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Protein

Butyrophilin subfamily 3 member A3

Gene

BTN3A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in T-cell responses in the adaptive immune response.1 Publication

GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

  • regulation of immune response Source: GO_Central
  • T cell mediated immunity Source: UniProtKB
  • T cell receptor signaling pathway Source: GO_Central

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 3 member A3
Gene namesi
Name:BTN3A3
Synonyms:BTF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111801.15
HGNCiHGNC:1140 BTN3A3
MIMi613595 gene
neXtProtiNX_O00478

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 248ExtracellularSequence analysisAdd BLAST219
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 584CytoplasmicSequence analysisAdd BLAST315

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10384
OpenTargetsiENSG00000111801
PharmGKBiPA25461

Polymorphism and mutation databases

BioMutaiBTN3A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000001453430 – 584Butyrophilin subfamily 3 member A3Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 126PROSITE-ProRule annotation1 Publication
Glycosylationi115N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi166 ↔ 220PROSITE-ProRule annotation1 Publication

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO00478
MaxQBiO00478
PaxDbiO00478
PeptideAtlasiO00478
PRIDEiO00478
ProteomicsDBi47923

PTM databases

GlyConnecti1050
iPTMnetiO00478
PhosphoSitePlusiO00478

Expressioni

Tissue specificityi

Detected in peripheral blood mononuclear cells and in T-cells (at protein level). Detected in spleen and lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000111801 Expressed in 217 organ(s), highest expression level in leukocyte
CleanExiHS_BTF3
HS_BTN3A3
ExpressionAtlasiO00478 baseline and differential
GenevisibleiO00478 HS

Organism-specific databases

HPAiHPA007904
HPA011871

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115657, 9 interactors
IntActiO00478, 4 interactors
STRINGi9606.ENSP00000244519

Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00478
SMRiO00478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 139Ig-like V-type 1Add BLAST110
Domaini145 – 236Ig-like V-type 2Add BLAST92
Domaini322 – 518B30.2/SPRYPROSITE-ProRule annotationAdd BLAST197

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00760000118933
HOGENOMiHOG000230860
HOVERGENiHBG050747
InParanoidiO00478
KOiK06712
OMAiTPFVHRY
OrthoDBiEOG091G05N6
PhylomeDBiO00478
TreeFamiTF331083

Family and domain databases

CDDicd15820 SPRY_PRY_BTN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
IPR037954 SPRY_PRY_BTN3
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00478-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMASSLAFL LLNFHVSLFL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL
60 70 80 90 100
PCHLFPTMSA ETMELRWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL
110 120 130 140 150
RDGITAGKAA LRIHNVTASD SGKYLCYFQD GDFYEKALVE LKVAALGSDL
160 170 180 190 200
HIEVKGYEDG GIHLECRSTG WYPQPQIKWS DTKGENIPAV EAPVVADGVG
210 220 230 240 250
LYAVAASVIM RGSSGGGVSC IIRNSLLGLE KTASISIADP FFRSAQPWIA
260 270 280 290 300
ALAGTLPISL LLLAGASYFL WRQQKEKIAL SRETEREREM KEMGYAATEQ
310 320 330 340 350
EISLREKLQE ELKWRKIQYM ARGEKSLAYH EWKMALFKPA DVILDPDTAN
360 370 380 390 400
AILLVSEDQR SVQRAEEPRD LPDNPERFEW RYCVLGCENF TSGRHYWEVE
410 420 430 440 450
VGDRKEWHIG VCSKNVERKK GWVKMTPENG YWTMGLTDGN KYRALTEPRT
460 470 480 490 500
NLKLPEPPRK VGIFLDYETG EISFYNATDG SHIYTFPHAS FSEPLYPVFR
510 520 530 540 550
ILTLEPTALT ICPIPKEVES SPDPDLVPDH SLETPLTPGL ANESGEPQAE
560 570 580
VTSLLLPAHP GAEVSPSATT NQNHKLQART EALY
Length:584
Mass (Da):65,002
Last modified:July 1, 1997 - v1
Checksum:i2B279B9141E0327F
GO
Isoform 2 (identifier: O00478-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     307-313: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):59,688
Checksum:i545FBB6D114FBB09
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUV8C9JUV8_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
250Annotation score:
C9JQT8C9JQT8_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
237Annotation score:
C9JVU4C9JVU4_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
127Annotation score:
C9J3Q8C9J3Q8_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
137Annotation score:
C9JZT5C9JZT5_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
210Annotation score:
C9JNZ3C9JNZ3_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
100Annotation score:
C9J877C9J877_HUMAN
Butyrophilin subfamily 3 member A3
BTN3A3
140Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229L → P in BAG63049 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450631 – 42Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_045064307 – 313Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90548 mRNA Translation: AAB53426.1
BT007251 mRNA Translation: AAP35915.1
AK301553 mRNA Translation: BAG63049.1
AL021917 Genomic DNA No translation available.
BC015815 mRNA Translation: AAH15815.1
CCDSiCCDS4611.1 [O00478-1]
CCDS4612.2 [O00478-2]
RefSeqiNP_001229732.1, NM_001242803.1
NP_008925.1, NM_006994.4 [O00478-1]
NP_932078.2, NM_197974.2 [O00478-2]
UniGeneiHs.167741

Genome annotation databases

EnsembliENST00000244519; ENSP00000244519; ENSG00000111801 [O00478-1]
ENST00000361232; ENSP00000355238; ENSG00000111801 [O00478-2]
GeneIDi10384
KEGGihsa:10384
UCSCiuc003nhz.3 human [O00478-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90548 mRNA Translation: AAB53426.1
BT007251 mRNA Translation: AAP35915.1
AK301553 mRNA Translation: BAG63049.1
AL021917 Genomic DNA No translation available.
BC015815 mRNA Translation: AAH15815.1
CCDSiCCDS4611.1 [O00478-1]
CCDS4612.2 [O00478-2]
RefSeqiNP_001229732.1, NM_001242803.1
NP_008925.1, NM_006994.4 [O00478-1]
NP_932078.2, NM_197974.2 [O00478-2]
UniGeneiHs.167741

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F8TX-ray2.38A30-246[»]
ProteinModelPortaliO00478
SMRiO00478
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115657, 9 interactors
IntActiO00478, 4 interactors
STRINGi9606.ENSP00000244519

PTM databases

GlyConnecti1050
iPTMnetiO00478
PhosphoSitePlusiO00478

Polymorphism and mutation databases

BioMutaiBTN3A3

Proteomic databases

EPDiO00478
MaxQBiO00478
PaxDbiO00478
PeptideAtlasiO00478
PRIDEiO00478
ProteomicsDBi47923

Protocols and materials databases

DNASUi10384
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244519; ENSP00000244519; ENSG00000111801 [O00478-1]
ENST00000361232; ENSP00000355238; ENSG00000111801 [O00478-2]
GeneIDi10384
KEGGihsa:10384
UCSCiuc003nhz.3 human [O00478-1]

Organism-specific databases

CTDi10384
DisGeNETi10384
EuPathDBiHostDB:ENSG00000111801.15
GeneCardsiBTN3A3
HGNCiHGNC:1140 BTN3A3
HPAiHPA007904
HPA011871
MIMi613595 gene
neXtProtiNX_O00478
OpenTargetsiENSG00000111801
PharmGKBiPA25461
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00760000118933
HOGENOMiHOG000230860
HOVERGENiHBG050747
InParanoidiO00478
KOiK06712
OMAiTPFVHRY
OrthoDBiEOG091G05N6
PhylomeDBiO00478
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

GeneWikiiBTN3A3
GenomeRNAii10384
PROiPR:O00478
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111801 Expressed in 217 organ(s), highest expression level in leukocyte
CleanExiHS_BTF3
HS_BTN3A3
ExpressionAtlasiO00478 baseline and differential
GenevisibleiO00478 HS

Family and domain databases

CDDicd15820 SPRY_PRY_BTN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR003877 SPRY_dom
IPR037954 SPRY_PRY_BTN3
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBT3A3_HUMAN
AccessioniPrimary (citable) accession number: O00478
Secondary accession number(s): B4DWI7, E9PCP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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