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Protein

High mobility group nucleosome-binding domain-containing protein 4

Gene

HMGN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 4
Alternative name(s):
Non-histone chromosomal protein HMG-17-like 3
Short name:
Non-histone chromosomal protein
Gene namesi
Name:HMGN4
Synonyms:HMG17L3, NHC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000182952.4
HGNCiHGNC:4989 HMGN4
neXtProtiNX_O00479

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10473
OpenTargetsiENSG00000182952
PharmGKBiPA35090

Polymorphism and mutation databases

BioMutaiHMGN4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067041 – 90High mobility group nucleosome-binding domain-containing protein 4Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29ADP-ribosylserine1 Publication1
Modified residuei80PhosphoserineCombined sources1
Modified residuei82N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiO00479
MaxQBiO00479
PaxDbiO00479
PeptideAtlasiO00479
PRIDEiO00479
ProteomicsDBi47924
TopDownProteomicsiO00479

PTM databases

iPTMnetiO00479
PhosphoSitePlusiO00479

Expressioni

Gene expression databases

BgeeiENSG00000182952 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExiHS_HMGN4
ExpressionAtlasiO00479 baseline and differential
GenevisibleiO00479 HS

Organism-specific databases

HPAiHPA077364

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-2867693,EBI-750109

Protein-protein interaction databases

BioGridi115736, 15 interactors
IntActiO00479, 4 interactors
STRINGi9606.ENSP00000327691

Structurei

3D structure databases

ProteinModelPortaliO00479
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J2S0 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiO00479
KOiK11302
OMAiNRDATTV
PhylomeDBiO00479

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

O00479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKRKAKGDA KGDKAKVKDE PQRRSARLSA KPAPPKPEPR PKKASAKKGE
60 70 80 90
KLPKGRKGKA DAGKDGNNPA KNRDASTLQS QKAEGTGDAK
Length:90
Mass (Da):9,539
Last modified:January 23, 2007 - v3
Checksum:i18738CF6EEA781CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90549 mRNA Translation: AAB53427.1
BT009824 mRNA Translation: AAP88826.1
AK311841 mRNA Translation: BAG34783.1
AL121936 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55586.1
BC001282 mRNA Translation: AAH01282.1
CCDSiCCDS4615.1
RefSeqiNP_006344.1, NM_006353.2
XP_016865660.1, XM_017010171.1
XP_016865661.1, XM_017010172.1
XP_016865662.1, XM_017010173.1
UniGeneiHs.236774

Genome annotation databases

EnsembliENST00000377575; ENSP00000366798; ENSG00000182952
GeneIDi10473
KEGGihsa:10473
UCSCiuc003nig.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90549 mRNA Translation: AAB53427.1
BT009824 mRNA Translation: AAP88826.1
AK311841 mRNA Translation: BAG34783.1
AL121936 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55586.1
BC001282 mRNA Translation: AAH01282.1
CCDSiCCDS4615.1
RefSeqiNP_006344.1, NM_006353.2
XP_016865660.1, XM_017010171.1
XP_016865661.1, XM_017010172.1
XP_016865662.1, XM_017010173.1
UniGeneiHs.236774

3D structure databases

ProteinModelPortaliO00479
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115736, 15 interactors
IntActiO00479, 4 interactors
STRINGi9606.ENSP00000327691

PTM databases

iPTMnetiO00479
PhosphoSitePlusiO00479

Polymorphism and mutation databases

BioMutaiHMGN4

Proteomic databases

EPDiO00479
MaxQBiO00479
PaxDbiO00479
PeptideAtlasiO00479
PRIDEiO00479
ProteomicsDBi47924
TopDownProteomicsiO00479

Protocols and materials databases

DNASUi10473
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377575; ENSP00000366798; ENSG00000182952
GeneIDi10473
KEGGihsa:10473
UCSCiuc003nig.4 human

Organism-specific databases

CTDi10473
DisGeNETi10473
EuPathDBiHostDB:ENSG00000182952.4
GeneCardsiHMGN4
HGNCiHGNC:4989 HMGN4
HPAiHPA077364
neXtProtiNX_O00479
OpenTargetsiENSG00000182952
PharmGKBiPA35090
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2S0 Eukaryota
ENOG410Z0UC LUCA
GeneTreeiENSGT00730000110660
HOGENOMiHOG000116395
HOVERGENiHBG073479
InParanoidiO00479
KOiK11302
OMAiNRDATTV
PhylomeDBiO00479

Miscellaneous databases

ChiTaRSiHMGN4 human
GeneWikiiHMGN4
GenomeRNAii10473
PROiPR:O00479

Gene expression databases

BgeeiENSG00000182952 Expressed in 233 organ(s), highest expression level in secondary oocyte
CleanExiHS_HMGN4
ExpressionAtlasiO00479 baseline and differential
GenevisibleiO00479 HS

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN4_HUMAN
AccessioniPrimary (citable) accession number: O00479
Secondary accession number(s): B2R4I6, Q53XL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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