UniProtKB - O00472 (ELL2_HUMAN)
RNA polymerase II elongation factor ELL2
ELL2
Functioni
GO - Biological processi
- snRNA transcription by RNA polymerase II Source: UniProtKB
- transcription elongation from RNA polymerase II promoter Source: ProtInc
Keywordsi
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O00472 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
Names & Taxonomyi
Protein namesi | Recommended name: RNA polymerase II elongation factor ELL2 |
Gene namesi | Name:ELL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000118985.15 |
HGNCi | HGNC:17064, ELL2 |
MIMi | 601874, gene |
neXtProti | NX_O00472 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- transcription elongation factor complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 22936 |
OpenTargetsi | ENSG00000118985 |
PharmGKBi | PA134935340 |
Miscellaneous databases
Pharosi | O00472, Tbio |
Polymorphism and mutation databases
BioMutai | ELL2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146735 | 1 – 640 | RNA polymerase II elongation factor ELL2Add BLAST | 640 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 503 | PhosphoserineCombined sources | 1 | |
Modified residuei | 580 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O00472 |
jPOSTi | O00472 |
MassIVEi | O00472 |
MaxQBi | O00472 |
PaxDbi | O00472 |
PeptideAtlasi | O00472 |
PRIDEi | O00472 |
ProteomicsDBi | 4705 47920 [O00472-1] |
PTM databases
GlyConnecti | 1720, 4 N-Linked glycans (1 site) |
GlyGeni | O00472, 1 site |
iPTMneti | O00472 |
PhosphoSitePlusi | O00472 |
Expressioni
Gene expression databases
Bgeei | ENSG00000118985, Expressed in saliva-secreting gland and 228 other tissues |
ExpressionAtlasi | O00472, baseline and differential |
Genevisiblei | O00472, HS |
Organism-specific databases
HPAi | ENSG00000118985, Low tissue specificity |
Interactioni
Subunit structurei
Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3).
Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2.
Interacts with AFF4; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination.
Interacts with EAF1 and EAF2.
5 PublicationsBinary interactionsi
Hide detailsO00472
With | #Exp. | IntAct |
---|---|---|
AFF4 [Q8TAX5] | 3 | EBI-395274,EBI-745478 |
EAF1 [Q96JC9] | 6 | EBI-395274,EBI-769261 |
EXOC8 [Q8IYI6] | 3 | EBI-395274,EBI-742102 |
PRKAB2 [O43741] | 3 | EBI-395274,EBI-1053424 |
Protein-protein interaction databases
BioGRIDi | 116595, 31 interactors |
CORUMi | O00472 |
IntActi | O00472, 31 interactors |
STRINGi | 9606.ENSP00000237853 |
Miscellaneous databases
RNActi | O00472, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O00472 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00472 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4796, Eukaryota |
GeneTreei | ENSGT00940000154828 |
HOGENOMi | CLU_021268_0_0_1 |
InParanoidi | O00472 |
OMAi | SDAFHNF |
PhylomeDBi | O00472 |
TreeFami | TF326161 |
Family and domain databases
Gene3Di | 1.10.10.2670, 1 hit |
InterProi | View protein in InterPro IPR042065, E3_ELL-like IPR031176, ELL/occludin IPR031179, ELL2 IPR019464, ELL_N IPR010844, Occludin_ELL IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR23288, PTHR23288, 2 hits PTHR23288:SF36, PTHR23288:SF36, 2 hits |
Pfami | View protein in Pfam PF10390, ELL, 1 hit PF07303, Occludin_ELL, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGGTGGLR EEQRYGLSCG RLGQDNITVL HVKLTETAIR ALETYQSHKN
60 70 80 90 100
LIPFRPSIQF QGLHGLVKIP KNDPLNEVHN FNFYLSNVGK DNPQGSFDCI
110 120 130 140 150
QQTFSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST
160 170 180 190 200
KVIKPGGPYV GKRVQIRKAP QAVSDTVPER KRSTPMNPAN TIRKTHSSST
210 220 230 240 250
ISQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN
260 270 280 290 300
LNSKDLSYTL KDYVFKELQR DWPGYSEIDR RSLESVLSRK LNPSQNAAGT
310 320 330 340 350
SRSESPVCSS RDAVSSPQKR LLDSEFIDPL MNKKARISHL TNRVPPTLNG
360 370 380 390 400
HLNPTSEKSA AGLPLPPAAA AIPTPPPLPS TYLPISHPPQ IVNSNSNSPS
410 420 430 440 450
TPEGRGTQDL PVDSFSQNDS IYEDQQDKYT SRTSLETLPP GSVLLKCPKP
460 470 480 490 500
MEENHSMSHK KSKKKSKKHK EKDQIKKHDI ETIEEKEEDL KREEEIAKLN
510 520 530 540 550
NSSPNSSGGV KEDCTASMEP SAIELPDYLI KYIAIVSYEQ RQNYKDDFNA
560 570 580 590 600
EYDEYRALHA RMETVARRFI KLDAQRKRLS PGSKEYQNVH EEVLQEYQKI
610 620 630 640
KQSSPNYHEE KYRCEYLHNK LAHIKRLIGE FDQQQAESWS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RC27 | D6RC27_HUMAN | RNA polymerase II elongation factor... | ELL2 | 151 | Annotation score: | ||
H0Y8G1 | H0Y8G1_HUMAN | RNA polymerase II elongation factor... | ELL2 | 137 | Annotation score: | ||
A0A0U1RR08 | A0A0U1RR08_HUMAN | RNA polymerase II elongation factor... | ELL2 | 65 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058406 | 298 | A → T2 PublicationsCorresponds to variant dbSNP:rs3815768Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055476 | 140 – 389 | Missing in isoform 2. 1 PublicationAdd BLAST | 250 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88629 Genomic DNA Translation: AAC51232.1 AK297956 mRNA Translation: BAG60269.1 AC008592 Genomic DNA No translation available. BC028412 mRNA Translation: AAH28412.1 |
CCDSi | CCDS4080.1 [O00472-1] |
RefSeqi | NP_036213.2, NM_012081.5 [O00472-1] |
Genome annotation databases
Ensembli | ENST00000237853; ENSP00000237853; ENSG00000118985 [O00472-1] |
GeneIDi | 22936 |
KEGGi | hsa:22936 |
UCSCi | uc003klr.4, human [O00472-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88629 Genomic DNA Translation: AAC51232.1 AK297956 mRNA Translation: BAG60269.1 AC008592 Genomic DNA No translation available. BC028412 mRNA Translation: AAH28412.1 |
CCDSi | CCDS4080.1 [O00472-1] |
RefSeqi | NP_036213.2, NM_012081.5 [O00472-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E5N | NMR | - | A | 200-292 | [»] | |
5JW9 | X-ray | 2.00 | B | 519-640 | [»] | |
SMRi | O00472 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116595, 31 interactors |
CORUMi | O00472 |
IntActi | O00472, 31 interactors |
STRINGi | 9606.ENSP00000237853 |
PTM databases
GlyConnecti | 1720, 4 N-Linked glycans (1 site) |
GlyGeni | O00472, 1 site |
iPTMneti | O00472 |
PhosphoSitePlusi | O00472 |
Polymorphism and mutation databases
BioMutai | ELL2 |
Proteomic databases
EPDi | O00472 |
jPOSTi | O00472 |
MassIVEi | O00472 |
MaxQBi | O00472 |
PaxDbi | O00472 |
PeptideAtlasi | O00472 |
PRIDEi | O00472 |
ProteomicsDBi | 4705 47920 [O00472-1] |
Protocols and materials databases
Antibodypediai | 13079, 168 antibodies |
DNASUi | 22936 |
Genome annotation databases
Ensembli | ENST00000237853; ENSP00000237853; ENSG00000118985 [O00472-1] |
GeneIDi | 22936 |
KEGGi | hsa:22936 |
UCSCi | uc003klr.4, human [O00472-1] |
Organism-specific databases
CTDi | 22936 |
DisGeNETi | 22936 |
EuPathDBi | HostDB:ENSG00000118985.15 |
GeneCardsi | ELL2 |
HGNCi | HGNC:17064, ELL2 |
HPAi | ENSG00000118985, Low tissue specificity |
MIMi | 601874, gene |
neXtProti | NX_O00472 |
OpenTargetsi | ENSG00000118985 |
PharmGKBi | PA134935340 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4796, Eukaryota |
GeneTreei | ENSGT00940000154828 |
HOGENOMi | CLU_021268_0_0_1 |
InParanoidi | O00472 |
OMAi | SDAFHNF |
PhylomeDBi | O00472 |
TreeFami | TF326161 |
Enzyme and pathway databases
PathwayCommonsi | O00472 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
Miscellaneous databases
BioGRID-ORCSi | 22936, 13 hits in 848 CRISPR screens |
ChiTaRSi | ELL2, human |
EvolutionaryTracei | O00472 |
GenomeRNAii | 22936 |
Pharosi | O00472, Tbio |
PROi | PR:O00472 |
RNActi | O00472, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118985, Expressed in saliva-secreting gland and 228 other tissues |
ExpressionAtlasi | O00472, baseline and differential |
Genevisiblei | O00472, HS |
Family and domain databases
Gene3Di | 1.10.10.2670, 1 hit |
InterProi | View protein in InterPro IPR042065, E3_ELL-like IPR031176, ELL/occludin IPR031179, ELL2 IPR019464, ELL_N IPR010844, Occludin_ELL IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR23288, PTHR23288, 2 hits PTHR23288:SF36, PTHR23288:SF36, 2 hits |
Pfami | View protein in Pfam PF10390, ELL, 1 hit PF07303, Occludin_ELL, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELL2_HUMAN | |
Accessioni | O00472Primary (citable) accession number: O00472 Secondary accession number(s): B4DNK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations