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Entry version 178 (08 May 2019)
Sequence version 3 (13 Nov 2007)
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Protein

Serine/threonine-protein kinase PLK4

Gene

PLK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41ATPCurated1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.11.21 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O00444

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00444

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase PLK4 (EC:2.7.11.213 Publications)
Alternative name(s):
Polo-like kinase 4
Short name:
PLK-4
Serine/threonine-protein kinase 18
Serine/threonine-protein kinase Sak
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLK4
Synonyms:SAK, STK18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11397 PLK4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605031 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O00444

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities.
See also OMIM:616171

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi41K → M: Abolishes ability to phosphorylate CDC25C and CHEK2. 2 Publications1
Mutagenesisi154D → A: Catalytically inactive mutant that causes some centrosome amplification above background levels when overexpressed. 1 Publication1
Mutagenesisi170T → D: Activating mutant. 2 Publications1

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
10733

MalaCards human disease database

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MalaCardsi
PLK4
MIMi616171 phenotype

Open Targets

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OpenTargetsi
ENSG00000142731

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2518 Autosomal recessive chorioretinopathy-microcephaly syndrome
808 Seckel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36205

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3788

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2171

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLK4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865671 – 970Serine/threonine-protein kinase PLK4Add BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45N6-acetyllysine1 Publication1
Modified residuei46N6-acetyllysine1 Publication1
Modified residuei401PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation.1 Publication
Ubiquitinated; leading to its degradation by the proteasome.By similarity
Tyrosine-phosphorylated by TEC.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O00444

MaxQB - The MaxQuant DataBase

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MaxQBi
O00444

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O00444

PeptideAtlas

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PeptideAtlasi
O00444

PRoteomics IDEntifications database

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PRIDEi
O00444

ProteomicsDB human proteome resource

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ProteomicsDBi
47893
47894 [O00444-2]
47895 [O00444-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O00444

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O00444

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in HCT 116 colorectal cancer cells, leading to aberrant centrioles composed of disorganized cylindrical microtubules and displaced appendages. Down-regulated by p53/TP53.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000142731 Expressed in 136 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00444 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00444 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA017327
HPA035026
HPA043198

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Interacts with CEP152 (via N-terminus). Interacts with CEP78; this interaction may be important for proper PLK4 localization to the centriole and PLK4-induced overduplication of centrioles (PubMed:27246242).By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115956, 56 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1161 CEP192-PLK4 complex
CPX-1299 CEP152-PLK4 complex

Database of interacting proteins

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DIPi
DIP-34467N

Protein interaction database and analysis system

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IntActi
O00444, 34 interactors

Molecular INTeraction database

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MINTi
O00444

STRING: functional protein association networks

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STRINGi
9606.ENSP00000270861

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O00444

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1970
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N19NMR-A884-970[»]
3COKX-ray2.25A/B2-275[»]
4JXFX-ray2.40A4-269[»]
4N7VX-ray2.76A/B580-808[»]
4N7ZX-ray2.85A580-808[»]
4N9JX-ray2.60A/B581-808[»]
4YURX-ray2.65A2-275[»]
4YYPX-ray2.60A884-970[»]
5LHYX-ray3.311/2/3/4/5/6/7/8/9/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U884-970[»]
5LHZX-ray2.51A/B/C884-970[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00444

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O00444

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 265Protein kinasePROSITE-ProRule annotationAdd BLAST254
Domaini892 – 956POLO boxPROSITE-ProRule annotationAdd BLAST65

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0575 Eukaryota
ENOG410XQBP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156316

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00444

KEGG Orthology (KO)

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KOi
K08863

Identification of Orthologs from Complete Genome Data

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OMAi
LHSHNIM

Database of Orthologous Groups

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OrthoDBi
1417203at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O00444

