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Protein

Synaptotagmin-5

Gene

SYT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca2+-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).By similarity

Cofactori

Ca2+1 PublicationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi139Calcium 1Combined sources1 Publication1
Metal bindingi139Calcium 2Combined sources1 Publication1
Metal bindingi145Calcium 2Combined sources1 Publication1
Metal bindingi197Calcium 1Combined sources1 Publication1
Metal bindingi197Calcium 2Combined sources1 Publication1
Metal bindingi198Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi199Calcium 1Combined sources1 Publication1
Metal bindingi199Calcium 2Combined sources1 Publication1
Metal bindingi199Calcium 3Combined sources1 Publication1
Metal bindingi202Calcium 3Combined sources1 Publication1
Metal bindingi203Calcium 3; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi205Calcium 1Combined sources1 Publication1
Metal bindingi205Calcium 3Combined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-5
Alternative name(s):
Synaptotagmin V
Short name:
SytV
Gene namesi
Name:SYT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000129990.14
HGNCiHGNC:11513 SYT5
MIMi600782 gene
neXtProtiNX_O00445

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24VesicularSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 386CytoplasmicSequence analysisAdd BLAST341

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi202S → G: Does not affect Ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein. 1 Publication1

Organism-specific databases

DisGeNETi6861
OpenTargetsiENSG00000129990
PharmGKBiPA36294

Polymorphism and mutation databases

BioMutaiSYT5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839511 – 386Synaptotagmin-5Add BLAST386

Proteomic databases

EPDiO00445
MaxQBiO00445
PaxDbiO00445
PeptideAtlasiO00445
PRIDEiO00445
ProteomicsDBi47896

PTM databases

iPTMnetiO00445
PhosphoSitePlusiO00445

Expressioni

Gene expression databases

BgeeiENSG00000129990 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExiHS_SYT5
ExpressionAtlasiO00445 baseline and differential
GenevisibleiO00445 HS

Organism-specific databases

HPAiHPA078390

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with both alpha- and beta-tubulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112725, 5 interactors
ELMiO00445
IntActiO00445, 2 interactors
MINTiO00445
STRINGi9606.ENSP00000346265

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00445
SMRiO00445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 211C2 1PROSITE-ProRule annotationAdd BLAST88
Domaini253 – 344C2 2PROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG005010
InParanoidiO00445
KOiK19905
OMAiCRRRMGK
OrthoDBiEOG091G0XMQ
PhylomeDBiO00445
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028689 SYT5
PANTHERiPTHR10024:SF282 PTHR10024:SF282, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFPEPPTPGP PSPDTPPDSS RISHGPVPPW ALATIVLVSG LLIFSCCFCL
60 70 80 90 100
YRKSCRRRTG KKSQAQAQVH LQEVKGLGQS YIDKVQPEVE ELEPAPSGPG
110 120 130 140 150
QQVADKHELG RLQYSLDYDF QSGQLLVGIL QAMGLAALDL GGSSDPYVRV
160 170 180 190 200
YLLPDKRRRY ETKVHRQTLN PHFGETFAFK VPYVELGGRV LVMAVYDFDR
210 220 230 240 250
FSRNDAIGEV RVPMSSVDLG RPVQAWRELQ AAPREEQEKL GDICFSLRYV
260 270 280 290 300
PTAGKLTVIV LEAKNLKKMD VGGLSDPYVK VHLLQGGKKV RKKKTTIKKN
310 320 330 340 350
TLNPYYNEAF SFEVPCDQVQ KVQVELTVLD YDKLGKNEAI GRVAVGAAAG
360 370 380
GAGLRHWADM LANPRRPIAQ WHSLRPPDRV RLLPAP
Length:386
Mass (Da):42,900
Last modified:July 11, 2003 - v2
Checksum:i96A36792D177FD55
GO
Isoform 2 (identifier: O00445-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MFPEPPTPGP...KGLGQSYIDK → MTRGGCPVSA...PTPVASATAQ
     237-237: Missing.

