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Entry version 192 (13 Feb 2019)
Sequence version 2 (30 May 2000)
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Protein

Nuclear receptor subfamily 5 group A member 2

Gene

NR5A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei516Lipid headgroup1
Binding sitei520Lipid headgroup1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi83 – 154Nuclear receptorPROSITE-ProRule annotationAdd BLAST72
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri86 – 106NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri122 – 146NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O00482

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00482

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001542

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor subfamily 5 group A member 2
Alternative name(s):
Alpha-1-fetoprotein transcription factor
B1-binding factor
Short name:
hB1F
CYP7A promoter-binding factor
Hepatocytic transcription factor
Liver receptor homolog 1
Short name:
LRH-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NR5A2
Synonyms:B1F, CPF, FTF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116833.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7984 NR5A2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604453 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00482

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi96Y → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-168 and A-172. 1 Publication1
Mutagenesisi168F → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-96 and A-172. 1 Publication1
Mutagenesisi169 – 170GP → VA: Reduced DNA binding. Loss of transactivation. 1 Publication2
Mutagenesisi172Y → A: Slightly reduced DNA binding. Strongly reduced transactivation; when associated with A-96 and A-168. 1 Publication1
Mutagenesisi270K → R: Impaired ability to act as an anti-inflammatory role during the hepatic acute phase response. 1 Publication1
Mutagenesisi342F → W: Reduced phospholipid binding. Strongly reduced transactivation; when associated with W-416. 1 Publication1
Mutagenesisi416I → W: Reduced phospholipid binding. Strongly reduced transactivation; when associated with W-342. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2494

Open Targets

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OpenTargetsi
ENSG00000116833

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31765

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3544

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NR5A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000537351 – 541Nuclear receptor subfamily 5 group A member 2Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00482

PeptideAtlas

More...
PeptideAtlasi
O00482

PRoteomics IDEntifications database

More...
PRIDEi
O00482

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47928
47929 [O00482-2]
47930 [O00482-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00482

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00482

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116833 Expressed in 110 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00482 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00482 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005455
HPA017067

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2 (PubMed:15707893, PubMed:15723037, PubMed:15897460, PubMed:16289203). Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108772, 21 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O00482

Database of interacting proteins

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DIPi
DIP-37952N

Protein interaction database and analysis system

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IntActi
O00482, 10 interactors

Molecular INTeraction database

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MINTi
O00482

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356331

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00482

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YOKX-ray2.50A300-541[»]
1YUCX-ray1.90A/B290-541[»]
1ZDUX-ray2.50A297-541[»]
2A66X-ray2.20A79-187[»]
3PLZX-ray1.75A/B300-541[»]
3TX7X-ray2.76B191-541[»]
4DORX-ray1.90A/B290-541[»]
4DOSX-ray2.00A299-538[»]
4IS8X-ray2.78A/B300-538[»]
4ONIX-ray1.80A/B291-541[»]
4PLDX-ray1.75A301-541[»]
4PLEX-ray1.75A/C/E/G301-541[»]
4RWVX-ray1.86A294-541[»]
5L0MX-ray2.20A79-187[»]
5L11X-ray1.85A299-541[»]
5SYZX-ray1.93A297-538[»]
5UNJX-ray1.96A299-541[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O00482

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00482

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O00482

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini300 – 539NR LBDPROSITE-ProRule annotationAdd BLAST240

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni419 – 424Lipid binding6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi155 – 184FTZ-F1 boxAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri86 – 106NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri122 – 146NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4218 Eukaryota
ENOG410YWC2 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153391

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000063718

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106677

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00482

KEGG Orthology (KO)

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KOi
K08027

Identification of Orthologs from Complete Genome Data

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OMAi
AMTQVIQ

Database of Orthologous Groups

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OrthoDBi
619653at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O00482

TreeFam database of animal gene trees

More...
TreeFami
TF350737

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

The PANTHER Classification System

More...
PANTHERi
PTHR24086 PTHR24086, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002530 Nuc_orph_FTZ-F1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: O00482-1) [UniParc]FASTAAdd to basket
Also known as: B1F2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL
60 70 80 90 100
GLARSHGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL
110 120 130 140 150
LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG
160 170 180 190 200
MKLEAVRADR MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMSQVI
210 220 230 240 250
QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF VTSPISMTMP
260 270 280 290 300
PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS
310 320 330 340 350
IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD
360 370 380 390 400
QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE
410 420 430 440 450
GSIFLVTGQQ VDYSIIASQA GATLNNLMSH AQELVAKLRS LQFDQREFVC
460 470 480 490 500
LKFLVLFSLD VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTEKFGQLL
510 520 530 540
LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR A
Length:541
Mass (Da):61,331
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B07170C075490FE
GO
Isoform 1 (identifier: O00482-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-67: Missing.

Show »
Length:495
Mass (Da):56,459
Checksum:iE73E60DCE9880855
GO
Isoform 3 (identifier: O00482-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-370: Missing.

Note: Does not induce CYP7A promoter activity.
Show »
Length:369
Mass (Da):42,102
Checksum:i1357C2AAEFB4E46B
GO
Isoform 4 (identifier: O00482-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):53,657
Checksum:i49F21C2F09CF0AB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y328H0Y328_HUMAN
Nuclear receptor subfamily 5 group ...
NR5A2
377Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQH2E9PQH2_HUMAN
Nuclear receptor subfamily 5 group ...
NR5A2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7S7H0Y7S7_HUMAN
Nuclear receptor subfamily 5 group ...
NR5A2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti250 – 251PP → L in AAD03155 (PubMed:9858833).Curated2
Sequence conflicti353L → V in AAD03155 (PubMed:9858833).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0545481 – 72Missing in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_00371622 – 67Missing in isoform 1. 3 PublicationsAdd BLAST46
Alternative sequenceiVSP_003717199 – 370Missing in isoform 3. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U80251 mRNA Translation: AAC78727.1
AF146343 mRNA Translation: AAD37378.1
AF124247 mRNA Translation: AAD26565.1
AF190464 Genomic DNA Translation: AAG17124.1
AF190464 Genomic DNA Translation: AAG17125.1
AK304365 mRNA Translation: BAG65205.1
AK316513 mRNA Translation: BAH14884.1
AC096633 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91306.1
BC118571 mRNA Translation: AAI18572.1
BC118652 mRNA Translation: AAI18653.1
U93553 mRNA Translation: AAD03155.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1400.1 [O00482-2]
CCDS1401.1 [O00482-1]
CCDS60383.1 [O00482-4]

NCBI Reference Sequences

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RefSeqi
NP_001263393.1, NM_001276464.1 [O00482-4]
NP_003813.1, NM_003822.4 [O00482-2]
NP_995582.1, NM_205860.2 [O00482-1]
XP_005245119.1, XM_005245062.3 [O00482-4]
XP_011507684.1, XM_011509382.1 [O00482-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.33446

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236914; ENSP00000236914; ENSG00000116833 [O00482-2]
ENST00000367362; ENSP00000356331; ENSG00000116833 [O00482-1]
ENST00000544748; ENSP00000439116; ENSG00000116833 [O00482-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2494

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2494

UCSC genome browser

More...
UCSCi
uc001gvb.5 human [O00482-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80251 mRNA Translation: AAC78727.1
AF146343 mRNA Translation: AAD37378.1
AF124247 mRNA Translation: AAD26565.1
AF190464 Genomic DNA Translation: AAG17124.1
AF190464 Genomic DNA Translation: AAG17125.1
AK304365 mRNA Translation: BAG65205.1
AK316513 mRNA Translation: BAH14884.1
AC096633 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91306.1
BC118571 mRNA Translation: AAI18572.1
BC118652 mRNA Translation: AAI18653.1
U93553 mRNA Translation: AAD03155.1
CCDSiCCDS1400.1 [O00482-2]
CCDS1401.1 [O00482-1]
CCDS60383.1 [O00482-4]
RefSeqiNP_001263393.1, NM_001276464.1 [O00482-4]
NP_003813.1, NM_003822.4 [O00482-2]
NP_995582.1, NM_205860.2 [O00482-1]
XP_005245119.1, XM_005245062.3 [O00482-4]
XP_011507684.1, XM_011509382.1 [O00482-4]
UniGeneiHs.33446

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YOKX-ray2.50A300-541[»]
1YUCX-ray1.90A/B290-541[»]
1ZDUX-ray2.50A297-541[»]
2A66X-ray2.20A79-187[»]
3PLZX-ray1.75A/B300-541[»]
3TX7X-ray2.76B191-541[»]
4DORX-ray1.90A/B290-541[»]
4DOSX-ray2.00A299-538[»]
4IS8X-ray2.78A/B300-538[»]
4ONIX-ray1.80A/B291-541[»]
4PLDX-ray1.75A301-541[»]
4PLEX-ray1.75A/C/E/G301-541[»]
4RWVX-ray1.86A294-541[»]
5L0MX-ray2.20A79-187[»]
5L11X-ray1.85A299-541[»]
5SYZX-ray1.93A297-538[»]
5UNJX-ray1.96A299-541[»]
ProteinModelPortaliO00482
SMRiO00482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108772, 21 interactors
CORUMiO00482
DIPiDIP-37952N
IntActiO00482, 10 interactors
MINTiO00482
STRINGi9606.ENSP00000356331

Chemistry databases

BindingDBiO00482
ChEMBLiCHEMBL3544
SwissLipidsiSLP:000001542

PTM databases

iPTMnetiO00482
PhosphoSitePlusiO00482

Polymorphism and mutation databases

BioMutaiNR5A2

Proteomic databases

PaxDbiO00482
PeptideAtlasiO00482
PRIDEiO00482
ProteomicsDBi47928
47929 [O00482-2]
47930 [O00482-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236914; ENSP00000236914; ENSG00000116833 [O00482-2]
ENST00000367362; ENSP00000356331; ENSG00000116833 [O00482-1]
ENST00000544748; ENSP00000439116; ENSG00000116833 [O00482-4]
GeneIDi2494
KEGGihsa:2494
UCSCiuc001gvb.5 human [O00482-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2494
DisGeNETi2494
EuPathDBiHostDB:ENSG00000116833.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NR5A2
HGNCiHGNC:7984 NR5A2
HPAiHPA005455
HPA017067
MIMi604453 gene
neXtProtiNX_O00482
OpenTargetsiENSG00000116833
PharmGKBiPA31765

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00940000153391
HOGENOMiHOG000063718
HOVERGENiHBG106677
InParanoidiO00482
KOiK08027
OMAiAMTQVIQ
OrthoDBi619653at2759
PhylomeDBiO00482
TreeFamiTF350737

Enzyme and pathway databases

ReactomeiR-HSA-210747 Regulation of gene expression in early pancreatic precursor cells
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiO00482
SIGNORiO00482

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NR5A2 human
EvolutionaryTraceiO00482

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Liver_receptor_homolog-1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2494

Protein Ontology

More...
PROi
PR:O00482

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116833 Expressed in 110 organ(s), highest expression level in body of pancreas
ExpressionAtlasiO00482 baseline and differential
GenevisibleiO00482 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNR5A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00482
Secondary accession number(s): B4E2P3, O95642, Q147U3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: February 13, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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