UniProtKB - O00505 (IMA4_HUMAN)
Importin subunit alpha-4
KPNA3
Functioni
Caution
GO - Molecular functioni
- nuclear import signal receptor activity Source: GO_Central
- nuclear localization sequence binding Source: GO_Central
- protein C-terminus binding Source: Ensembl
GO - Biological processi
- modulation by virus of host cellular process Source: Reactome
- NLS-bearing protein import into nucleus Source: GO_Central
- protein-containing complex assembly Source: ProtInc
- viral entry into host cell Source: UniProtKB-KW
- viral penetration into host nucleus Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Protein transport, Transport, Viral penetration into host nucleus, Virus entry into host cell |
Enzyme and pathway databases
PathwayCommonsi | O00505 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-168276, NS1 Mediated Effects on Host Pathways |
SignaLinki | O00505 |
SIGNORi | O00505 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Importin subunit alpha-4Alternative name(s): Importin alpha Q2 Short name: Qip2 Karyopherin subunit alpha-3 SRP1-gamma |
Gene namesi | Name:KPNA3 Synonyms:QIP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6396, KPNA3 |
MIMi | 601892, gene |
neXtProti | NX_O00505 |
VEuPathDBi | HostDB:ENSG00000102753.9 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear pore Source: ProtInc
- nucleoplasm Source: GO_Central
- nucleus Source: GO_Central
Other locations
- host cell Source: GOC
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3839 |
OpenTargetsi | ENSG00000102753 |
PharmGKBi | PA30187 |
Miscellaneous databases
Pharosi | O00505, Tbio |
Genetic variation databases
BioMutai | KPNA3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000120724 | 2 – 521 | Importin subunit alpha-4Add BLAST | 520 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 484 | PhosphotyrosineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O00505 |
jPOSTi | O00505 |
MassIVEi | O00505 |
MaxQBi | O00505 |
PaxDbi | O00505 |
PeptideAtlasi | O00505 |
PRIDEi | O00505 |
ProteomicsDBi | 47946 |
PTM databases
iPTMneti | O00505 |
PhosphoSitePlusi | O00505 |
SwissPalmi | O00505 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000102753, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | O00505, baseline and differential |
Genevisiblei | O00505, HS |
Organism-specific databases
HPAi | ENSG00000102753, Tissue enriched (skeletal) |
Interactioni
Subunit structurei
Forms a complex with importin subunit beta-1.
Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).
1 Publication(Microbial infection) Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex.
1 Publication(Microbial infection) Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome.
1 PublicationBinary interactionsi
Hide detailsO00505
GO - Molecular functioni
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 110037, 141 interactors |
ComplexPortali | CPX-1057, Importin complex, KPNA3 variant |
CORUMi | O00505 |
DIPi | DIP-27586N |
IntActi | O00505, 105 interactors |
MINTi | O00505 |
STRINGi | 9606.ENSP00000261667 |
Miscellaneous databases
RNActi | O00505, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 58 | IBBPROSITE-ProRule annotationAdd BLAST | 57 | |
Repeati | 66 – 106 | ARM 1; truncatedAdd BLAST | 41 | |
Repeati | 107 – 149 | ARM 2Add BLAST | 43 | |
Repeati | 150 – 194 | ARM 3Add BLAST | 45 | |
Repeati | 195 – 233 | ARM 4Add BLAST | 39 | |
Repeati | 234 – 278 | ARM 5Add BLAST | 45 | |
Repeati | 279 – 318 | ARM 6Add BLAST | 40 | |
Repeati | 319 – 360 | ARM 7Add BLAST | 42 | |
Repeati | 361 – 400 | ARM 8Add BLAST | 40 | |
Repeati | 401 – 443 | ARM 9Add BLAST | 43 | |
Repeati | 447 – 485 | ARM 10; atypicalAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 137 – 229 | NLS binding site (major)By similarityAdd BLAST | 93 | |
Regioni | 306 – 394 | NLS binding site (minor)By similarityAdd BLAST | 89 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 43 – 52 | Nuclear localization signalBy similarity | 10 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0166, Eukaryota |
GeneTreei | ENSGT01020000230547 |
HOGENOMi | CLU_018084_6_1_1 |
InParanoidi | O00505 |
OMAi | XEAVWFL |
OrthoDBi | 1111872at2759 |
PhylomeDBi | O00505 |
TreeFami | TF101178 |
Family and domain databases
Gene3Di | 1.20.5.690, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR032413, Arm_3 IPR000225, Armadillo IPR002652, Importin-a_IBB IPR036975, Importin-a_IBB_sf IPR024931, Importin_alpha |
Pfami | View protein in Pfam PF00514, Arm, 8 hits PF16186, Arm_3, 1 hit PF01749, IBB, 1 hit |
PIRSFi | PIRSF005673, Importin_alpha, 1 hit |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits PS51214, IBB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN
60 70 80 90 100
VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS
110 120 130 140 150
SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT
160 170 180 190 200
QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV
210 220 230 240 250
VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL
260 270 280 290 300
IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV
310 320 330 340 350
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL
360 370 380 390 400
SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR
410 420 430 440 450
KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA
460 470 480 490 500
EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA
510 520
TQGGTYNFDP TANLQTKEFN F
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y4S9 | H0Y4S9_HUMAN | Importin subunit alpha-4 | KPNA3 | 91 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | V → M in CAA73026 (PubMed:9395085).Curated | 1 | |
Sequence conflicti | 103 | R → Q in BAA20378 (PubMed:9154134).Curated | 1 | |
Sequence conflicti | 152 – 153 | AV → DI in AAH35090 (PubMed:15489334).Curated | 2 | |
Sequence conflicti | 154 | V → G in AAB87693 (PubMed:9435235).Curated | 1 | |
Sequence conflicti | 236 | P → T in AAB87693 (PubMed:9435235).Curated | 1 | |
Sequence conflicti | 237 | M → L in CAA73026 (PubMed:9395085).Curated | 1 | |
Sequence conflicti | 256 | I → V in CAA73026 (PubMed:9395085).Curated | 1 | |
Sequence conflicti | 259 | L → V in CAA73026 (PubMed:9395085).Curated | 1 | |
Sequence conflicti | 332 | P → Q in AAH35090 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 411 | N → D in AAH35090 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014454 | 291 | P → S. Corresponds to variant dbSNP:rs1043015Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89618 mRNA Translation: BAA20378.1 Y12394 mRNA Translation: CAA73026.1 AF034756 mRNA Translation: AAB87693.1 AF005263 mRNA Translation: AAQ13404.1 AK290528 mRNA Translation: BAF83217.1 AK291000 mRNA Translation: BAF83689.1 AL136301 Genomic DNA No translation available. AL135901 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08837.1 BC017355 mRNA Translation: AAH17355.1 BC024202 mRNA Translation: AAH24202.1 BC035090 mRNA Translation: AAH35090.1 |
CCDSi | CCDS9421.1 |
RefSeqi | NP_002258.2, NM_002267.3 |
Genome annotation databases
Ensembli | ENST00000261667; ENSP00000261667; ENSG00000102753 |
GeneIDi | 3839 |
KEGGi | hsa:3839 |
UCSCi | uc001vdj.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89618 mRNA Translation: BAA20378.1 Y12394 mRNA Translation: CAA73026.1 AF034756 mRNA Translation: AAB87693.1 AF005263 mRNA Translation: AAQ13404.1 AK290528 mRNA Translation: BAF83217.1 AK291000 mRNA Translation: BAF83689.1 AL136301 Genomic DNA No translation available. AL135901 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08837.1 BC017355 mRNA Translation: AAH17355.1 BC024202 mRNA Translation: AAH24202.1 BC035090 mRNA Translation: AAH35090.1 |
CCDSi | CCDS9421.1 |
RefSeqi | NP_002258.2, NM_002267.3 |
3D structure databases
SMRi | O00505 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110037, 141 interactors |
ComplexPortali | CPX-1057, Importin complex, KPNA3 variant |
CORUMi | O00505 |
DIPi | DIP-27586N |
IntActi | O00505, 105 interactors |
MINTi | O00505 |
STRINGi | 9606.ENSP00000261667 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | O00505 |
PhosphoSitePlusi | O00505 |
SwissPalmi | O00505 |
Genetic variation databases
BioMutai | KPNA3 |
Proteomic databases
EPDi | O00505 |
jPOSTi | O00505 |
MassIVEi | O00505 |
MaxQBi | O00505 |
PaxDbi | O00505 |
PeptideAtlasi | O00505 |
PRIDEi | O00505 |
ProteomicsDBi | 47946 |
Protocols and materials databases
Antibodypediai | 23966, 194 antibodies |
DNASUi | 3839 |
Genome annotation databases
Ensembli | ENST00000261667; ENSP00000261667; ENSG00000102753 |
GeneIDi | 3839 |
KEGGi | hsa:3839 |
UCSCi | uc001vdj.2, human |
Organism-specific databases
CTDi | 3839 |
DisGeNETi | 3839 |
GeneCardsi | KPNA3 |
HGNCi | HGNC:6396, KPNA3 |
HPAi | ENSG00000102753, Tissue enriched (skeletal) |
MIMi | 601892, gene |
neXtProti | NX_O00505 |
OpenTargetsi | ENSG00000102753 |
PharmGKBi | PA30187 |
VEuPathDBi | HostDB:ENSG00000102753.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0166, Eukaryota |
GeneTreei | ENSGT01020000230547 |
HOGENOMi | CLU_018084_6_1_1 |
InParanoidi | O00505 |
OMAi | XEAVWFL |
OrthoDBi | 1111872at2759 |
PhylomeDBi | O00505 |
TreeFami | TF101178 |
Enzyme and pathway databases
PathwayCommonsi | O00505 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-168276, NS1 Mediated Effects on Host Pathways |
SignaLinki | O00505 |
SIGNORi | O00505 |
Miscellaneous databases
BioGRID-ORCSi | 3839, 7 hits in 1000 CRISPR screens |
ChiTaRSi | KPNA3, human |
GeneWikii | KPNA3 |
GenomeRNAii | 3839 |
Pharosi | O00505, Tbio |
PROi | PR:O00505 |
RNActi | O00505, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102753, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | O00505, baseline and differential |
Genevisiblei | O00505, HS |
Family and domain databases
Gene3Di | 1.20.5.690, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR032413, Arm_3 IPR000225, Armadillo IPR002652, Importin-a_IBB IPR036975, Importin-a_IBB_sf IPR024931, Importin_alpha |
Pfami | View protein in Pfam PF00514, Arm, 8 hits PF16186, Arm_3, 1 hit PF01749, IBB, 1 hit |
PIRSFi | PIRSF005673, Importin_alpha, 1 hit |
SMARTi | View protein in SMART SM00185, ARM, 8 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 3 hits PS51214, IBB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IMA4_HUMAN | |
Accessioni | O00505Primary (citable) accession number: O00505 Secondary accession number(s): O00191 Q96AA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2002 | |
Last modified: | April 7, 2021 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families