SYT5

Functionⁱ

May be involved in Ca²⁺-dependent exocytosis of secretory vesicles through Ca²⁺ and phospholipid binding to the C2 domain or may serve as Ca²⁺ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca²⁺-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).By similarity

Cofactorⁱ

Ca²⁺1 PublicationNote: Binds 3 Ca²⁺ ions per subunit. The ions are bound to the C2 domains.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	138	Calcium 1; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	139	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	139	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	145	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	197	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	197	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	198	Calcium 2; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	199	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	199	Calcium 2Combined sources1 Publication	1
Metal bindingⁱ	199	Calcium 3Combined sources1 Publication	1
Metal bindingⁱ	202	Calcium 3Combined sources1 Publication	1
Metal bindingⁱ	203	Calcium 3; via carbonyl oxygenCombined sources1 Publication	1
Metal bindingⁱ	205	Calcium 1Combined sources1 Publication	1
Metal bindingⁱ	205	Calcium 3Combined sources1 Publication	1

GO - Molecular functionⁱ

calcium-dependent phospholipid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27793683
clathrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatidylinositol-4,5-bisphosphate binding Source: Ensembl
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion regulated exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium ion-regulated exocytosis of neurotransmitter
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 9177789
regulation of calcium ion-dependent exocytosis Source: Ensembl
regulation of dopamine secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle endocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic vesicle exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-422356 Regulation of insulin secretion

Reactomeⁱ

R-HSA-422356 Regulation of insulin secretion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptotagmin-5 Alternative name(s): Synaptotagmin V Short name: SytV
Gene namesⁱ	Name:SYT5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000129990.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11513 SYT5
MIMⁱ	600782 gene
neXtProtⁱ	NX_O00445

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 24	VesicularSequence analysisAdd BLAST	24
Transmembraneⁱ	25 – 45	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	46 – 386	CytoplasmicSequence analysisAdd BLAST	341

Keywords - Cellular componentⁱ

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	202	S → G: Does not affect Ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6861
Open Targets More...OpenTargetsⁱ	ENSG00000129990
PharmGKBⁱ	PA36294

Polymorphism and mutation databases

BioMutaⁱ	SYT5

BioMutaⁱ

SYT5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183951	1 – 386	Synaptotagmin-5Add BLAST		386

Proteomic databases

EPDⁱ	O00445
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00445
PaxDbⁱ	O00445
PeptideAtlas More...PeptideAtlasⁱ	O00445
PRIDEⁱ	O00445
ProteomicsDBⁱ	47896

PTM databases

iPTMnetⁱ	O00445
PhosphoSitePlusⁱ	O00445

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000129990 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SYT5
ExpressionAtlasⁱ	O00445 baseline and differential
Genevisibleⁱ	O00445 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA078390

HPAⁱ

HPA078390

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).By similarity

GO - Molecular functionⁱ

clathrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112725, 5 interactors
ELMⁱ	O00445
IntActⁱ	O00445, 2 interactors
Molecular INTeraction database More...MINTⁱ	O00445
STRINGⁱ	9606.ENSP00000346265

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	111 – 119	Combined sources	9
Turnⁱ	120 – 123	Combined sources	4
Beta strandⁱ	124 – 134	Combined sources	11
Beta strandⁱ	146 – 153	Combined sources	8
Beta strandⁱ	157 – 161	Combined sources	5
Beta strandⁱ	172 – 180	Combined sources	9
Helixⁱ	183 – 188	Combined sources	6
Beta strandⁱ	190 – 197	Combined sources	8
Beta strandⁱ	200 – 202	Combined sources	3
Beta strandⁱ	205 – 213	Combined sources	9
Helixⁱ	214 – 216	Combined sources	3
Beta strandⁱ	223 – 228	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	O00445
SMRⁱ	O00445
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	124 – 211	C2 1PROSITE-ProRule annotationAdd BLAST		88
Domainⁱ	253 – 344	C2 2PROSITE-ProRule annotationAdd BLAST		92

Sequence similaritiesⁱ

Belongs to the synaptotagmin family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1028 Eukaryota ENOG410XRME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232127
HOVERGENⁱ	HBG005010
InParanoidⁱ	O00445
KEGG Orthology (KO) More...KOⁱ	K19905
OMAⁱ	CRRRMGK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XMQ
PhylomeDBⁱ	O00445
TreeFamⁱ	TF315600

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028689 SYT5
PANTHERⁱ	PTHR10024:SF282 PTHR10024:SF282, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00445-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL 
        60         70         80         90        100
YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG 
       110        120        130        140        150
QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV 
       160        170        180        190        200
YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR 
       210        220        230        240        250
FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV 
       260        270        280        290        300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN 
       310        320        330        340        350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG 
       360        370        380 
GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP

Length:386

Mass (Da):42,900

Last modified:July 11, 2003 - v2

Checksum:ⁱ96A36792D177FD55

GO

Isoform 2 (identifier: O00445-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-84: MFPEPPTPGP...KGLGQSYIDK → MTRGGCPVSA...PTPVASATAQ
237-237: Missing.