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):42,474
Checksum:iDC71E8CE6086B701
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJC4K7EJC4_HUMAN
Synaptotagmin-5
SYT5
152Annotation score:
K7EQ59K7EQ59_HUMAN
Synaptotagmin-5
SYT5
154Annotation score:
K7EJS7K7EJS7_HUMAN
Synaptotagmin-5
SYT5
67Annotation score:
K7EJ95K7EJ95_HUMAN
Synaptotagmin-5
SYT5
49Annotation score:
M0QYJ7M0QYJ7_HUMAN
Synaptotagmin-5
SYT5
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24H → R in BAG54160 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0522404E → D. Corresponds to variant dbSNP:rs2301279Ensembl.1
Natural variantiVAR_034528111R → Q2 PublicationsCorresponds to variant dbSNP:rs11542503Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0571771 – 84MFPEP…SYIDK → MTRGGCPVSARLFAQRPHGS WSSLLCVGLKGRLGWEWGTR VLECLCRKDSRTPPPCSRSP QPRGLHRPTRLPTPVASATA Q in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_057178237Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96783 Genomic DNA Translation: CAA65579.1
AK125182 mRNA Translation: BAG54160.1
AK295337 mRNA Translation: BAH12036.1
AC010327 Genomic DNA No translation available.
BC046157 mRNA Translation: AAH46157.1
CCDSiCCDS12919.1 [O00445-1]
CCDS74455.1 [O00445-2]
RefSeqiNP_001284703.1, NM_001297774.1 [O00445-2]
NP_003171.2, NM_003180.2 [O00445-1]
XP_006723402.1, XM_006723339.3 [O00445-1]
XP_016882664.1, XM_017027175.1 [O00445-1]
XP_016882665.1, XM_017027176.1
UniGeneiHs.631566

Genome annotation databases

EnsembliENST00000354308; ENSP00000346265; ENSG00000129990 [O00445-1]
ENST00000537500; ENSP00000442896; ENSG00000129990 [O00445-1]
ENST00000590851; ENSP00000465576; ENSG00000129990 [O00445-2]
GeneIDi6861
KEGGihsa:6861
UCSCiuc002qjm.2 human [O00445-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96783 Genomic DNA Translation: CAA65579.1
AK125182 mRNA Translation: BAG54160.1
AK295337 mRNA Translation: BAH12036.1
AC010327 Genomic DNA No translation available.
BC046157 mRNA Translation: AAH46157.1
CCDSiCCDS12919.1 [O00445-1]
CCDS74455.1 [O00445-2]
RefSeqiNP_001284703.1, NM_001297774.1 [O00445-2]
NP_003171.2, NM_003180.2 [O00445-1]
XP_006723402.1, XM_006723339.3 [O00445-1]
XP_016882664.1, XM_017027175.1 [O00445-1]
XP_016882665.1, XM_017027176.1
UniGeneiHs.631566

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H4YX-ray1.90A107-233[»]
5H4ZX-ray3.01A/B105-233[»]
ProteinModelPortaliO00445
SMRiO00445
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112725, 5 interactors
ELMiO00445
IntActiO00445, 2 interactors
MINTiO00445
STRINGi9606.ENSP00000346265

PTM databases

iPTMnetiO00445
PhosphoSitePlusiO00445

Polymorphism and mutation databases

BioMutaiSYT5

Proteomic databases

EPDiO00445
MaxQBiO00445
PaxDbiO00445
PeptideAtlasiO00445
PRIDEiO00445
ProteomicsDBi47896

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354308; ENSP00000346265; ENSG00000129990 [O00445-1]
ENST00000537500; ENSP00000442896; ENSG00000129990 [O00445-1]
ENST00000590851; ENSP00000465576; ENSG00000129990 [O00445-2]
GeneIDi6861
KEGGihsa:6861
UCSCiuc002qjm.2 human [O00445-1]

Organism-specific databases

CTDi6861
DisGeNETi6861
EuPathDBiHostDB:ENSG00000129990.14
GeneCardsiSYT5
HGNCiHGNC:11513 SYT5
HPAiHPA078390
MIMi600782 gene
neXtProtiNX_O00445
OpenTargetsiENSG00000129990
PharmGKBiPA36294
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232127
HOVERGENiHBG005010
InParanoidiO00445
KOiK19905
OMAiCRRRMGK
OrthoDBiEOG091G0XMQ
PhylomeDBiO00445
TreeFamiTF315600

Enzyme and pathway databases

ReactomeiR-HSA-422356 Regulation of insulin secretion

Miscellaneous databases

GeneWikiiSYT5
GenomeRNAii6861
PROiPR:O00445
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129990 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExiHS_SYT5
ExpressionAtlasiO00445 baseline and differential
GenevisibleiO00445 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028689 SYT5
PANTHERiPTHR10024:SF282 PTHR10024:SF282, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT5_HUMAN
AccessioniPrimary (citable) accession number: O00445
Secondary accession number(s): B3KWJ8, B7Z300, Q86X72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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