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UniProtKB - O00458 (IFRD1_HUMAN)

Entry version 156 (07 Apr 2021)
Sequence version 4 (05 Jul 2005)
Previous versions | rss
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Protein

Interferon-related developmental regulator 1

Gene

IFRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00458

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-related developmental regulator 1
Alternative name(s):
Nerve growth factor-inducible protein PC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFRD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5456, IFRD1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603502, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00458

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000006652.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3475

MalaCards human disease database

More...MalaCardsi		IFRD1

Open Targets

More...OpenTargetsi		ENSG00000006652

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98771, Spinocerebellar ataxia type 18

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29691

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00458, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IFRD1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001532851 – 451Interferon-related developmental regulator 1Add BLAST451

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00458

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00458

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00458

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00458

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00458

PeptideAtlas

More...PeptideAtlasi		O00458

PRoteomics IDEntifications database

More...PRIDEi		O00458

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47909 [O00458-1]
6690

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00458

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00458

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000006652, Expressed in body of pancreas and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00458, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00458, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000006652, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PSIP1/LEDGF.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109697, 20 interactors

Protein interaction database and analysis system

More...IntActi		O00458, 7 interactors

Molecular INTeraction database

More...MINTi		O00458

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384477

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00458, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00458

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 22Poly-Gly6
Compositional biasi23 – 31Poly-Ala9
Compositional biasi144 – 149Poly-Ala6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFRD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2842, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013347

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031384_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00458

Identification of Orthologs from Complete Genome Data

More...OMAi		VYNLSME

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00458

TreeFam database of animal gene trees

More...TreeFami		TF313638

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR039777, IFRD
IPR006921, Interferon-rel_develop_reg_C
IPR007701, Interferon-rel_develop_reg_N

The PANTHER Classification System

More...PANTHERi		PTHR12354, PTHR12354, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05004, IFRD, 1 hit
PF04836, IFRD_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00458-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET 
        60         70         80         90        100
MSHCSGYSDP SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ 
       110        120        130        140        150
AALEGIKNAL ASKMLYEFIL ERRMTLTDSI ERCLKKGKSD EQRAAAALAS 
       160        170        180        190        200
VLCIQLGPGI ESEEILKTLG PILKKIICDG SASMQARQTC ATCFGVCCFI 
       210        220        230        240        250
ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL HISSLLAWTL 
       260        270        280        290        300
LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI 
       310        320        330        340        350
ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD 
       360        370        380        390        400
FPTETIKFGP ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE 
       410        420        430        440        450
LGPPVMLDAA TLKTMKISRF ERHLYNSAAF KARTKARSKC RDKRADVGEF 

F
Length:451
Mass (Da):50,269
Last modified:July 5, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1A086D34E471709
GO
Isoform 2 (identifier: O00458-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:401
Mass (Da):45,336
Checksum:i44DCB525C3F3DE55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PH75A0A6Q8PH75_HUMAN
Interferon-related developmental re...
IFRD1
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JA65C9JA65_HUMAN
Interferon-related developmental re...
IFRD1
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLG5C9JLG5_HUMAN
Interferon-related developmental re...
IFRD1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF03A0A6Q8PF03_HUMAN
Interferon-related developmental re...
IFRD1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHN0A0A6Q8PHN0_HUMAN
Interferon-related developmental re...
IFRD1
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFA5A0A6Q8PFA5_HUMAN
Interferon-related developmental re...
IFRD1
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNM6C9JNM6_HUMAN
Interferon-related developmental re...
IFRD1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMY4E9PMY4_HUMAN
Interferon-related developmental re...
IFRD1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7U6C9J7U6_HUMAN
Interferon-related developmental re...
IFRD1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J311C9J311_HUMAN
Interferon-related developmental re...
IFRD1
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44E → D in AAV38693 (Ref. 3) Curated1
Sequence conflicti84L → R in CAA71366 (PubMed:9722946).Curated1
Sequence conflicti314Q → R in AAV38693 (Ref. 3) Curated1
Sequence conflicti388 – 392HLQSN → PLAVKM in CAA71366 (PubMed:9722946).Curated5
Sequence conflicti396R → E in CAA71366 (PubMed:9722946).Curated1
Sequence conflicti401 – 411LGPPVMLDAAT → TWTPSDALMLQR in CAA71366 (PubMed:9722946).CuratedAdd BLAST11