« Hide

        10         20         30         40         50
MTRGGCPVSA RLFAQRPHGS WSSLLCVGLK GRLGWEWGTR VLECLCRKDS 
        60         70         80         90        100
RTPPPCSRSP QPRGLHRPTR LPTPVASATA QVQPEVEELE PAPSGPGQQV 
       110        120        130        140        150
ADKHELGRLQ YSLDYDFQSG QLLVGILQAM GLAALDLGGS SDPYVRVYLL 
       160        170        180        190        200
PDKRRRYETK VHRQTLNPHF GETFAFKVPY VELGGRVLVM AVYDFDRFSR 
       210        220        230        240        250
NDAIGEVRVP MSSVDLGRPV QAWRELQAAP REEEKLGDIC FSLRYVPTAG 
       260        270        280        290        300
KLTVIVLEAK NLKKMDVGGL SDPYVKVHLL QGGKKVRKKK TTIKKNTLNP 
       310        320        330        340        350
YYNEAFSFEV PCDQVQKVQV ELTVLDYDKL GKNEAIGRVA VGAAAGGAGL 
       360        370        380 
RHWADMLANP RRPIAQWHSL RPPDRVRLLP AP

Note: No experimental confirmation available.

Show »

Length:382

Mass (Da):42,474

Checksum:ⁱDC71E8CE6086B701

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EJC4	K7EJC4_HUMAN	Synaptotagmin-5 Synaptotagmin-5	SYT5	152	Annotation score:
K7EQ59	K7EQ59_HUMAN	Synaptotagmin-5 Synaptotagmin-5	SYT5	154	Annotation score:
K7EJS7	K7EJS7_HUMAN	Synaptotagmin-5 Synaptotagmin-5	SYT5	67	Annotation score:
K7EJ95	K7EJ95_HUMAN	Synaptotagmin-5 Synaptotagmin-5	SYT5	49	Annotation score:
M0QYJ7	M0QYJ7_HUMAN	Synaptotagmin-5 Synaptotagmin-5	SYT5	22	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	24	H → R in BAG54160 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052240	4	E → D. Corresponds to variant dbSNP:rs2301279Ensembl.		1
Natural variantⁱVAR_034528	111	R → Q2 PublicationsCorresponds to variant dbSNP:rs11542503Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057177	1 – 84	MFPEP…SYIDK → MTRGGCPVSARLFAQRPHGS WSSLLCVGLKGRLGWEWGTR VLECLCRKDSRTPPPCSRSP QPRGLHRPTRLPTPVASATA Q in isoform 2. 1 PublicationAdd BLAST		84
Alternative sequenceⁱVSP_057178	237	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X96783 Genomic DNA Translation: CAA65579.1 AK125182 mRNA Translation: BAG54160.1 AK295337 mRNA Translation: BAH12036.1 AC010327 Genomic DNA No translation available. BC046157 mRNA Translation: AAH46157.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12919.1 [O00445-1] CCDS74455.1 [O00445-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001284703.1, NM_001297774.1 [O00445-2] NP_003171.2, NM_003180.2 [O00445-1] XP_006723402.1, XM_006723339.3 [O00445-1] XP_016882664.1, XM_017027175.1 [O00445-1] XP_016882665.1, XM_017027176.1
UniGeneⁱ	Hs.631566

Genome annotation databases

Ensemblⁱ	ENST00000354308; ENSP00000346265; ENSG00000129990 [O00445-1] ENST00000537500; ENSP00000442896; ENSG00000129990 [O00445-1] ENST00000590851; ENSP00000465576; ENSG00000129990 [O00445-2]
GeneIDⁱ	6861
KEGGⁱ	hsa:6861
UCSC genome browser More...UCSCⁱ	uc002qjm.2 human [O00445-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00445	Synaptotagmin V, isoform CRA_a		HUMAN		386	UniRef100_O00445
SYT5 isoform 1		PANTR		386
Uncharacterized protein		PANPA		386
Synaptotagmin 5		GORGO		386

