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Entry version 191 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Importin-5

Gene

IPO5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-192905 vRNP Assembly

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Importin-5
Short name:
Imp5
Alternative name(s):
Importin subunit beta-3
Karyopherin beta-3
Ran-binding protein 5
Short name:
RanBP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IPO5
Synonyms:KPNB3, RANBP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6402 IPO5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602008 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3843

Open Targets

More...
OpenTargetsi
ENSG00000065150

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30193

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O00410

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IPO5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207712 – 1097Importin-5Add BLAST1096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei827PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-226

Encyclopedia of Proteome Dynamics

More...
EPDi
O00410

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00410

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O00410

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00410

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00410

PeptideAtlas

More...
PeptideAtlasi
O00410

PRoteomics IDEntifications database

More...
PRIDEi
O00410

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47872 [O00410-1]
47873 [O00410-2]
47874 [O00410-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00410

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00410

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065150 Expressed in 238 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00410 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00410 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009110
HPA040983
HPA056548

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds RPL23A, RPS7 and RPL5 (PubMed:9687515).

Interacts with H2A, H2B, H3 and H4 histones (By similarity).

Interacts with CPEB3; this mediates CPEB3 nuclear import following neuronal stimulation which enhances the interaction in a RAN-regulated manner (PubMed:22730302).

By similarity2 Publications

(Microbial infection) Interacts with HIV-1 Rev.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110041, 136 interactors

Database of interacting proteins

More...
DIPi
DIP-41042N

Protein interaction database and analysis system

More...
IntActi
O00410, 74 interactors

Molecular INTeraction database

More...
MINTi
O00410

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261574

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00410

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati5 – 38HEAT 1By similarity1 PublicationAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 99Importin N-terminalPROSITE-ProRule annotationAdd BLAST72
Repeati43 – 77HEAT 2By similarity1 PublicationAdd BLAST35
Repeati95 – 122HEAT 3By similarity1 PublicationAdd BLAST28
Repeati130 – 157HEAT 4By similarity1 PublicationAdd BLAST28
Repeati167 – 201HEAT 5By similarity1 PublicationAdd BLAST35
Repeati210 – 246HEAT 6By similarity1 PublicationAdd BLAST37
Repeati254 – 289HEAT 7By similarity1 PublicationAdd BLAST36
Repeati298 – 350HEAT 8By similarity1 PublicationAdd BLAST53
Repeati352 – 386HEAT 9By similarity1 PublicationAdd BLAST35
Repeati390 – 430HEAT 10By similarity1 PublicationAdd BLAST41
Repeati432 – 472HEAT 11By similarity1 PublicationAdd BLAST41
Repeati475 – 523HEAT 12By similarity1 PublicationAdd BLAST49
Repeati525 – 568HEAT 13By similarity1 PublicationAdd BLAST44
Repeati570 – 615HEAT 14By similarity1 PublicationAdd BLAST46
Repeati617 – 692HEAT 15By similarity1 PublicationAdd BLAST76
Repeati695 – 737HEAT 16By similarity1 PublicationAdd BLAST43
Repeati741 – 780HEAT 17By similarity1 PublicationAdd BLAST40
Repeati787 – 853HEAT 18By similarity1 PublicationAdd BLAST67
Repeati856 – 895HEAT 19By similarity1 PublicationAdd BLAST40
Repeati903 – 935HEAT 20By similarity1 PublicationAdd BLAST33
Repeati943 – 983HEAT 21By similarity1 PublicationAdd BLAST41
Repeati990 – 1021HEAT 22By similarity1 PublicationAdd BLAST32
Repeati1032 – 1067HEAT 23By similarity1 PublicationAdd BLAST36
Repeati1070 – 1093HEAT 24By similarity1 PublicationAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni325 – 375Ran-GTP bindingBy similarityAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 6Poly-Ala5
Compositional biasi460 – 465Poly-Ala6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2171 Eukaryota
ENOG410XQAJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000209725

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00410

KEGG Orthology (KO)

More...
KOi
K20222

Identification of Orthologs from Complete Genome Data

More...
OMAi
AQYLMHC

Database of Orthologous Groups

More...
OrthoDBi
90499at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00410

TreeFam database of animal gene trees

More...
TreeFami
TF300344

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR001494 Importin-beta_N
IPR040122 Importin_beta
IPR041653 Importin_rep_4
IPR041389 Importin_rep_6
IPR034085 TOG

