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UniProtKB - O00445 (SYT5_HUMAN)

Entry version 188 (25 May 2022)
Sequence version 2 (11 Jul 2003)
Previous versions | rss
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Protein

Synaptotagmin-5

Gene

SYT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).

By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation1 PublicationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi138Calcium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi139Calcium 1PROSITE-ProRule annotation1
Metal bindingi139Calcium 2PROSITE-ProRule annotation1
Metal bindingi145Calcium 1PROSITE-ProRule annotation1
Metal bindingi197Calcium 1PROSITE-ProRule annotation1
Metal bindingi197Calcium 2PROSITE-ProRule annotation1
Metal bindingi198Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi199Calcium 1PROSITE-ProRule annotation1
Metal bindingi199Calcium 2PROSITE-ProRule annotation1
Metal bindingi199Calcium 3PROSITE-ProRule annotation1
Metal bindingi202Calcium 3PROSITE-ProRule annotation1
Metal bindingi205Calcium 2PROSITE-ProRule annotation1
Metal bindingi205Calcium 3PROSITE-ProRule annotation1
Metal bindingi270Calcium 4PROSITE-ProRule annotation1
Metal bindingi276Calcium 4PROSITE-ProRule annotation1
Metal bindingi330Calcium 4PROSITE-ProRule annotation1
Metal bindingi332Calcium 4PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00445

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-422356, Regulation of insulin secretion

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00445

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-5
Alternative name(s):
Synaptotagmin V
Short name:
SytV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYT5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11513, SYT5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600782, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00445

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000129990

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24VesicularSequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 386CytoplasmicSequence analysisAdd BLAST341

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi202S → G: Does not affect Ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6861

Open Targets

More...OpenTargetsi		ENSG00000129990

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36294

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00445, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYT5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001839511 – 386Synaptotagmin-5Add BLAST386

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00445

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00445

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00445

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00445

PeptideAtlas

More...PeptideAtlasi		O00445

PRoteomics IDEntifications database

More...PRIDEi		O00445

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47896 [O00445-1]
6480

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00445

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00445

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000129990, Expressed in frontal cortex and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00445, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00445, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000129990, Group enriched (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with both alpha- and beta-tubulin (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112725, 11 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		O00445

Protein interaction database and analysis system

More...IntActi		O00445, 8 interactors

Molecular INTeraction database

More...MINTi		O00445

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000346265

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00445, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O00445

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00445

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 227C2 1PROSITE-ProRule annotationAdd BLAST120
Domaini239 – 372C2 2PROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161816

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023008_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00445

Identification of Orthologs from Complete Genome Data

More...OMAi		CLCRKRC

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00445

TreeFam database of animal gene trees

More...TreeFami		TF315600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028689, SYT5

The PANTHER Classification System

More...PANTHERi		PTHR10024:SF282, PTHR10024:SF282, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL 
        60         70         80         90        100
YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG 
       110        120        130        140        150
QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV 
       160        170        180        190        200
YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR 
       210        220        230        240        250
FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV 
       260        270        280        290        300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 
       310        320        330        340        350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG 
       360        370        380 
GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP
Length:386
Mass (Da):42,900
Last modified:July 11, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96A36792D177FD55
GO
Isoform 2 (identifier: O00445-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MFPEPPTPGP...KGLGQSYIDK → MTRGGCPVSA...PTPVASATAQ
     237-237: Missing.

Show »
Length:382
Mass (Da):42,474
Checksum:iDC71E8CE6086B701
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJC4K7EJC4_HUMAN
Synaptotagmin-5
SYT5
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ59K7EQ59_HUMAN
Synaptotagmin-5
SYT5
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ95K7EJ95_HUMAN
Synaptotagmin-5
SYT5
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJS7K7EJS7_HUMAN
Synaptotagmin-5
SYT5
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYJ7M0QYJ7_HUMAN
Synaptotagmin-5
SYT5
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24H → R in BAG54160 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0522404E → D. Corresponds to variant dbSNP:rs2301279Ensembl.1
Natural variantiVAR_034528111R → Q2 PublicationsCorresponds to variant dbSNP:rs11542503Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571771 – 84MFPEP…SYIDK → MTRGGCPVSARLFAQRPHGS WSSLLCVGLKGRLGWEWGTR VLECLCRKDSRTPPPCSRSP QPRGLHRPTRLPTPVASATA Q in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_057178237Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X96783 Genomic DNA Translation: CAA65579.1
AK125182 mRNA Translation: BAG54160.1
AK295337 mRNA Translation: BAH12036.1
AC010327 Genomic DNA No translation available.
BC046157 mRNA Translation: AAH46157.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12919.1 [O00445-1]
CCDS74455.1 [O00445-2]

NCBI Reference Sequences

More...RefSeqi		NP_001284703.1, NM_001297774.1 [O00445-2]
NP_003171.2, NM_003180.2 [O00445-1]
XP_006723402.1, XM_006723339.3 [O00445-1]
XP_016882664.1, XM_017027175.1 [O00445-1]
XP_016882665.1, XM_017027176.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354308.8; ENSP00000346265.2; ENSG00000129990.15
ENST00000537500.5; ENSP00000442896.1; ENSG00000129990.15
ENST00000590851.5; ENSP00000465576.1; ENSG00000129990.15 [O00445-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6861

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6861

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000354308.8; ENSP00000346265.2; NM_003180.3; NP_003171.2

UCSC genome browser

More...UCSCi		uc002qjm.2, human [O00445-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96783 Genomic DNA Translation: CAA65579.1
AK125182 mRNA Translation: BAG54160.1
AK295337 mRNA Translation: BAH12036.1
AC010327 Genomic DNA No translation available.
BC046157 mRNA Translation: AAH46157.1
CCDSiCCDS12919.1 [O00445-1]
CCDS74455.1 [O00445-2]
RefSeqiNP_001284703.1, NM_001297774.1 [O00445-2]
NP_003171.2, NM_003180.2 [O00445-1]
XP_006723402.1, XM_006723339.3 [O00445-1]
XP_016882664.1, XM_017027175.1 [O00445-1]
XP_016882665.1, XM_017027176.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H4YX-ray1.90A102-242[»]
5H4ZX-ray3.01A/B102-242[»]
AlphaFoldDBiO00445
SMRiO00445
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112725, 11 interactors
ELMiO00445
IntActiO00445, 8 interactors
MINTiO00445
STRINGi9606.ENSP00000346265

PTM databases

iPTMnetiO00445
PhosphoSitePlusiO00445

Genetic variation databases

BioMutaiSYT5

Proteomic databases

jPOSTiO00445
MassIVEiO00445
MaxQBiO00445
PaxDbiO00445
PeptideAtlasiO00445
PRIDEiO00445
ProteomicsDBi47896 [O00445-1]
6480

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2420, 213 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		6861

Genome annotation databases

EnsembliENST00000354308.8; ENSP00000346265.2; ENSG00000129990.15
ENST00000537500.5; ENSP00000442896.1; ENSG00000129990.15
ENST00000590851.5; ENSP00000465576.1; ENSG00000129990.15 [O00445-2]
GeneIDi6861
KEGGihsa:6861
MANE-SelectiENST00000354308.8; ENSP00000346265.2; NM_003180.3; NP_003171.2
UCSCiuc002qjm.2, human [O00445-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6861
DisGeNETi6861

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYT5
HGNCiHGNC:11513, SYT5
HPAiENSG00000129990, Group enriched (brain, pituitary gland)
MIMi600782, gene
neXtProtiNX_O00445
OpenTargetsiENSG00000129990
PharmGKBiPA36294
VEuPathDBiHostDB:ENSG00000129990

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000161816
HOGENOMiCLU_023008_0_1_1
InParanoidiO00445
OMAiCLCRKRC
PhylomeDBiO00445
TreeFamiTF315600

Enzyme and pathway databases

PathwayCommonsiO00445
ReactomeiR-HSA-422356, Regulation of insulin secretion
SignaLinkiO00445

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6861, 29 hits in 1075 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SYT5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6861
PharosiO00445, Tbio

Protein Ontology

More...PROi		PR:O00445
RNActiO00445, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000129990, Expressed in frontal cortex and 147 other tissues
ExpressionAtlasiO00445, baseline and differential
GenevisibleiO00445, HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028689, SYT5
PANTHERiPTHR10024:SF282, PTHR10024:SF282, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PRINTSiPR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF49562, SSF49562, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00445
Secondary accession number(s): B3KWJ8, B7Z300, Q86X72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2003
Last modified: May 25, 2022
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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