UniProtKB - O00458 (IFRD1_HUMAN)
Protein
Interferon-related developmental regulator 1
Gene
IFRD1
Organism
Homo sapiens (Human)
Status
Functioni
Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).By similarity
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- myoblast fate determination Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | O00458 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-related developmental regulator 1Alternative name(s): Nerve growth factor-inducible protein PC4 |
Gene namesi | Name:IFRD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5456, IFRD1 |
MIMi | 603502, gene |
neXtProti | NX_O00458 |
VEuPathDBi | HostDB:ENSG00000006652.13 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3475 |
MalaCardsi | IFRD1 |
OpenTargetsi | ENSG00000006652 |
Orphaneti | 98771, Spinocerebellar ataxia type 18 |
PharmGKBi | PA29691 |
Miscellaneous databases
Pharosi | O00458, Tbio |
Genetic variation databases
BioMutai | IFRD1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153285 | 1 – 451 | Interferon-related developmental regulator 1Add BLAST | 451 |
Proteomic databases
EPDi | O00458 |
jPOSTi | O00458 |
MassIVEi | O00458 |
MaxQBi | O00458 |
PaxDbi | O00458 |
PeptideAtlasi | O00458 |
PRIDEi | O00458 |
ProteomicsDBi | 47909 [O00458-1] 6690 |
PTM databases
iPTMneti | O00458 |
PhosphoSitePlusi | O00458 |
Expressioni
Tissue specificityi
Expressed in a variety of tissues.
Gene expression databases
Bgeei | ENSG00000006652, Expressed in body of pancreas and 247 other tissues |
ExpressionAtlasi | O00458, baseline and differential |
Genevisiblei | O00458, HS |
Organism-specific databases
HPAi | ENSG00000006652, Tissue enhanced (pancreas) |
Interactioni
Subunit structurei
Interacts with PSIP1/LEDGF.
1 PublicationProtein-protein interaction databases
BioGRIDi | 109697, 20 interactors |
IntActi | O00458, 7 interactors |
MINTi | O00458 |
STRINGi | 9606.ENSP00000384477 |
Miscellaneous databases
RNActi | O00458, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 17 – 22 | Poly-Gly | 6 | |
Compositional biasi | 23 – 31 | Poly-Ala | 9 | |
Compositional biasi | 144 – 149 | Poly-Ala | 6 |
Sequence similaritiesi
Belongs to the IFRD family.Curated
Phylogenomic databases
eggNOGi | KOG2842, Eukaryota |
GeneTreei | ENSGT00390000013347 |
HOGENOMi | CLU_031384_1_0_1 |
InParanoidi | O00458 |
OMAi | VYNLSME |
PhylomeDBi | O00458 |
TreeFami | TF313638 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR039777, IFRD IPR006921, Interferon-rel_develop_reg_C IPR007701, Interferon-rel_develop_reg_N |
PANTHERi | PTHR12354, PTHR12354, 1 hit |
Pfami | View protein in Pfam PF05004, IFRD, 1 hit PF04836, IFRD_C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O00458-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET
60 70 80 90 100
MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ
110 120 130 140 150
AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS
160 170 180 190 200
VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI
210 220 230 240 250
ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL
260 270 280 290 300
LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI
310 320 330 340 350
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD
360 370 380 390 400
FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE
410 420 430 440 450
LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF
F
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q8PH75 | A0A6Q8PH75_HUMAN | Interferon-related developmental re... | IFRD1 | 351 | Annotation score: | ||
C9JA65 | C9JA65_HUMAN | Interferon-related developmental re... | IFRD1 | 148 | Annotation score: | ||
C9JLG5 | C9JLG5_HUMAN | Interferon-related developmental re... | IFRD1 | 62 | Annotation score: | ||
A0A6Q8PF03 | A0A6Q8PF03_HUMAN | Interferon-related developmental re... | IFRD1 | 256 | Annotation score: | ||
A0A6Q8PHN0 | A0A6Q8PHN0_HUMAN | Interferon-related developmental re... | IFRD1 | 261 | Annotation score: | ||
A0A6Q8PFA5 | A0A6Q8PFA5_HUMAN | Interferon-related developmental re... | IFRD1 | 141 | Annotation score: | ||
C9JNM6 | C9JNM6_HUMAN | Interferon-related developmental re... | IFRD1 | 127 | Annotation score: | ||
E9PMY4 | E9PMY4_HUMAN | Interferon-related developmental re... | IFRD1 | 103 | Annotation score: | ||
C9J7U6 | C9J7U6_HUMAN | Interferon-related developmental re... | IFRD1 | 40 | Annotation score: | ||
C9J311 | C9J311_HUMAN | Interferon-related developmental re... | IFRD1 | 30 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | E → D in AAV38693 (Ref. 3) Curated | 1 | |
Sequence conflicti | 84 | L → R in CAA71366 (PubMed:9722946).Curated | 1 | |
Sequence conflicti | 314 | Q → R in AAV38693 (Ref. 3) Curated | 1 | |