The PANTHER Classification System

More...
PANTHERi
PTHR10527 PTHR10527, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02985 HEAT, 1 hit
PF18808 Importin_rep_4, 1 hit
PF18829 Importin_rep_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349 TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00410-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAEQQQ FYLLLGNLLS PDNVVRKQAE ETYENIPGQS KITFLLQAIR
60 70 80 90 100
NTTAAEEARQ MAAVLLRRLL SSAFDEVYPA LPSDVQTAIK SELLMIIQME
110 120 130 140 150
TQSSMRKKVC DIAAELARNL IDEDGNNQWP EGLKFLFDSV SSQNVGLREA
160 170 180 190 200
ALHIFWNFPG IFGNQQQHYL DVIKRMLVQC MQDQEHPSIR TLSARATAAF
210 220 230 240 250
ILANEHNVAL FKHFADLLPG FLQAVNDSCY QNDDSVLKSL VEIADTVPKY
260 270 280 290 300
LRPHLEATLQ LSLKLCGDTS LNNMQRQLAL EVIVTLSETA AAMLRKHTNI
310 320 330 340 350
VAQTIPQMLA MMVDLEEDED WANADELEDD DFDSNAVAGE SALDRMACGL
360 370 380 390 400
GGKLVLPMIK EHIMQMLQNP DWKYRHAGLM ALSAIGEGCH QQMEGILNEI
410 420 430 440 450
VNFVLLFLQD PHPRVRYAAC NAVGQMATDF APGFQKKFHE KVIAALLQTM
460 470 480 490 500
EDQGNQRVQA HAAAALINFT EDCPKSLLIP YLDNLVKHLH SIMVLKLQEL
510 520 530 540 550
IQKGTKLVLE QVVTSIASVA DTAEEKFVPY YDLFMPSLKH IVENAVQKEL
560 570 580 590 600
RLLRGKTIEC ISLIGLAVGK EKFMQDASDV MQLLLKTQTD FNDMEDDDPQ
610 620 630 640 650
ISYMISAWAR MCKILGKEFQ QYLPVVMGPL MKTASIKPEV ALLDTQDMEN
660 670 680 690 700
MSDDDGWEFV NLGDQQSFGI KTAGLEEKST ACQMLVCYAK ELKEGFVEYT
710 720 730 740 750
EQVVKLMVPL LKFYFHDGVR VAAAESMPLL LECARVRGPE YLTQMWHFMC
760 770 780 790 800
DALIKAIGTE PDSDVLSEIM HSFAKCIEVM GDGCLNNEHF EELGGILKAK
810 820 830 840 850
LEEHFKNQEL RQVKRQDEDY DEQVEESLQD EDDNDVYILT KVSDILHSIF
860 870 880 890 900
SSYKEKVLPW FEQLLPLIVN LICPHRPWPD RQWGLCIFDD VIEHCSPASF
910 920 930 940 950
KYAEYFLRPM LQYVCDNSPE VRQAAAYGLG VMAQYGGDNY RPFCTEALPL
960 970 980 990 1000
LVRVIQSADS KTKENVNATE NCISAVGKIM KFKPDCVNVE EVLPHWLSWL
1010 1020 1030 1040 1050
PLHEDKEEAV QTFNYLCDLI ESNHPIVLGP NNTNLPKIFS IIAEGEMHEA
1060 1070 1080 1090
IKHEDPCAKR LANVVRQVQT SGGLWTECIA QLSPEQQAAI QELLNSA
Length:1,097
Mass (Da):123,630
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1864AD23513F2DE1
GO
Isoform 2 (identifier: O00410-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Show »
Length:1,037
Mass (Da):116,982
Checksum:i7D9A925F7DBC1DE0
GO
Isoform 3 (identifier: O00410-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPEDQVGKLEATENTISAM

Show »
Length:1,115
Mass (Da):125,545
Checksum:i5296EF23A427A0FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8C6H0Y8C6_HUMAN
Importin-5
IPO5
1,099Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EQT5E7EQT5_HUMAN
Importin-5
IPO5
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETV3E7ETV3_HUMAN
Importin-5
IPO5
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV12E7EV12_HUMAN
Importin-5
IPO5
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWK4E7EWK4_HUMAN
Importin-5
IPO5
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX05E7EX05_HUMAN
Importin-5
IPO5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3V4H0Y3V4_HUMAN
Importin-5
IPO5
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J875C9J875_HUMAN
Importin-5
IPO5
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQT6C9JQT6_HUMAN
Importin-5
IPO5
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZD8C9JZD8_HUMAN
Importin-5
IPO5
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA70103 differs from that shown. Reason: Frameshift.Curated
Isoform 3 : The sequence CAA70103 differs from that shown. Reason: Frameshift.

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti538L → R in AAH45640 (PubMed:15489334).Curated1
Sequence conflicti826 – 827ES → GT in AAC51317 (PubMed:9114010).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012029286L → I. Corresponds to variant dbSNP:rs1053814Ensembl.1
Natural variantiVAR_012030525E → K. Corresponds to variant dbSNP:rs632729Ensembl.1
Natural variantiVAR_012031549E → K. Corresponds to variant dbSNP:rs484770Ensembl.1
Natural variantiVAR_012032905Y → C. Corresponds to variant dbSNP:rs1804740Ensembl.1
Natural variantiVAR_012033969T → I. Corresponds to variant dbSNP:rs1804741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0375871 – 60Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0377741M → MPEDQVGKLEATENTISAM in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U72761 mRNA Translation: AAC51317.1
Y08890 mRNA Translation: CAA70103.1 Frameshift.
AK302812 mRNA Translation: BAG64012.1
AL137120 Genomic DNA No translation available.
AL356580 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08980.1
BC001497 mRNA Translation: AAH01497.1
BC019309 mRNA Translation: AAH19309.1
BC045640 mRNA Translation: AAH45640.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31999.1 [O00410-1]

NCBI Reference Sequences

More...
RefSeqi
NP_002262.3, NM_002271.4 [O00410-1]
XP_005254109.1, XM_005254052.3 [O00410-3]
XP_005254110.1, XM_005254053.3 [O00410-3]
XP_011519389.1, XM_011521087.2 [O00410-3]
XP_011519390.1, XM_011521088.2 [O00410-3]
XP_011519391.1, XM_011521089.2 [O00410-3]
XP_011519392.1, XM_011521090.2 [O00410-3]
XP_016876051.1, XM_017020562.1 [O00410-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261574; ENSP00000261574; ENSG00000065150 [O00410-3]
ENST00000357602; ENSP00000350219; ENSG00000065150 [O00410-1]
ENST00000490680; ENSP00000418393; ENSG00000065150 [O00410-1]
ENST00000651721; ENSP00000499125; ENSG00000065150 [O00410-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3843

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3843

UCSC genome browser

More...
UCSCi
uc001vne.4 human [O00410-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72761 mRNA Translation: AAC51317.1
Y08890 mRNA Translation: CAA70103.1 Frameshift.
AK302812 mRNA Translation: BAG64012.1
AL137120 Genomic DNA No translation available.
AL356580 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08980.1
BC001497 mRNA Translation: AAH01497.1
BC019309 mRNA Translation: AAH19309.1
BC045640 mRNA Translation: AAH45640.1
CCDSiCCDS31999.1 [O00410-1]
RefSeqiNP_002262.3, NM_002271.4 [O00410-1]
XP_005254109.1, XM_005254052.3 [O00410-3]
XP_005254110.1, XM_005254053.3 [O00410-3]
XP_011519389.1, XM_011521087.2 [O00410-3]
XP_011519390.1, XM_011521088.2 [O00410-3]
XP_011519391.1, XM_011521089.2 [O00410-3]
XP_011519392.1, XM_011521090.2 [O00410-3]
XP_016876051.1, XM_017020562.1 [O00410-3]

3D structure databases

SMRiO00410
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110041, 136 interactors
DIPiDIP-41042N
IntActiO00410, 74 interactors
MINTiO00410
STRINGi9606.ENSP00000261574

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO00410
PhosphoSitePlusiO00410
SwissPalmiO00410

Polymorphism and mutation databases

BioMutaiIPO5

Proteomic databases

CPTACiCPTAC-226
EPDiO00410
jPOSTiO00410
MassIVEiO00410
MaxQBiO00410
PaxDbiO00410
PeptideAtlasiO00410
PRIDEiO00410
ProteomicsDBi47872 [O00410-1]
47873 [O00410-2]
47874 [O00410-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3843

Genome annotation databases

EnsembliENST00000261574; ENSP00000261574; ENSG00000065150 [O00410-3]
ENST00000357602; ENSP00000350219; ENSG00000065150 [O00410-1]
ENST00000490680; ENSP00000418393; ENSG00000065150 [O00410-1]
ENST00000651721; ENSP00000499125; ENSG00000065150 [O00410-1]
GeneIDi3843
KEGGihsa:3843
UCSCiuc001vne.4 human [O00410-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3843
DisGeNETi3843

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IPO5
HGNCiHGNC:6402 IPO5
HPAiCAB009110
HPA040983
HPA056548
MIMi602008 gene
neXtProtiNX_O00410
OpenTargetsiENSG00000065150
PharmGKBiPA30193

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2171 Eukaryota
ENOG410XQAJ LUCA
GeneTreeiENSGT00940000155502
HOGENOMiHOG000209725
InParanoidiO00410
KOiK20222
OMAiAQYLMHC
OrthoDBi90499at2759
PhylomeDBiO00410
TreeFamiTF300344

Enzyme and pathway databases

ReactomeiR-HSA-192905 vRNP Assembly

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IPO5 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RANBP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3843
PharosiO00410

Protein Ontology

More...
PROi
PR:O00410

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065150 Expressed in 238 organ(s), highest expression level in testis
ExpressionAtlasiO00410 baseline and differential
GenevisibleiO00410 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR001494 Importin-beta_N
IPR040122 Importin_beta
IPR041653 Importin_rep_4
IPR041389 Importin_rep_6
IPR034085 TOG
PANTHERiPTHR10527 PTHR10527, 1 hit
PfamiView protein in Pfam
PF02985 HEAT, 1 hit
PF18808 Importin_rep_4, 1 hit
PF18829 Importin_rep_6, 1 hit
SMARTiView protein in SMART
SM01349 TOG, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPO5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00410
Secondary accession number(s): B4DZA0
, O15257, Q5T578, Q86XC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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