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Protein

Interferon-related developmental regulator 1

Gene

IFRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-related developmental regulator 1
Alternative name(s):
Nerve growth factor-inducible protein PC4
Gene namesi
Name:IFRD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006652.13
HGNCiHGNC:5456 IFRD1
MIMi603502 gene
neXtProtiNX_O00458

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3475
MalaCardsiIFRD1
OpenTargetsiENSG00000006652
Orphaneti98771 Spinocerebellar ataxia type 18
PharmGKBiPA29691

Polymorphism and mutation databases

BioMutaiIFRD1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001532851 – 451Interferon-related developmental regulator 1Add BLAST451

Proteomic databases

EPDiO00458
MaxQBiO00458
PaxDbiO00458
PeptideAtlasiO00458
PRIDEiO00458
ProteomicsDBi47909

PTM databases

iPTMnetiO00458
PhosphoSitePlusiO00458

Expressioni

Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

BgeeiENSG00000006652 Expressed in 236 organ(s), highest expression level in body of pancreas
CleanExiHS_IFRD1
ExpressionAtlasiO00458 baseline and differential
GenevisibleiO00458 HS

Organism-specific databases

HPAiHPA024122

Interactioni

Subunit structurei

Interacts with PSIP1/LEDGF.1 Publication

Protein-protein interaction databases

BioGridi109697, 16 interactors
IntActiO00458, 4 interactors
MINTiO00458
STRINGi9606.ENSP00000005558

Structurei

3D structure databases

ProteinModelPortaliO00458
SMRiO00458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 22Poly-Gly6
Compositional biasi23 – 31Poly-Ala9
Compositional biasi144 – 149Poly-Ala6

Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGiKOG2842 Eukaryota
ENOG410XSIZ LUCA
GeneTreeiENSGT00390000013347
HOGENOMiHOG000252918
HOVERGENiHBG052089
InParanoidiO00458
OMAiSDDVNMR
OrthoDBiEOG091G083T
PhylomeDBiO00458
TreeFamiTF313638

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039777 IFRD
IPR006921 Interferon-rel_develop_reg_C
IPR007701 Interferon-rel_develop_reg_N
PANTHERiPTHR12354 PTHR12354, 1 hit
PfamiView protein in Pfam
PF05004 IFRD, 1 hit
PF04836 IFRD_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00458-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET
60 70 80 90 100
MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ
110 120 130 140 150
AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS
160 170 180 190 200
VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI
210 220 230 240 250
ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL
260 270 280 290 300
LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI
310 320 330 340 350
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD
360 370 380 390 400
FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE
410 420 430 440 450
LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF

F
Length:451
Mass (Da):50,269
Last modified:July 5, 2005 - v4
Checksum:iE1A086D34E471709
GO
Isoform 2 (identifier: O00458-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:401
Mass (Da):45,336
Checksum:i44DCB525C3F3DE55
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNM6C9JNM6_HUMAN
Interferon-related developmental re...
IFRD1
127Annotation score:
C9JA65C9JA65_HUMAN
Interferon-related developmental re...
IFRD1
148Annotation score:
C9JLG5C9JLG5_HUMAN
Interferon-related developmental re...
IFRD1
62Annotation score:
E9PMY4E9PMY4_HUMAN
Interferon-related developmental re...
IFRD1
103Annotation score:
H0YEE3H0YEE3_HUMAN
Interferon-related developmental re...
IFRD1
98Annotation score:
C9J7U6C9J7U6_HUMAN
Interferon-related developmental re...
IFRD1
40Annotation score:
C9J311C9J311_HUMAN
Interferon-related developmental re...
IFRD1
30Annotation score:
C9JK78C9JK78_HUMAN
Interferon-related developmental re...
IFRD1
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44E → D in AAV38693 (Ref. 3) Curated1
Sequence conflicti84L → R in CAA71366 (PubMed:9722946).Curated1
Sequence conflicti314Q → R in AAV38693 (Ref. 3) Curated1
Sequence conflicti388 – 392HLQSN → PLAVKM in CAA71366 (PubMed:9722946).Curated5
Sequence conflicti396R → E in CAA71366 (PubMed:9722946).Curated1
Sequence conflicti401 – 411LGPPVMLDAAT → TWTPSDALMLQR in CAA71366 (PubMed:9722946).CuratedAdd BLAST11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06472339Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443041 – 50Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10313 mRNA Translation: CAA71366.1
AK298894 mRNA Translation: BAH12897.1
AK315967 mRNA Translation: BAH14338.1
BT019889 mRNA Translation: AAV38692.1
BT019890 mRNA Translation: AAV38693.1
AC002459 Genomic DNA No translation available.
AC005192 Genomic DNA Translation: AAC24562.1
AC079741 Genomic DNA No translation available.
BC001272 mRNA Translation: AAH01272.1
CCDSiCCDS34736.1 [O00458-1]
CCDS56504.1 [O00458-2]
RefSeqiNP_001007246.1, NM_001007245.2 [O00458-1]
NP_001184008.1, NM_001197079.1 [O00458-2]
NP_001184009.1, NM_001197080.1 [O00458-2]
NP_001541.2, NM_001550.3 [O00458-1]
XP_016867640.1, XM_017012151.1
UniGeneiHs.744747
Hs.7879

Genome annotation databases

EnsembliENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1]
ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1]
ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2]
ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
GeneIDi3475
KEGGihsa:3475
UCSCiuc003vgh.4 human [O00458-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10313 mRNA Translation: CAA71366.1
AK298894 mRNA Translation: BAH12897.1
AK315967 mRNA Translation: BAH14338.1
BT019889 mRNA Translation: AAV38692.1
BT019890 mRNA Translation: AAV38693.1
AC002459 Genomic DNA No translation available.
AC005192 Genomic DNA Translation: AAC24562.1
AC079741 Genomic DNA No translation available.
BC001272 mRNA Translation: AAH01272.1
CCDSiCCDS34736.1 [O00458-1]
CCDS56504.1 [O00458-2]
RefSeqiNP_001007246.1, NM_001007245.2 [O00458-1]
NP_001184008.1, NM_001197079.1 [O00458-2]
NP_001184009.1, NM_001197080.1 [O00458-2]
NP_001541.2, NM_001550.3 [O00458-1]
XP_016867640.1, XM_017012151.1
UniGeneiHs.744747
Hs.7879

3D structure databases

ProteinModelPortaliO00458
SMRiO00458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109697, 16 interactors
IntActiO00458, 4 interactors
MINTiO00458
STRINGi9606.ENSP00000005558

PTM databases

iPTMnetiO00458
PhosphoSitePlusiO00458

Polymorphism and mutation databases

BioMutaiIFRD1

Proteomic databases

EPDiO00458
MaxQBiO00458
PaxDbiO00458
PeptideAtlasiO00458
PRIDEiO00458
ProteomicsDBi47909

Protocols and materials databases

DNASUi3475
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1]
ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1]
ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2]
ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
GeneIDi3475
KEGGihsa:3475
UCSCiuc003vgh.4 human [O00458-1]

Organism-specific databases

CTDi3475
DisGeNETi3475
EuPathDBiHostDB:ENSG00000006652.13
GeneCardsiIFRD1
HGNCiHGNC:5456 IFRD1
HPAiHPA024122
MalaCardsiIFRD1
MIMi603502 gene
neXtProtiNX_O00458
OpenTargetsiENSG00000006652
Orphaneti98771 Spinocerebellar ataxia type 18
PharmGKBiPA29691
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2842 Eukaryota
ENOG410XSIZ LUCA
GeneTreeiENSGT00390000013347
HOGENOMiHOG000252918
HOVERGENiHBG052089
InParanoidiO00458
OMAiSDDVNMR
OrthoDBiEOG091G083T
PhylomeDBiO00458
TreeFamiTF313638

Miscellaneous databases

ChiTaRSiIFRD1 human
GeneWikiiIFRD1
GenomeRNAii3475
PROiPR:O00458
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006652 Expressed in 236 organ(s), highest expression level in body of pancreas
CleanExiHS_IFRD1
ExpressionAtlasiO00458 baseline and differential
GenevisibleiO00458 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039777 IFRD
IPR006921 Interferon-rel_develop_reg_C
IPR007701 Interferon-rel_develop_reg_N
PANTHERiPTHR12354 PTHR12354, 1 hit
PfamiView protein in Pfam
PF05004 IFRD, 1 hit
PF04836 IFRD_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFRD1_HUMAN
AccessioniPrimary (citable) accession number: O00458
Secondary accession number(s): B7Z5G1
, O75234, Q5U013, Q9BVE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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