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06472339Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0443041 – 50Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y10313 mRNA Translation: CAA71366.1
AK298894 mRNA Translation: BAH12897.1
AK315967 mRNA Translation: BAH14338.1
BT019889 mRNA Translation: AAV38692.1
BT019890 mRNA Translation: AAV38693.1
AC002459 Genomic DNA No translation available.
AC005192 Genomic DNA Translation: AAC24562.1
AC079741 Genomic DNA No translation available.
BC001272 mRNA Translation: AAH01272.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34736.1 [O00458-1]
CCDS56504.1 [O00458-2]

NCBI Reference Sequences

More...RefSeqi		NP_001007246.1, NM_001007245.2 [O00458-1]
NP_001184008.1, NM_001197079.1 [O00458-2]
NP_001184009.1, NM_001197080.1 [O00458-2]
NP_001541.2, NM_001550.3 [O00458-1]
XP_016867640.1, XM_017012151.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1]
ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1]
ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2]
ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
ENST00000675578; ENSP00000502336; ENSG00000006652 [O00458-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3475

UCSC genome browser

More...UCSCi		uc003vgh.4, human [O00458-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10313 mRNA Translation: CAA71366.1
AK298894 mRNA Translation: BAH12897.1
AK315967 mRNA Translation: BAH14338.1
BT019889 mRNA Translation: AAV38692.1
BT019890 mRNA Translation: AAV38693.1
AC002459 Genomic DNA No translation available.
AC005192 Genomic DNA Translation: AAC24562.1
AC079741 Genomic DNA No translation available.
BC001272 mRNA Translation: AAH01272.1
CCDSiCCDS34736.1 [O00458-1]
CCDS56504.1 [O00458-2]
RefSeqiNP_001007246.1, NM_001007245.2 [O00458-1]
NP_001184008.1, NM_001197079.1 [O00458-2]
NP_001184009.1, NM_001197080.1 [O00458-2]
NP_001541.2, NM_001550.3 [O00458-1]
XP_016867640.1, XM_017012151.1

3D structure databases

SMRiO00458
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109697, 20 interactors
IntActiO00458, 7 interactors
MINTiO00458
STRINGi9606.ENSP00000384477

PTM databases

iPTMnetiO00458
PhosphoSitePlusiO00458

Genetic variation databases

BioMutaiIFRD1

Proteomic databases

EPDiO00458
jPOSTiO00458
MassIVEiO00458
MaxQBiO00458
PaxDbiO00458
PeptideAtlasiO00458
PRIDEiO00458
ProteomicsDBi47909 [O00458-1]
6690

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17367, 169 antibodies

The DNASU plasmid repository

More...DNASUi		3475

Genome annotation databases

EnsembliENST00000005558; ENSP00000005558; ENSG00000006652 [O00458-1]
ENST00000403825; ENSP00000384477; ENSG00000006652 [O00458-1]
ENST00000535603; ENSP00000439188; ENSG00000006652 [O00458-2]
ENST00000621379; ENSP00000483255; ENSG00000006652 [O00458-2]
ENST00000675578; ENSP00000502336; ENSG00000006652 [O00458-1]
GeneIDi3475
KEGGihsa:3475
UCSCiuc003vgh.4, human [O00458-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3475
DisGeNETi3475

GeneCards: human genes, protein and diseases

More...GeneCardsi		IFRD1
HGNCiHGNC:5456, IFRD1
HPAiENSG00000006652, Tissue enhanced (pancreas)
MalaCardsiIFRD1
MIMi603502, gene
neXtProtiNX_O00458
OpenTargetsiENSG00000006652
Orphaneti98771, Spinocerebellar ataxia type 18
PharmGKBiPA29691
VEuPathDBiHostDB:ENSG00000006652.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2842, Eukaryota
GeneTreeiENSGT00390000013347
HOGENOMiCLU_031384_1_0_1
InParanoidiO00458
OMAiVYNLSME
PhylomeDBiO00458
TreeFamiTF313638

Enzyme and pathway databases

PathwayCommonsiO00458

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3475, 13 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IFRD1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IFRD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3475
PharosiO00458, Tbio

Protein Ontology

More...PROi		PR:O00458
RNActiO00458, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000006652, Expressed in body of pancreas and 247 other tissues
ExpressionAtlasiO00458, baseline and differential
GenevisibleiO00458, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR039777, IFRD
IPR006921, Interferon-rel_develop_reg_C
IPR007701, Interferon-rel_develop_reg_N
PANTHERiPTHR12354, PTHR12354, 1 hit
PfamiView protein in Pfam
PF05004, IFRD, 1 hit
PF04836, IFRD_C, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFRD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00458
Secondary accession number(s): B7Z5G1
, O75234, Q5U013, Q9BVE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 5, 2005
Last modified: April 7, 2021
This is version 156 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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