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Protein

Myc box-dependent-interacting protein 1

Gene

BIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: WormBase
  • chaperone binding Source: ARUK-UCL
  • clathrin binding Source: ARUK-UCL
  • identical protein binding Source: IntAct
  • phospholipid binding Source: GO_Central
  • protease binding Source: ARUK-UCL
  • RNA polymerase binding Source: AgBase
  • tau protein binding Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Endocytosis, Host-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8856828 Clathrin-mediated endocytosis

SIGNOR Signaling Network Open Resource

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SIGNORi
O00499

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
O00499 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myc box-dependent-interacting protein 1
Alternative name(s):
Amphiphysin II
Amphiphysin-like protein
Box-dependent myc-interacting protein 1
Bridging integrator 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BIN1
Synonyms:AMPHL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136717.14

Human Gene Nomenclature Database

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HGNCi
HGNC:1052 BIN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601248 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00499

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy, centronuclear, 2 (CNM2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
See also OMIM:255200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03742535K → N in CNM2. 2 PublicationsCorresponds to variant dbSNP:rs121909273EnsemblClinVar.1
Natural variantiVAR_081082145R → C in CNM2. 1 Publication1
Natural variantiVAR_037426151D → N in CNM2; results in severely decreased membrane tubulation. 2 PublicationsCorresponds to variant dbSNP:rs121909274EnsemblClinVar.1
Natural variantiVAR_081083154R → Q in CNM2; results in severely decreased membrane tubulation. 2 Publications1
Natural variantiVAR_081084234R → C in CNM2. 1 Publication1
Natural variantiVAR_081085575 – 593Missing in CNM2; decreased interaction with DNM2. 1 PublicationAdd BLAST19
BIN1 mutations have been found in families segregating autosomal dominant centronuclear myopathy. Patients show adult-onset, mildly progressive muscle weakness affecting selected proximal muscles and all distal muscles of the lower limbs.1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
274

MalaCards human disease database

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MalaCardsi
BIN1
MIMi255200 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000136717

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
169189 Autosomal dominant centronuclear myopathy
169186 Autosomal recessive centronuclear myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25355

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BIN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001929512 – 593Myc box-dependent-interacting protein 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei307PhosphothreonineCombined sources1
Modified residuei323PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by protein kinase C.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O00499

MaxQB - The MaxQuant DataBase

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MaxQBi
O00499

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O00499

PeptideAtlas

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PeptideAtlasi
O00499

PRoteomics IDEntifications database

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PRIDEi
O00499

ProteomicsDB human proteome resource

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ProteomicsDBi
47934
47935 [O00499-10]
47936 [O00499-11]
47937 [O00499-2]
47938 [O00499-3]
47939 [O00499-4]
47940 [O00499-5]
47941 [O00499-6]
47942 [O00499-7]
47943 [O00499-8]
47944 [O00499-9]

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
O00499

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O00499

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O00499

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136717 Expressed in 227 organ(s), highest expression level in gastrocnemius

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00499 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00499 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001945
HPA003894
HPA005437

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with AMPH (By similarity). Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with DNM1. Interacts with SYNJ1 (By similarity). Interacts (via SH3 domain) with DNM2 (PubMed:17676042). Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC (PubMed:9603201). Interacts with AP2A2. Interacts with AP2B1 (By similarity). Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2 (By similarity). Interacts with BIN2 (PubMed:10903846). Interacts with SNX4 (PubMed:12668730). Interacts (via BAR domain) with BACE1 (PubMed:27179792). Binds (via BAR domain) F-actin (PubMed:28893863).By similarity6 Publications
(Microbial infection) Interacts (SH3 domain) with HCV NS5A.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106771, 71 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-514 c-MYC-BIN1 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O00499

Database of interacting proteins

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DIPi
DIP-41480N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O00499

Protein interaction database and analysis system

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IntActi
O00499, 24 interactors

Molecular INTeraction database

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MINTi
O00499

STRING: functional protein association networks

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STRINGi
9606.ENSP00000316779

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O00499

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00499

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O00499

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 276BARPROSITE-ProRule annotationAdd BLAST248
Domaini520 – 593SH3PROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 122Interaction with BIN21 PublicationAdd BLAST121
Regioni378 – 421Clathrin-bindingAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili15 – 42Sequence analysisAdd BLAST28
Coiled coili193 – 267Sequence analysisAdd BLAST75

