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Protein

Sodium-dependent phosphate transport protein 4

Gene

SLC17A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na+ cotransport.

GO - Molecular functioni

GO - Biological processi

  • drug transport Source: UniProtKB
  • glucose-6-phosphate transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
  • organic anion transport Source: UniProtKB
  • phosphate ion transport Source: UniProtKB
  • sialic acid transport Source: GO_Central
  • sodium ion transport Source: UniProtKB
  • urate metabolic process Source: UniProtKB
  • urate transport Source: UniProtKB

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

TCDBi2.A.1.14.28 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 4
Alternative name(s):
Na(+)/PI cotransporter 4
Sodium/phosphate cotransporter 4
Solute carrier family 17 member 3
Gene namesi
Name:SLC17A3
Synonyms:NPT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124564.17
HGNCiHGNC:10931 SLC17A3
MIMi611034 gene
neXtProtiNX_O00476

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei292 – 314HelicalSequence analysisAdd BLAST23
Transmembranei319 – 341HelicalSequence analysisAdd BLAST23
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10786
MalaCardsiSLC17A3
MIMi612671 phenotype
OpenTargetsiENSG00000124564
PharmGKBiPA35822

Polymorphism and mutation databases

BioMutaiSLC17A3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003511381 – 420Sodium-dependent phosphate transport protein 4Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO00476
PeptideAtlasiO00476
PRIDEiO00476
ProteomicsDBi47921
47922 [O00476-2]

PTM databases

iPTMnetiO00476
PhosphoSitePlusiO00476

Expressioni

Tissue specificityi

Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000124564 Expressed in 62 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC17A3
ExpressionAtlasiO00476 baseline and differential
GenevisibleiO00476 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000380250

Structurei

3D structure databases

ProteinModelPortaliO00476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230813
HOVERGENiHBG008834
InParanoidiO00476
KOiK12300
OMAiILTIIDM
OrthoDBiEOG091G077Z
PhylomeDBiO00476
TreeFamiTF313535

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR017373 Na-dep_P-transpt_4_prd
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF038072 Na(+)/PI_cotransporter4_prd, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00476-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATKTELSPT ARESKNAQDM QVDETLIPRK VPSLCSARYG IALVLHFCNF
60 70 80 90 100
TTIAQNVIMN ITMVAMVNST SPQSQLNDSS EVLPVDSFGG LSKAPKSLPA
110 120 130 140 150
KSSILGGQFA IWEKWGPPQE RSRLCSIALS GMLLGCFTAI LIGGFISETL
160 170 180 190 200
GWPFVFYIFG GVGCVCCLLW FVVIYDDPVS YPWISTSEKE YIISSLKQQV
210 220 230 240 250
GSSKQPLPIK AMLRSLPIWS ICLGCFSHQW LVSTMVVYIP TYISSVYHVN
260 270 280 290 300
IRDNGLLSAL PFIVAWVIGM VGGYLADFLL TKKFRLITVR KIATILGSLP
310 320 330 340 350
SSALIVSLPY LNSGYITATA LLTLSCGLST LCQSGIYINV LDIAPRYSSF
360 370 380 390 400
LMGASRGFSS IAPVIVPTVS GFLLSQDPEF GWRNVFFLLF AVNLLGLLFY
410 420
LIFGEADVQE WAKERKLTRL
Length:420
Mass (Da):46,106
Last modified:September 23, 2008 - v2
Checksum:iBFDFCC7F4345F573
GO
Isoform 2 (identifier: O00476-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-101: K → KAPVYDWSPQ...VTRIVQGLSQ

Note: No experimental confirmation available.
Show »
Length:498
Mass (Da):54,259
Checksum:i28523A1A29FD2562
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8R7H0Y8R7_HUMAN
Sodium-dependent phosphate transpor...
SLC17A3
99Annotation score:
H0Y9F7H0Y9F7_HUMAN
Sodium-dependent phosphate transpor...
SLC17A3
51Annotation score:
E9PBQ8E9PBQ8_HUMAN
Sodium-dependent phosphate transpor...
SLC17A3
112Annotation score:

Sequence cautioni

The sequence AAB53423 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31V → G in AAB53423 (PubMed:9149941).Curated1
Sequence conflicti179V → F in AAB53423 (PubMed:9149941).Curated1

Polymorphismi

Genetic variations in SLC17A3 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 4 (UAQTL4) [MIMi:612671]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06868068N → H Found in a patient with gout; does not affect isoform 2 localization at the cell membrane; results in reduced urate efflux. 1 PublicationCorresponds to variant dbSNP:rs387907257EnsemblClinVar.1
Natural variantiVAR_024533100A → T1 PublicationCorresponds to variant dbSNP:rs1165165Ensembl.1
Natural variantiVAR_034700201G → R1 PublicationCorresponds to variant dbSNP:rs56027330Ensembl.1
Natural variantiVAR_068681226F → S Found in a patient with hyperuricemia; decreased expression of isoform 2 at the cell membrane; results in highly reduced urate efflux. 1 PublicationCorresponds to variant dbSNP:rs387907256Ensembl.1
Natural variantiVAR_046633300P → L. Corresponds to variant dbSNP:rs11966370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042888101K → KAPVYDWSPQIQGIIFGAVG YGGILTMAPSGYLAGRVGTK RVVGISLFATSFLTLCIPLA TDFGIVLLIVTRIVQGLSQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90545 mRNA Translation: AAB53423.1 Different initiation.
AK298271 mRNA Translation: BAH12747.1
AL138726 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55495.1
BC017952 mRNA Translation: AAH17952.1
CCDSiCCDS4566.2 [O00476-1]
CCDS47385.1 [O00476-2]
RefSeqiNP_001091956.1, NM_001098486.1 [O00476-2]
NP_006623.2, NM_006632.3 [O00476-1]
UniGeneiHs.327179

Genome annotation databases

EnsembliENST00000360657; ENSP00000353873; ENSG00000124564 [O00476-1]
ENST00000361703; ENSP00000355307; ENSG00000124564 [O00476-1]
ENST00000397060; ENSP00000380250; ENSG00000124564 [O00476-2]
GeneIDi10786
KEGGihsa:10786
UCSCiuc003nfi.5 human [O00476-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90545 mRNA Translation: AAB53423.1 Different initiation.
AK298271 mRNA Translation: BAH12747.1
AL138726 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55495.1
BC017952 mRNA Translation: AAH17952.1
CCDSiCCDS4566.2 [O00476-1]
CCDS47385.1 [O00476-2]
RefSeqiNP_001091956.1, NM_001098486.1 [O00476-2]
NP_006623.2, NM_006632.3 [O00476-1]
UniGeneiHs.327179

3D structure databases

ProteinModelPortaliO00476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000380250

Protein family/group databases

TCDBi2.A.1.14.28 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiO00476
PhosphoSitePlusiO00476

Polymorphism and mutation databases

BioMutaiSLC17A3

Proteomic databases

PaxDbiO00476
PeptideAtlasiO00476
PRIDEiO00476
ProteomicsDBi47921
47922 [O00476-2]

Protocols and materials databases

DNASUi10786
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360657; ENSP00000353873; ENSG00000124564 [O00476-1]
ENST00000361703; ENSP00000355307; ENSG00000124564 [O00476-1]
ENST00000397060; ENSP00000380250; ENSG00000124564 [O00476-2]
GeneIDi10786
KEGGihsa:10786
UCSCiuc003nfi.5 human [O00476-1]

Organism-specific databases

CTDi10786
DisGeNETi10786
EuPathDBiHostDB:ENSG00000124564.17
GeneCardsiSLC17A3
H-InvDBiHIX0005635
HGNCiHGNC:10931 SLC17A3
MalaCardsiSLC17A3
MIMi611034 gene
612671 phenotype
neXtProtiNX_O00476
OpenTargetsiENSG00000124564
PharmGKBiPA35822
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2532 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119079
HOGENOMiHOG000230813
HOVERGENiHBG008834
InParanoidiO00476
KOiK12300
OMAiILTIIDM
OrthoDBiEOG091G077Z
PhylomeDBiO00476
TreeFamiTF313535

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

GenomeRNAii10786
PROiPR:O00476
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124564 Expressed in 62 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_SLC17A3
ExpressionAtlasiO00476 baseline and differential
GenevisibleiO00476 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR017373 Na-dep_P-transpt_4_prd
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF038072 Na(+)/PI_cotransporter4_prd, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPT4_HUMAN
AccessioniPrimary (citable) accession number: O00476
Secondary accession number(s): B7WNJ5
, B7Z511, Q8WWC7, Q9H533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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