TreeFam database of animal gene trees

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TreeFami
TF101090

Family and domain databases

Conserved Domains Database

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CDDi
cd13114 POLO_box_Plk4_1, 1 hit
cd13115 POLO_box_Plk4_2, 1 hit
cd13116 POLO_box_Plk4_3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033700 Plk4
IPR000959 POLO_box_dom
IPR033699 POLO_box_Plk4_1
IPR033698 POLO_box_Plk4_2
IPR033696 POLO_box_Plk4_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR24345:SF82 PTHR24345:SF82, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit
PF18190 Plk4_PB1, 1 hit
PF18409 Plk4_PB2, 1 hit
PF00659 POLO_box, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50078 POLO_BOX, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00444-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK
60 70 80 90 100
AGMVQRVQNE VKIHCQLKHP SILELYNYFE DSNYVYLVLE MCHNGEMNRY
110 120 130 140 150
LKNRVKPFSE NEARHFMHQI ITGMLYLHSH GILHRDLTLS NLLLTRNMNI
160 170 180 190 200
KIADFGLATQ LKMPHEKHYT LCGTPNYISP EIATRSAHGL ESDVWSLGCM
210 220 230 240 250
FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PSFLSIEAKD LIHQLLRRNP
260 270 280 290 300
ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST
310 320 330 340 350
SISGSLFDKR RLLIGQPLPN KMTVFPKNKS STDFSSSGDG NSFYTQWGNQ
360 370 380 390 400
ETSNSGRGRV IQDAEERPHS RYLRRAYSSD RSGTSNSQSQ AKTYTMERCH
410 420 430 440 450
SAEMLSVSKR SGGGENEERY SPTDNNANIF NFFKEKTSSS SGSFERPDNN
460 470 480 490 500
QALSNHLCPG KTPFPFADPT PQTETVQQWF GNLQINAHLR KTTEYDSISP
510 520 530 540 550
NRDFQGHPDL QKDTSKNAWT DTKVKKNSDA SDNAHSVKQQ NTMKYMTALH
560 570 580 590 600
SKPEIIQQEC VFGSDPLSEQ SKTRGMEPPW GYQNRTLRSI TSPLVAHRLK
610 620 630 640 650
PIRQKTKKAV VSILDSEEVC VELVKEYASQ EYVKEVLQIS SDGNTITIYY
660 670 680 690 700
PNGGRGFPLA DRPPSPTDNI SRYSFDNLPE KYWRKYQYAS RFVQLVRSKS
710 720 730 740 750
PKITYFTRYA KCILMENSPG ADFEVWFYDG VKIHKTEDFI QVIEKTGKSY
760 770 780 790 800
TLKSESEVNS LKEEIKMYMD HANEGHRICL ALESIISEEE RKTRSAPFFP
810 820 830 840 850
IIIGRKPGST SSPKALSPPP SVDSNYPTRE RASFNRMVMH SAASPTQAPI
860 870 880 890 900
LNPSMVTNEG LGLTTTASGT DISSNSLKDC LPKSAQLLKS VFVKNVGWAT
910 920 930 940 950
QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGE NEKLPDYIKQ
960 970
KLQCLSSILL MFSNPTPNFH
Length:970
Mass (Da):108,972
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D56F5FD983211A6
GO
Isoform 2 (identifier: O00444-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-74: Missing.

Note: No experimental confirmation available.
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Length:938
Mass (Da):105,253
Checksum:i3605FA717C82C2B7
GO
Isoform 3 (identifier: O00444-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
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Length:929
Mass (Da):104,636
Checksum:iECD6808B29B9D8D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KR84J3KR84_HUMAN
Serine/threonine-protein kinase PLK...
PLK4
909Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KR82J3KR82_HUMAN
Serine/threonine-protein kinase PLK...
PLK4
892Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAL6H0YAL6_HUMAN
Serine/threonine-protein kinase PLK...
PLK4
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti34T → S in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti58Q → K in CAA73575 (Ref. 1) Curated1
Sequence conflicti333D → N in BAH13823 (PubMed:14702039).Curated1
Sequence conflicti387S → R in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti692F → S in BAH13823 (PubMed:14702039).Curated1
Sequence conflicti696V → L in BAB69958 (PubMed:11489907).Curated1
Sequence conflicti768Y → F in CAA73575 (Ref. 1) Curated1
Sequence conflicti842A → D in BAB69958 (PubMed:11489907).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04102786Y → C1 PublicationCorresponds to variant dbSNP:rs34156294Ensembl.1
Natural variantiVAR_041028146R → H1 PublicationCorresponds to variant dbSNP:rs35232579Ensembl.1
Natural variantiVAR_041029226A → T1 PublicationCorresponds to variant dbSNP:rs35448573Ensembl.1
Natural variantiVAR_019632232S → T4 PublicationsCorresponds to variant dbSNP:rs3811740Ensembl.1
Natural variantiVAR_041030317P → L1 PublicationCorresponds to variant dbSNP:rs35049837Ensembl.1
Natural variantiVAR_041031449N → D1 PublicationCorresponds to variant dbSNP:rs34906574Ensembl.1
Natural variantiVAR_041032519W → S1 PublicationCorresponds to variant dbSNP:rs56043017Ensembl.1
Natural variantiVAR_041033830E → D4 PublicationsCorresponds to variant dbSNP:rs17012739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0381161 – 41Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_03811743 – 74Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y13115 mRNA Translation: CAA73575.1
AB006972 mRNA Translation: BAB69958.1
AK302858 mRNA Translation: BAH13823.1
AK303399 mRNA Translation: BAH13953.1
AK314238 mRNA Translation: BAG36907.1
BC036023 mRNA Translation: AAH36023.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3735.1 [O00444-1]
CCDS54803.1 [O00444-2]
CCDS54804.1 [O00444-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001177728.1, NM_001190799.1 [O00444-2]
NP_001177730.1, NM_001190801.1 [O00444-3]
NP_055079.3, NM_014264.4 [O00444-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000270861; ENSP00000270861; ENSG00000142731 [O00444-1]
ENST00000513090; ENSP00000427554; ENSG00000142731 [O00444-2]
ENST00000514379; ENSP00000423582; ENSG00000142731 [O00444-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10733

