Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Meis1

Gene

MEIS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi272 – 334Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SignaLinkiO00470
SIGNORiO00470

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Meis1
Gene namesi
Name:MEIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143995.19
HGNCiHGNC:7000 MEIS1
MIMi601739 gene
neXtProtiNX_O00470

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Restless legs syndrome 7 (RLS7)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.
See also OMIM:612853

Organism-specific databases

DisGeNETi4211
MIMi612853 phenotype
OpenTargetsiENSG00000143995
PharmGKBiPA30740

Polymorphism and mutation databases

BioMutaiMEIS1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491051 – 390Homeobox protein Meis1Add BLAST390

Proteomic databases

EPDiO00470
MaxQBiO00470
PaxDbiO00470
PeptideAtlasiO00470
PRIDEiO00470
ProteomicsDBi47917
47918 [O00470-2]

PTM databases

iPTMnetiO00470
PhosphoSitePlusiO00470

Expressioni

Tissue specificityi

Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

Gene expression databases

BgeeiENSG00000143995
CleanExiHS_MEIS1
ExpressionAtlasiO00470 baseline and differential
GenevisibleiO00470 HS

Organism-specific databases

HPAiCAB011521
HPA056000
HPA058641

Interactioni

Subunit structurei

Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner. Heterodimer with DLX3 (PubMed:26550823). Heterodimer with HOXB13 (PubMed:28473536).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110375, 27 interactors
IntActiO00470, 12 interactors
MINTiO00470
STRINGi9606.ENSP00000272369

Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi281 – 293Combined sources13
Turni294 – 296Combined sources3
Helixi302 – 312Combined sources11
Helixi316 – 329Combined sources14
Turni330 – 333Combined sources4

3D structure databases

ProteinModelPortaliO00470
SMRiO00470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni299 – 329Interaction with DNA2 PublicationsAdd BLAST31
Regioni335 – 390Required for transcriptional activationBy similarityAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 240Ser/Thr-richAdd BLAST47
Compositional biasi242 – 269Asp/Glu-rich (acidic)Add BLAST28
Compositional biasi262 – 269Poly-Asp8

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253923
HOVERGENiHBG055193
InParanoidiO00470
KOiK15613
OMAiVSQGAPY
OrthoDBiEOG091G0KDP
PhylomeDBiO00470
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O00470-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRYDDLPH YGGMDGVGIP STMYGDPHAA RSMQPVHHLN HGPPLHSHQY
60 70 80 90 100
PHTAHTNAMA PSMGSSVNDA LKRDKDAIYG HPLFPLLALI FEKCELATCT
110 120 130 140 150
PREPGVAGGD VCSSESFNED IAVFAKQIRA EKPLFSSNPE LDNLMIQAIQ
160 170 180 190 200
VLRFHLLELE KVHELCDNFC HRYISCLKGK MPIDLVIDDR EGGSKSDSED
210 220 230 240 250
ITRSANLTDQ PSWNRDHDDT ASTRSGGTPG PSSGGHTSHS GDNSSEQGDG
260 270 280 290 300
LDNSVASPST GDDDDPDKDK KRHKKRGIFP KVATNIMRAW LFQHLTHPYP
310 320 330 340 350
SEEQKKQLAQ DTGLTILQVN NWFINARRRI VQPMIDQSNR AVSQGTPYNP
360 370 380 390
DGQPMGGFVM DGQQHMGIRA PGPMSGMGMN MGMEGQWHYM
Length:390
Mass (Da):43,016
Last modified:July 1, 1997 - v1
Checksum:i3B6A0ACCF0C39121
GO
Isoform 2 (identifier: O00470-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MAQR → MQ
     373-390: PMSGMGMNMGMEGQWHYM → LQSMPGEYVA...SGQVMDIHAQ

Show »
Length:463
Mass (Da):50,576
Checksum:iD8F5B46D79D60A71
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063166272R → H Found in a patient with susceptibility to restless legs syndrome. 1 PublicationCorresponds to variant dbSNP:rs61752693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349571 – 4MAQR → MQ in isoform 2. 1 Publication4
Alternative sequenceiVSP_034958373 – 390PMSGM…QWHYM → LQSMPGEYVARGGPMGVSMG QPSYTQPQMPPHPAQLRHGP PMHTYIPGHPHHPTVMMHGG PPHPGMPMSASSPTVLNTGD PTMSGQVMDIHAQ in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85707 mRNA Translation: AAC51642.1
CR612956 mRNA No translation available.
AC007392 Genomic DNA No translation available.
AC092669 Genomic DNA No translation available.
AC093641 Genomic DNA No translation available.
BC043503 mRNA Translation: AAH43503.1
CCDSiCCDS46309.1 [O00470-1]
RefSeqiNP_002389.1, NM_002398.2 [O00470-1]
UniGeneiHs.526754
Hs.603755

Genome annotation databases

EnsembliENST00000272369; ENSP00000272369; ENSG00000143995 [O00470-1]
ENST00000398506; ENSP00000381518; ENSG00000143995 [O00470-2]
GeneIDi4211
KEGGihsa:4211
UCSCiuc002sdu.4 human [O00470-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMEIS1_HUMAN
AccessioniPrimary (citable) accession number: O00470
Secondary accession number(s): A8MV50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 18, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health