UniProtKB - O00399 (DCTN6_HUMAN)
Protein
Dynactin subunit 6
Gene
DCTN6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- dynein complex binding Source: GO_Central
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- mitotic spindle organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | O00399 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: Dynactin subunit 6Alternative name(s): Dynactin subunit p27 Protein WS-3 |
Gene namesi | Name:DCTN6 Synonyms:WS3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104671.7 |
HGNCi | HGNC:16964, DCTN6 |
MIMi | 612963, gene |
neXtProti | NX_O00399 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- kinetochore 1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
- dynactin complex Source: GO_Central
Cytosol
- cytosol Source: Reactome
Other locations
- condensed chromosome kinetochore Source: UniProtKB-SubCell
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, KinetochorePathology & Biotechi
Organism-specific databases
DisGeNETi | 10671 |
OpenTargetsi | ENSG00000104671 |
PharmGKBi | PA134927975 |
Miscellaneous databases
Pharosi | O00399, Tdark |
Polymorphism and mutation databases
BioMutai | DCTN6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079830 | 1 – 190 | Dynactin subunit 6Add BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | Phosphothreonine; by CDK11 Publication | 1 |
Post-translational modificationi
Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O00399 |
jPOSTi | O00399 |
MassIVEi | O00399 |
MaxQBi | O00399 |
PaxDbi | O00399 |
PeptideAtlasi | O00399 |
PRIDEi | O00399 |
ProteomicsDBi | 47865 |
PTM databases
iPTMneti | O00399 |
MetOSitei | O00399 |
PhosphoSitePlusi | O00399 |
Expressioni
Tissue specificityi
Ubiquitous.
Gene expression databases
Bgeei | ENSG00000104671, Expressed in C1 segment of cervical spinal cord and 243 other tissues |
ExpressionAtlasi | O00399, baseline and differential |
Genevisiblei | O00399, HS |
Organism-specific databases
HPAi | ENSG00000104671, Low tissue specificity |
Interactioni
Subunit structurei
Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.
Interacts with PLK1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 115913, 51 interactors |
IntActi | O00399, 43 interactors |
MINTi | O00399 |
STRINGi | 9606.ENSP00000221114 |
Miscellaneous databases
RNActi | O00399, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O00399 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4042, Eukaryota |
GeneTreei | ENSGT00390000017890 |
HOGENOMi | CLU_085418_1_0_1 |
InParanoidi | O00399 |
OMAi | TIVHPKA |
OrthoDBi | 1278795at2759 |
PhylomeDBi | O00399 |
TreeFami | TF352888 |
Family and domain databases
InterProi | View protein in InterPro IPR027777, DCTN6 IPR001451, Hexapep IPR011004, Trimer_LpxA-like_sf |
PANTHERi | PTHR13072, PTHR13072, 1 hit |
Pfami | View protein in Pfam PF00132, Hexapep, 1 hit |
SUPFAMi | SSF51161, SSF51161, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O00399-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEKTQKSVK IAPGAVVCVE SEIRGDVTIG PRTVIHPKAR IIAEAGPIVI
60 70 80 90 100
GEGNLIEEQA LIINAYPDNI TPDTEDPEPK PMIIGTNNVF EVGCYSQAMK
110 120 130 140 150
MGDNNVIESK AYVGRNVILT SGCIIGACCN LNTFEVIPEN TVIYGADCLR
160 170 180 190
RVQTERPQPQ TLQLDFLMKI LPNYHHLKKT MKGSSTPVKN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFU3 | E5RFU3_HUMAN | Dynactin subunit 6 | DCTN6 | 73 | Annotation score: | ||
