UniProtKB - O00458 (IFRD1_HUMAN)

BLAST

>sp|O00458|IFRD1_HUMAN Interferon-related developmental regulator 1 OS=Homo sapiens OX=9606 GN=IFRD1 PE=1 SV=4
MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDEDASIETMSHCSGYSDP
SSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFIL
ERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPILKKIICDG
SASMQARQTCATCFGVCCFIATDDITELYSTLECLENIFTKSYLKEKDTTVICSTPNTVL
HISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARGI
ESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETIKFGP
ERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMKISRF
ERHLYNSAAFKARTKARSKCRDKRADVGEFF

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History
Entry version 140 (07 Nov 2018)
Sequence version 4 (05 Jul 2005)
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Protein

Interferon-related developmental regulator 1

Gene

IFRD1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).By similarity

GO - Biological processⁱ

muscle cell differentiation Source: Ensembl
myoblast fate determination
Source: ProtInc
Traceable author statementⁱ
- 7756174
negative regulation of axon extension Source: Ensembl
negative regulation of collateral sprouting Source: Ensembl
skeletal muscle tissue regeneration Source: Ensembl
striated muscle tissue development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon-related developmental regulator 1 Alternative name(s): Nerve growth factor-inducible protein PC4
Gene namesⁱ	Name:IFRD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000006652.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5456 IFRD1
MIMⁱ	603502 gene
neXtProtⁱ	NX_O00458

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3475
MalaCards human disease database More...MalaCardsⁱ	IFRD1
Open Targets More...OpenTargetsⁱ	ENSG00000006652
Orphanetⁱ	98771 Spinocerebellar ataxia type 18
PharmGKBⁱ	PA29691

Polymorphism and mutation databases

BioMutaⁱ	IFRD1

BioMutaⁱ

IFRD1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153285	1 – 451	Interferon-related developmental regulator 1Add BLAST		451

Proteomic databases

EPDⁱ	O00458
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00458
PaxDbⁱ	O00458
PeptideAtlas More...PeptideAtlasⁱ	O00458
PRIDEⁱ	O00458
ProteomicsDBⁱ	47909

PTM databases

iPTMnetⁱ	O00458
PhosphoSitePlusⁱ	O00458

Expressionⁱ

Tissue specificityⁱ

Expressed in a variety of tissues.

Gene expression databases

Bgeeⁱ	ENSG00000006652 Expressed in 236 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_IFRD1
ExpressionAtlasⁱ	O00458 baseline and differential
Genevisibleⁱ	O00458 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024122

HPAⁱ

HPA024122

Interactionⁱ

Subunit structureⁱ

Interacts with PSIP1/LEDGF.1 Publication

Protein-protein interaction databases

BioGridⁱ	109697, 16 interactors
IntActⁱ	O00458, 4 interactors
Molecular INTeraction database More...MINTⁱ	O00458
STRINGⁱ	9606.ENSP00000005558

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00458
SMRⁱ	O00458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	17 – 22	Poly-Gly	6
Compositional biasⁱ	23 – 31	Poly-Ala	9
Compositional biasⁱ	144 – 149	Poly-Ala	6

Sequence similaritiesⁱ

Belongs to the IFRD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2842 Eukaryota ENOG410XSIZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013347
HOGENOMⁱ	HOG000252918
HOVERGENⁱ	HBG052089
InParanoidⁱ	O00458
OMAⁱ	SDDVNMR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G083T
PhylomeDBⁱ	O00458
TreeFamⁱ	TF313638

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR039777 IFRD IPR006921 Interferon-rel_develop_reg_C IPR007701 Interferon-rel_develop_reg_N
PANTHERⁱ	PTHR12354 PTHR12354, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05004 IFRD, 1 hit PF04836 IFRD_C, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00458-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET 
        60         70         80         90        100
MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ 
       110        120        130        140        150
AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS 
       160        170        180        190        200
VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI 
       210        220        230        240        250
ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL 
       260        270        280        290        300
LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI 
       310        320        330        340        350
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD 
       360        370        380        390        400
FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE 
       410        420        430        440        450
LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF 

F

Length:451

Mass (Da):50,269

Last modified:July 5, 2005 - v4

Checksum:ⁱE1A086D34E471709

Isoform 2 (identifier: O00458-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-50: Missing.