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ITR4 Eukaryota
ENOG410XQXT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153586

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004224

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00499

KEGG Orthology (KO)

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KOi
K12562

Identification of Orthologs from Complete Genome Data

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OMAi
DRIYEVP

Database of Orthologous Groups

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OrthoDBi
EOG091G07IE

Database for complete collections of gene phylogenies

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PhylomeDBi
O00499

TreeFam database of animal gene trees

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TreeFami
TF313542

Family and domain databases

Conserved Domains Database

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CDDi
cd12139 SH3_Bin1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1270.60, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR035471 Amphiphysin-2_SH3
IPR003023 Amphiphysin_2
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR45479 PTHR45479, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01251 AMPHIPHYSIN
PR01253 AMPHIPHYSIN2
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform IIA (identifier: O00499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN
60 70 80 90 100
FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA
110 120 130 140 150
NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY
160 170 180 190 200
DSARHHYESL QTAKKKDEAK IAKPVSLLEK AAPQWCQGKL QAHLVAQTNL
210 220 230 240 250
LRNQAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE
260 270 280 290 300
NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP
310 320 330 340 350
DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQLRKGPP VPPPPKHTPS
360 370 380 390 400
KEVKQEQILS LFEDTFVPEI SVTTPSQFEA PGPFSEQASL LDLDFDPLPP
410 420 430 440 450
VTSPVKAPTP SGQSIPWDLW EPTESPAGSL PSGEPSAAEG TFAVSWPSQT
460 470 480 490 500
AEPGPAQPAE ASEVAGGTQP AAGAQEPGET AASEAASSSL PAVVVETFPA
510 520 530 540 550
TVNGTVEGGS GAGRLDLPPG FMFKVQAQHD YTATDTDELQ LKAGDVVLVI
560 570 580 590
PFQNPEEQDE GWLMGVKESD WNQHKELEKC RGVFPENFTE RVP
Length:593
Mass (Da):64,699
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FF1956F0C7E3B50
GO
Isoform IIB (identifier: O00499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     378-421: Missing.

Show »
Length:518
Mass (Da):56,499
Checksum:i9BEF82FC2C28C845
GO
Isoform IIC1 (identifier: O00499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-421: Missing.

Show »
Length:506
Mass (Da):55,175
Checksum:iF3EA5A2EF666CE59
GO
Isoform IIC2 (identifier: O00499-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-421: Missing.

Show »
Length:475
Mass (Da):51,737
Checksum:i876B8A866F96BA14
GO
Isoform IID (identifier: O00499-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-377: Missing.

Show »
Length:550
Mass (Da):59,937
Checksum:i99FC3F5471E1926B
GO
Isoform II2 (identifier: O00499-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     378-457: Missing.

Show »
Length:482
Mass (Da):53,020
Checksum:iDF00A44348B6F1BF
GO
Isoform II3 (identifier: O00499-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-457: Missing.

Show »
Length:439
Mass (Da):48,258
Checksum:i350E429F13AF49C6
GO
Isoform BIN1 (identifier: O00499-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     335-457: Missing.

Show »
Length:454
Mass (Da):50,185
Checksum:i7E2ADD14E9D56D9E
GO
Isoform BIN1-10-13 (identifier: O00499-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     335-487: Missing.

Show »
Length:409
Mass (Da):45,563
Checksum:i08C5B23D79252350
GO
Isoform BIN1-13 (identifier: O00499-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     335-487: Missing.

Show »
Length:424
Mass (Da):47,491
Checksum:i1C86B9D4C8C204C6
GO
Isoform BIN1+12A (identifier: O00499-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-204: Missing.
     285-285: P → PRKKSKLFSRLRRKKN
     378-457: Missing.