E5RK00 | E5RK00_HUMAN | Dynactin subunit 6 | DCTN6 | 170 | Annotation score: | ||
E5RGW9 | E5RGW9_HUMAN | Dynactin subunit 6 | DCTN6 | 46 | Annotation score: | ||
E5RIK5 | E5RIK5_HUMAN | Dynactin subunit 6 | DCTN6 | 37 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84145 mRNA Translation: BAA19984.1 CR456851 mRNA Translation: CAG33132.1 AK314128 mRNA Translation: BAG36818.1 CH471080 Genomic DNA Translation: EAW63466.1 BC013175 mRNA Translation: AAH13175.1 |
CCDSi | CCDS6076.1 |
RefSeqi | NP_006562.1, NM_006571.3 |
Genome annotation databases
Ensembli | ENST00000221114; ENSP00000221114; ENSG00000104671 |
GeneIDi | 10671 |
KEGGi | hsa:10671 |
UCSCi | uc003xhy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84145 mRNA Translation: BAA19984.1 CR456851 mRNA Translation: CAG33132.1 AK314128 mRNA Translation: BAG36818.1 CH471080 Genomic DNA Translation: EAW63466.1 BC013175 mRNA Translation: AAH13175.1 |
CCDSi | CCDS6076.1 |
RefSeqi | NP_006562.1, NM_006571.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3TV0 | X-ray | 2.15 | A/B | 1-190 | [»] | |
SMRi | O00399 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115913, 51 interactors |
IntActi | O00399, 43 interactors |
MINTi | O00399 |
STRINGi | 9606.ENSP00000221114 |
PTM databases
iPTMneti | O00399 |
MetOSitei | O00399 |
PhosphoSitePlusi | O00399 |
Polymorphism and mutation databases
BioMutai | DCTN6 |
Proteomic databases
EPDi | O00399 |
jPOSTi | O00399 |
MassIVEi | O00399 |
MaxQBi | O00399 |
PaxDbi | O00399 |
PeptideAtlasi | O00399 |
PRIDEi | O00399 |
ProteomicsDBi | 47865 |
Protocols and materials databases
Antibodypediai | 10535, 158 antibodies |
DNASUi | 10671 |
Genome annotation databases
Ensembli | ENST00000221114; ENSP00000221114; ENSG00000104671 |
GeneIDi | 10671 |
KEGGi | hsa:10671 |
UCSCi | uc003xhy.4, human |
Organism-specific databases
CTDi | 10671 |
DisGeNETi | 10671 |
EuPathDBi | HostDB:ENSG00000104671.7 |
GeneCardsi | DCTN6 |
HGNCi | HGNC:16964, DCTN6 |
HPAi | ENSG00000104671, Low tissue specificity |
MIMi | 612963, gene |
neXtProti | NX_O00399 |
OpenTargetsi | ENSG00000104671 |
PharmGKBi | PA134927975 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4042, Eukaryota |
GeneTreei | ENSGT00390000017890 |
HOGENOMi | CLU_085418_1_0_1 |
InParanoidi | O00399 |
OMAi | TIVHPKA |
OrthoDBi | 1278795at2759 |
PhylomeDBi | O00399 |
TreeFami | TF352888 |
Enzyme and pathway databases
PathwayCommonsi | O00399 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811436, COPI-independent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 10671, 632 hits in 848 CRISPR screens |
ChiTaRSi | DCTN6, human |
GenomeRNAii | 10671 |
Pharosi | O00399, Tdark |
PROi | PR:O00399 |
RNActi | O00399, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104671, Expressed in C1 segment of cervical spinal cord and 243 other tissues |
ExpressionAtlasi | O00399, baseline and differential |
Genevisiblei | O00399, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027777, DCTN6 IPR001451, Hexapep IPR011004, Trimer_LpxA-like_sf |
PANTHERi | PTHR13072, PTHR13072, 1 hit |
Pfami | View protein in Pfam PF00132, Hexapep, 1 hit |
SUPFAMi | SSF51161, SSF51161, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DCTN6_HUMAN | |
Accessioni | O00399Primary (citable) accession number: O00399 Secondary accession number(s): B2RAC1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM