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Protein

Golgi integral membrane protein 4

Gene

GOLIM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.1 Publication

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi integral membrane protein 4
Alternative name(s):
Golgi integral membrane protein, cis
Short name:
GIMPc
Golgi phosphoprotein 4
Golgi-localized phosphoprotein of 130 kDa
Short name:
Golgi phosphoprotein of 130 kDa
Gene namesi
Name:GOLIM4
Synonyms:GIMPC, GOLPH4, GPP130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173905.8
HGNCiHGNC:15448 GOLIM4
MIMi606805 gene
neXtProtiNX_O00461

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 12CytoplasmicSequence analysisAdd BLAST11
Transmembranei13 – 33Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini34 – 696LumenalSequence analysisAdd BLAST663

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27333
OpenTargetsiENSG00000173905
PharmGKBiPA162390001

Polymorphism and mutation databases

BioMutaiGOLIM4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002850972 – 696Golgi integral membrane protein 4Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei364PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei613PhosphotyrosineCombined sources1
Modified residuei626PhosphothreonineCombined sources1
Modified residuei673PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.1 Publication
O-glycosylated; modified by sialic acid residues.By similarity
N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiO00461
MaxQBiO00461
PaxDbiO00461
PeptideAtlasiO00461
PRIDEiO00461
ProteomicsDBi47911

PTM databases

iPTMnetiO00461
PhosphoSitePlusiO00461
SwissPalmiO00461

Expressioni

Gene expression databases

BgeeiENSG00000173905 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_GOLIM4
ExpressionAtlasiO00461 baseline and differential
GenevisibleiO00461 HS

Organism-specific databases

HPAiHPA001677
HPA002315

Interactioni

Protein-protein interaction databases

BioGridi118146, 66 interactors
DIPiDIP-61898N
IntActiO00461, 30 interactors
MINTiO00461
STRINGi9606.ENSP00000417354

Structurei

3D structure databases

ProteinModelPortaliO00461
SMRiO00461
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 107Golgi targetingAdd BLAST70
Regioni80 – 175Endosome targetingAdd BLAST96
Regioni176 – 248Golgi targetingAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili35 – 244Sequence analysisAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 681Glu-richAdd BLAST371
Compositional biasi404 – 513Gln-richAdd BLAST110

Sequence similaritiesi

Belongs to the GOLIM4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGPG Eukaryota
ENOG410XRK9 LUCA
GeneTreeiENSGT00390000004096
HOGENOMiHOG000112755
HOVERGENiHBG107959
InParanoidiO00461
OMAiAHQDMHT
OrthoDBiEOG091G053H
PhylomeDBiO00461
TreeFamiTF333101

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00461-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNGMCSRKQ KRIFQTLLLL TVVFGFLYGA MLYYELQTQL RKAEAVALKY
60 70 80 90 100
QQHQESLSAQ LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL
110 120 130 140 150
NKGRQDSNSR YSALNVQHQM LKSQHEELKK QHSDLEEEHR KQGEDFSRTF
160 170 180 190 200
NDHKQKYLQL QQEKEQELSK LKETVYNLRE ENRQLRKAHQ DIHTQLQDVK
210 220 230 240 250
QQHKNLLSEH EQLVVTLEDH KSALAAAQTQ VAEYKQLKDT LNRIPSLRKP
260 270 280 290 300
DPAEQQNVTQ VAHSPQGYNT AREKPTREVQ EVSRNNDVWQ NHEAVPGRAE
310 320 330 340 350
DTKLYAPTHK EAEFQAPPEP IQQEVERREP EEHQVEEEHR KALEEEEMEQ
360 370 380 390 400
VGQAEHLEEE HDPSPEEQDR EWKEQHEQRE AANLLEGHAR AEVYPSAKPM
410 420 430 440 450
IKFQSPYEEQ LEQQRLAVQQ VEEAQQLREH QEALHQQRLQ GHLLRQQEQQ
460 470 480 490 500
QQQVAREMAL QRQAELEEGR PQHQEQLRQQ AHYDAMDNDI VQGAEDQGIQ
510 520 530 540 550
GEEGAYERDN QHQDEAEGDP GNRHEPREQG PREADPESEA DRAAVEDINP
560 570 580 590 600
ADDPNNQGED EFEEAEQVRE ENLPDENEEQ KQSNQKQENT EVEEHLVMAG
610 620 630 640 650
NPDQQEDNVD EQYQEEAEEE VQEDLTEEKK RELEHNAEET YGENDENTDD
660 670 680 690
KNNDGEEQEV RDDNRPKGRE EHYEEEEEEE EDGAAVAEKS HRRAEM
Length:696
Mass (Da):81,880
Last modified:July 1, 1997 - v1
Checksum:iA3BA9AE3D52F7174
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W785F8W785_HUMAN
Golgi integral membrane protein 4
GOLIM4
668Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036611312A → V in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA Translation: AAB58419.1
CCDSiCCDS3204.1
RefSeqiNP_055313.1, NM_014498.4
UniGeneiHs.143600
Hs.592880

Genome annotation databases

EnsembliENST00000470487; ENSP00000417354; ENSG00000173905
GeneIDi27333
KEGGihsa:27333
UCSCiuc003ffe.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55853 mRNA Translation: AAB58419.1
CCDSiCCDS3204.1
RefSeqiNP_055313.1, NM_014498.4
UniGeneiHs.143600
Hs.592880

3D structure databases

ProteinModelPortaliO00461
SMRiO00461
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118146, 66 interactors
DIPiDIP-61898N
IntActiO00461, 30 interactors
MINTiO00461
STRINGi9606.ENSP00000417354

PTM databases

iPTMnetiO00461
PhosphoSitePlusiO00461
SwissPalmiO00461

Polymorphism and mutation databases

BioMutaiGOLIM4

Proteomic databases

EPDiO00461
MaxQBiO00461
PaxDbiO00461
PeptideAtlasiO00461
PRIDEiO00461
ProteomicsDBi47911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470487; ENSP00000417354; ENSG00000173905
GeneIDi27333
KEGGihsa:27333
UCSCiuc003ffe.3 human

Organism-specific databases

CTDi27333
DisGeNETi27333
EuPathDBiHostDB:ENSG00000173905.8
GeneCardsiGOLIM4
HGNCiHGNC:15448 GOLIM4
HPAiHPA001677
HPA002315
MIMi606805 gene
neXtProtiNX_O00461
OpenTargetsiENSG00000173905
PharmGKBiPA162390001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPG Eukaryota
ENOG410XRK9 LUCA
GeneTreeiENSGT00390000004096
HOGENOMiHOG000112755
HOVERGENiHBG107959
InParanoidiO00461
OMAiAHQDMHT
OrthoDBiEOG091G053H
PhylomeDBiO00461
TreeFamiTF333101

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiGOLIM4 human
GenomeRNAii27333
PROiPR:O00461
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173905 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_GOLIM4
ExpressionAtlasiO00461 baseline and differential
GenevisibleiO00461 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGOLI4_HUMAN
AccessioniPrimary (citable) accession number: O00461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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