Show »
Length:497
Mass (Da):54,948
Checksum:i55E3246DD05172AA
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC23441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti474A → P in AAB63263 (PubMed:9182667).Curated1
Sequence conflicti481A → S in AAC24126 (PubMed:15815621).Curated1
Sequence conflicti481A → S in AAC23750 (PubMed:15815621).Curated1
Sequence conflicti481A → S in AAC23751 (PubMed:15815621).Curated1
Sequence conflicti510S → C in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti510S → C in AAC23441 (PubMed:9395479).Curated1
Sequence conflicti528Q → H in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti528Q → H in AAC23441 (PubMed:9395479).Curated1
Sequence conflicti576E → K in AAC23440 (PubMed:9395479).Curated1
Sequence conflicti576E → K in AAC23441 (PubMed:9395479).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08108021Missing Probable disease-associated mutation found in a sporadic case of centronulear myopathy; does not induce membrane tubulation in cultured cells. 1 Publication1
Natural variantiVAR_08108124R → C Probable disease-associated mutation found in a sporadic case of centronulear myopathy; does not induce membrane tubulation in cultured cells. 1 Publication1
Natural variantiVAR_03742535K → N in CNM2. 2 PublicationsCorresponds to variant dbSNP:rs121909273EnsemblClinVar.1
Natural variantiVAR_081082145R → C in CNM2. 1 Publication1
Natural variantiVAR_037426151D → N in CNM2; results in severely decreased membrane tubulation. 2 PublicationsCorresponds to variant dbSNP:rs121909274EnsemblClinVar.1
Natural variantiVAR_081083154R → Q in CNM2; results in severely decreased membrane tubulation. 2 Publications1
Natural variantiVAR_081084234R → C in CNM2. 1 Publication1
Natural variantiVAR_081085575 – 593Missing in CNM2; decreased interaction with DNM2. 1 PublicationAdd BLAST19

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000246174 – 204Missing in isoform IIB, isoform IIC2, isoform II2, isoform II3, isoform BIN1, isoform BIN1+12A, isoform BIN1-10-13 and isoform BIN1-13. 5 PublicationsAdd BLAST31
Alternative sequenceiVSP_000247285P → PRKKSKLFSRLRRKKN in isoform BIN1, isoform BIN1+12A and isoform BIN1-13. 3 Publications1
Alternative sequenceiVSP_000251335 – 487Missing in isoform BIN1-10-13 and isoform BIN1-13. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_000250335 – 457Missing in isoform II3 and isoform BIN1. 4 PublicationsAdd BLAST123
Alternative sequenceiVSP_000249335 – 421Missing in isoform IIC1 and isoform IIC2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_000248335 – 377Missing in isoform IID. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_000253378 – 457Missing in isoform II2 and isoform BIN1+12A. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_000252378 – 421Missing in isoform IIB. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF004015 mRNA Translation: AAC51345.1
AF070576 mRNA Translation: AAC28646.1
AF001383 mRNA Translation: AAB61363.1
U68485 mRNA Translation: AAC17461.1
AF043898 mRNA Translation: AAC39710.1
AF043899 mRNA Translation: AAC39711.1
AF043900 mRNA Translation: AAC39712.1
AF043901 mRNA Translation: AAC39713.1
U87558 mRNA Translation: AAB63263.1
AF068914 mRNA Translation: AAC24126.1
AF068915 mRNA Translation: AAC24127.1
AF068916 mRNA Translation: AAC24128.1
AF068917 mRNA Translation: AAC23750.1
AF068918 mRNA Translation: AAC23751.1
U84004
, U83999, U84001, U84002, U84003 Genomic DNA Translation: AAC23440.1
U84004
, U83999, U84001, U84002, U84003 Genomic DNA Translation: AAC23441.1 Different initiation.
AL713697 mRNA Translation: CAD28496.1
AC012508 Genomic DNA Translation: AAY24328.1
CH471103 Genomic DNA Translation: EAW95302.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2137.1 [O00499-8]
CCDS2138.1 [O00499-1]
CCDS2139.1 [O00499-5]
CCDS2140.1 [O00499-3]
CCDS2141.1 [O00499-11]
CCDS2142.1 [O00499-2]
CCDS2143.1 [O00499-9]
CCDS42743.1 [O00499-4]
CCDS42744.1 [O00499-6]
CCDS46403.1 [O00499-7]
CCDS82508.1 [O00499-10]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5593