« Hide

        10         20         30         40         50
MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ 
        60         70         80         90        100
AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS 
       110        120        130        140        150
VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI 
       160        170        180        190        200
ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL 
       210        220        230        240        250
LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI 
       260        270        280        290        300
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD 
       310        320        330        340        350
FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE 
       360        370        380        390        400
LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF 

F

Show »

Length:401

Mass (Da):45,336

Checksum:ⁱ44DCB525C3F3DE55

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JNM6	C9JNM6_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	127	Annotation score:
C9JA65	C9JA65_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	148	Annotation score:
C9JLG5	C9JLG5_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	62	Annotation score:
E9PMY4	E9PMY4_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	103	Annotation score:
H0YEE3	H0YEE3_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	98	Annotation score:
C9J7U6	C9J7U6_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	40	Annotation score:
C9J311	C9J311_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	30	Annotation score:
C9JK78	C9JK78_HUMAN	Interferon-related developmental re... Interferon-related developmental regulator 1	IFRD1	17	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	44	E → D in AAV38693 (Ref. 3) Curated	1
Sequence conflictⁱ	84	L → R in CAA71366 (PubMed:9722946).Curated	1
Sequence conflictⁱ	314	Q → R in AAV38693 (Ref. 3) Curated	1
Sequence conflictⁱ	388 – 392	HLQSN → PLAVKM in CAA71366 (PubMed:9722946).Curated	5
Sequence conflictⁱ	396	R → E in CAA71366 (PubMed:9722946).Curated	1
Sequence conflictⁱ	401 – 411	LGPPVMLDAAT → TWTPSDALMLQR in CAA71366 (PubMed:9722946).CuratedAdd BLAST	11

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064723	39	Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044304	1 – 50	Missing in isoform 2. 1 PublicationAdd BLAST		50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10313 mRNA Translation: CAA71366.1 AK298894 mRNA Translation: BAH12897.1 AK315967 mRNA Translation: BAH14338.1 BT019889 mRNA Translation: AAV38692.1 BT019890 mRNA Translation: AAV38693.1 AC002459 Genomic DNA No translation available. AC005192 Genomic DNA Translation: AAC24562.1 AC079741 Genomic DNA No translation available. BC001272 mRNA Translation: AAH01272.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34736.1 [O00458-1] CCDS56504.1 [O00458-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001007246.1, NM_001007245.2 [O00458-1] NP_001184008.1, NM_001197079.1 [O00458-2] NP_001184009.1, NM_001197080.1 [O00458-2] NP_001541.2, NM_001550.3 [O00458-1] XP_016867640.1, XM_017012151.1
UniGeneⁱ	Hs.744747 Hs.7879

Genome annotation databases

Ensemblⁱ	ENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1] ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1] ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2] ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
GeneIDⁱ	3475
KEGGⁱ	hsa:3475
UCSC genome browser More...UCSCⁱ	uc003vgh.4 human [O00458-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O00458	Interferon-related developmental regulator 1		HUMAN		451	UniRef100_O00458
Isoform 2 of Interferon-related developmental regulator 1		HUMAN		401

Protein	Similar proteins		Species	Score	Length	Source
O00458	Interferon-related developmental regulator 1		HUMAN		451	UniRef90_O00458
Interferon-related developmental regulator 1		TUPCH		471
Uncharacterized protein		CHLSB		456
Interferon related developmental regulator 1		MACMU		451
Uncharacterized protein		MANLE		451
+96

Protein	Similar proteins		Species	Score	Length	Source
O00458	Interferon-related developmental regulator 1		MOUSE		449	UniRef50_P19182
Interferon-related developmental regulator 1		PIG		450
Interferon-related developmental regulator 1		RAT		449
Uncharacterized protein		MANLE		492
Interferon-related developmental regulator 1 (Fragment)		HUMAN		103
+523

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10313 mRNA Translation: CAA71366.1 AK298894 mRNA Translation: BAH12897.1 AK315967 mRNA Translation: BAH14338.1 BT019889 mRNA Translation: AAV38692.1 BT019890 mRNA Translation: AAV38693.1 AC002459 Genomic DNA No translation available. AC005192 Genomic DNA Translation: AAC24562.1 AC079741 Genomic DNA No translation available. BC001272 mRNA Translation: AAH01272.1
CCDSⁱ	CCDS34736.1 [O00458-1] CCDS56504.1 [O00458-2]
RefSeqⁱ	NP_001007246.1, NM_001007245.2 [O00458-1] NP_001184008.1, NM_001197079.1 [O00458-2] NP_001184009.1, NM_001197080.1 [O00458-2] NP_001541.2, NM_001550.3 [O00458-1] XP_016867640.1, XM_017012151.1
UniGeneⁱ	Hs.744747 Hs.7879

3D structure databases

ProteinModelPortalⁱ	O00458
SMRⁱ	O00458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109697, 16 interactors
IntActⁱ	O00458, 4 interactors
MINTⁱ	O00458
STRINGⁱ	9606.ENSP00000005558

PTM databases

iPTMnetⁱ	O00458
PhosphoSitePlusⁱ	O00458

Polymorphism and mutation databases

BioMutaⁱ	IFRD1

BioMutaⁱ

IFRD1

Proteomic databases

EPDⁱ	O00458
MaxQBⁱ	O00458
PaxDbⁱ	O00458
PeptideAtlasⁱ	O00458
PRIDEⁱ	O00458
ProteomicsDBⁱ	47909

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3475
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1] ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1] ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2] ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
GeneIDⁱ	3475
KEGGⁱ	hsa:3475
UCSCⁱ	uc003vgh.4 human [O00458-1]

Organism-specific databases

CTDⁱ	3475
DisGeNETⁱ	3475
EuPathDBⁱ	HostDB:ENSG00000006652.13
GeneCardsⁱ	IFRD1
HGNCⁱ	HGNC:5456 IFRD1
HPAⁱ	HPA024122
MalaCardsⁱ	IFRD1
MIMⁱ	603502 gene
neXtProtⁱ	NX_O00458
OpenTargetsⁱ	ENSG00000006652
Orphanetⁱ	98771 Spinocerebellar ataxia type 18
PharmGKBⁱ	PA29691
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2842 Eukaryota ENOG410XSIZ LUCA
GeneTreeⁱ	ENSGT00390000013347
HOGENOMⁱ	HOG000252918
HOVERGENⁱ	HBG052089
InParanoidⁱ	O00458
OMAⁱ	SDDVNMR
OrthoDBⁱ	EOG091G083T
PhylomeDBⁱ	O00458
TreeFamⁱ	TF313638

Miscellaneous databases

ChiTaRSⁱ	IFRD1 human
GeneWikiⁱ	IFRD1
GenomeRNAiⁱ	3475
Protein Ontology More...PROⁱ	PR:O00458
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000006652 Expressed in 236 organ(s), highest expression level in body of pancreas
CleanExⁱ	HS_IFRD1
ExpressionAtlasⁱ	O00458 baseline and differential
Genevisibleⁱ	O00458 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR039777 IFRD IPR006921 Interferon-rel_develop_reg_C IPR007701 Interferon-rel_develop_reg_N
PANTHERⁱ	PTHR12354 PTHR12354, 1 hit
Pfamⁱ	View protein in Pfam PF05004 IFRD, 1 hit PF04836 IFRD_C, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFRD1_HUMAN
Accessionⁱ	O00458Primary (citable) accession number: O00458 Secondary accession number(s): B7Z5G1 , O75234, Q5U013, Q9BVE4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	July 5, 2005
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - O00458 (IFRD1_HUMAN)

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Interferon-related developmental regulator 1

IFRD1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