Sequence conflicti | 388 – 392 | HLQSN → PLAVKM in CAA71366 (PubMed:9722946).Curated | 5 | |
Sequence conflicti | 396 | R → E in CAA71366 (PubMed:9722946).Curated | 1 | |
Sequence conflicti | 401 – 411 | LGPPVMLDAAT → TWTPSDALMLQR in CAA71366 (PubMed:9722946).CuratedAdd BLAST | 11 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064723 | 39 | Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044304 | 1 – 50 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10313 mRNA Translation: CAA71366.1 AK298894 mRNA Translation: BAH12897.1 AK315967 mRNA Translation: BAH14338.1 BT019889 mRNA Translation: AAV38692.1 BT019890 mRNA Translation: AAV38693.1 AC002459 Genomic DNA No translation available. AC005192 Genomic DNA Translation: AAC24562.1 AC079741 Genomic DNA No translation available. BC001272 mRNA Translation: AAH01272.1 |
CCDSi | CCDS34736.1 [O00458-1] CCDS56504.1 [O00458-2] |
RefSeqi | NP_001007246.1, NM_001007245.2 [O00458-1] NP_001184008.1, NM_001197079.1 [O00458-2] NP_001184009.1, NM_001197080.1 [O00458-2] NP_001541.2, NM_001550.3 [O00458-1] XP_016867640.1, XM_017012151.1 |
Genome annotation databases
Ensembli | ENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1] ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1] ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2] ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2] ENST00000675578; ENSP00000502336; ENSG00000006652 [O00458-1] |
GeneIDi | 3475 |
KEGGi | hsa:3475 |
UCSCi | uc003vgh.4, human [O00458-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10313 mRNA Translation: CAA71366.1 AK298894 mRNA Translation: BAH12897.1 AK315967 mRNA Translation: BAH14338.1 BT019889 mRNA Translation: AAV38692.1 BT019890 mRNA Translation: AAV38693.1 AC002459 Genomic DNA No translation available. AC005192 Genomic DNA Translation: AAC24562.1 AC079741 Genomic DNA No translation available. BC001272 mRNA Translation: AAH01272.1 |
CCDSi | CCDS34736.1 [O00458-1] CCDS56504.1 [O00458-2] |
RefSeqi | NP_001007246.1, NM_001007245.2 [O00458-1] NP_001184008.1, NM_001197079.1 [O00458-2] NP_001184009.1, NM_001197080.1 [O00458-2] NP_001541.2, NM_001550.3 [O00458-1] XP_016867640.1, XM_017012151.1 |
3D structure databases
SMRi | O00458 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109697, 20 interactors |
IntActi | O00458, 7 interactors |
MINTi | O00458 |
STRINGi | 9606.ENSP00000384477 |
PTM databases
iPTMneti | O00458 |
PhosphoSitePlusi | O00458 |
Genetic variation databases
BioMutai | IFRD1 |
Proteomic databases
EPDi | O00458 |
jPOSTi | O00458 |
MassIVEi | O00458 |
MaxQBi | O00458 |
PaxDbi | O00458 |
PeptideAtlasi | O00458 |
PRIDEi | O00458 |
ProteomicsDBi | 47909 [O00458-1] 6690 |
Protocols and materials databases
Antibodypediai | 17367, 169 antibodies |
DNASUi | 3475 |
Genome annotation databases
Ensembli | ENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1] ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1] ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2] ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2] ENST00000675578; ENSP00000502336; ENSG00000006652 [O00458-1] |
GeneIDi | 3475 |
KEGGi | hsa:3475 |
UCSCi | uc003vgh.4, human [O00458-1] |
Organism-specific databases
CTDi | 3475 |
DisGeNETi | 3475 |
GeneCardsi | IFRD1 |
HGNCi | HGNC:5456, IFRD1 |
HPAi | ENSG00000006652, Tissue enhanced (pancreas) |
MalaCardsi | IFRD1 |
MIMi | 603502, gene |
neXtProti | NX_O00458 |
OpenTargetsi | ENSG00000006652 |
Orphaneti | 98771, Spinocerebellar ataxia type 18 |
PharmGKBi | PA29691 |
VEuPathDBi | HostDB:ENSG00000006652.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2842, Eukaryota |
GeneTreei | ENSGT00390000013347 |
HOGENOMi | CLU_031384_1_0_1 |
InParanoidi | O00458 |
OMAi | VYNLSME |
PhylomeDBi | O00458 |
TreeFami | TF313638 |
Enzyme and pathway databases
PathwayCommonsi | O00458 |
Miscellaneous databases
BioGRID-ORCSi | 3475, 13 hits in 1000 CRISPR screens |
ChiTaRSi | IFRD1, human |
GeneWikii | IFRD1 |
GenomeRNAii | 3475 |
Pharosi | O00458, Tbio |
PROi | PR:O00458 |
RNActi | O00458, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006652, Expressed in body of pancreas and 247 other tissues |
ExpressionAtlasi | O00458, baseline and differential |
Genevisiblei | O00458, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR039777, IFRD IPR006921, Interferon-rel_develop_reg_C IPR007701, Interferon-rel_develop_reg_N |
PANTHERi | PTHR12354, PTHR12354, 1 hit |
Pfami | View protein in Pfam PF05004, IFRD, 1 hit PF04836, IFRD_C, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFRD1_HUMAN | |
Accessioni | O00458Primary (citable) accession number: O00458 Secondary accession number(s): B7Z5G1 Q9BVE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | July 5, 2005 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families