NCBI Reference Sequences

More...
RefSeqi
NP_001307561.1, NM_001320632.1 [O00499-10]
NP_001307562.1, NM_001320633.1
NP_001307569.1, NM_001320640.1
NP_001307570.1, NM_001320641.1
NP_001307571.1, NM_001320642.1
NP_004296.1, NM_004305.3 [O00499-8]
NP_647593.1, NM_139343.2 [O00499-1]
NP_647594.1, NM_139344.2 [O00499-5]
NP_647595.1, NM_139345.2 [O00499-3]
NP_647596.1, NM_139346.2 [O00499-11]
NP_647597.1, NM_139347.2 [O00499-2]
NP_647598.1, NM_139348.2 [O00499-6]
NP_647599.1, NM_139349.2 [O00499-4]
NP_647600.1, NM_139350.2 [O00499-7]
NP_647601.1, NM_139351.2 [O00499-9]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.193163

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259238; ENSP00000259238; ENSG00000136717 [O00499-11]
ENST00000316724; ENSP00000316779; ENSG00000136717 [O00499-1]
ENST00000346226; ENSP00000315411; ENSG00000136717 [O00499-2]
ENST00000348750; ENSP00000259237; ENSG00000136717 [O00499-9]
ENST00000351659; ENSP00000315388; ENSG00000136717 [O00499-3]
ENST00000352848; ENSP00000315284; ENSG00000136717 [O00499-8]
ENST00000357970; ENSP00000350654; ENSG00000136717 [O00499-5]
ENST00000376113; ENSP00000365281; ENSG00000136717 [O00499-10]
ENST00000393040; ENSP00000376760; ENSG00000136717 [O00499-6]
ENST00000393041; ENSP00000376761; ENSG00000136717 [O00499-4]
ENST00000409400; ENSP00000386797; ENSG00000136717 [O00499-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:274

UCSC genome browser

More...
UCSCi
uc002tns.3 human [O00499-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004015 mRNA Translation: AAC51345.1
AF070576 mRNA Translation: AAC28646.1
AF001383 mRNA Translation: AAB61363.1
U68485 mRNA Translation: AAC17461.1
AF043898 mRNA Translation: AAC39710.1
AF043899 mRNA Translation: AAC39711.1
AF043900 mRNA Translation: AAC39712.1
AF043901 mRNA Translation: AAC39713.1
U87558 mRNA Translation: AAB63263.1
AF068914 mRNA Translation: AAC24126.1
AF068915 mRNA Translation: AAC24127.1
AF068916 mRNA Translation: AAC24128.1
AF068917 mRNA Translation: AAC23750.1
AF068918 mRNA Translation: AAC23751.1
U84004
, U83999, U84001, U84002, U84003 Genomic DNA Translation: AAC23440.1
U84004
, U83999, U84001, U84002, U84003 Genomic DNA Translation: AAC23441.1 Different initiation.
AL713697 mRNA Translation: CAD28496.1
AC012508 Genomic DNA Translation: AAY24328.1
CH471103 Genomic DNA Translation: EAW95302.1
CCDSiCCDS2137.1 [O00499-8]
CCDS2138.1 [O00499-1]
CCDS2139.1 [O00499-5]
CCDS2140.1 [O00499-3]
CCDS2141.1 [O00499-11]
CCDS2142.1 [O00499-2]
CCDS2143.1 [O00499-9]
CCDS42743.1 [O00499-4]
CCDS42744.1 [O00499-6]
CCDS46403.1 [O00499-7]
CCDS82508.1 [O00499-10]
PIRiJC5593
RefSeqiNP_001307561.1, NM_001320632.1 [O00499-10]
NP_001307562.1, NM_001320633.1
NP_001307569.1, NM_001320640.1
NP_001307570.1, NM_001320641.1
NP_001307571.1, NM_001320642.1
NP_004296.1, NM_004305.3 [O00499-8]
NP_647593.1, NM_139343.2 [O00499-1]
NP_647594.1, NM_139344.2 [O00499-5]
NP_647595.1, NM_139345.2 [O00499-3]
NP_647596.1, NM_139346.2 [O00499-11]
NP_647597.1, NM_139347.2 [O00499-2]
NP_647598.1, NM_139348.2 [O00499-6]
NP_647599.1, NM_139349.2 [O00499-4]
NP_647600.1, NM_139350.2 [O00499-7]
NP_647601.1, NM_139351.2 [O00499-9]
UniGeneiHs.193163