UCSC genome browser

More...
UCSCi
uc003ifo.4 human [O00444-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13115 mRNA Translation: CAA73575.1
AB006972 mRNA Translation: BAB69958.1
AK302858 mRNA Translation: BAH13823.1
AK303399 mRNA Translation: BAH13953.1
AK314238 mRNA Translation: BAG36907.1
BC036023 mRNA Translation: AAH36023.1
CCDSiCCDS3735.1 [O00444-1]
CCDS54803.1 [O00444-2]
CCDS54804.1 [O00444-3]
RefSeqiNP_001177728.1, NM_001190799.1 [O00444-2]
NP_001177730.1, NM_001190801.1 [O00444-3]
NP_055079.3, NM_014264.4 [O00444-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N19NMR-A884-970[»]
3COKX-ray2.25A/B2-275[»]
4JXFX-ray2.40A4-269[»]
4N7VX-ray2.76A/B580-808[»]
4N7ZX-ray2.85A580-808[»]
4N9JX-ray2.60A/B581-808[»]
4YURX-ray2.65A2-275[»]
4YYPX-ray2.60A884-970[»]
5LHYX-ray3.311/2/3/4/5/6/7/8/9/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U884-970[»]
5LHZX-ray2.51A/B/C884-970[»]
SMRiO00444
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115956, 56 interactors
ComplexPortaliCPX-1161 CEP192-PLK4 complex
CPX-1299 CEP152-PLK4 complex
DIPiDIP-34467N
IntActiO00444, 34 interactors
MINTiO00444
STRINGi9606.ENSP00000270861

Chemistry databases

BindingDBiO00444
ChEMBLiCHEMBL3788
GuidetoPHARMACOLOGYi2171

PTM databases

iPTMnetiO00444
PhosphoSitePlusiO00444

Polymorphism and mutation databases

BioMutaiPLK4

Proteomic databases

jPOSTiO00444
MaxQBiO00444
PaxDbiO00444
PeptideAtlasiO00444
PRIDEiO00444
ProteomicsDBi47893
47894 [O00444-2]
47895 [O00444-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10733
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270861; ENSP00000270861; ENSG00000142731 [O00444-1]
ENST00000513090; ENSP00000427554; ENSG00000142731 [O00444-2]
ENST00000514379; ENSP00000423582; ENSG00000142731 [O00444-3]
GeneIDi10733
KEGGihsa:10733
UCSCiuc003ifo.4 human [O00444-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10733
DisGeNETi10733

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLK4
HGNCiHGNC:11397 PLK4
HPAiHPA017327
HPA035026
HPA043198
MalaCardsiPLK4
MIMi605031 gene
616171 phenotype
neXtProtiNX_O00444
OpenTargetsiENSG00000142731
Orphaneti2518 Autosomal recessive chorioretinopathy-microcephaly syndrome
808 Seckel syndrome
PharmGKBiPA36205

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0575 Eukaryota
ENOG410XQBP LUCA
GeneTreeiENSGT00940000156316
InParanoidiO00444
KOiK08863
OMAiLHSHNIM
OrthoDBi1417203at2759
PhylomeDBiO00444
TreeFamiTF101090

Enzyme and pathway databases

BRENDAi2.7.11.21 2681
ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiO00444
SIGNORiO00444

Miscellaneous databases

EvolutionaryTraceiO00444

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PLK4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10733

Protein Ontology

More...
PROi
PR:O00444

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142731 Expressed in 136 organ(s), highest expression level in female gonad
ExpressionAtlasiO00444 baseline and differential
GenevisibleiO00444 HS

Family and domain databases

CDDicd13114 POLO_box_Plk4_1, 1 hit
cd13115 POLO_box_Plk4_2, 1 hit
cd13116 POLO_box_Plk4_3, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR033700 Plk4
IPR000959 POLO_box_dom
IPR033699 POLO_box_Plk4_1
IPR033698 POLO_box_Plk4_2
IPR033696 POLO_box_Plk4_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
PANTHERiPTHR24345:SF82 PTHR24345:SF82, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF18190 Plk4_PB1, 1 hit
PF18409 Plk4_PB2, 1 hit
PF00659 POLO_box, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50078 POLO_BOX, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLK4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00444
Secondary accession number(s): B2RAL0
, B7Z837, B7Z8G7, Q8IYF0, Q96Q95, Q9UD84, Q9UDE2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 13, 2007
Last modified: May 8, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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