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UniProtKB - O00505 (IMA4_HUMAN)

Entry version 210 (02 Jun 2021)
Sequence version 2 (23 Jan 2002)
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Protein

Importin subunit alpha-4

Gene

KPNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

Caution

Was termed importin alpha-4.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport, Viral penetration into host nucleus, Virus entry into host cell

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00505

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1169408, ISG15 antiviral mechanism
R-HSA-168276, NS1 Mediated Effects on Host Pathways

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00505

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00505

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin subunit alpha-4
Alternative name(s):
Importin alpha Q2
Short name:
Qip2
Karyopherin subunit alpha-3
SRP1-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KPNA3
Synonyms:QIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6396, KPNA3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601892, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00505

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000102753.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3839

Open Targets

More...OpenTargetsi		ENSG00000102753

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30187

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00505, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523119

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KPNA3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207242 – 521Importin subunit alpha-4Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei484PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00505

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00505

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00505

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00505

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00505

PeptideAtlas

More...PeptideAtlasi		O00505

PRoteomics IDEntifications database

More...PRIDEi		O00505

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47946

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00505

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00505

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O00505

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels in heart and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102753, Expressed in biceps brachii and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00505, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00505, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102753, Tissue enriched (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with importin subunit beta-1.

Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).

1 Publication

(Microbial infection) Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex.

1 Publication

(Microbial infection) Interacts with influenza virus nucleoprotein; this interaction might play a role in nuclear import of viral genome.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O00505
With#Exp.IntAct
AICDA [Q9GZX7]2EBI-358297,EBI-3834328
ANKRD11 [X5D778]3EBI-358297,EBI-17183751
ApoL6 [B3KTP4]3EBI-358297,EBI-10175904
BAHD1 [Q8TBE0]3EBI-358297,EBI-742750
BRD3 - isoform 2 [Q15059-2]3EBI-358297,EBI-13468085
CCDC102B [Q68D86]3EBI-358297,EBI-10171570
CDKN1B [P46527]4EBI-358297,EBI-519280
CYHR1 - isoform 3 [Q6ZMK1-3]3EBI-358297,EBI-11997340
DDX21 [Q9NR30]3EBI-358297,EBI-357942
ERCC3 [P19447]4EBI-358297,EBI-1183307
ESR2 - isoform 3 [Q92731-3]3EBI-358297,EBI-12259414
FAM214B [Q7L5A3]3EBI-358297,EBI-745689
FAM90A1 [Q86YD7]3EBI-358297,EBI-6658203
FTL [P02792]3EBI-358297,EBI-713279
GRB10 - isoform 4 [Q13322-4]3EBI-358297,EBI-12353035
HEXIM2 [Q96MH2]3EBI-358297,EBI-5460660
HNRNPC [P07910]5EBI-358297,EBI-357966
HTT [P42858]11EBI-358297,EBI-466029
KAT5 [Q92993]3EBI-358297,EBI-399080
KPNB1 [Q14974]2EBI-358297,EBI-286758
L3MBTL4 - isoform 2 [Q8NA19-2]3EBI-358297,EBI-12778187
MAPK9 [P45984]3EBI-358297,EBI-713568
MAT2B [Q9NZL9]6EBI-358297,EBI-10317491
MTA1 [Q13330]3EBI-358297,EBI-714236
NMNAT1 [Q9HAN9]3EBI-358297,EBI-3917542
NUP50 [Q9UKX7]6EBI-358297,EBI-2371082
POLR3C [Q9BUI4]3EBI-358297,EBI-5452779
RAD52 [P43351]3EBI-358297,EBI-706448
RPRD1A [Q96P16]3EBI-358297,EBI-1053506
SLC5A11 [Q8WWX8]3EBI-358297,EBI-10277669
SLC5A11 - isoform 3 [Q8WWX8-3]3EBI-358297,EBI-12697471
TEX37 [Q96LM6]3EBI-358297,EBI-743976
TNIP3 [Q96KP6]3EBI-358297,EBI-2509913
TSSC4 [Q9Y5U2]4EBI-358297,EBI-717229
UVSSA [Q2YD98]3EBI-358297,EBI-11153331
ZBTB24 [O43167]3EBI-358297,EBI-744471
ZCCHC10 [Q8TBK6]3EBI-358297,EBI-597063
ZCCHC12 [Q6PEW1]3EBI-358297,EBI-748373
ZNF76 [P36508]3EBI-358297,EBI-7254550
ZNF764 [Q96H86]3EBI-358297,EBI-745775
Q9BRL83EBI-358297,EBI-10297046
ORF4b [K9N643] from Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012).4EBI-358297,EBI-25641007
PB2 [P03427] from Influenza A virus (strain A/Wilson-Smith/1933 H1N1).3EBI-358297,EBI-8430745

