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Protein

Forkhead box protein N3

Gene

FOXN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi113 – 204Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • craniofacial suture morphogenesis Source: Ensembl
  • mitotic G2 DNA damage checkpoint Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein N3
Alternative name(s):
Checkpoint suppressor 1
Gene namesi
Name:FOXN3
Synonyms:C14orf116, CHES1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000053254.15
HGNCiHGNC:1928 FOXN3
MIMi602628 gene
neXtProtiNX_O00409

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1112
OpenTargetsiENSG00000053254
PharmGKBiPA26460

Polymorphism and mutation databases

BioMutaiFOXN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918691 – 490Forkhead box protein N3Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphoserineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Modified residuei97PhosphoserineBy similarity1
Modified residuei448PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00409
MaxQBiO00409
PaxDbiO00409
PeptideAtlasiO00409
PRIDEiO00409
ProteomicsDBi47870
47871 [O00409-2]

PTM databases

iPTMnetiO00409
PhosphoSitePlusiO00409

Expressioni

Gene expression databases

BgeeiENSG00000053254 Expressed in 247 organ(s), highest expression level in paraflocculus
CleanExiHS_FOXN3
ExpressionAtlasiO00409 baseline and differential
GenevisibleiO00409 HS

Organism-specific databases

HPAiHPA059209

Interactioni

Subunit structurei

Interacts through its C-terminus with the C-terminus of SNW1/SKIP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SNW1Q135733EBI-372721,EBI-632715

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107537, 18 interactors
IntActiO00409, 9 interactors
MINTiO00409
STRINGi9606.ENSP00000261302

Structurei

3D structure databases

ProteinModelPortaliO00409
SMRiO00409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150842
HOGENOMiHOG000095166
HOVERGENiHBG051654
InParanoidiO00409
KOiK09407
OMAiTESEQSC
OrthoDBiEOG091G0EJR
PhylomeDBiO00409
TreeFamiTF105083

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00409-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPVMPPSKK PESSGISVSS GLSQCYGGSG FSKALQEDDD LDFSLPDIRL
60 70 80 90 100
EEGAMEDEEL TNLNWLHESK NLLKSFGESV LRSVSPVQDL DDDTPPSPAH
110 120 130 140 150
SDMPYDARQN PNCKPPYSFS CLIFMAIEDS PTKRLPVKDI YNWILEHFPY
160 170 180 190 200
FANAPTGWKN SVRHNLSLNK CFKKVDKERS QSIGKGSLWC IDPEYRQNLI
210 220 230 240 250
QALKKTPYHP HPHVFNTPPT CPQAYQSTSG PPIWPGSTFF KRNGALLQDP
260 270 280 290 300
DIDAASAMML LNTPPEIQAG FPPGVIQNGA RVLSRGLFPG VRPLPITPIG
310 320 330 340 350
VTAAMRNGIT SCRMRTESEP SCGSPVVSGD PKEDHNYSSA KSSNARSTSP
360 370 380 390 400
TSDSISSSSS SADDHYEFAT KGSQEGSEGS EGSFRSHESP SDTEEDDRKH
410 420 430 440 450
SQKEPKDSLG DSGYASQHKK RQHFAKARKV PSDTLPLKKR RTEKPPESDD
460 470 480 490
EEMKEAAGSL LHLAGIRSCL NNITNRTAKG QKEQKETTKN
Length:490
Mass (Da):53,835
Last modified:July 1, 1997 - v1
Checksum:iEE07975A592C8C01
GO
Isoform 2 (identifier: O00409-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-271: DPDIDAASAMMLLNTPPEIQAGF → V

Note: No experimental confirmation available.
Show »
Length:468
Mass (Da):51,534
Checksum:iFE3B5805FE885680
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3A7G3V3A7_HUMAN
Forkhead box protein N3
FOXN3
208Annotation score:
H0YJG3H0YJG3_HUMAN
Forkhead box protein N3
FOXN3
76Annotation score:
H0YJ22H0YJ22_HUMAN
Forkhead box protein N3
FOXN3
111Annotation score:
H0YJ54H0YJ54_HUMAN
Forkhead box protein N3
FOXN3
185Annotation score:
H0YJ94H0YJ94_HUMAN
Forkhead box protein N3
FOXN3
91Annotation score:
G3V4N5G3V4N5_HUMAN
Forkhead box protein N3
FOXN3
54Annotation score:
G3V5C7G3V5C7_HUMAN
Forkhead box protein N3
FOXN3
93Annotation score:
H0YJY0H0YJY0_HUMAN
Forkhead box protein N3
FOXN3
122Annotation score:
H0YJ43H0YJ43_HUMAN
Forkhead box protein N3
FOXN3
79Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049163337Y → H. Corresponds to variant dbSNP:rs1804717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001551249 – 271DPDID…IQAGF → V in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68723 mRNA Translation: AAB58252.1
AC007263 Genomic DNA Translation: AAF18259.1
AL138478 Genomic DNA No translation available.
AL356805 Genomic DNA No translation available.
AL357093 Genomic DNA No translation available.
BC007506 mRNA Translation: AAH07506.1
CCDSiCCDS32138.1 [O00409-2]
CCDS41977.1 [O00409-1]
RefSeqiNP_001078940.1, NM_001085471.1 [O00409-1]
NP_005188.2, NM_005197.3 [O00409-2]
UniGeneiHs.434286

Genome annotation databases

EnsembliENST00000261302; ENSP00000261302; ENSG00000053254 [O00409-1]
ENST00000345097; ENSP00000343288; ENSG00000053254 [O00409-1]
ENST00000555353; ENSP00000452227; ENSG00000053254 [O00409-2]
ENST00000557258; ENSP00000452005; ENSG00000053254 [O00409-2]
ENST00000615335; ENSP00000479114; ENSG00000053254 [O00409-2]
GeneIDi1112
KEGGihsa:1112
UCSCiuc001xxn.5 human [O00409-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68723 mRNA Translation: AAB58252.1
AC007263 Genomic DNA Translation: AAF18259.1
AL138478 Genomic DNA No translation available.
AL356805 Genomic DNA No translation available.
AL357093 Genomic DNA No translation available.
BC007506 mRNA Translation: AAH07506.1
CCDSiCCDS32138.1 [O00409-2]
CCDS41977.1 [O00409-1]
RefSeqiNP_001078940.1, NM_001085471.1 [O00409-1]
NP_005188.2, NM_005197.3 [O00409-2]
UniGeneiHs.434286

3D structure databases

ProteinModelPortaliO00409
SMRiO00409
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107537, 18 interactors
IntActiO00409, 9 interactors
MINTiO00409
STRINGi9606.ENSP00000261302

PTM databases

iPTMnetiO00409
PhosphoSitePlusiO00409

Polymorphism and mutation databases

BioMutaiFOXN3

Proteomic databases

EPDiO00409
MaxQBiO00409
PaxDbiO00409
PeptideAtlasiO00409
PRIDEiO00409
ProteomicsDBi47870
47871 [O00409-2]

Protocols and materials databases

DNASUi1112
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261302; ENSP00000261302; ENSG00000053254 [O00409-1]
ENST00000345097; ENSP00000343288; ENSG00000053254 [O00409-1]
ENST00000555353; ENSP00000452227; ENSG00000053254 [O00409-2]
ENST00000557258; ENSP00000452005; ENSG00000053254 [O00409-2]
ENST00000615335; ENSP00000479114; ENSG00000053254 [O00409-2]
GeneIDi1112
KEGGihsa:1112
UCSCiuc001xxn.5 human [O00409-1]

Organism-specific databases

CTDi1112
DisGeNETi1112
EuPathDBiHostDB:ENSG00000053254.15
GeneCardsiFOXN3
HGNCiHGNC:1928 FOXN3
HPAiHPA059209
MIMi602628 gene
neXtProtiNX_O00409
OpenTargetsiENSG00000053254
PharmGKBiPA26460
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00930000150842
HOGENOMiHOG000095166
HOVERGENiHBG051654
InParanoidiO00409
KOiK09407
OMAiTESEQSC
OrthoDBiEOG091G0EJR
PhylomeDBiO00409
TreeFamiTF105083

Miscellaneous databases

ChiTaRSiFOXN3 human
GeneWikiiFOXN3
GenomeRNAii1112
PROiPR:O00409
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000053254 Expressed in 247 organ(s), highest expression level in paraflocculus
CleanExiHS_FOXN3
ExpressionAtlasiO00409 baseline and differential
GenevisibleiO00409 HS

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXN3_HUMAN
AccessioniPrimary (citable) accession number: O00409
Secondary accession number(s): Q96II7, Q9UIE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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