Protein	Similar proteins		Species	Score	Length	Source
O00445	Synaptotagmin-5		RAT		386	UniRef90_P47861
Uncharacterized protein		COLAP		387
Synaptotagmin 5		SHEEP		386
Uncharacterized protein		PROCO		386
Uncharacterized protein		MANLE		386
+137
O00445-2	Uncharacterized protein		PAPAN		382	UniRef90_O00445-2
Uncharacterized protein		AOTNA		382
Uncharacterized protein		MACMU		382
Uncharacterized protein		CALJA		382
Uncharacterized protein		MACFA		382
+7

Protein	Similar proteins		Species	Score	Length	Source
O00445	Synaptotagmin-5		RAT		386	UniRef50_P47861
Uncharacterized protein		COLAP		387
SYT5 isoform 2		PONAB		386
Synaptotagmin 5		PIG		386
synaptotagmin-5 isoform X1		LIPVE		386
+150
O00445-2	Uncharacterized protein		CALJA		382	UniRef50_O00445-2
Uncharacterized protein		MACNE		382
Uncharacterized protein		MACMU		382
Uncharacterized protein		MACFA		382
Uncharacterized protein		AOTNA		382
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X96783 Genomic DNA Translation: CAA65579.1 AK125182 mRNA Translation: BAG54160.1 AK295337 mRNA Translation: BAH12036.1 AC010327 Genomic DNA No translation available. BC046157 mRNA Translation: AAH46157.1
CCDSⁱ	CCDS12919.1 [O00445-1] CCDS74455.1 [O00445-2]
RefSeqⁱ	NP_001284703.1, NM_001297774.1 [O00445-2] NP_003171.2, NM_003180.2 [O00445-1] XP_006723402.1, XM_006723339.3 [O00445-1] XP_016882664.1, XM_017027175.1 [O00445-1] XP_016882665.1, XM_017027176.1
UniGeneⁱ	Hs.631566

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5H4Y	X-ray	1.90	A	107-233	[»]
	5H4Z	X-ray	3.01	A/B	105-233	[»]
ProteinModelPortalⁱ	O00445
SMRⁱ	O00445
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112725, 5 interactors
ELMⁱ	O00445
IntActⁱ	O00445, 2 interactors
MINTⁱ	O00445
STRINGⁱ	9606.ENSP00000346265

PTM databases

iPTMnetⁱ	O00445
PhosphoSitePlusⁱ	O00445

Polymorphism and mutation databases

BioMutaⁱ	SYT5

BioMutaⁱ

SYT5

Proteomic databases

EPDⁱ	O00445
MaxQBⁱ	O00445
PaxDbⁱ	O00445
PeptideAtlasⁱ	O00445
PRIDEⁱ	O00445
ProteomicsDBⁱ	47896

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000354308; ENSP00000346265; ENSG00000129990 [O00445-1] ENST00000537500; ENSP00000442896; ENSG00000129990 [O00445-1] ENST00000590851; ENSP00000465576; ENSG00000129990 [O00445-2]
GeneIDⁱ	6861
KEGGⁱ	hsa:6861
UCSCⁱ	uc002qjm.2 human [O00445-1]

Organism-specific databases

CTDⁱ	6861
DisGeNETⁱ	6861
EuPathDBⁱ	HostDB:ENSG00000129990.14
GeneCardsⁱ	SYT5
HGNCⁱ	HGNC:11513 SYT5
HPAⁱ	HPA078390
MIMⁱ	600782 gene
neXtProtⁱ	NX_O00445
OpenTargetsⁱ	ENSG00000129990
PharmGKBⁱ	PA36294
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1028 Eukaryota ENOG410XRME LUCA
GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232127
HOVERGENⁱ	HBG005010
InParanoidⁱ	O00445
KOⁱ	K19905
OMAⁱ	CRRRMGK
OrthoDBⁱ	EOG091G0XMQ
PhylomeDBⁱ	O00445
TreeFamⁱ	TF315600

Enzyme and pathway databases

Reactomeⁱ	R-HSA-422356 Regulation of insulin secretion

Reactomeⁱ

R-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

GeneWikiⁱ	SYT5
GenomeRNAiⁱ	6861
Protein Ontology More...PROⁱ	PR:O00445
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000129990 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_SYT5
ExpressionAtlasⁱ	O00445 baseline and differential
Genevisibleⁱ	O00445 HS

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028689 SYT5
PANTHERⁱ	PTHR10024:SF282 PTHR10024:SF282, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYT5_HUMAN
Accessionⁱ	O00445Primary (citable) accession number: O00445 Secondary accession number(s): B3KWJ8, B7Z300, Q86X72
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	July 11, 2003
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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Supporting data

UniProtKB - O00445 (SYT5_HUMAN)

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Synaptotagmin-5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