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MUZNMR-A513-593[»]
1MV0NMR-B513-593[»]
1MV3NMR-A301-593[»]
2FICX-ray1.99A/B1-272[»]
2RMYNMR-A1-33[»]
2RNDNMR-A1-33[»]
5I22NMR-A513-593[»]
ProteinModelPortaliO00499
SMRiO00499
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106771, 71 interactors
ComplexPortaliCPX-514 c-MYC-BIN1 complex
CORUMiO00499
DIPiDIP-41480N
ELMiO00499
IntActiO00499, 24 interactors
MINTiO00499
STRINGi9606.ENSP00000316779

Protein family/group databases

MoonDBiO00499 Predicted

PTM databases

iPTMnetiO00499
PhosphoSitePlusiO00499

Polymorphism and mutation databases

BioMutaiBIN1

2D gel databases

UCD-2DPAGEiO00499

Proteomic databases

EPDiO00499
MaxQBiO00499
PaxDbiO00499
PeptideAtlasiO00499
PRIDEiO00499
ProteomicsDBi47934
47935 [O00499-10]
47936 [O00499-11]
47937 [O00499-2]
47938 [O00499-3]
47939 [O00499-4]
47940 [O00499-5]
47941 [O00499-6]
47942 [O00499-7]
47943 [O00499-8]
47944 [O00499-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
274
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259238; ENSP00000259238; ENSG00000136717 [O00499-11]
ENST00000316724; ENSP00000316779; ENSG00000136717 [O00499-1]
ENST00000346226; ENSP00000315411; ENSG00000136717 [O00499-2]
ENST00000348750; ENSP00000259237; ENSG00000136717 [O00499-9]
ENST00000351659; ENSP00000315388; ENSG00000136717 [O00499-3]
ENST00000352848; ENSP00000315284; ENSG00000136717 [O00499-8]
ENST00000357970; ENSP00000350654; ENSG00000136717 [O00499-5]
ENST00000376113; ENSP00000365281; ENSG00000136717 [O00499-10]
ENST00000393040; ENSP00000376760; ENSG00000136717 [O00499-6]
ENST00000393041; ENSP00000376761; ENSG00000136717 [O00499-4]
ENST00000409400; ENSP00000386797; ENSG00000136717 [O00499-7]
GeneIDi274
KEGGihsa:274
UCSCiuc002tns.3 human [O00499-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
274
DisGeNETi274
EuPathDBiHostDB:ENSG00000136717.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BIN1
HGNCiHGNC:1052 BIN1
HPAiCAB001945
HPA003894
HPA005437
MalaCardsiBIN1
MIMi255200 phenotype
601248 gene
neXtProtiNX_O00499
OpenTargetsiENSG00000136717
Orphaneti169189 Autosomal dominant centronuclear myopathy
169186 Autosomal recessive centronuclear myopathy
PharmGKBiPA25355

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITR4 Eukaryota
ENOG410XQXT LUCA
GeneTreeiENSGT00940000153586
HOVERGENiHBG004224
InParanoidiO00499
KOiK12562
OMAiDRIYEVP
OrthoDBiEOG091G07IE
PhylomeDBiO00499
TreeFamiTF313542

Enzyme and pathway databases

ReactomeiR-HSA-8856828 Clathrin-mediated endocytosis
SIGNORiO00499

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BIN1 human
EvolutionaryTraceiO00499

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
274

Protein Ontology

More...
PROi
PR:O00499

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136717 Expressed in 227 organ(s), highest expression level in gastrocnemius
ExpressionAtlasiO00499 baseline and differential
GenevisibleiO00499 HS

Family and domain databases

CDDicd12139 SH3_Bin1, 1 hit
Gene3Di1.20.1270.60, 2 hits
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR035471 Amphiphysin-2_SH3
IPR003023 Amphiphysin_2
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR45479 PTHR45479, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR01251 AMPHIPHYSIN
PR01253 AMPHIPHYSIN2
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00499
Secondary accession number(s): O00297
, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q659B7, Q92944, Q99688
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: July 1, 1997
Last modified: December 5, 2018
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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