identifier: O00507-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2071-2555: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
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Length:2,070
Mass (Da):235,723
Checksum:i70219CB0CCD269C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2M9H7C2M9_HUMAN
Probable ubiquitin carboxyl-termina...
USP9Y
237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206D → E in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti206D → E in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti282I → M in AAC51833 (PubMed:9381176).Curated1
Sequence conflicti524D → Y in AAC51833 (PubMed:9381176).Curated1
Sequence conflicti542S → A in AAC51833 (PubMed:9381176).Curated1
Sequence conflicti666L → V in AAC51833 (PubMed:9381176).Curated1
Sequence conflicti883R → C in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti883R → C in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti907S → F in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti907S → F in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti946D → N in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti946D → N in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1002E → K in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1002E → K in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1017R → K in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1017R → K in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1025 – 1027VAD → FAN in CAA73940 (PubMed:9384609).Curated3
Sequence conflicti1025 – 1027VAD → FAN in CAA73941 (PubMed:9384609).Curated3
Sequence conflicti1038 – 1039RD → KN in CAA73940 (PubMed:9384609).Curated2
Sequence conflicti1038 – 1039RD → KN in CAA73941 (PubMed:9384609).Curated2
Sequence conflicti1067K → N in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1067K → N in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1258V → F in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1258V → F in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1733Y → F in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1733Y → F in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti1953L → P in CAA73940 (PubMed:9384609).Curated1
Sequence conflicti1953L → P in CAA73941 (PubMed:9384609).Curated1
Sequence conflicti2086R → G in AAC51833 (PubMed:9381176).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05535065E → D. Corresponds to variant dbSNP:rs7067496Ensembl.1
Natural variantiVAR_055351211R → C. Corresponds to variant dbSNP:rs2032596Ensembl.1
Natural variantiVAR_0293281035P → S. Corresponds to variant dbSNP:rs20319Ensembl.1
Natural variantiVAR_0161941060A → T1 PublicationCorresponds to variant dbSNP:rs20320Ensembl.1
Natural variantiVAR_0553521705A → S. Corresponds to variant dbSNP:rs2032606Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0052722071 – 2555Missing in isoform Short. CuratedAdd BLAST485

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF000986 mRNA Translation: AAC51833.1
Y13618 mRNA Translation: CAA73940.1
Y13619 mRNA Translation: CAA73941.1
AC002531 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14781.1 [O00507-1]

NCBI Reference Sequences

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RefSeqi
NP_004645.2, NM_004654.3 [O00507-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.598540

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338981; ENSP00000342812; ENSG00000114374 [O00507-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8287

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8287

UCSC genome browser

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UCSCi
uc004fst.2 human [O00507-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000986 mRNA Translation: AAC51833.1
Y13618 mRNA Translation: CAA73940.1
Y13619 mRNA Translation: CAA73941.1
AC002531 Genomic DNA No translation available.
CCDSiCCDS14781.1 [O00507-1]
RefSeqiNP_004645.2, NM_004654.3 [O00507-1]
UniGeneiHs.598540

3D structure databases

ProteinModelPortaliO00507
SMRiO00507
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113892, 18 interactors
IntActiO00507, 7 interactors
MINTiO00507
STRINGi9606.ENSP00000342812

Protein family/group databases

MEROPSiC19.028

PTM databases

CarbonylDBiO00507
iPTMnetiO00507
PhosphoSitePlusiO00507

Polymorphism and mutation databases

BioMutaiUSP9Y

Proteomic databases

EPDiO00507
jPOSTiO00507
MaxQBiO00507
PaxDbiO00507
PeptideAtlasiO00507
PRIDEiO00507
ProteomicsDBi47948
47949 [O00507-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338981; ENSP00000342812; ENSG00000114374 [O00507-1]
GeneIDi8287
KEGGihsa:8287
UCSCiuc004fst.2 human [O00507-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8287
DisGeNETi8287
EuPathDBiHostDB:ENSG00000114374.12

GeneCards: human genes, protein and diseases

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GeneCardsi
USP9Y
GeneReviewsiUSP9Y
HGNCiHGNC:12633 USP9Y
HPAiHPA057687
MalaCardsiUSP9Y
MIMi400005 gene
415000 phenotype
neXtProtiNX_O00507
OpenTargetsiENSG00000114374
Orphaneti1646 Partial chromosome Y deletion
PharmGKBiPA37258

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1866 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000155375
HOGENOMiHOG000231283
HOVERGENiHBG073749
InParanoidiO00507
KOiK11840
OMAiERMILPM
OrthoDBi1016440at2759
PhylomeDBiO00507
TreeFamiTF323966

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
USP9Y human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
USP9Y

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8287

Protein Ontology

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PROi
PR:O00507

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114374 Expressed in 174 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_USP10
HS_USP9Y
ExpressionAtlasiO00507 baseline and differential
GenevisibleiO00507 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSP9Y_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00507
Secondary accession number(s): O14601
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: January 16, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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