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Protein

Exocyst complex component 5

Gene

EXOC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • protein N-terminus binding Source: Ensembl
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 5
Alternative name(s):
Exocyst complex component Sec10
Short name:
hSec10
Gene namesi
Name:EXOC5
Synonyms:SEC10, SEC10L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000070367.15
HGNCiHGNC:10696 EXOC5
MIMi604469 gene
neXtProtiNX_O00471

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10640
OpenTargetsiENSG00000070367
PharmGKBiPA35619

Polymorphism and mutation databases

BioMutaiEXOC5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001189432 – 708Exocyst complex component 5Add BLAST707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
Modified residuei395PhosphothreonineBy similarity1
Modified residuei405PhosphothreonineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00471
MaxQBiO00471
PaxDbiO00471
PeptideAtlasiO00471
PRIDEiO00471
ProteomicsDBi47919

PTM databases

iPTMnetiO00471
PhosphoSitePlusiO00471

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000070367 Expressed in 209 organ(s), highest expression level in testis
CleanExiHS_EXOC5
ExpressionAtlasiO00471 baseline and differential
GenevisibleiO00471 HS

Organism-specific databases

HPAiHPA060837

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115884, 67 interactors
CORUMiO00471
IntActiO00471, 58 interactors
MINTiO00471
STRINGi9606.ENSP00000389934

Structurei

3D structure databases

ProteinModelPortaliO00471
SMRiO00471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 101Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the SEC10 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3745 Eukaryota
ENOG410XSQQ LUCA
GeneTreeiENSGT00390000012837
HOGENOMiHOG000007911
HOVERGENiHBG055591
InParanoidiO00471
KOiK19984
PhylomeDBiO00471
TreeFamiTF314966

Family and domain databases

InterProiView protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like
PANTHERiPTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit
PfamiView protein in Pfam
PF07393 Sec10, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O00471-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI
60 70 80 90 100
QELQIMDERI QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD
110 120 130 140 150
EHISYVATKV CHLGDQLEGV NTPRQRAVEA QKLMKYFNEF LDGELKSDVF
160 170 180 190 200
TNSEKIKEAA DIIQKLHLIA QELPFDRFSE VKSKIASKYH DLECQLIQEF
210 220 230 240 250
TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA YLRNDIFEDA
260 270 280 290 300
GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA
310 320 330 340 350
EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI
360 370 380 390 400
EVETGYLKSR SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG
410 420 430 440 450
PSIDTHGETF LSQEVVVNLL QETKQAFERC HRLSDPSDLP RNAFRIFTIL
460 470 480 490 500
VEFLCIEHID YALETGLAGI PSSDSRNANL YFLDVVQQAN TIFHLFDKQF
510 520 530 540 550
NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL NCMIGQMKHI
560 570 580 590 600
LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD
610 620 630 640 650
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV
660 670 680 690 700
LHLFDTLHAL CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS

ARLARHFS
Length:708
Mass (Da):81,853
Last modified:July 1, 1997 - v1
Checksum:iCB03AC6C64DAB50C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSI8A0A0A0MSI8_HUMAN
Exocyst complex component 5
EXOC5
711Annotation score:
F8W9B8F8W9B8_HUMAN
Exocyst complex component 5
EXOC5
643Annotation score:
G3V4Z7G3V4Z7_HUMAN
Exocyst complex component 5
EXOC5
62Annotation score:
G3V377G3V377_HUMAN
Exocyst complex component 5
EXOC5
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545G → R in AAH41126 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04895710E → D. Corresponds to variant dbSNP:rs35132458Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85946 mRNA Translation: AAB53388.1
AK312523 mRNA Translation: BAG35422.1
CH471061 Genomic DNA Translation: EAW80699.1
BC041126 mRNA Translation: AAH41126.1
CCDSiCCDS45111.1
RefSeqiNP_006535.1, NM_006544.3
UniGeneiHs.743987

Genome annotation databases

EnsembliENST00000621441; ENSP00000484855; ENSG00000070367
GeneIDi10640
KEGGihsa:10640
UCSCiuc001xct.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85946 mRNA Translation: AAB53388.1
AK312523 mRNA Translation: BAG35422.1
CH471061 Genomic DNA Translation: EAW80699.1
BC041126 mRNA Translation: AAH41126.1
CCDSiCCDS45111.1
RefSeqiNP_006535.1, NM_006544.3
UniGeneiHs.743987

3D structure databases

ProteinModelPortaliO00471
SMRiO00471
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115884, 67 interactors
CORUMiO00471
IntActiO00471, 58 interactors
MINTiO00471
STRINGi9606.ENSP00000389934

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiO00471
PhosphoSitePlusiO00471

Polymorphism and mutation databases

BioMutaiEXOC5

Proteomic databases

EPDiO00471
MaxQBiO00471
PaxDbiO00471
PeptideAtlasiO00471
PRIDEiO00471
ProteomicsDBi47919

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621441; ENSP00000484855; ENSG00000070367
GeneIDi10640
KEGGihsa:10640
UCSCiuc001xct.4 human

Organism-specific databases

CTDi10640
DisGeNETi10640
EuPathDBiHostDB:ENSG00000070367.15
GeneCardsiEXOC5
HGNCiHGNC:10696 EXOC5
HPAiHPA060837
MIMi604469 gene
neXtProtiNX_O00471
OpenTargetsiENSG00000070367
PharmGKBiPA35619
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3745 Eukaryota
ENOG410XSQQ LUCA
GeneTreeiENSGT00390000012837
HOGENOMiHOG000007911
HOVERGENiHBG055591
InParanoidiO00471
KOiK19984
PhylomeDBiO00471
TreeFamiTF314966

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

ChiTaRSiEXOC5 human
GeneWikiiEXOC5
GenomeRNAii10640
PROiPR:O00471
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070367 Expressed in 209 organ(s), highest expression level in testis
CleanExiHS_EXOC5
ExpressionAtlasiO00471 baseline and differential
GenevisibleiO00471 HS

Family and domain databases

InterProiView protein in InterPro
IPR033960 EXOC5/Sec10
IPR009976 Sec10-like
PANTHERiPTHR12100 PTHR12100, 1 hit
PTHR12100:SF0 PTHR12100:SF0, 1 hit
PfamiView protein in Pfam
PF07393 Sec10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC5_HUMAN
AccessioniPrimary (citable) accession number: O00471
Secondary accession number(s): B2R6C5, Q8IW24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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