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110037, 142 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1057, Importin complex, KPNA3 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O00505

Database of interacting proteins

More...DIPi		DIP-27586N

Protein interaction database and analysis system

More...IntActi		O00505, 105 interactors

Molecular INTeraction database

More...MINTi		O00505

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261667

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00505, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00505

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 58IBBPROSITE-ProRule annotationAdd BLAST57
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati66 – 106ARM 1; truncatedAdd BLAST41
Repeati107 – 149ARM 2Add BLAST43
Repeati150 – 194ARM 3Add BLAST45
Repeati195 – 233ARM 4Add BLAST39
Repeati234 – 278ARM 5Add BLAST45
Repeati279 – 318ARM 6Add BLAST40
Repeati319 – 360ARM 7Add BLAST42
Repeati361 – 400ARM 8Add BLAST40
Repeati401 – 443ARM 9Add BLAST43
Repeati447 – 485ARM 10; atypicalAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni137 – 229NLS binding site (major)By similarityAdd BLAST93
Regioni306 – 394NLS binding site (minor)By similarityAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi43 – 52Nuclear localization signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 29Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).By similarity
The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin alpha family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0166, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018084_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00505

Identification of Orthologs from Complete Genome Data

More...OMAi		XEAVWFL

Database of Orthologous Groups

More...OrthoDBi		1111872at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00505

TreeFam database of animal gene trees

More...TreeFami		TF101178

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.690, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR032413, Arm_3
IPR000225, Armadillo
IPR002652, Importin-a_IBB
IPR036975, Importin-a_IBB_sf
IPR024931, Importin_alpha

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00514, Arm, 8 hits
PF16186, Arm_3, 1 hit
PF01749, IBB, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005673, Importin_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00185, ARM, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50176, ARM_REPEAT, 3 hits
PS51214, IBB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00505-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENPSLENH RIKSFKNKGR DVETMRRHRN EVTVELRKNK RDEHLLKKRN 
        60         70         80         90        100
VPQEESLEDS DVDADFKAQN VTLEAILQNA TSDNPVVQLS AVQAARKLLS 
       110        120        130        140        150
SDRNPPIDDL IKSGILPILV KCLERDDNPS LQFEAAWALT NIASGTSAQT 
       160        170        180        190        200
QAVVQSNAVP LFLRLLRSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV 
       210        220        230        240        250
VKPLLSFISP SIPITFLRNV TWVIVNLCRN KDPPPPMETV QEILPALCVL 
       260        270        280        290        300
IYHTDINILV DTVWALSYLT DGGNEQIQMV IDSGVVPFLV PLLSHQEVKV 
       310        320        330        340        350
QTAALRAVGN IVTGTDEQTQ VVLNCDVLSH FPNLLSHPKE KINKEAVWFL 
       360        370        380        390        400
SNITAGNQQQ VQAVIDAGLI PMIIHQLAKG DFGTQKEAAW AISNLTISGR 
       410        420        430        440        450
KDQVEYLVQQ NVIPPFCNLL SVKDSQVVQV VLDGLKNILI MAGDEASTIA 
       460        470        480        490        500
EIIEECGGLE KIEVLQQHEN EDIYKLAFEI IDQYFSGDDI DEDPCLIPEA 
       510        520 
TQGGTYNFDP TANLQTKEFN F
Length:521
Mass (Da):57,811
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC4FF132C3F346B7F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4S9H0Y4S9_HUMAN
Importin subunit alpha-4
KPNA3
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34V → M in CAA73026 (PubMed:9395085).Curated1
Sequence conflicti103R → Q in BAA20378 (PubMed:9154134).Curated1
Sequence conflicti152 – 153AV → DI in AAH35090 (PubMed:15489334).Curated2
Sequence conflicti154V → G in AAB87693 (PubMed:9435235).Curated1
Sequence conflicti236P → T in AAB87693 (PubMed:9435235).Curated1
Sequence conflicti237M → L in CAA73026 (PubMed:9395085).Curated1
Sequence conflicti256I → V in CAA73026 (PubMed:9395085).Curated1
Sequence conflicti259L → V in CAA73026 (PubMed:9395085).Curated1
Sequence conflicti332P → Q in AAH35090 (PubMed:15489334).Curated1
Sequence conflicti411N → D in AAH35090 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014454291P → S. Corresponds to variant dbSNP:rs1043015Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D89618 mRNA Translation: BAA20378.1
Y12394 mRNA Translation: CAA73026.1
AF034756 mRNA Translation: AAB87693.1
AF005263 mRNA Translation: AAQ13404.1
AK290528 mRNA Translation: BAF83217.1
AK291000 mRNA Translation: BAF83689.1
AL136301 Genomic DNA No translation available.
AL135901 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08837.1
BC017355 mRNA Translation: AAH17355.1
BC024202 mRNA Translation: AAH24202.1
BC035090 mRNA Translation: AAH35090.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9421.1

NCBI Reference Sequences

More...RefSeqi		NP_002258.2, NM_002267.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261667; ENSP00000261667; ENSG00000102753

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3839

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3839

UCSC genome browser

More...UCSCi		uc001vdj.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89618 mRNA Translation: BAA20378.1
Y12394 mRNA Translation: CAA73026.1
AF034756 mRNA Translation: AAB87693.1
AF005263 mRNA Translation: AAQ13404.1
AK290528 mRNA Translation: BAF83217.1
AK291000 mRNA Translation: BAF83689.1
AL136301 Genomic DNA No translation available.
AL135901 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08837.1
BC017355 mRNA Translation: AAH17355.1
BC024202 mRNA Translation: AAH24202.1
BC035090 mRNA Translation: AAH35090.1
CCDSiCCDS9421.1
RefSeqiNP_002258.2, NM_002267.3

3D structure databases

SMRiO00505
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110037, 142 interactors
ComplexPortaliCPX-1057, Importin complex, KPNA3 variant
CORUMiO00505
DIPiDIP-27586N
IntActiO00505, 105 interactors
MINTiO00505
STRINGi9606.ENSP00000261667

Chemistry databases

ChEMBLiCHEMBL4523119

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiO00505
PhosphoSitePlusiO00505
SwissPalmiO00505

Genetic variation databases

BioMutaiKPNA3

Proteomic databases

EPDiO00505
jPOSTiO00505
MassIVEiO00505
MaxQBiO00505
PaxDbiO00505
PeptideAtlasiO00505
PRIDEiO00505
ProteomicsDBi47946

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23966, 196 antibodies

The DNASU plasmid repository

More...DNASUi		3839

Genome annotation databases

EnsembliENST00000261667; ENSP00000261667; ENSG00000102753
GeneIDi3839
KEGGihsa:3839
UCSCiuc001vdj.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3839
DisGeNETi3839

GeneCards: human genes, protein and diseases

More...GeneCardsi		KPNA3
HGNCiHGNC:6396, KPNA3
HPAiENSG00000102753, Tissue enriched (skeletal)
MIMi601892, gene
neXtProtiNX_O00505
OpenTargetsiENSG00000102753
PharmGKBiPA30187
VEuPathDBiHostDB:ENSG00000102753.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0166, Eukaryota
GeneTreeiENSGT01030000234650
HOGENOMiCLU_018084_6_1_1
InParanoidiO00505
OMAiXEAVWFL
OrthoDBi1111872at2759
PhylomeDBiO00505
TreeFamiTF101178

Enzyme and pathway databases

PathwayCommonsiO00505
ReactomeiR-HSA-1169408, ISG15 antiviral mechanism
R-HSA-168276, NS1 Mediated Effects on Host Pathways
SignaLinkiO00505
SIGNORiO00505

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3839, 7 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KPNA3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KPNA3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3839
PharosiO00505, Tbio

Protein Ontology

More...PROi		PR:O00505
RNActiO00505, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102753, Expressed in biceps brachii and 250 other tissues
ExpressionAtlasiO00505, baseline and differential
GenevisibleiO00505, HS

Family and domain databases

Gene3Di1.20.5.690, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR032413, Arm_3
IPR000225, Armadillo
IPR002652, Importin-a_IBB
IPR036975, Importin-a_IBB_sf
IPR024931, Importin_alpha
PfamiView protein in Pfam
PF00514, Arm, 8 hits
PF16186, Arm_3, 1 hit
PF01749, IBB, 1 hit
PIRSFiPIRSF005673, Importin_alpha, 1 hit
SMARTiView protein in SMART
SM00185, ARM, 8 hits
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176, ARM_REPEAT, 3 hits
PS51214, IBB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIMA4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00505
Secondary accession number(s): O00191
, O43195, Q5JVM9, Q8IYQ9, Q96AA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2002
Last modified: June 2, 2021
This is version 210 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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